Clinical Characteristics and Outcomes of Polyarteritis Nodosa: An International Study
Objective We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL‐PAN). Methods Patients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japan,...
Saved in:
| Published in | Arthritis & Rheumatology Vol. 76; no. 7; pp. 1120 - 1129 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Boston, USA
Wiley
01.07.2024
Wiley Periodicals, Inc Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2326-5191 2326-5205 2326-5205 |
| DOI | 10.1002/art.42817 |
Cover
| Abstract | Objective
We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL‐PAN).
Methods
Patients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japan, and North America. Eligibility was retrospectively defined using the European Medicines Agency classification algorithm. Patients with PAN related to hepatitis B virus (n = 12) and two monogenic diseases mimicking PAN, deficiency of adenosine deaminase 2 enzyme (n = 16) or familial Mediterranean fever (n = 11), were excluded. Data regarding organ involvement, relapse, disease‐related damage, and survival were analyzed.
Results
Three hundred fifty‐eight patients (female:male ratio 174:184), including those with systemic PAN (sPAN, n = 282) and cutaneous PAN (n = 76), were included. Twenty‐five were pediatric onset. Mean ± SD age at diagnosis was 44.3 ± 18.1 years. Constitutional symptoms (71.5%), cutaneous involvement (70.5%), musculoskeletal findings (69.1%), and neurologic features (48.0%) were common manifestations. Among patients with sPAN, gastrointestinal involvement and proteinuria over 400 mg/day were reported in 52.2% and 11.2%, respectively. During a median (interquartile range) 59.6 (99.5) months of follow‐up, relapse occurred in 48.5% of patients. One, 5‐ and 10‐year survival rates for sPAN were 97.1%, 94.0%, and 89.0%, respectively. Predictors of death for sPAN included age ≥65 years at diagnosis, serum creatinine at diagnosis >140 μmol/L, gastrointestinal manifestations, and central nervous system (CNS) involvement.
Conclusion
The spectrum of PAN remains a complex, multifaceted disease. Relapse is common. Age ≥65 years and serum creatinine >140 μmol/L at diagnosis, as well as gastrointestinal and CNS involvement, are independent predictors of death in sPAN. |
|---|---|
| AbstractList | ObjectiveWe describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL‐PAN).MethodsPatients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japan, and North America. Eligibility was retrospectively defined using the European Medicines Agency classification algorithm. Patients with PAN related to hepatitis B virus (n = 12) and two monogenic diseases mimicking PAN, deficiency of adenosine deaminase 2 enzyme (n = 16) or familial Mediterranean fever (n = 11), were excluded. Data regarding organ involvement, relapse, disease‐related damage, and survival were analyzed.ResultsThree hundred fifty‐eight patients (female:male ratio 174:184), including those with systemic PAN (sPAN, n = 282) and cutaneous PAN (n = 76), were included. Twenty‐five were pediatric onset. Mean ± SD age at diagnosis was 44.3 ± 18.1 years. Constitutional symptoms (71.5%), cutaneous involvement (70.5%), musculoskeletal findings (69.1%), and neurologic features (48.0%) were common manifestations. Among patients with sPAN, gastrointestinal involvement and proteinuria over 400 mg/day were reported in 52.2% and 11.2%, respectively. During a median (interquartile range) 59.6 (99.5) months of follow‐up, relapse occurred in 48.5% of patients. One, 5‐ and 10‐year survival rates for sPAN were 97.1%, 94.0%, and 89.0%, respectively. Predictors of death for sPAN included age ≥65 years at diagnosis, serum creatinine at diagnosis >140 μmol/L, gastrointestinal manifestations, and central nervous system (CNS) involvement.ConclusionThe spectrum of PAN remains a complex, multifaceted disease. Relapse is common. Age ≥65 years and serum creatinine >140 μmol/L at diagnosis, as well as gastrointestinal and CNS involvement, are independent predictors of death in sPAN. We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL-PAN).OBJECTIVEWe describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL-PAN).Patients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japan, and North America. Eligibility was retrospectively defined using the European Medicines Agency classification algorithm. Patients with PAN related to hepatitis B virus (n = 12) and two