Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma
Whether microbiome characteristics of induced sputum or oral samples demonstrate unique relationships to features of atopy or mild asthma in adults is unknown. We sought to determine sputum and oral microbiota relationships to clinical or immunologic features in mild atopic asthma and the impact on...
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| Published in | Journal of allergy and clinical immunology Vol. 146; no. 5; pp. 1016 - 1026 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.11.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0091-6749 1097-6825 1097-6825 |
| DOI | 10.1016/j.jaci.2020.03.028 |
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| Abstract | Whether microbiome characteristics of induced sputum or oral samples demonstrate unique relationships to features of atopy or mild asthma in adults is unknown.
We sought to determine sputum and oral microbiota relationships to clinical or immunologic features in mild atopic asthma and the impact on the microbiota of inhaled corticosteroid (ICS) treatment administered to ICS-naive subjects with asthma.
Bacterial microbiota profiles were analyzed in induced sputum and oral wash samples from 32 subjects with mild atopic asthma before and after inhaled fluticasone treatment, 18 atopic subjects without asthma, and 16 nonatopic healthy subjects in a multicenter study (NCT01537133). Associations with clinical and immunologic features were examined, including markers of atopy, type 2 inflammation, immune cell populations, and cytokines.
Sputum bacterial burden inversely associated with bronchial expression of type 2 (T2)-related genes. Differences in specific sputum microbiota also associated with T2-low asthma phenotype, a subgroup of whom displayed elevations in lung inflammatory mediators and reduced sputum bacterial diversity. Differences in specific oral microbiota were more reflective of atopic status. After ICS treatment of patients with asthma, the compositional structure of sputum microbiota showed greater deviation from baseline in ICS nonresponders than in ICS responders.
Novel associations of sputum and oral microbiota to immunologic features were observed in this cohort of subjects with or without ICS-naive mild asthma. These findings confirm and extend our previous report of reduced bronchial bacterial burden and compositional complexity in subjects with T2-high asthma, with additional identification of a T2-low subgroup with a distinct microbiota-immunologic relationship.
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| AbstractList | Whether microbiome characteristics of induced sputum or oral samples demonstrate unique relationships to features of atopy or mild asthma in adults is unknown.
We sought to determine sputum and oral microbiota relationships to clinical or immunologic features in mild atopic asthma and the impact on the microbiota of inhaled corticosteroid (ICS) treatment administered to ICS-naive subjects with asthma.
Bacterial microbiota profiles were analyzed in induced sputum and oral wash samples from 32 subjects with mild atopic asthma before and after inhaled fluticasone treatment, 18 atopic subjects without asthma, and 16 nonatopic healthy subjects in a multicenter study (NCT01537133). Associations with clinical and immunologic features were examined, including markers of atopy, type 2 inflammation, immune cell populations, and cytokines.
Sputum bacterial burden inversely associated with bronchial expression of type 2 (T2)-related genes. Differences in specific sputum microbiota also associated with T2-low asthma phenotype, a subgroup of whom displayed elevations in lung inflammatory mediators and reduced sputum bacterial diversity. Differences in specific oral microbiota were more reflective of atopic status. After ICS treatment of patients with asthma, the compositional structure of sputum microbiota showed greater deviation from baseline in ICS nonresponders than in ICS responders.
Novel associations of sputum and oral microbiota to immunologic features were observed in this cohort of subjects with or without ICS-naive mild asthma. These findings confirm and extend our previous report of reduced bronchial bacterial burden and compositional complexity in subjects with T2-high asthma, with additional identification of a T2-low subgroup with a distinct microbiota-immunologic relationship.
