Integrative Analysis of 1q23.3 Copy-Number Gain in Metastatic Urothelial Carcinoma
Purpose: Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic urothelial carcinoma treated with platinum-based chemotherapy. Experimental Design: We o...
Saved in:
| Published in | Clinical cancer research Vol. 20; no. 7; pp. 1873 - 1883 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Philadelphia, PA
American Association for Cancer Research
01.04.2014
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1078-0432 1557-3265 1557-3265 |
| DOI | 10.1158/1078-0432.CCR-13-0759 |
Cover
| Abstract | Purpose: Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic urothelial carcinoma treated with platinum-based chemotherapy.
Experimental Design: We obtained overall survival (OS) and array DNA copy-number data from patients with metastatic urothelial carcinoma in two cohorts. Associations between recurrent SCNAs and OS were determined by a Cox proportional hazard model adjusting for performance status and visceral disease. mRNA expression was evaluated for potential candidate genes by NanoString nCounter to identify transcripts from the region that are associated with copy-number gain. In addition, expression data from an independent cohort were used to identify candidate genes.
Results: Multiple areas of recurrent significant gains and losses were identified. Gain of 1q23.3 was independently associated with a shortened OS in both cohorts [adjusted HR, 2.96; 95% confidence interval (CI), 1.35–6.48; P = 0.01 and adjusted HR, 5.03; 95% CI, 1.43–17.73; P < 0.001]. The F11R, PFDN2, PPOX, USP21, and DEDD genes, all located on 1q23.3, were closely associated with poor outcome.
Conclusions: 1q23.3 copy-number gain displayed association with poor survival in two cohorts of metastatic urothelial carcinoma. The identification of the target of this copy-number gain is ongoing, and exploration of this finding in other disease states may be useful for the early identification of patients with poor-risk urothelial carcinoma. Prospective validation of the survival association is necessary to demonstrate clinical relevance. Clin Cancer Res; 20(7); 1873–83. ©2014 AACR. |
|---|---|
| AbstractList | Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic urothelial carcinoma treated with platinum-based chemotherapy.PURPOSEMetastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic urothelial carcinoma treated with platinum-based chemotherapy.We obtained overall survival (OS) and array DNA copy-number data from patients with metastatic urothelial carcinoma in two cohorts. Associations between recurrent SCNAs and OS were determined by a Cox proportional hazard model adjusting for performance status and visceral disease. mRNA expression was evaluated for potential candidate genes by NanoString nCounter to identify transcripts from the region that are associated with copy-number gain. In addition, expression data from an independent cohort were used to identify candidate genes.EXPERIMENTAL DESIGNWe obtained overall survival (OS) and array DNA copy-number data from patients with metastatic urothelial carcinoma in two cohorts. Associations between recurrent SCNAs and OS were determined by a Cox proportional hazard model adjusting for performance status and visceral disease. mRNA expression was evaluated for potential candidate genes by NanoString nCounter to identify transcripts from the region that are associated with copy-number gain. In addition, expression data from an independent cohort were used to identify candidate genes.Multiple areas of recurrent significant gains and losses were identified. Gain of 1q23.3 was independently associated with a shortened OS in both cohorts [adjusted HR, 2.96; 95% confidence interval (CI), 1.35-6.48; P = 0.01 and adjusted HR, 5.03; 95% CI, 1.43-17.73; P < 0.001]. The F11R, PFDN2, PPOX, USP21, and DEDD genes, all located on 1q23.3, were closely associated with poor outcome.RESULTSMultiple areas of recurrent significant gains and losses were identified. Gain of 1q23.3 was independently associated with a shortened OS in both cohorts [adjusted HR, 2.96; 95% confidence interval (CI), 1.35-6.48; P = 0.01 and adjusted HR, 5.03; 95% CI, 1.43-17.73; P < 0.001]. The F11R, PFDN2, PPOX, USP21, and DEDD genes, all located on 1q23.3, were closely