A carnosine intervention study in overweight human volunteers: bioavailability and reactive carbonyl species sequestering effect
Carnosine is a natural dipeptide able to react with reactive carbonyl species, which have been recently associated with the onset and progression of several human diseases. Herein, we report an intervention study in overweight individuals. Carnosine (2 g/day) was orally administered for twelve weeks...
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| Published in | Scientific reports Vol. 6; no. 1; p. 27224 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
06.06.2016
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/srep27224 |
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| Abstract | Carnosine is a natural dipeptide able to react with reactive carbonyl species, which have been recently associated with the onset and progression of several human diseases. Herein, we report an intervention study in overweight individuals. Carnosine (2 g/day) was orally administered for twelve weeks in order to evaluate its bioavailability and metabolic fate. Two carnosine adducts were detected in the urine samples of all subjects. Such adducts are generated from a reaction with acrolein, which is one of the most toxic and reactive compounds among reactive carbonyl species. However, neither carnosine nor adducts have been detected in plasma. Urinary excretion of adducts and carnosine showed a positive correlation although a high variability of individual response to carnosine supplementation was observed. Interestingly, treated subjects showed a significant decrease in the percentage of excreted adducts in reduced form, accompanied by a significant increase of the urinary excretion of both carnosine and carnosine-acrolein adducts. Altogether, data suggest that acrolein is entrapped
in vivo
by carnosine although the response to its supplementation is possibly influenced by individual diversities in terms of carnosine dietary intake, metabolism and basal production of reactive carbonyl species. |
|---|---|
| AbstractList | Carnosine is a natural dipeptide able to react with reactive carbonyl species, which have been recently associated with the onset and progression of several human diseases. Herein, we report an intervention study in overweight individuals. Carnosine (2 g/day) was orally administered for twelve weeks in order to evaluate its bioavailability and metabolic fate. Two carnosine adducts were detected in the urine samples of all subjects. Such adducts are generated from a reaction with acrolein, which is one of the most toxic and reactive compounds among reactive carbonyl species. However, neither carnosine nor adducts have been detected in plasma. Urinary excretion of adducts and carnosine showed a positive correlation although a high variability of individual response to carnosine supplementation was observed. Interestingly, treated subjects showed a significant decrease in the percentage of excreted adducts in reduced form, accompanied by a significant increase of the urinary excretion of both carnosine and carnosine-acrolein adducts. Altogether, data suggest that acrolein is entrapped in vivo by carnosine although the response to its supplementation is possibly influenced by individual diversities in terms of carnosine dietary intake, metabolism and basal production of reactive carbonyl species. Carnosine is a natural dipeptide able to react with reactive carbonyl species, which have been recently associated with the onset and progression of several human diseases. Herein, we report an intervention study in overweight individuals. Carnosine (2 g/day) was orally administered for twelve weeks in order to evaluate its bioavailability and metabolic fate. Two carnosine adducts were detected in the urine samples of all subjects. Such adducts are generated from a reaction with acrolein, which is one of the most toxic and reactive compounds among reactive carbonyl species. However, neither carnosine nor adducts have been detected in plasma. Urinary excretion of adducts and carnosine showed a positive correlation although a high variability of individual response to carnosine supplementation was observed. Interestingly, treated subjects showed a significant decrease in the percentage of excreted adducts in reduced form, accompanied by a significant increase of the urinary excretion of both carnosine and carnosine-acrolein adducts. Altogether, data suggest that acrolein is entrapped in vivo by carnosine although the response to its supplementation is possibly influenced by individual diversities in terms of carnosine dietary intake, metabolism and basal production of reactive carbonyl species. Carnosine is a natural dipeptide able to react with reactive carbonyl species, which have been recently associated with the onset and progression of several human diseases. Herein, we report an intervention study in overweight individuals. Carnosine (2 g/day) was orally administered for twelve weeks in order to evaluate its bioavailability and metabolic fate. Two carnosine adducts were detected in the urine samples of all subjects. Such adducts are generated from a reaction with acrolein, which is one of the most toxic and reactive compounds among reactive carbonyl species. However, neither carnosine nor adducts have been detected in plasma. Urinary excretion of adducts and carnosine showed a positive correlation although a high variability of individual response to carnosine supplementation was