Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis - Brown, Victoria A.; Patel, Ketan R.; Viskaduraki, Maria; Crowell, James A.; Perloff, Marjorie; Booth, Tristan D.; Vasilinin, Grygoriy; Sen, Ananda; Schinas, Anna Maria; Piccirilli, Gianfranca; Brown, Karen; Steward, William P.; et al. (Cancer research (Chicago, Ill.), 2010)
Keywords: Abdominal Pain - chemically induced; Adult; Antineoplastic agents; Antineoplastic Agents, Phytogenic - adverse effects; Antineoplastic Agents, Phytogenic - metabolism; Antineoplastic Agents, Phytogenic - pharmacokinetics; Area Under Curve; Biological and medical sciences; Chromatography, High Pressure Liquid; Diarrhea - chemically induced; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glucuronides - blood; Glucuronides - metabolism; Humans; Insulin-Like Growth Factor Binding Protein 3 - blood; Insulin-Like Growth Factor I - metabolism; Medical sciences; Metabolic Clearance Rate; Middle Aged; Nausea - chemically induced; Pharmacology. Drug treatments; Resveratrol; Stilbenes - adverse effects; Stilbenes - blood; Stilbenes - metabolism; Stilbenes - pharmacokinetics; Tumors; Young Adult; Human; Healthy subject; Toxicity; Anticarcinogen; Stilbene derivatives; Multiple dose; Insulin like growth factor; Polyphenol; Phytoalexin; Resveratrol; Phenols; Safety; Pharmacokinetics