associated with poor outcome.1q23.3 copy-number gain displayed association with poor survival in two cohorts of metastatic urothelial carcinoma. The identification of the target of this copy-number gain is ongoing, and exploration of this finding in other disease states may be useful for the early identification of patients with poor-risk urothelial carcinoma. Prospective validation of the survival association is necessary to demonstrate clinical relevance.CONCLUSIONS1q23.3 copy-number gain displayed association with poor survival in two cohorts of metastatic urothelial carcinoma. The identification of the target of this copy-number gain is ongoing, and exploration of this finding in other disease states may be useful for the early identification of patients with poor-risk urothelial carcinoma. Prospective validation of the survival association is necessary to demonstrate clinical relevance. Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic urothelial carcinoma treated with platinum-based chemotherapy. We obtained overall survival (OS) and array DNA copy-number data from patients with metastatic urothelial carcinoma in two cohorts. Associations between recurrent SCNAs and OS were determined by a Cox proportional hazard model adjusting for performance status and visceral disease. mRNA expression was evaluated for potential candidate genes by NanoString nCounter to identify transcripts from the region that are associated with copy-number gain. In addition, expression data from an independent cohort were used to identify candidate genes. Multiple areas of recurrent significant gains and losses were identified. Gain of 1q23.3 was independently associated with a shortened OS in both cohorts [adjusted HR, 2.96; 95% confidence interval (CI), 1.35-6.48; P = 0.01 and adjusted HR, 5.03; 95% CI, 1.43-17.73; P < 0.001]. The F11R, PFDN2, PPOX, USP21, and DEDD genes, all located on 1q23.3, were closely associated with poor outcome. 1q23.3 copy-number gain displayed association with poor survival in two cohorts of metastatic urothelial carcinoma. The identification of the target of this copy-number gain is ongoing, and exploration of this finding in other disease states may be useful for the early identification of patients with poor-risk urothelial carcinoma. Prospective validation of the survival association is necessary to demonstrate clinical relevance. Purpose: Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic urothelial carcinoma treated with platinum-based chemotherapy. Experimental Design: We obtained overall survival (OS) and array DNA copy-number data from patients with metastatic urothelial carcinoma in two cohorts. Associations between recurrent SCNAs and OS were determined by a Cox proportional hazard model adjusting for performance status and visceral disease. mRNA expression was evaluated for potential candidate genes by NanoString nCounter to identify transcripts from the region that are associated with copy-number gain. In addition, expression data from an independent cohort were used to identify candidate genes. Results: Multiple areas of recurrent significant gains and losses were identified. Gain of 1q23.3 was independently associated with a shortened OS in both cohorts [adjusted HR, 2.96; 95% confidence interval (CI), 1.35–6.48; P = 0.01 and adjusted HR, 5.03; 95% CI, 1.43–17.73; P < 0.001]. The F11R, PFDN2, PPOX, USP21, and DEDD genes, all located on 1q23.3, were closely associated with poor outcome. Conclusions: 1q23.3 copy-number gain displayed association with poor survival in two cohorts of metastatic urothelial carcinoma. The identification of the target of this copy-number gain is ongoing, and exploration of this finding in other disease states may be useful for the early identification of patients with poor-risk urothelial carcinoma. Prospective validation of the survival association is necessary to demonstrate clinical relevance. Clin Cancer Res; 20(7); 1873–83. ©2014 AACR. |
| Author | Gallardo, Enrique Kwiatkowski, David J. Riester, Markus O'Brien, Robert Kantoff, Philip W. Selvarajah, Shamini Rojo, Federico Choueiri, Toni K. Barletta, Justine A. Park, Rachel S. Bochner, Bernard H. Bellmunt, Joaquim Berman, David M. Michor, Franziska Guancial, Elizabeth A. Stack, Edward C. Weir, Barbara A. Schutz, Fabio A.B. Signoretti, Sabina Ligon, Azra H. Rosenberg, Jonathan E. Garcia, Denise I. Lloreta, Josep Chekaluk, Yvonne Werner, Lillian Loda, Massimo Hahn, William C. Marchionni, Luigi |