monogenic diseases mimicking PAN, deficiency of adenosine deaminase 2 enzyme (n = 16) or familial Mediterranean fever (n = 11), were excluded. Data regarding organ involvement, relapse, disease-related damage, and survival were analyzed.METHODSPatients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japan, and North America. Eligibility was retrospectively defined using the European Medicines Agency classification algorithm. Patients with PAN related to hepatitis B virus (n = 12) and two monogenic diseases mimicking PAN, deficiency of adenosine deaminase 2 enzyme (n = 16) or familial Mediterranean fever (n = 11), were excluded. Data regarding organ involvement, relapse, disease-related damage, and survival were analyzed.Three hundred fifty-eight patients (female:male ratio 174:184), including those with systemic PAN (sPAN, n = 282) and cutaneous PAN (n = 76), were included. Twenty-five were pediatric onset. Mean ± SD age at diagnosis was 44.3 ± 18.1 years. Constitutional symptoms (71.5%), cutaneous involvement (70.5%), musculoskeletal findings (69.1%), and neurologic features (48.0%) were common manifestations. Among patients with sPAN, gastrointestinal involvement and proteinuria over 400 mg/day were reported in 52.2% and 11.2%, respectively. During a median (interquartile range) 59.6 (99.5) months of follow-up, relapse occurred in 48.5% of patients. One, 5- and 10-year survival rates for sPAN were 97.1%, 94.0%, and 89.0%, respectively. Predictors of death for sPAN included age ≥65 years at diagnosis, serum creatinine at diagnosis >140 μmol/L, gastrointestinal manifestations, and central nervous system (CNS) involvement.RESULTSThree hundred fifty-eight patients (female:male ratio 174:184), including those with systemic PAN (sPAN, n = 282) and cutaneous PAN (n = 76), were included. Twenty-five were pediatric onset. Mean ± SD age at diagnosis was 44.3 ± 18.1 years. Constitutional symptoms (71.5%), cutaneous involvement (70.5%), musculoskeletal findings (69.1%), and neurologic features (48.0%) were common manifestations. Among patients with sPAN, gastrointestinal involvement and proteinuria over 400 mg/day were reported in 52.2% and 11.2%, respectively. During a median (interquartile range) 59.6 (99.5) months of follow-up, relapse occurred in 48.5% of patients. One, 5- and 10-year survival rates for sPAN were 97.1%, 94.0%, and 89.0%, respectively. Predictors of death for sPAN included age ≥65 years at diagnosis, serum creatinine at diagnosis >140 μmol/L, gastrointestinal manifestations, and central nervous system (CNS) involvement.The spectrum of PAN remains a complex, multifaceted disease. Relapse is common. Age ≥65 years and serum creatinine >140 μmol/L at diagnosis, as well as gastrointestinal and CNS involvement, are independent predictors of death in sPAN.CONCLUSIONThe spectrum of PAN remains a complex, multifaceted disease. Relapse is common. Age ≥65 years and serum creatinine >140 μmol/L at diagnosis, as well as gastrointestinal and CNS involvement, are independent predictors of death in sPAN. Objective We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL‐PAN). Methods Patients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japan, and North America. Eligibility was retrospectively defined using the European Medicines Agency classification algorithm. Patients with PAN related to hepatitis B virus (n = 12) and two monogenic diseases mimicking PAN, deficiency of adenosine deaminase 2 enzyme (n = 16) or familial Mediterranean fever (n = 11), were excluded. Data regarding organ involvement, relapse, disease‐related damage, and survival were analyzed. Results Three hundred fifty‐eight patients (female:male ratio 174:184), including those with systemic PAN (sPAN, n = 282) and cutaneous PAN (n = 76), were included. Twenty‐five were pediatric onset. Mean ± SD age at diagnosis was 44.3 ± 18.1 years. Constitutional symptoms (71.5%), cutaneous involvement (70.5%), musculoskeletal findings (69.1%), and neurologic features (48.0%) were common manifestations. Among patients with sPAN, gastrointestinal involvement and proteinuria over 400 mg/day were reported in 52.2% and 11.2%, respectively. During a median (interquartile range) 59.6 (99.5) months of follow‐up, relapse occurred in 48.5% of patients. One, 5‐ and 10‐year survival rates for sPAN were 97.1%, 94.0%, and 89.0%, respectively. Predictors of death for sPAN included age ≥65 years at diagnosis, serum creatinine at diagnosis >140 