Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis - Kuriyama, Takuro; Takenaka, Katsuto; Kohno, Kentaro; Yamauchi, Takuji; Daitoku, Shinya; Yoshimoto, Goichi; Kikushige, Yoshikane; Kishimoto, Junji; Abe, Yasunobu; Harada, Naoki; Miyamoto, Toshihiro; Iwasaki, Hiromi; et al. (Blood, 2012)
Keywords: Adolescent; ADP-ribosyl Cyclase 1 - metabolism; Adult; Aged; Antigens, CD34 - metabolism; Antigens, Differentiation - genetics; Biological and medical sciences; CD47 Antigen - genetics; CD47 Antigen - metabolism; Cell Line; Cytokines - pharmacology; Cytophagocytosis - immunology; Down-Regulation - drug effects; Hematologic and hematopoietic diseases; Hematopoietic Stem Cells - metabolism; Humans; Inflammation Mediators - pharmacology; Lymphohistiocytosis, Hemophagocytic - etiology; Macrophage Activation - immunology; Macrophages - metabolism; Medical sciences; Middle Aged; Models, Biological; Mutation; Receptors, Immunologic - genetics; RNA Interference; Young Adult; Immunopathology; Hemophagocytic lymphohistiocytosis; Hematology; Pathogenesis; Integrin associated protein; Stem cell; Hematopoietic cell