| AuthorAffiliation | 11 Translational Medicine Division, Brigham and Women’s Hospital, Boston, MA, USA 4 Dept. of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA 10 Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA 3 Dept. of Pathology, Brigham and Women’s Hospital, Boston, MA 7 Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD, USA 2 Hospital del Mar Research Institute-IMIM, Barcelona, Spain 9 Department of Pathology, Johns Hopkins University, Baltimore, MD 5 Broad Institute of Harvard and MIT, Cambridge, MA, USA 1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, MA 02215, USA 8 Hospital Parc Tauli, Sabadell, Spain 6 Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA |
| AuthorAffiliation_xml | – name: 4 Dept. of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA – name: 1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, MA 02215, USA – name: 2 Hospital del Mar Research Institute-IMIM, Barcelona, Spain – name: 3 Dept. of Pathology, Brigham and Women’s Hospital, Boston, MA – name: 9 Department of Pathology, Johns Hopkins University, Baltimore, MD – name: 10 Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA – name: 5 Broad Institute of Harvard and MIT, Cambridge, MA, USA – name: 6 Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA – name: 7 Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD, USA – name: 8 Hospital Parc Tauli, Sabadell, Spain – name: 11 Translational Medicine Division, Brigham and Women’s Hospital, Boston, MA, USA |
| Author_xml | – sequence: 1 givenname: Markus surname: Riester fullname: Riester, Markus – sequence: 2 givenname: Lillian surname: Werner fullname: Werner, Lillian – sequence: 3 givenname: Joaquim surname: Bellmunt fullname: Bellmunt, Joaquim – sequence: 4 givenname: Shamini surname: Selvarajah fullname: Selvarajah, Shamini – sequence: 5 givenname: Elizabeth A. surname: Guancial fullname: Guancial, Elizabeth A. – sequence: 6 givenname: Barbara A. surname: Weir fullname: Weir, Barbara A. – sequence: 7 givenname: Edward C. surname: Stack fullname: Stack, Edward C. – sequence: 8 givenname: Rachel S. surname: Park fullname: Park, Rachel S. – sequence: 9 givenname: Robert surname: O'Brien fullname: O'Brien, Robert – sequence: 10 givenname: Fabio A.B. surname: Schutz fullname: Schutz, Fabio A.B. – sequence: 11 givenname: Toni K. surname: Choueiri fullname: Choueiri, Toni K. – sequence: 12 givenname: Sabina surname: Signoretti fullname: Signoretti, Sabina – sequence: 13 givenname: Josep surname: Lloreta fullname: Lloreta, Josep – sequence: 14 givenname: Luigi surname: Marchionni fullname: Marchionni, Luigi – sequence: 15 givenname: Enrique surname: Gallardo fullname: Gallardo, Enrique – sequence: 16 givenname: Federico surname: Rojo fullname: Rojo, Federico – sequence: 17 givenname: Denise I. surname: Garcia fullname: Garcia, Denise I. – sequence: 18 givenname: Yvonne surname: Chekaluk fullname: Chekaluk, Yvonne – sequence: 19 givenname: David J. surname: Kwiatkowski fullname: Kwiatkowski, David J. – sequence: 20 givenname: Bernard H. surname: Bochner fullname: Bochner, Bernard H. – sequence: 21 givenname: William C. surname: Hahn fullname: Hahn, William C. – sequence: 22 givenname: Azra H. surname: Ligon fullname: Ligon, Azra H. – sequence: 23 givenname: Justine A. surname: Barletta fullname: Barletta, Justine A. – sequence: 24 givenname: Massimo surname: Loda fullname: Loda, Massimo – sequence: 25 givenname: David M. surname: Berman fullname: Berman, David M. – sequence: 26 givenname: Philip W. surname: Kantoff fullname: Kantoff, Philip W. – sequence: 27 givenname: Franziska surname: Michor fullname: Michor, Franziska – sequence: 28 givenname: Jonathan E. surname: Rosenberg fullname: Rosenberg, Jonathan E. |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28569457$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/24486590$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkd1rFDEUxYNU7If-Ccq8CL7Mmq87mUEQyqBtoSoU-xzuZLJtJJNsk9nC_vdm6LZWX4RAAud3zuXmHJODEIMl5C2jK8ag_cioamsqBV_1_VXNRE0VdC_IEQNQteANHJT3I3NIjnP-RSmTjMpX5JBL2TbQ0SNydRFme5Nwdve2Og3od9nlKq4rdsfFSlR93Ozq79tpsKk6Qxeqcr7ZGfNcLKa6TnG-td6hr3pMxoU44Wvyco0-2zf7-4Rcf_3ysz-vL3-cXfSnl7UBquZa4SjRWJBqsO0guRooM-MIKDvbSA6GFxWZss3IRzDAEBVYQWXRigvECfn8kLvZDpMdjQ1zQq83yU2Ydjqi038rwd3qm3ivRaegUaoEfNgHpHi3tXnWk8vGeo_Bxm3WDBgHgFYu6Lvns56GPH5kAd7vAcwG_TphMC7_4VpoOglLEDxwJsWck10_IYzqpVi9lKaX0nQpVjOhl2KL79M_PuOWCuKymvP_cf8GBYWoiA |