μmol/L, gastrointestinal manifestations, and central nervous system (CNS) involvement. Conclusion The spectrum of PAN remains a complex, multifaceted disease. Relapse is common. Age ≥65 years and serum creatinine >140 μmol/L at diagnosis, as well as gastrointestinal and CNS involvement, are independent predictors of death in sPAN. We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL-PAN). Patients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japan, and North America. Eligibility was retrospectively defined using the European Medicines Agency classification algorithm. Patients with PAN related to hepatitis B virus (n = 12) and two monogenic diseases mimicking PAN, deficiency of adenosine deaminase 2 enzyme (n = 16) or familial Mediterranean fever (n = 11), were excluded. Data regarding organ involvement, relapse, disease-related damage, and survival were analyzed. Three hundred fifty-eight patients (female:male ratio 174:184), including those with systemic PAN (sPAN, n = 282) and cutaneous PAN (n = 76), were included. Twenty-five were pediatric onset. Mean ± SD age at diagnosis was 44.3 ± 18.1 years. Constitutional symptoms (71.5%), cutaneous involvement (70.5%), musculoskeletal findings (69.1%), and neurologic features (48.0%) were common manifestations. Among patients with sPAN, gastrointestinal involvement and proteinuria over 400 mg/day were reported in 52.2% and 11.2%, respectively. During a median (interquartile range) 59.6 (99.5) months of follow-up, relapse occurred in 48.5% of patients. One, 5- and 10-year survival rates for sPAN were 97.1%, 94.0%, and 89.0%, respectively. Predictors of death for sPAN included age ≥65 years at diagnosis, serum creatinine at diagnosis >140 μmol/L, gastrointestinal manifestations, and central nervous system (CNS) involvement. The spectrum of PAN remains a complex, multifaceted disease. Relapse is common. Age ≥65 years and serum creatinine >140 μmol/L at diagnosis, as well as gastrointestinal and CNS involvement, are independent predictors of death in sPAN. |
| Author | Treppo, Elena Gercik, Onay Furuta, Shunsuke Ertenli, Ihsan Jayne, David Tufan, Abdurrahman Ozen, Seza Moroni, Luca Chung, Sharon Tomsic, Matija Vaglio, Augusto Langford, Carol A. Kawakami, Tamihiro Conticini, Edoardo Forbess, Lindsy Padoan, Roberto Kilickap, Saadettin Seo, Phillip Cefle, Ayse Dagna, Lorenzo Amudala, Naomi Grayson, Peter C. Alibaz-Oner, Fatma Schiavon, Franco Yazisiz, Veli Ramirez, Giuseppe Quartuccio, Luca McAlear, Carol A. Merkel, Peter A. Karadag, Omer Akar, Servet Tezcan, Mehmet Engin Kasifoglu, Timucin Kono, Hajime Emmi, Giacomo Armagan, Berkan Felicetti, Mara Pastore, Serena Karadeniz, Hazan Gregoni, Gina Mohammad, Aladdin J. Monti, Sara Pagnoux, Christian Martín-Nares, Eduardo Bozzola, Enrico Simonini, Gabriele Direskeneli, Haner Hinojosa-Azaola, Andrea Ugurlu, Serdal Gazel, Ummugulsum Sánchez-Cubías, Susy Marcela Abe, Yoshiyuki YAZICI, AYTEN Khalidi, Nader A. Hocevar, Alojzija Gopaluni, Seerapani Koening, Curry Monach, Paul A. Warrington, Kenneth J. Lopalco, Giuseppe Springer, Jason Rhee, Rennie Bolek, Ertugrul Cagri Guido, |
| Author_xml | – sequence: 1 fullname: Ramirez, Giuseppe – sequence: 2 fullname: Treppo, Elena – sequence: 3 fullname: Quartuccio, Luca – sequence: 4 fullname: Pastore, Serena – sequence: 5 orcidid: 0000-0002-7911-1269 fullname: Martín-Nares, Eduardo – sequence: 6 orcidid: 0000-0001-6287-9549 fullname: Pagnoux, Christian – sequence: 7 fullname: Grayson, Peter C. – sequence: 8 orcidid: 0000-0002-7169-6936 fullname: Mohammad, Aladdin J. – sequence: 9 fullname: Ozen, Seza – sequence: 10 fullname: Emmi, Giacomo – sequence: 11 fullname: Furuta, Shunsuke – sequence: 12 fullname: Hinojosa-Azaola, Andrea – sequence: 13 orcidid: 0000-0003-1889-9619 fullname: Ayan, Gizem – sequence: 14 orcidid: 0000-0003-3886-2813 fullname: Bolek, Ertugrul Cagri – sequence: 15 fullname: Hocevar, Alojzija – sequence: 16 fullname: Warrington, Kenneth J. – sequence: 17 orcidid: 0000-0002-3443-3117 fullname: Karadag, Omer – sequence: 18 fullname: YAZICI, AYTEN – sequence: 19 fullname: Seo, Phillip – sequence: 20 fullname: Kilickap, Saadettin – sequence: 21 fullname: Kawakami, Tamihiro – sequence: 22 fullname: Kasifoglu, Timucin – sequence: 23 fullname: Tufan, Abdurrahman – sequence: 24 fullname: Karadeniz, Hazan – sequence: 25 fullname: Kono, Hajime – sequence: 26 orcidid: 0000-0002-3903-6049 fullname: Springer, Jason – sequence: 27 fullname: Tezcan, Mehmet Engin – sequence: 