[Display omitted] Whether microbiome characteristics of induced sputum or oral samples demonstrate unique relationships to features of atopy or mild asthma in adults is unknown. We sought to determine sputum and oral microbiota relationships to clinical or immunologic features in mild atopic asthma and the impact on the microbiota of inhaled corticosteroid (ICS) treatment administered to ICS-naive subjects with asthma. Bacterial microbiota profiles were analyzed in induced sputum and oral wash samples from 32 subjects with mild atopic asthma before and after inhaled fluticasone treatment, 18 atopic subjects without asthma, and 16 nonatopic healthy subjects in a multicenter study (NCT01537133). Associations with clinical and immunologic features were examined, including markers of atopy, type 2 inflammation, immune cell populations, and cytokines. Sputum bacterial burden inversely associated with bronchial expression of type 2 (T2)-related genes. Differences in specific sputum microbiota also associated with T2-low asthma phenotype, a subgroup of whom displayed elevations in lung inflammatory mediators and reduced sputum bacterial diversity. Differences in specific oral microbiota were more reflective of atopic status. After ICS treatment of patients with asthma, the compositional structure of sputum microbiota showed greater deviation from baseline in ICS nonresponders than in ICS responders. Novel associations of sputum and oral microbiota to immunologic features were observed in this cohort of subjects with or without ICS-naive mild asthma. These findings confirm and extend our previous report of reduced bronchial bacterial burden and compositional complexity in subjects with T2-high asthma, with additional identification of a T2-low subgroup with a distinct microbiota-immunologic relationship. In mild atopic asthma, sputum bacterial microbiome characteristics associate with several immunologic features, including type 2-low airway inflammation, and display differential changes related to response to inhaled corticosteroid treatment. Whether microbiome characteristics of induced sputum or oral samples demonstrate unique relationships to features of atopy or mild asthma in adults is unknown.BACKGROUNDWhether microbiome characteristics of induced sputum or oral samples demonstrate unique relationships to features of atopy or mild asthma in adults is unknown.We sought to determine sputum and oral microbiota relationships to clinical or immunologic features in mild atopic asthma and the impact on the microbiota of inhaled corticosteroid (ICS) treatment administered to ICS-naive subjects with asthma.OBJECTIVEWe sought to determine sputum and oral microbiota relationships to clinical or immunologic features in mild atopic asthma and the impact on the microbiota of inhaled corticosteroid (ICS) treatment administered to ICS-naive subjects with asthma.Bacterial microbiota profiles were analyzed in induced sputum and oral wash samples from 32 subjects with mild atopic asthma before and after inhaled fluticasone treatment, 18 atopic subjects without asthma, and 16 nonatopic healthy subjects in a multicenter study (NCT01537133). Associations with clinical and immunologic features were examined, including markers of atopy, type 2 inflammation, immune cell populations, and cytokines.METHODSBacterial microbiota profiles were analyzed in induced sputum and oral wash samples from 32 subjects with mild atopic asthma before and after inhaled fluticasone treatment, 18 atopic subjects without asthma, and 16 nonatopic healthy subjects in a multicenter study (NCT01537133). Associations with clinical and immunologic features were examined, including markers of atopy, type 2 inflammation, immune cell populations, and cytokines.Sputum bacterial burden inversely associated with bronchial expression of type 2 (T2)-related genes. Differences in specific sputum microbiota also associated with T2-low asthma phenotype, a subgroup of whom displayed elevations in lung inflammatory mediators and reduced sputum bacterial diversity. Differences in specific oral microbiota were more reflective of atopic status. After ICS treatment of patients with asthma, the compositional structure of sputum microbiota showed greater deviation from baseline in ICS nonresponders than in ICS responders.RESULTSSputum bacterial burden inversely associated with bronchial expression of type 2 (T2)-related genes. Differences in specific sputum microbiota also associated with T2-low asthma phenotype, a subgroup of whom displayed elevations in lung inflammatory mediators and reduced sputum bacterial diversity. Differences in specific oral microbiota were more reflective of atopic status. After ICS treatment of patients with asthma, the compositional structure of sputum microbiota showed greater deviation from baseline in ICS nonresponders than in ICS responders.Novel associations of sputum and oral microbiota to immunologic features were observed in this cohort of subjects with or without ICS-naive mild asthma. These findings confirm and extend our previous report of reduced bronchial bacterial burden and compositional complexity in subjects with T2-high asthma, with additional identification of a T2-low subgroup with a distinct microbiota-immunologic relationship.CONCLUSIONSNovel associations of sputum and oral microbiota to immunologic features were observed in this cohort of subjects with or without ICS-naive mild asthma. These findings confirm and extend our previous report of reduced bronchial bacterial burden and compositional complexity in subjects with T2-high asthma, with additional identification of a T2-low subgroup with a distinct microbiota-immunologic relationship. |