observed. Interestingly, treated subjects showed a significant decrease in the percentage of excreted adducts in reduced form, accompanied by a significant increase of the urinary excretion of both carnosine and carnosine-acrolein adducts. Altogether, data suggest that acrolein is entrapped in vivo by carnosine although the response to its supplementation is possibly influenced by individual diversities in terms of carnosine dietary intake, metabolism and basal production of reactive carbonyl species.Carnosine is a natural dipeptide able to react with reactive carbonyl species, which have been recently associated with the onset and progression of several human diseases. Herein, we report an intervention study in overweight individuals. Carnosine (2 g/day) was orally administered for twelve weeks in order to evaluate its bioavailability and metabolic fate. Two carnosine adducts were detected in the urine samples of all subjects. Such adducts are generated from a reaction with acrolein, which is one of the most toxic and reactive compounds among reactive carbonyl species. However, neither carnosine nor adducts have been detected in plasma. Urinary excretion of adducts and carnosine showed a positive correlation although a high variability of individual response to carnosine supplementation was observed. Interestingly, treated subjects showed a significant decrease in the percentage of excreted adducts in reduced form, accompanied by a significant increase of the urinary excretion of both carnosine and carnosine-acrolein adducts. Altogether, data suggest that acrolein is entrapped in vivo by carnosine although the response to its supplementation is possibly influenced by individual diversities in terms of carnosine dietary intake, metabolism and basal production of reactive carbonyl species. |
| ArticleNumber | 27224 |
| Author | Altomare, Alessandra Marinello, Cristina Krumpolec, Patrik Ukropec, Jozef Jakubova, Michaela de Courten, Barbora Carini, Marina Garzon, Davide Ukropcova, Barbara Vallova, Silvia Regazzoni, Luca Aldini, Giancarlo |
| Author_xml | – sequence: 1 givenname: Luca surname: Regazzoni fullname: Regazzoni, Luca organization: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy – sequence: 2 givenname: Barbora surname: de Courten fullname: de Courten, Barbora organization: Monash Centre for Health, Research and Implementation, School of Public health and Preventive Medicine, Diabetes and Vascular Medicine Unit – sequence: 3 givenname: Davide surname: Garzon fullname: Garzon, Davide organization: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy – sequence: 4 givenname: Alessandra surname: Altomare fullname: Altomare, Alessandra organization: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy – sequence: 5 givenname: Cristina surname: Marinello fullname: Marinello, Cristina organization: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy – sequence: 6 givenname: Michaela surname: Jakubova fullname: Jakubova, Michaela organization: Institute of Pathological Physiology, Faculty of Medicine, Comenius University – sequence: 7 givenname: Silvia surname: Vallova fullname: Vallova, Silvia organization: Institute of Pathological Physiology, Faculty of Medicine, Comenius University – sequence: 8 givenname: Patrik surname: Krumpolec fullname: Krumpolec, Patrik organization: Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences – sequence: 9 givenname: Marina surname: Carini fullname: Carini, Marina organization: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy – sequence: 10 givenname: Jozef surname: Ukropec fullname: Ukropec, Jozef organization: Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences – sequence: 11 givenname: Barbara surname: Ukropcova fullname: Ukropcova, Barbara email: barbara.ukropcova@savba.sk organization: Institute of Pathological Physiology, Faculty of Medicine, Comenius University, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences – sequence: 12 givenname: Giancarlo surname: Aldini fullname: Aldini, Giancarlo email: giancarlo.aldini@unimi.it organization: Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27265207$$D View this record in MEDLINE/PubMed |
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| Snippet | Carnosine is a natural dipeptide able to react with reactive carbonyl species, which have been recently associated with the onset and progression of several... |
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| SubjectTerms | 631/92/349 639/638/11/296 639/638/11/872 692/699/1702/393 Acrolein - urine Aldehydes Bioavailability Biological Availability Biomarkers Carbonyl compounds Carnosine - administration & dosage Carnosine - pharmacokinetics Carnosine - urine Diabetes Diet Enzymes Excretion Health care Human subjects Humanities and Social Sciences Humans Male Metabolism Metabolites multidisciplinary Obesity Obesity - metabolism Obesity - urine Overweight Overweight - metabolism Overweight - urine Oxidative Stress Proteins Science |
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| Title | A carnosine intervention study in overweight human volunteers: bioavailability and reactive carbonyl species sequestering effect |
| URI | https://link.springer.com/article/10.1038/srep27224 https://www.ncbi.nlm.nih.gov/pubmed/27265207 https://www.proquest.com/docview/1794127668 https://www.proquest.com/docview/1794469074 https://pubmed.ncbi.nlm.nih.gov/PMC4893669 https://www.nature.com/articles/srep27224.pdf |
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