28 fullname: Guido, Jeannin – sequence: 29 fullname: Gregoni, Gina – sequence: 30 fullname: Gopaluni, Seerapani – sequence: 31 fullname: Gazel, Ummugulsum – sequence: 32 fullname: Forbess, Lindsy – sequence: 33 fullname: Schiavon, Franco – sequence: 34 fullname: Felicetti, Mara – sequence: 35 fullname: Ertenli, Ihsan – sequence: 36 fullname: Tomsic, Matija – sequence: 37 fullname: Sánchez-Cubías, Susy Marcela – sequence: 38 fullname: Conticini, Edoardo – sequence: 39 fullname: Chung, Sharon – sequence: 40 fullname: Cefle, Ayse – sequence: 41 fullname: Bozzola, Enrico – sequence: 42 fullname: Lopalco, Giuseppe – sequence: 43 fullname: Vaglio, Augusto – sequence: 44 fullname: Moreland, Larry – sequence: 45 fullname: Ugurlu, Serdal – sequence: 46 fullname: Yazisiz, Veli – sequence: 47 fullname: Armagan, Berkan – sequence: 48 fullname: Gercik, Onay – sequence: 49 fullname: Akar, Servet – sequence: 50 fullname: Rhee, Rennie – sequence: 51 fullname: Amudala, Naomi – sequence: 52 fullname: Merkel, Peter A. – sequence: 53 fullname: Jayne, David – sequence: 54 fullname: Simonini, Gabriele – sequence: 55 fullname: Khalidi, Nader A. – sequence: 56 fullname: Padoan, Roberto – sequence: 57 fullname: Koening, Curry – sequence: 58 fullname: Langford, Carol A. – sequence: 59 fullname: McAlear, Carol A. – sequence: 60 fullname: Cuthbertson, David – sequence: 61 fullname: Dagna, Lorenzo – sequence: 62 fullname: Direskeneli, Haner – sequence: 63 fullname: Alberici, Federico – sequence: 64 fullname: Abe, Yoshiyuki – sequence: 65 fullname: Alibaz-Oner, Fatma – sequence: 66 orcidid: 0000-0002-1800-6772 fullname: Monti, Sara – sequence: 67 fullname: Monach, Paul A. – sequence: 68 fullname: Moroni, Luca |
| BackLink | https://cir.nii.ac.jp/crid/1873116917609132800$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/38343337$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kd9vFCEQx4mpsbX2wX_AbKIP9eFaYGBZfDGXiz-aNNZo-0xGlrU0HLQLa3P_vVyv12gT5QEI85kv35l5TnZiio6Ql4weMUr5MY7lSPCOqSdkjwNvZ5JTubO9M812yUHOV7QurWhL5TOyCx0IAFB75GIRfPQWQ7O4xBFtcaPPxdvcYOybs6nYtHS5SUPzNYVV_avGi8_Nl9SnjO-aeWxOYn2MWHyKVeZ7mfrVC_J0wJDdwf25Ty4-fjhffJ6dnn06WcxPZ1ZSoWaoJdpODSitQG3FALyXUjGkMEjBVae41o5jdc77QVirwTEByomBC3AC9sn7je719GPpeutiGTGY69EvcVyZhN78HYn-0vxMvwxjnEGr1gqH9wpjuplcLmbps3UhYHRpyoZr3lLVMtlV9PUj9CpNtfCQDdDqtAUp1tSrPy09eNm2vAJvN4AdU86jGx4QRs16oqZ22dxNtLLHj1jry12nazU-_C_j1ge3-re0mX8732a82WRE76v8emedAsZazVRLNQPeUQq_ATLyuzU |
| CitedBy_id | crossref_primary_10_1111_1756_185X_15366 crossref_primary_10_1097_MD_0000000000039445 crossref_primary_10_1002_art_42851 crossref_primary_10_1016_j_mpmed_2024_09_012 crossref_primary_10_3390_jcm13216571 crossref_primary_10_1093_rheumatology_keae593 crossref_primary_10_1111_1756_185X_70038 crossref_primary_10_1055_a_2318_3923 crossref_primary_10_1093_rheumatology_keaf014 crossref_primary_10_1007_s00296_024_05582_9 crossref_primary_10_1161_ATVBAHA_124_319982 |
| Cites_doi | 10.1056/NEJMoa1307361 10.1002/art.41549 10.1136/ard.2006.054593 10.1016/j.jpeds.2004.06.046 10.1097/MD.0b013e318205a4c6 10.1002/art.20077 10.1053/sarh.2001.19958 10.1097/00005792-199601000-00003 10.1002/art.27240 10.1002/acr.23007 10.1038/s41584-021-00718-8 10.1056/NEJMoa2026834 10.1007/s10157-013-0830-8 10.1007/s00296-018-4122-1 10.1136/ard.2009.116657 10.1002/art.1780370206 10.1002/art.1780400222 10.1111/1756-185X.13120 10.1002/art.1780330805 |
| ContentType | Journal Article |
| Contributor | Treppo, Elena Felicetti, Mara Gercik, Onay Ertenli, Ihsan Gregoni, Gina Karadeniz, Hazan Tufan, Abdurrahman Pastore, Serena Bozzola, Enrico Simonini, Gabriele Ugurlu, Serdal Chung, Sharon Sánchez-Cubías, Susy Marcela Gazel, Ummugulsum Vaglio, Augusto Tomsic, Matija Kawakami, Tamihiro Conticini, Edoardo Forbess, Lindsy Kilickap, Saadettin Cefle, Ayse Gopaluni, Seerapani Amudala, Naomi Schiavon, Franco Yazisiz, Veli Ramirez, Giuseppe Quartuccio, Luca Lopalco, Giuseppe Springer, Jason Rhee, Rennie Yazici, Ayten Akar, Servet Tezcan, Mehmet Engin Kasifoglu, Timucin Guido, Jeannin Kono, Hajime Armagan, Berkan Moreland, Larry |