| CODEN | CCREF4 |
| CitedBy_id | crossref_primary_10_1007_s13277_015_4410_2 crossref_primary_10_1093_annonc_mdv009 crossref_primary_10_1200_JCO_23_01983 crossref_primary_10_1186_s13578_020_00446_8 crossref_primary_10_1038_cddis_2017_9 crossref_primary_10_1038_s41419_018_0523_z crossref_primary_10_1007_s10142_023_01205_x crossref_primary_10_3892_ol_2020_11597 crossref_primary_10_3390_cancers13236040 crossref_primary_10_1002_iub_2254 crossref_primary_10_3389_fonc_2021_632387 crossref_primary_10_1038_s41598_023_38923_y crossref_primary_10_1186_s12885_020_06737_0 crossref_primary_10_18632_oncotarget_3671 crossref_primary_10_3389_fimmu_2024_1430792 crossref_primary_10_1186_s13046_024_03017_8 crossref_primary_10_3892_ol_2018_9330 crossref_primary_10_1016_j_jksus_2021_101812 crossref_primary_10_3390_biomedicines10010008 crossref_primary_10_1002_jcp_28546 crossref_primary_10_1007_s13402_023_00820_x crossref_primary_10_1016_j_biopha_2019_109433 crossref_primary_10_3389_fimmu_2023_955949 crossref_primary_10_1016_j_compbiomed_2022_105727 crossref_primary_10_1371_journal_pone_0248342 crossref_primary_10_1007_s12672_024_01187_7 crossref_primary_10_1155_2017_4893921 crossref_primary_10_3390_ijms241814081 crossref_primary_10_3389_fphar_2022_944089 crossref_primary_10_3389_fphys_2017_00947 crossref_primary_10_1158_0008_5472_CAN_14_1211 crossref_primary_10_18632_aging_204753 crossref_primary_10_1158_1541_7786_MCR_18_0963 crossref_primary_10_1186_s12967_024_05186_8 crossref_primary_10_3389_fimmu_2023_1202633 crossref_primary_10_18632_aging_205166 crossref_primary_10_1097_MD_0000000000010091 crossref_primary_10_1186_s12885_015_1192_2 crossref_primary_10_18632_oncotarget_6128 crossref_primary_10_1097_MD_0000000000033536 crossref_primary_10_18632_oncotarget_9751 crossref_primary_10_1590_s1677_5538_ibju_2022_0373 crossref_primary_10_1371_journal_pone_0103325 crossref_primary_10_1038_s41585_020_00394_5 crossref_primary_10_1038_s41467_019_09878_4 crossref_primary_10_1002_path_5274 crossref_primary_10_1155_2022_6737241 crossref_primary_10_1186_s12920_023_01525_8 crossref_primary_10_3389_fimmu_2022_782982 crossref_primary_10_3389_fonc_2018_00659 crossref_primary_10_1158_1940_6207_CAPR_17_0198 |
| Cites_doi | 10.1186/1479-5876-11-182 10.1200/JCO.2009.25.4599 10.1016/j.bbrc.2009.01.100 10.1016/j.cell.2010.11.013 10.1371/journal.pone.0038863 10.1093/bioinformatics/bth418 10.1158/0008-5472.CAN-09-4213 10.1073/pnas.0611167104 10.1093/hmg/5.3.407 10.1158/1078-0432.CCR-11-0755 10.1186/gb-2011-12-4-r41 10.1038/sj.onc.1207260 10.1038/nature11404 10.1186/1476-4598-9-3 10.1093/bioinformatics/btp702 10.1245/s10434-012-2381-8 10.1371/journal.pgen.1002368 10.1186/bcr2853 10.1002/gcc.2870120309 10.1016/S0092-8674(00)81446-4 10.1016/j.ejca.2012.04.016 10.1093/nar/gkq929 10.1016/S0022-5347(17)35014-0 10.1038/nrc1299 10.1158/1078-0432.CCR-12-1807 10.1158/0008-5472.CAN-11-3832 10.1038/onc.2010.386 10.1093/emboj/17.20.5974 10.1158/1078-0432.CCR-05-0177 10.1186/1471-2407-7-73 10.1200/JCO.1992.10.7.1066 10.1038/nature08822 10.1158/0008-5472.CAN-08-4405 10.1016/j.cell.2009.04.042 10.1101/gad.1609708 10.1038/sj.onc.1204989 10.1158/1078-0432.CCR-11-2271 10.5603/FHC.2011.0005 10.1186/1475-9268-4-1 10.1016/S0002-9440(10)65750-1 10.1038/sj.onc.1206099 10.1200/JCO.1999.17.10.3173 10.3322/caac.21166 10.1111/j.2517-6161.1995.tb02031.x 10.1200/JCO.2005.03.2375 |
| ContentType | Journal Article |
| Copyright | 2015 INIST-CNRS 2014 AACR. |
| Copyright_xml | – notice: 2015 INIST-CNRS – notice: 2014 AACR. |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1158/1078-0432.CCR-13-0759 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1557-3265 |
| EndPage | 1883 |
| ExternalDocumentID | PMC3975677 24486590 28569457 10_1158_1078_0432_CCR_13_0759 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: U54 CA143798 – fundername: NCI NIH HHS grantid: R21 CA164613-01 – fundername: NCI NIH HHS grantid: R21 CA164613 – fundername: NCI NIH HHS grantid: P30 CA008748 – fundername: NCI NIH HHS grantid: U54CA1437980 |