| Author | Durack, Juliana Beigelman, Avraham Wenzel, Sally E. Dyer, Anne-Marie Castro, Mario Huang, Yvonne J. Gonzalez, Jeanmarie Israel, Elliot Boushey, Homer A. Christian, Laura S. Ansel, K. Mark Peters, Stephen P. Kraft, Monica Martin, Richard J. Nariya, Snehal White, Steven R. Wechsler, Michael E. Rosenberg, Sharon R. Lynch, Susan V. Sorkness, Christine A. Mauger, David T. Bhakta, Nirav R. |
| AuthorAffiliation | 12 Wake Forest School of Medicine, Winston-Salem, NC 11 National Jewish Hospital, Dept. of Medicine, Denver, CO 4 University of California, Dept. Microbiology & Immunology and Sandler Asthma Basic Research Center, San Francisco, CA 9 Brigham & Women’s Hospital, Dept. of Medicine, Boston, MA 2 University of Michigan, Dept. of Internal Medicine, Division of Pulmonary/Critical Care Medicine, Ann Arbor, MI 5 Washington University School of Medicine, Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, St Louis, MO 7 Washington University School of Medicine, Division of Pulmonary and Critical Care Medicine, St Louis, MO 16 University of Chicago, Dept. of Medicine, Chicago, IL 15 University of Pittsburgh Asthma Institute at UPMC/UPSOM, Pittsburgh, PA 1 University of California, Dept. of Medicine, Division of Gastroenterology, San Francisco, CA 10 University of Arizona, Health Sciences, Tucson, AZ 8 Penn State University, Dept. of Public Health Sciences, Hershey, PA Juliana Durack, PhD, is |
| AuthorAffiliation_xml | – name: 3 University of California, Dept. of Medicine, Division of Pulmonary/Critical Care Medicine, San Francisco, CA – name: 6 The Kipper Institute of Allergy and Immunology. Schneider Children’s Medical Center of Israel, Tel Aviv University, Israel – name: 10 University of Arizona, Health Sciences, Tucson, AZ – name: 7 Washington University School of Medicine, Division of Pulmonary and Critical Care Medicine, St Louis, MO – name: 2 University of Michigan, Dept. of Internal Medicine, Division of Pulmonary/Critical Care Medicine, Ann Arbor, MI – name: 5 Washington University School of Medicine, Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, St Louis, MO – name: 16 University of Chicago, Dept. of Medicine, Chicago, IL – name: 12 Wake Forest School of Medicine, Winston-Salem, NC – name: 8 Penn State University, Dept. of Public Health Sciences, Hershey, PA – name: 11 National Jewish Hospital, Dept. of Medicine, Denver, CO – name: 1 University of California, Dept. of Medicine, Division of Gastroenterology, San Francisco, CA – name: Juliana Durack, PhD, is currently affiliated with Symbiome Inc, San Francisco, CA – name: 15 University of Pittsburgh Asthma Institute at UPMC/UPSOM, Pittsburgh, PA – name: 13 Northwestern University, Dept. of Medicine, Chicago, IL – name: 4 University of California, Dept. Microbiology & Immunology and Sandler Asthma Basic Research Center, San Francisco, CA – name: 9 Brigham & Women’s Hospital, Dept. of Medicine, Boston, MA – name: 14 University of Wisconsin-Madison, Dept. of Medicine, Madison, WI |
| Author_xml | – sequence: 1 givenname: Juliana surname: Durack fullname: Durack, Juliana organization: Department of Medicine, Division of Gastroenterology, University of California, San Francisco, Calif – sequence: 2 givenname: Laura S. surname: Christian fullname: Christian, Laura S. organization: Department of Microbiology & Immunology and Sandler Asthma Basic Research Center, San Francisco, Calif – sequence: 3 givenname: Snehal surname: Nariya fullname: Nariya, Snehal organization: Department of Medicine, Division of Pulmonary/Critical Care Medicine, University of California, San Francisco, Calif – sequence: 4 givenname: Jeanmarie surname: Gonzalez fullname: Gonzalez, Jeanmarie organization: Department of Microbiology & Immunology and Sandler Asthma Basic Research Center, San Francisco, Calif – sequence: 5 givenname: Nirav R. surname: Bhakta fullname: Bhakta, Nirav R. organization: Department of Medicine, Division of Pulmonary/Critical Care Medicine, University of California, San Francisco, Calif – sequence: 6 givenname: K. Mark surname: Ansel fullname: Ansel, K. Mark organization: Department of Microbiology & Immunology and Sandler Asthma Basic Research Center, San Francisco, Calif – sequence: 7 givenname: Avraham surname: Beigelman fullname: Beigelman, Avraham organization: Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, Washington University School of Medicine, St Louis, Mo – sequence: 8 givenname: Mario surname: Castro fullname: Castro, Mario organization: Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Mo – sequence: 9 givenname: Anne-Marie surname: Dyer fullname: Dyer, Anne-Marie organization: Department of Public Health Sciences, Penn State University, Hershey, Pa – sequence: 10 givenname: Elliot surname: Israel fullname: Israel, Elliot organization: Department of Medicine, Brigham & Women’s Hospital, Boston, Mass – sequence: 11 givenname: Monica surname: Kraft fullname: Kraft, Monica organization: University of Arizona, Health Sciences, Tucson, Ariz – sequence: 12 givenname: Richard J. surname: Martin fullname: Martin, Richard J. organization: Department of Medicine, National Jewish