| Contributor_xml | – sequence: 1 givenname: Naomi surname: Amudala fullname: Amudala, Naomi – sequence: 2 givenname: Rennie surname: Rhee fullname: Rhee, Rennie – sequence: 3 givenname: Servet surname: Akar fullname: Akar, Servet – sequence: 4 givenname: Onay surname: Gercik fullname: Gercik, Onay – sequence: 5 givenname: Berkan surname: Armagan fullname: Armagan, Berkan – sequence: 6 givenname: Enrico surname: Bozzola fullname: Bozzola, Enrico – sequence: 7 givenname: Ayse surname: Cefle fullname: Cefle, Ayse – sequence: 8 givenname: Ayten surname: Yazici fullname: Yazici, Ayten – sequence: 9 givenname: Sharon surname: Chung fullname: Chung, Sharon – sequence: 10 givenname: Edoardo surname: Conticini fullname: Conticini, Edoardo – sequence: 11 givenname: Susy Marcela surname: Sánchez-Cubías fullname: Sánchez-Cubías, Susy Marcela – sequence: 12 givenname: Ihsan surname: Ertenli fullname: Ertenli, Ihsan – sequence: 13 givenname: Mara surname: Felicetti fullname: Felicetti, Mara – sequence: 14 givenname: Franco surname: Schiavon fullname: Schiavon, Franco – sequence: 15 givenname: Lindsy surname: Forbess fullname: Forbess, Lindsy – sequence: 16 givenname: Ummugulsum surname: Gazel fullname: Gazel, Ummugulsum – sequence: 17 givenname: Seerapani surname: Gopaluni fullname: Gopaluni, Seerapani – sequence: 18 givenname: Gina surname: Gregoni fullname: Gregoni, Gina – sequence: 19 givenname: Jeannin surname: Guido fullname: Guido, Jeannin – sequence: 20 givenname: Hajime surname: Kono fullname: Kono, Hajime – sequence: 21 givenname: Hazan surname: Karadeniz fullname: Karadeniz, Hazan – sequence: 22 givenname: Abdurrahman surname: Tufan fullname: Tufan, Abdurrahman – sequence: 23 givenname: Timucin surname: Kasifoglu fullname: Kasifoglu, Timucin – sequence: 24 givenname: Tamihiro surname: Kawakami fullname: Kawakami, Tamihiro – sequence: 25 givenname: Saadettin surname: Kilickap fullname: Kilickap, Saadettin – sequence: 26 givenname: Giuseppe surname: Lopalco fullname: Lopalco, Giuseppe – sequence: 27 givenname: Larry surname: Moreland fullname: Moreland, Larry – sequence: 28 givenname: Serena surname: Pastore fullname: Pastore, Serena – sequence: 29 givenname: Luca surname: Quartuccio fullname: Quartuccio, Luca – sequence: 30 givenname: Elena surname: Treppo fullname: Treppo, Elena – sequence: 31 givenname: Giuseppe surname: Ramirez fullname: Ramirez, Giuseppe – sequence: 32 givenname: Gabriele surname: Simonini fullname: Simonini, Gabriele – sequence: 33 givenname: Augusto surname: Vaglio fullname: Vaglio, Augusto – sequence: 34 givenname: Jason surname: Springer fullname: Springer, Jason – sequence: 35 givenname: Mehmet Engin surname: Tezcan fullname: Tezcan, Mehmet Engin – sequence: 36 givenname: Matija surname: Tomsic fullname: Tomsic, Matija – sequence: 37 givenname: Serdal surname: Ugurlu fullname: Ugurlu, Serdal – sequence: 38 givenname: Veli surname: Yazisiz fullname: Yazisiz, Veli |
| Copyright | 2024 American College of Rheumatology 2024 American College of Rheumatology. |
| Copyright_xml | – notice: 2024 American College of Rheumatology – notice: 2024 American College of Rheumatology. |
| CorporateAuthor | for the GLOBAL‐PAN Collaborators GLOBAL‐PAN Collaborators |
| CorporateAuthor_xml | – name: for the GLOBAL‐PAN Collaborators – name: GLOBAL‐PAN Collaborators |
| DBID | RYH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QL 7QP 7T5 7TM 7U7 C1K H94 K9. 7X8 5PM |
| DOI | 10.1002/art.42817 |
| DatabaseName | CiNii Complete CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Immunology Abstracts Nucleic Acids Abstracts Toxicology Abstracts Environmental Sciences and Pollution Management AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Toxicology Abstracts Bacteriology Abstracts (Microbiology B) Nucleic Acids Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Calcium & Calcified Tissue Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | Toxicology Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2326-5205 |
| EndPage | 1129 |
| ExternalDocumentID | PMC11213674 38343337 10_1002_art_42817 ART42817 |
| Genre | researchArticle Multicenter Study Journal Article Observational Study |
| GeographicLocations | North America Europe Japan |
| GeographicLocations_xml | – name: Europe – name: North America – name: Japan |
| GrantInformation_xml | – fundername: National Institute for Health Research Cambridge Biomedical Research Centre – fundername: National Center for Advancing Translational Science, the National Institute of Arthritis and Musculoskeletal and Skin Diseases funderid: U54‐AR‐057319 – fundername: National Center for Research Resources funderid: U54‐RR‐019497 – fundername: NIAMS NIH HHS grantid: U54 AR057319 – fundername: National Center for Advancing Translational Science, the National Institute of Arthritis and Musculoskeletal and Skin Diseases grantid: U54-AR-057319 – fundername: Intramural NIH HHS grantid: ZIA AR041204 – fundername: NCRR NIH HHS grantid: U54 RR019497 – fundername: NCRR NIH HHS grantid: U54-RR-019497 |