| GroupedDBID | --- 18M 29B 2FS 2WC 34G 39C 53G 5GY 5RE 5VS 6J9 AAFWJ AAJMC AAYXX ABOCM ACGFO ACIWK ACPRK ACSVP ADBBV ADCOW ADNWM AENEX AFHIN AFOSN AFRAH AFUMD ALMA_UNASSIGNED_HOLDINGS BAWUL BR6 BTFSW CITATION CS3 DIK DU5 E3Z EBS EJD F5P FRP GX1 H13 IH2 KQ8 L7B LSO OK1 P0W P2P QTD RCR RHI RNS SJN TR2 W2D W8F WOQ YKV .55 .GJ 1CY 3O- 4H- AETEA AFFNX AI. C1A H~9 IQODW J5H MVM OHT UDS VH1 WHG X7M XJT ZCG ZGI CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c507t-7ad4ace547be8b427b01cdd5a49e6425c2acea17e6d2d5c51aa75e304425e5453 |
| ISSN | 1078-0432 1557-3265 |
| IngestDate | Thu Aug 21 18:32:38 EDT 2025 Thu Sep 04 19:59:37 EDT 2025 Thu Apr 03 07:05:24 EDT 2025 Wed Apr 02 07:20:31 EDT 2025 Tue Jul 01 03:06:49 EDT 2025 Thu Apr 24 23:11:17 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Keywords | Advanced stage Malignant tumor Transitional cell carcinoma Metastasis Copy number Cancer |
| Language | English |
| License | CC BY 4.0 2014 AACR. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c507t-7ad4ace547be8b427b01cdd5a49e6425c2acea17e6d2d5c51aa75e304425e5453 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/3975677 |
| PMID | 24486590 |
| PQID | 1512555847 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3975677 proquest_miscellaneous_1512555847 pubmed_primary_24486590 pascalfrancis_primary_28569457 crossref_primary_10_1158_1078_0432_CCR_13_0759 crossref_citationtrail_10_1158_1078_0432_CCR_13_0759 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2014-04-01 |
| PublicationDateYYYYMMDD | 2014-04-01 |
| PublicationDate_xml | – month: 04 year: 2014 text: 2014-04-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Philadelphia, PA |
| PublicationPlace_xml | – name: Philadelphia, PA – name: United States |
| PublicationTitle | Clinical cancer research |
| PublicationTitleAlternate | Clin Cancer Res |
| PublicationYear | 2014 |
| Publisher | American Association for Cancer Research |
| Publisher_xml | – name: American Association for Cancer Research |
| References | Benjamini (2022061113151188500_bib18) 1995; 57 Sowa (2022061113151188500_bib31) 2009; 138 Takano (2022061113151188500_bib44) 2009; 69 Salari (2022061113151188500_bib19) 2010; 26 Vainberg (2022061113151188500_bib34) 1998; 93 Forbes (2022061113151188500_bib42) 2011; 39 Nakagawa (2022061113151188500_bib33) 2008; 22 Fadl-Elmula (2022061113151188500_bib20) 2005; 4 Hurst (2022061113151188500_bib10) 2012; 18 Hupe (2022061113151188500_bib16) 2004; 20 Riester (2022061113151188500_bib12) 2012; 18 Gutwein (2022061113151188500_bib37) 2009; 380 Loehrer (2022061113151188500_bib2) 1992; 10 Stegh (2022061113151188500_bib28) 1998; 17 Lopez (2022061113151188500_bib35) 2013; 11 Deybach (2022061113151188500_bib30) 1996; 5 Mermel (2022061113151188500_bib17) 2011; 12 Siegel (2022061113151188500_bib1) 2013; 63 Chen (2022061113151188500_bib46) 2001; 20 Magnani (2022061113151188500_bib47) 2011; 7 Hammerman (2022061113151188500_bib43) 2012; 489 Wang (2022061113151188500_bib13) 2009; 69 Lindgren (2022061113151188500_bib23) 2010; 70 Lv (2022061113151188500_bib29) 2012; 72 Fong (2022061113151188500_bib36) 2012; 19 Athanassiadou (2022061113151188500_bib45) 2011; 49 Bajorin (2022061113151188500_bib3) 1999; 17 Sandberg (2022061113151188500_bib8) 1994; 151 Beroukhim (2022061113151188500_bib24) 2010; 463 Bellmunt (2022061113151188500_bib4) 2010; 28 Sanchez-Carbayo (2022061113151188500_bib15) 2006; 24 Hassounah (2022061113151188500_bib32) 2012; 18 Blaveri (2022061113151188500_bib11) 2005; 11 Gotte (2022061113151188500_bib39) 2010; 29 Alcivar (2022061113151188500_bib26) 2003; 22 McSherry (2022061113151188500_bib38) 2011; 13 Lindgren (2022061113151188500_bib22) 2012; 7 Wang (2022061113151188500_bib40) 2012; 48 Kallioniemi (2022061113151188500_bib6) 1995; 12 Richter (2022061113151188500_bib7) 1998; 153 Fabre-Lafay (2022061113151188500_bib41) 2007; 7 Knowles (2022061113151188500_bib21) 1994; 54 Kim (2022061113151188500_bib14) 2010; 9 Hurst (2022061113151188500_bib5) 2004; 23 Arai (2022061113151188500_bib27) 2007; 104 Hoglund (2022061113151188500_bib9) 2001; 61 Futreal (2022061113151188500_bib48) 2004; 4 Akavia (2022061113151188500_bib25) 2010; 143 |