Hospital, Denver, Colo – sequence: 13 givenname: David T. surname: Mauger fullname: Mauger, David T. organization: Department of Public Health Sciences, Penn State University, Hershey, Pa – sequence: 14 givenname: Stephen P. surname: Peters fullname: Peters, Stephen P. organization: Wake Forest School of Medicine, Winston-Salem, NC – sequence: 15 givenname: Sharon R. surname: Rosenberg fullname: Rosenberg, Sharon R. organization: Department of Medicine, Northwestern University, Chicago, Ill – sequence: 16 givenname: Christine A. surname: Sorkness fullname: Sorkness, Christine A. organization: Department of Medicine, University of Wisconsin-Madison, Madison, Wis – sequence: 17 givenname: Michael E. surname: Wechsler fullname: Wechsler, Michael E. organization: Department of Medicine, National Jewish Hospital, Denver, Colo – sequence: 18 givenname: Sally E. surname: Wenzel fullname: Wenzel, Sally E. organization: University of Pittsburgh Asthma Institute at UPMC/UPSOM, Pittsburgh, Pa – sequence: 19 givenname: Steven R. surname: White fullname: White, Steven R. organization: Department of Medicine, University of Chicago, Chicago, Ill – sequence: 20 givenname: Susan V. surname: Lynch fullname: Lynch, Susan V. organization: Department of Medicine, Division of Gastroenterology, University of California, San Francisco, Calif – sequence: 21 givenname: Homer A. surname: Boushey fullname: Boushey, Homer A. organization: Department of Medicine, Division of Pulmonary/Critical Care Medicine, University of California, San Francisco, Calif – sequence: 22 givenname: Yvonne J. surname: Huang fullname: Huang, Yvonne J. email: yvjhuang@umich.edu organization: Department of Internal Medicine, Division of Pulmonary/Critical Care Medicine, University of Michigan, Ann Arbor, Mich |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32298699$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1371/journal.pone.0100645 10.1016/j.jaci.2018.05.026 10.1016/j.jaci.2019.06.025 10.1126/scitranslmed.aav3879 10.1016/j.jaci.2019.05.035 10.1186/2045-7022-3-24 10.1038/s41598-017-11492-7 10.1007/s11882-016-0631-8 10.1128/mBio.02287-16 10.1016/j.jaci.2017.05.026 10.1590/S1415-47572013000400002 10.33590/emjallergyimmunol/10310151 10.1016/j.jaci.2016.10.046 10.1038/nmeth.f.303 10.1016/j.jaci.2016.08.055 10.1186/s40168-018-0487-3 10.1016/j.jaci.2012.11.013 10.1128/AEM.03006-05 10.1371/journal.pone.0008578 10.4049/jimmunol.182.3.1404 10.1016/j.jaci.2017.03.032 10.1164/rccm.201507-1499OC 10.1016/j.immuni.2015.07.015 10.1016/j.jaci.2015.10.017 10.1016/j.jaci.2010.10.048 10.1183/13993003.00405-2015 10.1073/pnas.0707413104 10.1038/s41467-019-13698-x 10.1111/j.2517-6161.1995.tb02031.x 10.1016/S0140-6736(17)30879-6 10.1016/j.jaci.2015.05.044 10.1111/all.13449 10.1164/rccm.200903-0392OC 10.1093/bioinformatics/btq461 10.1371/journal.pone.0152724 10.1164/rccm.201304-0775OC 10.1371/journal.pone.0184566 10.1080/02770903.2017.1283696 10.1186/s12890-016-0208-2 |
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| References | Green, Wiriyachaiporn, Grainge, Rogers, Kehagia, Lau (bib17) 2014; 9 Dickson, Erb-Downward, Freeman, McCloskey, Falkowski, Huffnagle (bib32) 2017; 8 Denner, Sangwan, Becker, Hogarth, Oldham, Castillo (bib1) 2015; 137 Liu, Verma, Michalec, Liu, Sripada, Rollins (bib41) 2018; 141 Ndum, Huang (bib10) 2016; 1 Anderson (bib29) 2001; 26 Pavord, Beasley, Agusti, Anderson, Bel, Brusselle (bib8) 2018; 391 Turturice, McGee, Oliver, Baraket, Nguyen, Ascoli (bib12) 2017; 12 Ramstein, Broos, Simpson, Ansel, Sun, Ho (bib24) 2016; 193 Edgar (bib26) 2010; 26 Goleva, Jackson, Kirk Harris, Robertson, Sutherland, Hall (bib4) 2013; 188 McCauley, Durack, Valladares, Fadrosh, Lin, Calatroni (bib35) 2019; 144 Halwani, Sultana, Vazquez-Tello, Jamhawi, Al-Masri, Al-Muhsen (bib38) 2017; 54 Zhou, Jackson, Bacharier, Mauger, Boushey, Castro (bib34) 2019; 10 Taylor, Leong, Choo, Wesselingh, Yang, Upham (bib18) 2017 Woodruff, Boushey, Dolganov, Barker, Yang, Donnelly (bib22) 2007; 104 Dzidic, Abrahamsson, Artacho, Collado, Mira, Jenmalm (bib19) 2018; 73 Simpson, Daly, Baines, Yang, Upham, Reynolds (bib14) 2016; 47 Zhang, Cox, Liang, Brinkmann, Cardenas, Duff (bib15) 2016; 11 Huang, Nelson, Brodie, Desantis, Baek, Liu (bib7) 2011; 127 Durack, Lynch, Nariya, Bhakta, Beigelman, Castro (bib3) 2017; 140 Kelly, Koziol-White, Clay, Liu, Bates, Bertics (bib39) 2009; 182 Sverrild, Kiilerich, Brejnrod, Pedersen, Porsbjerg, Bergqvist (bib11) 2017; 140 Huang, Nariya, Harris, Lynch, Choy, Arron (bib6) 2015; 136 Sharma, Laxman, Naureckas, Hogarth, Sperling, Solway (bib13) 2019; 144 Durack, Huang, Nariya, Christian, Mark Ansel, Beigelman (bib20) 2018; 6 Marri, Stern, Wright, Billheimer, Martinez (bib33) 2013; 131 Hilty, Burke, Pedro, Cardenas, Bush, Bossley (bib5) 2010; 5 Benjamini, Hochberg (bib28) 1995; 57 Woodruff, Modrek, Choy, Jia, Abbas, Ellwanger (bib23) 2009; 180 Anderson (bib30) 2017 Jevnikar, Östling, Ax, Calvén, Thörn, Israelsson (bib36) 2019; 143 Coquet, Schuijs, Smyth, Deswarte, Beyaert, Braun (bib37) 2015; 43 Bhakta, Solberg, Nguyen, Nguyen, Arron, Fahy (bib21) 2013; 3 