| GroupedDBID | 0R~ 1OC 33P 3SF 4.4 52O 52U 52V 53G 5VS AAESR AAEVG AAFWJ AAHHS AAHQN AAIPD AAMNL AANLZ AAWTL AAXRX AAYCA AAZKR ABCUV ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACCFJ ACCZN ACFBH ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUYR AEYWJ AFBPY AFFPM AFGKR AFRAH AFWVQ AFZJQ AGHNM AGYGG AHBTC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AZFZN AZVAB BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 DCZOG DIK DRFUL DRMAN DRSTM EBS EMOBN EX3 F00 FUBAC G-S G.N GODZA HGLYW KBYEO LATKE LEEKS LITHE LOXES LUTES LYRES MEWTI MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM NF~ O66 OVD P2W PQQKQ QB0 ROL RYH SUPJJ TEORI V9Y WBKPD WHWMO WIH WIJ WIK WOHZO WVDHM WXSBR 24P AANHP AAQQT AASGY ACBWZ ACRPL ACYXJ ADNMO AEUQT AFPWT BDRZF EJD LH4 LW6 O9- OK1 SV3 YCJ AAMMB AAYXX AEFGJ AGQPQ AGXDD AIDQK AIDYY CITATION CGR CUY CVF ECM EIF NPM 7QL 7QP 7T5 7TM 7U7 C1K H94 K9. 7X8 5PM |
| ID | FETCH-LOGICAL-c5047-a95ac87fa5c4a9c4f32d5571a03f542787299e2a0092df4cc93e1437e4f243e43 |
| ISSN | 2326-5191 2326-5205 |
| IngestDate | Thu Aug 21 18:33:29 EDT 2025 Fri Jul 11 15:12:20 EDT 2025 Tue Oct 07 06:03:16 EDT 2025 Thu Jul 03 03:54:28 EDT 2025 Thu Oct 16 04:44:31 EDT 2025 Thu Apr 24 23:10:14 EDT 2025 Wed Jan 22 17:18:35 EST 2025 Thu Jun 26 22:38:46 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| License | 2024 American College of Rheumatology. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c5047-a95ac87fa5c4a9c4f32d5571a03f542787299e2a0092df4cc93e1437e4f243e43 |
| Notes | Author disclosures and graphical abstract are available at https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.42817 https://onlinelibrary.wiley.com/doi/10.1002/art.42817 Supported by the Vasculitis Clinical Research Consortium, which received funding from the National Center for Advancing Translational Science, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant U54‐AR‐057319), and the National Center for Research Resources (grant U54‐RR‐019497) of the NIH. Dr Jayne's work was supported by the National Institute for Health Research Cambridge Biomedical Research Centre. . Additional supplementary information cited in this article can be found online in the Supporting Information section ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 |
| ORCID | 0000-0002-3903-6049 0000-0002-7911-1269 0000-0003-3886-2813 0000-0001-6287-9549 0000-0003-1889-9619 0000-0002-7169-6936 0000-0002-3443-3117 0000-0002-1800-6772 0000-0002-6653-1758 0000-0003-2883-7868 0000-0001-7708-2487 0000-0002-4001-3995 0000-0002-8269-9438 0000-0002-0016-6866 0000-0002-8270-2617 0000-0001-9284-7345 0000-0002-3785-9834 0000-0002-1712-0637 0000-0002-1014-2868 0000-0002-7361-6549 0000-0003-2598-5806 0000-0003-4483-0359 0000 0003 2883 7868 0000-0001-7310-3594 0000 0003 2598 5806 0000-0001-7783-700X 0000-0002-2238-2287 0000-0002-4507-9010 |
| PMID | 38343337 |
| PQID | 3072963548 |
| PQPubID | 946334 |
| PageCount | 10 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_11213674 proquest_miscellaneous_2926076158 proquest_journals_3072963548 pubmed_primary_38343337 crossref_primary_10_1002_art_42817 crossref_citationtrail_10_1002_art_42817 wiley_primary_10_1002_art_42817_ART42817 nii_cinii_1873116917609132800 |
| PublicationCentury | 2000 |
| PublicationDate | July 2024 |
| PublicationDateYYYYMMDD | 2024-07-01 |
| PublicationDate_xml | – month: 07 year: 2024 text: July 2024 |
| PublicationDecade | 2020 |
| PublicationPlace | Boston, USA |
| PublicationPlace_xml | – name: Boston, USA – name: United States – name: Atlanta |
| PublicationTitle | Arthritis & Rheumatology |
| PublicationTitleAlternate | Arthritis Rheumatol |
| PublicationYear | 2024 |
| Publisher | Wiley Wiley Periodicals, Inc Wiley Subscription Services, Inc |
| Publisher_xml | – name: Wiley – name: Wiley Periodicals, Inc – name: Wiley Subscription Services, Inc |
| References | 2004; 145 2017; 20 1990; 33 1997; 40 2004; 51 2013; 17 2010; 69 2020; 383 2017; 69 2018; 36 Suppl 111 2011; 90 2014; 370 1994; 37 2007; 66 2021; 73 2018; 38 2001; 30 2010; 62 1996; 75 2022; 18 1994; 87 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 Karadag O (e_1_2_7_7_1) 2018; 36 e_1_2_7_9_1 e_1_2_7_8_1 Luqmani RA (e_1_2_7_16_1) 1994; 87 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_22_1 e_1_2_7_10_1 e_1_2_7_21_1 e_1_2_7_20_1 |