| References_xml | – volume: 11 start-page: 182 year: 2013 ident: 2022061113151188500_bib35 article-title: Identification of prefoldin amplification (1q23.3-q24.1) in bladder cancer using comparative genomic hybridization (CGH) arrays of urinary DNA publication-title: J Transl Med doi: 10.1186/1479-5876-11-182 – volume: 28 start-page: 1850 year: 2010 ident: 2022061113151188500_bib4 article-title: Prognostic factors in patients with advanced transitional cell carcinoma of the urothelial tract experiencing treatment failure with platinum-containing regimens publication-title: J Clin Oncol doi: 10.1200/JCO.2009.25.4599 – volume: 380 start-page: 387 year: 2009 ident: 2022061113151188500_bib37 article-title: Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2009.01.100 – volume: 143 start-page: 1005 year: 2010 ident: 2022061113151188500_bib25 article-title: An integrated approach to uncover drivers of cancer publication-title: Cell doi: 10.1016/j.cell.2010.11.013 – volume: 7 start-page: e38863 year: 2012 ident: 2022061113151188500_bib22 article-title: Integrated genomic and gene expression profiling identifies two major genomic circuits in urothelial carcinoma publication-title: PLoS ONE doi: 10.1371/journal.pone.0038863 – volume: 20 start-page: 3413 year: 2004 ident: 2022061113151188500_bib16 article-title: Analysis of array CGH data: from signal ratio to gain and loss of DNA regions publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth418 – volume: 70 start-page: 3463 year: 2010 ident: 2022061113151188500_bib23 article-title: Combined gene expression and genomic profiling define two intrinsic molecular subtypes of urothelial carcinoma and gene signatures for molecular grading and outcome publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-09-4213 – volume: 104 start-page: 2289 year: 2007 ident: 2022061113151188500_bib27 article-title: Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0611167104 – volume: 5 start-page: 407 year: 1996 ident: 2022061113151188500_bib30 article-title: Mutations in the protoporphyrinogen oxidase gene in patients with variegate porphyria publication-title: Hum Mol Genet doi: 10.1093/hmg/5.3.407 – volume: 18 start-page: 2429 year: 2012 ident: 2022061113151188500_bib32 article-title: Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on Hedgehog signaling publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-11-0755 – volume: 61 start-page: 8241 year: 2001 ident: 2022061113151188500_bib9 article-title: Identification of cytogenetic subgroups and karyotypic pathways in transitional cell carcinoma publication-title: Cancer Res – volume: 12 start-page: R41 year: 2011 ident: 2022061113151188500_bib17 article-title: GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers publication-title: Genome Biol doi: 10.1186/gb-2011-12-4-r41 – volume: 23 start-page: 2250 year: 2004 ident: 2022061113151188500_bib5 article-title: High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization publication-title: Oncogene doi: 10.1038/sj.onc.1207260 – volume: 489 start-page: 519 year: 2012 ident: 2022061113151188500_bib43 article-title: Comprehensive genomic characterization of squamous cell lung cancers publication-title: Nature doi: 10.1038/nature11404 – volume: 9 start-page: 3 year: 2010 ident: 2022061113151188500_bib14 article-title: Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer publication-title: Mol Cancer doi: 10.1186/1476-4598-9-3 – volume: 26 start-page: 414 year: 2010 ident: 2022061113151188500_bib19 article-title: DR-Integrator: a new analytic tool for integrating DNA copy number and gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp702 – volume: 19 start-page: 4330 year: 2012 ident: 2022061113151188500_bib36 article-title: Low expression of junctional adhesion molecule A is associated with metastasis and poor survival in pancreatic cancer publication-title: Ann Surg Oncol doi: 10.1245/s10434-012-2381-8 – volume: 7 start-page: e1002368 year: 2011 ident: 2022061113151188500_bib47 article-title: PBX1 genomic pioneer function drives ERalpha signaling underlying progression in breast cancer publication-title: PLoS Genet doi: 10.1371/journal.pgen.1002368 – volume: 13 start-page: R31 year: 2011 ident: 2022061113151188500_bib38 article-title: Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase publication-title: Breast Cancer Res doi: 10.1186/bcr2853 – volume: 12 start-page: 213 year: 1995 