Diniz-Filho, Soares, Lima, Dobrovolski, Landeiro, de Campos Telles (bib31) 2013; 36 Caporaso, Kuczynski, Stombaugh, Bittinger, Bushman, Costello (bib25) 2010; 7 Durack, Boushey, Huang (bib16) 2018; 141 Singanayagam, Glanville, Cuthbertson, Bartlett, Finney, Turek (bib42) 2019; 11 Demarche, Schleich, Henket, Paulus, Van Hees, Louis (bib9) 2016; 16 Durack, Boushey, Lynch (bib2) 2016; 16 DeSantis, Hugenholtz, Larsen, Rojas, Brodie, Keller (bib27) 2006; 72 Yeon, Halim, Chandele, Perry, Kim, Kim (bib40) 2017; 7 Sverrild (10.1016/j.jaci.2020.03.028_bib11) 2017; 140 Durack (10.1016/j.jaci.2020.03.028_bib2) 2016; 16 Huang (10.1016/j.jaci.2020.03.028_bib6) 2015; 136 Coquet (10.1016/j.jaci.2020.03.028_bib37) 2015; 43 Durack (10.1016/j.jaci.2020.03.028_bib16) 2018; 141 Green (10.1016/j.jaci.2020.03.028_bib17) 2014; 9 Dickson (10.1016/j.jaci.2020.03.028_bib32) 2017; 8 Halwani (10.1016/j.jaci.2020.03.028_bib38) 2017; 54 Goleva (10.1016/j.jaci.2020.03.028_bib4) 2013; 188 Huang (10.1016/j.jaci.2020.03.028_bib7) 2011; 127 Hilty (10.1016/j.jaci.2020.03.028_bib5) 2010; 5 Demarche (10.1016/j.jaci.2020.03.028_bib9) 2016; 16 Sharma (10.1016/j.jaci.2020.03.028_bib13) 2019; 144 Benjamini (10.1016/j.jaci.2020.03.028_bib28) 1995; 57 Woodruff (10.1016/j.jaci.2020.03.028_bib22) 2007; 104 Liu (10.1016/j.jaci.2020.03.028_bib41) 2018; 141 Pavord (10.1016/j.jaci.2020.03.028_bib8) 2018; 391 Durack (10.1016/j.jaci.2020.03.028_bib20) 2018; 6 Anderson (10.1016/j.jaci.2020.03.028_bib29) 2001; 26 Turturice (10.1016/j.jaci.2020.03.028_bib12) 2017; 12 Denner (10.1016/j.jaci.2020.03.028_bib1) 2015; 137 Taylor (10.1016/j.jaci.2020.03.028_bib18) 2017 Edgar (10.1016/j.jaci.2020.03.028_bib26) 2010; 26 Ramstein (10.1016/j.jaci.2020.03.028_bib24) 2016; 193 DeSantis (10.1016/j.jaci.2020.03.028_bib27) 2006; 72 Bhakta (10.1016/j.jaci.2020.03.028_bib21) 2013; 3 McCauley (10.1016/j.jaci.2020.03.028_bib35) 2019; 144 Zhang (10.1016/j.jaci.2020.03.028_bib15) 2016; 11 Anderson (10.1016/j.jaci.2020.03.028_bib30) 2017 Marri (10.1016/j.jaci.2020.03.028_bib33) 2013; 131 Durack (10.1016/j.jaci.2020.03.028_bib3) 2017; 140 Singanayagam (10.1016/j.jaci.2020.03.028_bib42) 2019; 11 Woodruff (10.1016/j.jaci.2020.03.028_bib23) 2009; 180 Ndum (10.1016/j.jaci.2020.03.028_bib10) 2016; 1 Diniz-Filho (10.1016/j.jaci.2020.03.028_bib31) 2013; 36 Jevnikar (10.1016/j.jaci.2020.03.028_bib36) 2019; 143 Kelly (10.1016/j.jaci.2020.03.028_bib39) 2009; 182 Simpson (10.1016/j.jaci.2020.03.028_bib14) 2016; 47 Yeon (10.1016/j.jaci.2020.03.028_bib40) 2017; 7 Caporaso (10.1016/j.jaci.2020.03.028_bib25) 2010; 7 Dzidic (10.1016/j.jaci.2020.03.028_bib19) 2018; 73 Zhou (10.1016/j.jaci.2020.03.028_bib34) 2019; 10 |
| References_xml | – year: 2017 ident: bib18 article-title: Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology publication-title: J Allergy Clin Immunol – volume: 127 start-page: 372 year: 2011 end-page: 381.e1-3 ident: bib7 article-title: Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma publication-title: J Allergy Clin Immunol – volume: 140 start-page: 407 year: 2017 end-page: 417.e11 ident: bib11 article-title: Eosinophilic airway inflammation in asthmatic patients is associated with an altered airway microbiome publication-title: J Allergy Clin Immunol – volume: 6 start-page: 104 year: 2018 ident: bib20 article-title: Bacterial biogeography of adult airways in atopic asthma publication-title: Microbiome – volume: 11 start-page: e0152724 year: 2016 ident: bib15 article-title: Airway microbiota in severe asthma and relationship to asthma severity and phenotypes publication-title: PLoS One – volume: 104 start-page: 15858 year: 2007 end-page: 15868 ident: bib22 article-title: Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids publication-title: Proc Natl Acad Sci U S A – volume: 140 start-page: 63 year: 2017 end-page: 75 ident: bib3 article-title: Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment publication-title: J Allergy Clin Immunol – volume: 144 start-page: 1214 year: 2019 end-page: 1227.e7 ident: bib13 article-title: Associations between fungal and bacterial microbiota of airways and asthma endotypes publication-title: J Allergy Clin Immunol – volume: 73 start-page: 2000 year: 2018 end-page: 2011 ident: bib19 article-title: Oral microbiota maturation during the first 7 years of life in relation to allergy development publication-title: Allergy – volume: 43 start-page: 318 year: 2015 end-page: 330 ident: bib37 article-title: Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites publication-title: Immunity – volume: 26 start-page: 2460 year: 2010 end-page: 2461 ident: bib26 article-title: Search and clustering orders of magnitude faster than BLAST publication-title: Bioinformatics (Oxford, England) – volume: 141 start-page: 82 year: 2018 end-page: 83 ident: bib16 article-title: Incorporating the airway microbiome into asthma phenotyping: moving toward personalized medicine for noneosinophilic asthma publication-title: J Allergy Clin Immunol – volume: 143 start-page: 577 year: 2019 end-page: 590 ident: bib36 article-title: Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group. Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation publication-title: J Allergy Clin Immunol – volume: 7 year: 2010 ident: bib25 article-title: QIIME allows analysis of high-throughput community sequencing data publication-title: Nat Meth – volume: 193 start-page: 1281 year: 2016 end-page: 1291 ident: bib24 article-title: IFN-γ-producing T-helper 17.1 cells are increased in sarcoidosis and are more prevalent than T-helper type 1 cells publication-title: Am J Respir Crit Care Med – volume: 36 start-page: 475 year: 2013 end-page: 485 ident: bib31 article-title: Mantel test in population genetics publication-title: Genet Mol Biol – volume: 137 start-page: 1398 year: 2015 end-page: 1405.e3 ident: bib1 article-title: Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways publication-title: J Allergy Clin Immunol – volume: 3 start-page: 24 year: 2013 ident: bib21 article-title: A qPCR-based metric of Th2 airway inflammation in asthma publication-title: Clin Transl Allergy – volume: 131 start-page: 346 year: 2013 end-page: 352.e1-3 ident: bib33 article-title: Asthma-associated differences in microbial composition of induced sputum publication-title: J Allergy Clin Immunol – volume: 1 start-page: 82 year: 2016 end-page: 90 ident: bib10 article-title: Asthma phenotypes and the microbiome publication-title: EMJ Allergy Immunol – volume: 47 year: 2016 ident: bib14 article-title: Airway dysbiosis: publication-title: Eur Respir J – volume: 9 start-page: e100645 year: 2014 ident: bib17 article-title: Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma publication-title: PLoS One – volume: 8 year: 2017 ident: bib32 article-title: Bacterial topography of the healthy human lower respiratory tract publication-title: MBio – volume: 16 start-page: 46 year: 2016 ident: bib9 article-title: Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory? publication-title: BMC Pulmon Med – volume: 188 start-page: 1193 year: 2013 end-page: 1201 ident: bib4 article-title: The effects of airway microbiome on corticosteroid responsiveness in asthma publication-title: Am J Respir Crit Care Med – volume: 7 start-page: 11155 year: 2017 ident: bib40 article-title: IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways publication-title: Sci Rep – volume: 54 start-page: 893 year: 2017 end-page: 904 ident: bib38 article-title: Th-17 regulatory cytokines IL-21, IL-23, and IL-6 enhance neutrophil production of IL-17 cytokines during asthma publication-title: J Asthma – volume: 11 year: 2019 ident: bib42 article-title: Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease publication-title: Sci Transl Med – volume: 144 start-page: 1187 year: 2019 end-page: 1197 ident: bib35 article-title: Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma publication-title: J Allergy Clin Immunol – volume: 16 start-page: 52 year: 2016 ident: bib2 article-title: Airway microbiota and the implications of dysbiosis in asthma publication-title: Curr Allergy Asthma Rep – volume: 136 start-page: 874 year: 2015 end-page: 884 ident: bib6 article-title: The airway microbiome in patients with severe asthma: associations with disease features and severity publication-title: J Allergy Clin Immunol – volume: 12 start-page: e0184566 year: 2017 ident: bib12 article-title: Atopic asthmatic immune phenotypes associated with airway microbiota and airway obstruction publication-title: PLoS One – volume: 72 start-page: 5069 year: 2006 end-page: 5072 ident: bib27 article-title: Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB publication-title: Appl Environ Microbiol – volume: 141 start-page: 257 year: 2018 end-page: 268.e6 ident: bib41 article-title: Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: the role of thymic stromal lymphopoietin publication-title: J Allergy Clin Immunol – volume: 180 year: 2009 ident: bib23 article-title: T-helper type 2-driven inflammation defines major subphenotypes of asthma publication-title: Am J Respir Crit Care Med – year: 2017 ident: bib30 article-title: Permutational Multivariate Analysis of Variance (PERMANOVA) – volume: 391 start-page: 350 year: 2018 end-page: 400 ident: bib8 article-title: After asthma: redefining airways diseases publication-title: Lancet – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib28 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J Royal Stat Soc Ser B (Methodological) – volume: 182 start-page: 1404 year: 2009 end-page: 1410 ident: bib39 article-title: Potential contribution of IL-7 to allergen-induced eosinophilic airway inflammation in asthma publication-title: J Immunol (Baltimore, Md: 1950) – volume: 10 start-page: 5714 year: 2019 ident: bib34 article-title: The upper-airway microbiota and loss of asthma control among asthmatic children publication-title: Nat Commun – volume: 26 start-page: 32 year: 2001 end-page: 46 ident: bib29 article-title: A new method for non-parametric multivariate analysis of variance publication-title: Austral Ecol – volume: 5 start-page: e8578 year: 2010 ident: bib5 article-title: Disordered microbial communities in asthmatic airways publication-title: PLoS One – volume: 9 start-page: e100645 year: 2014 ident: 10.1016/j.jaci.2020.03.028_bib17 article-title: Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma publication-title: PLoS One doi: 10.1371/journal.pone.0100645 – volume: 143 start-page: 577 year: 2019 ident: 10.1016/j.jaci.2020.03.028_bib36 article-title: Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group. Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2018.05.026 – volume: 144 start-page: 1214 year: 2019 ident: 10.1016/j.jaci.2020.03.028_bib13 article-title: Associations between fungal and bacterial microbiota of airways and asthma endotypes publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2019.06.025 – year: 2017 ident: 10.1016/j.jaci.2020.03.028_bib30 – volume: 11 year: 2019 ident: 10.1016/j.jaci.2020.03.028_bib42 article-title: Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aav3879 – volume: 144 start-page: 1187 year: 2019 ident: 10.1016/j.jaci.2020.03.028_bib35 article-title: Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2019.05.035 – volume: 3 start-page: 24 year: 2013 ident: 10.1016/j.jaci.2020.03.028_bib21 article-title: A qPCR-based metric of Th2 airway inflammation in asthma publication-title: Clin Transl Allergy doi: 10.1186/2045-7022-3-24 – volume: 7 start-page: 11155 year: 2017 ident: 10.1016/j.jaci.2020.03.028_bib40 article-title: IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways publication-title: Sci Rep doi: 10.1038/s41598-017-11492-7 – volume: 16 start-page: 52 year: 2016 ident: 10.1016/j.jaci.2020.03.028_bib2 article-title: Airway microbiota and the implications of dysbiosis in asthma publication-title: Curr Allergy Asthma Rep doi: 10.1007/s11882-016-0631-8 – volume: 26 start-page: 32 year: 2001 ident: 10.1016/j.jaci.2020.03.028_bib29 article-title: A new method for non-parametric multivariate analysis of variance publication-title: Austral Ecol – volume: 8 year: 2017 ident: 10.1016/j.jaci.2020.03.028_bib32 article-title: Bacterial topography of the healthy human lower respiratory tract publication-title: MBio doi: 10.1128/mBio.02287-16 – volume: 141 start-page: 82 year: 2018 ident: 10.1016/j.jaci.2020.03.028_bib16 article-title: Incorporating the airway microbiome into asthma phenotyping: moving toward personalized medicine for noneosinophilic asthma publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2017.05.026 – volume: 36 start-page: 475 year: 2013 ident: 10.1016/j.jaci.2020.03.028_bib31 article-title: Mantel test in population genetics publication-title: Genet Mol Biol doi: 10.1590/S1415-47572013000400002 – volume: 1 start-page: 82 year: 2016 ident: 10.1016/j.jaci.2020.03.028_bib10 article-title: Asthma phenotypes and the microbiome publication-title: EMJ Allergy Immunol doi: 10.33590/emjallergyimmunol/10310151 – volume: 140 start-page: 407 year: 2017 ident: 10.1016/j.jaci.2020.03.028_bib11 article-title: Eosinophilic airway inflammation in asthmatic patients is associated with an altered airway microbiome publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2016.10.046 – volume: 7 year: 2010 ident: 10.1016/j.jaci.2020.03.028_bib25 article-title: QIIME allows analysis of high-throughput community sequencing data publication-title: Nat Meth doi: 10.1038/nmeth.f.303 – volume: 140 start-page: 63 year: 2017 ident: 10.1016/j.jaci.2020.03.028_bib3 article-title: Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2016.08.055 – volume: 6 start-page: 104 year: 2018 ident: 10.1016/j.jaci.2020.03.028_bib20 article-title: Bacterial biogeography of adult airways in atopic asthma publication-title: Microbiome doi: 10.1186/s40168-018-0487-3 – volume: 131 start-page: 346 year: 2013 ident: 10.1016/j.jaci.2020.03.028_bib33 article-title: Asthma-associated differences in microbial composition of induced sputum publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2012.11.013 – volume: 72 start-page: 5069 year: 2006 ident: 10.1016/j.jaci.2020.03.028_bib27 article-title: Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB publication-title: Appl Environ Microbiol doi: 10.1128/AEM.03006-05 – volume: 5 start-page: e8578 year: 2010 ident: 10.1016/j.jaci.2020.03.028_bib5 article-title: Disordered microbial communities in asthmatic airways publication-title: PLoS One doi: 10.1371/journal.pone.0008578 – volume: 182 start-page: 1404 year: 2009 ident: 10.1016/j.jaci.2020.03.028_bib39 article-title: Potential contribution of IL-7 to allergen-induced eosinophilic airway inflammation in asthma publication-title: J Immunol (Baltimore, Md: 1950) doi: 10.4049/jimmunol.182.3.1404 – volume: 141 start-page: 257 year: 2018 ident: 10.1016/j.jaci.2020.03.028_bib41 article-title: Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: the role of thymic stromal lymphopoietin publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2017.03.032 – volume: 193 start-page: 1281 year: 2016 ident: 10.1016/j.jaci.2020.03.028_bib24 article-title: IFN-γ-producing T-helper 17.1 cells are increased in sarcoidosis and are more prevalent than T-helper type 1 cells publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201507-1499OC – volume: 43 start-page: 318 year: 2015 ident: 10.1016/j.jaci.2020.03.028_bib37 article-title: Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites publication-title: Immunity doi: 10.1016/j.immuni.2015.07.015 – volume: 137 start-page: 1398 year: 2015 ident: 10.1016/j.jaci.2020.03.028_bib1 article-title: Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2015.10.017 – volume: 127 start-page: 372 year: 2011 ident: 10.1016/j.jaci.2020.03.028_bib7 article-title: Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.10.048 – volume: 47 year: 2016 ident: 10.1016/j.jaci.2020.03.028_bib14 article-title: Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma publication-title: Eur Respir J doi: 10.1183/13993003.00405-2015 – volume: 104 start-page: 15858 year: 2007 ident: 10.1016/j.jaci.2020.03.028_bib22 article-title: Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0707413104 – volume: 10 start-page: 5714 year: 2019 ident: 10.1016/j.jaci.2020.03.028_bib34 article-title: The upper-airway microbiota and loss of asthma control among asthmatic children publication-title: Nat Commun doi: 10.1038/s41467-019-13698-x – volume: 57 start-page: 289 year: 1995 ident: 10.1016/j.jaci.2020.03.028_bib28 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J Royal Stat Soc Ser B (Methodological) doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 391 start-page: 350 year: 2018 ident: 10.1016/j.jaci.2020.03.028_bib8 article-title: After asthma: redefining airways diseases publication-title: Lancet doi: 10.1016/S0140-6736(17)30879-6 – volume: 136 start-page: 874 year: 2015 ident: 10.1016/j.jaci.2020.03.028_bib6 article-title: The airway microbiome in patients with severe asthma: associations with disease features and severity publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2015.05.044 – year: 2017 ident: 10.1016/j.jaci.2020.03.028_bib18 article-title: Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology publication-title: J Allergy Clin Immunol – volume: 73 start-page: 2000 year: 2018 ident: 10.1016/j.jaci.2020.03.028_bib19 article-title: Oral microbiota maturation during the first 7 years of life in relation to allergy development publication-title: Allergy doi: 10.1111/all.13449 – volume: 180 year: 2009 ident: 10.1016/j.jaci.2020.03.028_bib23 article-title: T-helper type 2-driven inflammation defines major subphenotypes of asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200903-0392OC – volume: 26 start-page: 2460 year: 2010 ident: 10.1016/j.jaci.2020.03.028_bib26 article-title: Search and clustering orders of magnitude faster than BLAST publication-title: Bioinformatics (Oxford, England) doi: 10.1093/bioinformatics/btq461 – volume: 11 start-page: e0152724 year: 2016 ident: 10.1016/j.jaci.2020.03.028_bib15 article-title: Airway microbiota in severe asthma and relationship to asthma severity and phenotypes publication-title: PLoS One doi: 10.1371/journal.pone.0152724 – volume: 188 start-page: 1193 year: 2013 ident: 10.1016/j.jaci.2020.03.028_bib4 article-title: The effects of airway microbiome on corticosteroid responsiveness in asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201304-0775OC – volume: 12 start-page: e0184566 year: 2017 ident: 10.1016/j.jaci.2020.03.028_bib12 article-title: Atopic asthmatic immune phenotypes associated with airway microbiota and airway obstruction publication-title: PLoS One doi: 10.1371/journal.pone.0184566 – volume: 54 start-page: 893 year: 2017 ident: 10.1016/j.jaci.2020.03.028_bib38 article-title: Th-17 regulatory cytokines IL-21, IL-23, and IL-6 enhance neutrophil production of IL-17 cytokines during asthma publication-title: J Asthma doi: 10.1080/02770903.2017.1283696 – volume: 16 start-page: 46 year: 2016 ident: 10.1016/j.jaci.2020.03.028_bib9 article-title: Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory? publication-title: BMC Pulmon Med doi: 10.1186/s12890-016-0208-2 |
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| Snippet | Whether microbiome characteristics of induced sputum or oral samples demonstrate unique relationships to features of atopy or mild asthma in adults is unknown.... Whether microbiome characteristics of induced sputum or oral samples demonstrate unique relationships to features of atopy or mild asthma in adults is... In mild atopic asthma, sputum bacterial microbiome characteristics associate with several immunologic features, including type 2-low airway inflammation, and... |
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| SubjectTerms | Administration, Inhalation Adrenal Cortex Hormones - therapeutic use Adult allergic asthma Asthma - drug therapy Asthma - microbiology Biomarkers corticosteroids cytokines Cytokines - metabolism Female Humans Hypersensitivity, Immediate - drug therapy Hypersensitivity, Immediate - microbiology Male Microbiome Microbiota - genetics Mouth - microbiology oral sputum Sputum - microbiology Th2 Cells - immunology Treatment Outcome type 2 inflammation |
| Title | Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma |
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