| References_xml | – volume: 17 start-page: 607 issue: 5 year: 2013 end-page: 610 article-title: Epidemiology and clinical features of systemic vasculitis publication-title: Clin Exp Nephrol – volume: 145 start-page: 517 issue: 4 year: 2004 end-page: 522 article-title: Juvenile polyarteritis: results of a multicenter survey of 110 children publication-title: J Pediatr – volume: 33 start-page: 1088 issue: 8 year: 1990 end-page: 1093 article-title: The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa publication-title: Arthritis Rheum – volume: 18 start-page: 22 issue: 1 year: 2022 end-page: 34 article-title: Global epidemiology of vasculitis publication-title: Nat Rev Rheumatol – volume: 370 start-page: 911 issue: 10 year: 2014 end-page: 920 article-title: Early‐onset stroke and vasculopathy associated with mutations in ADA2 publication-title: N Engl J Med – volume: 51 start-page: 92 issue: 1 year: 2004 end-page: 99 article-title: Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener's granulomatosis, and Churg‐Strauss syndrome in a French urban multiethnic population in 2000: a capture‐recapture estimate publication-title: Arthritis Rheum – volume: 36 Suppl 111 start-page: 135 issue: 2 year: 2018 end-page: 142 article-title: Polyarteritis nodosa revisited: a review of historical approaches, subphenotypes and a research agenda publication-title: Clin Exp Rheumatol – volume: 30 start-page: 281 issue: 4 year: 2001 end-page: 287 article-title: Polyarteritis nodosa in patients with Familial Mediterranean Fever (FMF): a concomitant disease or a feature of FMF? publication-title: Semin Arthritis Rheum – volume: 37 start-page: 187 issue: 2 year: 1994 end-page: 192 article-title: Nomenclature of systemic vasculitides. Proposal of an international consensus conference publication-title: Arthritis Rheum – volume: 383 start-page: 2628 issue: 27 year: 2020 end-page: 2638 article-title: Somatic mutations in UBA1 and severe adult‐onset autoinflammatory disease publication-title: N Engl J Med – volume: 69 start-page: 884 issue: 6 year: 2017 end-page: 891 article-title: Clinical spectrum of medium‐sized vessel vasculitis publication-title: Arthritis Care Res (Hoboken) – volume: 20 start-page: 1016 issue: 8 year: 2017 end-page: 1022 article-title: Comparing polyarteritis nodosa in children and adults: a single center study publication-title: Int J Rheum Dis – volume: 73 start-page: 512 issue: 3 year: 2021 end-page: 519 article-title: Vasculitis Clinical Research Consortium. Sequence‐based screening of patients with idiopathic polyarteritis nodosa, granulomatosis with polyangiitis, and microscopic polyangiitis for deleterious genetic variants in ADA2 publication-title: Arthritis Rheumatol – volume: 90 start-page: 19 issue: 1 year: 2011 end-page: 27 article-title: The Five‐Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort publication-title: Medicine (Baltimore) – volume: 38 start-page: 1833 issue: 10 year: 2018 end-page: 1840 article-title: A retrospective study comparing the phenotype and outcomes of patients with polyarteritis nodosa between UK and Turkish cohorts publication-title: Rheumatol Int – volume: 75 start-page: 17 issue: 1 year: 1996 end-page: 28 article-title: Prognostic factors in polyarteritis nodosa and Churg‐Strauss syndrome. A prospective study in 342 patients publication-title: Medicine (Baltimore) – volume: 40 start-page: 371 issue: 2 year: 1997 end-page: 380 article-title: Development and initial validation of the Vasculitis Damage Index for the standardized clinical assessment of damage in the systemic vasculitides publication-title: Arthritis Rheum – volume: 66 start-page: 222 issue: 2 year: 2007 end-page: 227 article-title: Development and validation of a consensus methodology for the classification of the ANCA‐associated vasculitides and polyarteritis nodosa for epidemiological studies publication-title: Ann Rheum Dis – volume: 69 start-page: 798 issue: 5 year: 2010 end-page: 806 article-title: EULAR/PRINTO/PRES criteria for Henoch‐Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: final classification criteria publication-title: Ann Rheum Dis – volume: 87 start-page: 671 issue: 11 year: 1994 end-page: 678 article-title: Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis publication-title: QJM – volume: 62 start-page: 616 issue: 2 year: 2010 end-page: 626 article-title: Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database publication-title: Arthritis Rheum – ident: e_1_2_7_9_1 