ident: 2022061113151188500_bib6 article-title: Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization publication-title: Genes Chromosomes Cancer doi: 10.1002/gcc.2870120309 – volume: 93 start-page: 863 year: 1998 ident: 2022061113151188500_bib34 article-title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin publication-title: Cell doi: 10.1016/S0092-8674(00)81446-4 – volume: 54 start-page: 531 year: 1994 ident: 2022061113151188500_bib21 article-title: Allelotype of human bladder cancer publication-title: Cancer Res – volume: 48 start-page: 3475 year: 2012 ident: 2022061113151188500_bib40 article-title: Transforming growth factor-beta1 attenuates junctional adhesion molecule-A and contributes to breast cancer cell invasion publication-title: Eur J Cancer doi: 10.1016/j.ejca.2012.04.016 – volume: 39 start-page: D945 year: 2011 ident: 2022061113151188500_bib42 article-title: COSMIC: mining complete cancer genomes in the catalogue of somatic mutations in cancer publication-title: Nucleic Acids Res doi: 10.1093/nar/gkq929 – volume: 151 start-page: 545 year: 1994 ident: 2022061113151188500_bib8 article-title: Review of chromosome studies in urological tumors. II. Cytogenetics and molecular genetics of bladder cancer publication-title: J Urol doi: 10.1016/S0022-5347(17)35014-0 – volume: 4 start-page: 177 year: 2004 ident: 2022061113151188500_bib48 article-title: A census of human cancer genes publication-title: Nat Rev Cancer doi: 10.1038/nrc1299 – volume: 18 start-page: 5865 year: 2012 ident: 2022061113151188500_bib10 article-title: Novel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-12-1807 – volume: 72 start-page: 3238 year: 2012 ident: 2022061113151188500_bib29 article-title: DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-3832 – volume: 29 start-page: 6569 year: 2010 ident: 2022061113151188500_bib39 article-title: miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness publication-title: Oncogene doi: 10.1038/onc.2010.386 – volume: 17 start-page: 5974 year: 1998 ident: 2022061113151188500_bib28 article-title: DEDD, a novel death effector domain-containing protein, targeted to the nucleolus publication-title: EMBO J doi: 10.1093/emboj/17.20.5974 – volume: 69 start-page: 6694 year: 2009 ident: 2022061113151188500_bib44 article-title: Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Cancer research – volume: 11 start-page: 7012 year: 2005 ident: 2022061113151188500_bib11 article-title: Bladder cancer stage and outcome by array-based comparative genomic hybridization publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-05-0177 – volume: 7 start-page: 73 year: 2007 ident: 2022061113151188500_bib41 article-title: Nectin-4 is a new histological and serological tumor associated marker for breast cancer publication-title: BMC Cancer doi: 10.1186/1471-2407-7-73 – volume: 10 start-page: 1066 year: 1992 ident: 2022061113151188500_bib2 article-title: A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study publication-title: J Clin Oncol doi: 10.1200/JCO.1992.10.7.1066 – volume: 463 start-page: 899 year: 2010 ident: 2022061113151188500_bib24 article-title: The landscape of somatic copy-number alteration across human cancers publication-title: Nature doi: 10.1038/nature08822 – volume: 69 start-page: 3810 year: 2009 ident: 2022061113151188500_bib13 article-title: Development of a multiplex quantitative PCR signature to predict progression in non-muscle-invasive bladder cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-4405 – volume: 138 start-page: 389 year: 2009 ident: 2022061113151188500_bib31 article-title: Defining the human deubiquitinating enzyme interaction landscape publication-title: Cell doi: 10.1016/j.cell.2009.04.042 – volume: 22 start-page: 37 year: 2008 ident: 2022061113151188500_bib33 article-title: Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation publication-title: Genes Dev doi: 10.1101/gad.1609708 – volume: 20 start-page: 7686 year: 2001 ident: 2022061113151188500_bib46 article-title: Deregulation of FCGR2B expression by 1q21 rearrangements in follicular lymphomas publication-title: Oncogene doi: 10.1038/sj.onc.1204989 – volume: 18 start-page: 1323 year: 2012 ident: 2022061113151188500_bib12 article-title: Combination of a novel gene expression signature with a clinical