doi: 10.1056/NEJMoa1307361 – ident: e_1_2_7_10_1 doi: 10.1002/art.41549 – ident: e_1_2_7_12_1 doi: 10.1136/ard.2006.054593 – ident: e_1_2_7_20_1 doi: 10.1016/j.jpeds.2004.06.046 – ident: e_1_2_7_22_1 doi: 10.1097/MD.0b013e318205a4c6 – ident: e_1_2_7_3_1 doi: 10.1002/art.20077 – ident: e_1_2_7_8_1 doi: 10.1053/sarh.2001.19958 – volume: 36 start-page: 135 issue: 2 year: 2018 ident: e_1_2_7_7_1 article-title: Polyarteritis nodosa revisited: a review of historical approaches, subphenotypes and a research agenda publication-title: Clin Exp Rheumatol – volume: 87 start-page: 671 issue: 11 year: 1994 ident: e_1_2_7_16_1 article-title: Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis publication-title: QJM – ident: e_1_2_7_18_1 doi: 10.1097/00005792-199601000-00003 – ident: e_1_2_7_15_1 doi: 10.1002/art.27240 – ident: e_1_2_7_19_1 doi: 10.1002/acr.23007 – ident: e_1_2_7_4_1 doi: 10.1038/s41584-021-00718-8 – ident: e_1_2_7_11_1 doi: 10.1056/NEJMoa2026834 – ident: e_1_2_7_6_1 doi: 10.1007/s10157-013-0830-8 – ident: e_1_2_7_14_1 doi: 10.1007/s00296-018-4122-1 – ident: e_1_2_7_13_1 doi: 10.1136/ard.2009.116657 – ident: e_1_2_7_2_1 doi: 10.1002/art.1780370206 – ident: e_1_2_7_17_1 doi: 10.1002/art.1780400222 – ident: e_1_2_7_21_1 doi: 10.1111/1756-185X.13120 – ident: e_1_2_7_5_1 doi: 10.1002/art.1780330805 |
| SSID | ssj0000970605 ssib053799017 ssib048395117 ssib029851468 ssib020716651 ssib050995385 |
| Score | 2.5153103 |
| Snippet | Objective
We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration... We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration... ObjectiveWe describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration... |
| SourceID | pubmedcentral proquest pubmed crossref wiley nii |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1120 |
| SubjectTerms | Adenosine Adenosine deaminase Adult Age Aged Algorithms Central nervous system Creatinine Demographics Diagnosis Disease Europe - epidemiology Familial Mediterranean fever Female Hepatitis B Humans International cooperation International studies Japan - epidemiology Male Middle Aged North America - epidemiology Patients Pediatrics Polyarteritis Nodosa Proteinuria Proteinuria - etiology Recurrence Retrospective Studies Signs and symptoms Survival Survival Rate Young Adult |
| Title | Clinical Characteristics and Outcomes of Polyarteritis Nodosa: An International Study |
| URI | https://cir.nii.ac.jp/crid/1873116917609132800 https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fart.42817 https://www.ncbi.nlm.nih.gov/pubmed/38343337 https://www.proquest.com/docview/3072963548 https://www.proquest.com/docview/2926076158 https://pubmed.ncbi.nlm.nih.gov/PMC11213674 |
| Volume | 76 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 2326-5205 dateEnd: 20241105 omitProxy: true ssIdentifier: ssj0000970605 issn: 2326-5191 databaseCode: DIK dateStart: 19990101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe6ISFeEN8rbCggHpBQRuKPOOFtKh9jsIFGK-0tchxHLYK0WpsH-Ou5cxI3gSA-XqI0cR3bdzn_7nL-mZAnXGhoH8fsKW18nmnhqySLfKojYyjLpLTJmKdn0fGMn1yIi9HopJO1VG2yQ_19cF3J_0gVroFccZXsP0jWVQoX4BzkC0eQMBz_SsaTdlnjZIB2-UO1gWeaNsvtm03eRAajZ2fgiq7VYEjwk2Obdcy0m3n9L9SR87mpAOL2QvHn6iuYTRuHfrOo1ma1croyvYRfyzp7zJRuArCJpJXWC3vrfbXNFvqoMFmzjorjOkTVDUpQ7hJYO6Zva8kAtUU-QMW6gOlco4HommLZtaWABIPOvIzAcNDm1xyy0PBDcKVCuUOuULDwuI3Hy7fvWttCAUpF0fYLKE0AavKtq8UBKIrOmlvAUQnMBc7WCSbxC6J08bsgQd4hYfcubHrXElcF9LlrTQ_u7JSLxZAn82tCbtdRskhneoNcb1wU76jWt5tk9FndIldPmySM22TWqp33k9p5oHZeq3besvB6aufVavfCOyq9ntJ5VunukNnrV9PJsd_szuFrgfQeKhFKx7JQQnOVaF4wmgshQxWwQuAGLuC2JYYqZPXKC651wgyAc2l4QTkznN0lu-WyNHvEk1Lmuchh-uAZz3UGw50HWEmRhZmWwZg8bQcx1Q11Pe6g8iWtSbdpCn1J7XiPyWNXdFXztQwVOgBJQFV4DGPJQqSMkhFy5FLwoMZkv5VR2rzu65Qhxz7Acx6PySN3G4wxfmFTpVlW65QmNMLAoIAy92qRulawmHHGGDw87gnbFUCi9_6dcjG3hO8h8i5GksM4WL34fc9S8ILtyf0_dPEBubZ9b_fJ7uayMgcArzfZQ_ve_ACb88Td |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clinical+Characteristics+and+Outcomes+of+Polyarteritis+Nodosa%3A+An+International+Study&rft.jtitle=Arthritis+%26+Rheumatology&rft.au=Ramirez%2C+Giuseppe&rft.au=Treppo%2C+Elena&rft.au=Quartuccio%2C+Luca&rft.au=Pastore%2C+Serena&rft.date=2024-07-01&rft.pub=Wiley&rft.issn=2326-5191&rft.eissn=2326-5205&rft.volume=76&rft.spage=1120&rft.epage=1129&rft_id=info:doi/10.1002%2Fart.42817 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2326-5191&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2326-5191&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2326-5191&client=summon |