nomogram improves the prediction of survival in high-risk bladder cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-11-2271 – volume: 49 start-page: 26 year: 2011 ident: 2022061113151188500_bib45 article-title: The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma publication-title: Folia Histochem Cytobiol doi: 10.5603/FHC.2011.0005 – volume: 4 start-page: 1 year: 2005 ident: 2022061113151188500_bib20 article-title: Chromosomal changes in uroepithelial carcinomas publication-title: Cell Chromosome doi: 10.1186/1475-9268-4-1 – volume: 153 start-page: 1615 year: 1998 ident: 2022061113151188500_bib7 article-title: Patterns of chromosomal imbalances in advanced urinary bladder cancer detected by comparative genomic hybridization publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)65750-1 – volume: 22 start-page: 291 year: 2003 ident: 2022061113151188500_bib26 article-title: DEDD and DEDD2 associate with caspase-8/10 and signal cell death publication-title: Oncogene doi: 10.1038/sj.onc.1206099 – volume: 17 start-page: 3173 year: 1999 ident: 2022061113151188500_bib3 article-title: Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy publication-title: J Clin Oncol doi: 10.1200/JCO.1999.17.10.3173 – volume: 63 start-page: 11 year: 2013 ident: 2022061113151188500_bib1 article-title: Cancer statistics, 2013 publication-title: CA Cancer J Clin doi: 10.3322/caac.21166 – volume: 57 start-page: 289 year: 1995 ident: 2022061113151188500_bib18 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J R Stat Soc B doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 24 start-page: 778 year: 2006 ident: 2022061113151188500_bib15 article-title: Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays publication-title: J Clin Oncol doi: 10.1200/JCO.2005.03.2375 |
| SSID | ssj0014104 |
| Score | 2.3878515 |
| Snippet | Purpose: Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify... Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1873 |
| SubjectTerms | Adult Aged Antineoplastic agents Biological and medical sciences Chromosomes, Human, Pair 1 - genetics Disease-Free Survival DNA Copy Number Variations - genetics Female Humans Male Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pharmacology. Drug treatments Prognosis Proportional Hazards Models Prospective Studies Tumors Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urologic Neoplasms - genetics Urologic Neoplasms - pathology |
| Title | Integrative Analysis of 1q23.3 Copy-Number Gain in Metastatic Urothelial Carcinoma |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24486590 https://www.proquest.com/docview/1512555847 https://pubmed.ncbi.nlm.nih.gov/PMC3975677 |
| Volume | 20 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ta9swEBZZB2Mwxt6XvRQP9i04i2zJUj6OsNF2yxhZy_rNyLLSeiR2msaD7tfvzlIUpwtsKwQTLMs2fh6fTyfdc4S8TYbZUEotwfpFLGQiUmE21TSUTMZKwSuimhnd8Zfk4IQdnfLTTueqtWqpXmV9_WtnXslNUIV9gCtmyf4Hsv6ksAP-A76wBYRh-08YHzqtB1z9o1rqIvQiivtxT1eLq54t-dE7U0WzpnFuVgqTiArdq5eYfTXDkLnGikJl5Wz0WrhgnTSpkRnLntMF8vHjSeHLemDGT-298-9m6dJoPjfRHM8_TAaaO6WDo0pd1MXcR3jM7Kdaqh-qCfN8O1eoedIOSdD2ShZrRQco28viLTMbDVp0Ei2bSaUtZuK-v1TayjZ_2nYumzCDO3d_NJqEWJpCWEnxFt6LeQM4eC4y4bYa6TVR7a_jEThiPBHiFrkdCXC70J8-_OQnoBhtKk_6q7nkL7iHdzvvAEWl3eW2PJx7C3UJSE1tlZRdw5jrq3Fb7s3xA3LfjUuC95ZkD0nHlI_InbFbefGYTFpcC9ZcC6ppYLkWINcCy7UAuRbAb8O1YMO1wHPtCTn5-OF4dBC6ehyhhlHDKhQqZ0obzkRmZMYikQ2oznOu2NDAMJbrCFoVFSbJo5xrTpUS3MQDBm3Qi8dPyV5ZleY5CeIpZTnTGpx5DZ_qOMsEyyKjGc1oPhywLmHrZ5hqJ1aPNVNmaTNo5TJFFFJEIQUUUhqniEKX9H23hVVr-VuH_S2AfK9I8mTIuOiSN2vEUjC8OJumSlPVlym6yiiWx-CYZxbBTW9HhS4RW9j6A1DUfbulLM4bcXdHyxc37vmS3N28k6_I3mpZm9fgOK-y_YbivwGwL8Go |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Integrative+analysis+of+1q23.3+copy+number+gain+in+metastatic+urothelial+carcinoma&rft.jtitle=Clinical+cancer+research&rft.au=Riester%2C+Markus&rft.au=Werner%2C+Lillian&rft.au=Bellmunt%2C+Joaquim&rft.au=Selvarajah%2C+Shamini&rft.date=2014-04-01&rft.issn=1078-0432&rft.volume=20&rft.issue=7&rft.spage=1873&rft.epage=1883&rft_id=info:doi/10.1158%2F1078-0432.CCR-13-0759&rft_id=info%3Apmid%2F24486590&rft.externalDocID=PMC3975677 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1078-0432&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1078-0432&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1078-0432&client=summon |