Mechanisms of T-cell metabolic reprogramming in the microenvironment of acute myeloid leukemia and its therapeutic potential (Review)
Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is often resistant to conventional therapies. The present narrative review discusses on the role of T cell metabolic reprogramming in the AML tumor microenvironment (TME), which markedly impacts the effectiveness of immunoth...
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| Published in | Oncology letters Vol. 30; no. 4; pp. 1 - 11 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Greece
D.A. Spandidos
01.10.2025
Spandidos Publications Spandidos Publications UK Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1792-1074 1792-1082 1792-1082 |
| DOI | 10.3892/ol.2025.15201 |
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| Abstract | Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is often resistant to conventional therapies. The present narrative review discusses on the role of T cell metabolic reprogramming in the AML tumor microenvironment (TME), which markedly impacts the effectiveness of immunotherapy. The TME of AML, influenced by factors such as high lactic acid (LA) levels, hypoxia and nutrient competition, hampers T cell functions such as glycolysis, lipid metabolism and amino acid metabolism, leading to impaired T cell proliferation and antitumor response. Metabolic waste products, including LA and adenosine, further contribute to the immunosuppressive environment. T cell exhaustion, induced by nutrient deprivation and metabolic dysregulation, serves a key role in the failure of immune responses. Moreover, strategies to modulate T cell metabolism, such as targeting glycolysis and fatty acid oxidation, show promise in enhancing immunotherapy outcomes. The current review also highlights emerging technologies, such as single-cell metabolomics and CRISPR screening, which are critical for identifying metabolic targets and advancing personalized therapies. Despite challenges in translating these findings to clinical settings, understanding T cell metabolism in the AML TME offers new therapeutic avenues for improving patient outcomes. |
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| AbstractList | Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is often resistant to conventional therapies. The present narrative review discusses on the role of T cell metabolic reprogramming in the AML tumor microenvironment (TME), which markedly impacts the effectiveness of immunotherapy. The TME of AML, influenced by factors such as high lactic acid (LA) levels, hypoxia and nutrient competition, hampers T cell functions such as glycolysis, lipid metabolism and amino acid metabolism, leading to impaired T cell proliferation and antitumor response. Metabolic waste products, including LA and adenosine, further contribute to the immunosuppressive environment. T cell exhaustion, induced by nutrient deprivation and metabolic dysregulation, serves a key role in the failure of immune responses. Moreover, strategies to modulate T cell metabolism, such as targeting glycolysis and fatty acid oxidation, show promise in enhancing immunotherapy outcomes. The current review also highlights emerging technologies, such as single-cell metabolomics and CRISPR screening, which are critical for identifying metabolic targets and advancing personalized therapies. Despite challenges in translating these findings to clinical settings, understanding T cell metabolism in the AML TME offers new therapeutic avenues for improving patient outcomes. Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is often resistant to conventional therapies. The present narrative review discusses on the role of T cell metabolic reprogramming in the AML tumor microenvironment (TME), which markedly impacts the effectiveness of immunotherapy. The TME of AML, influenced by factors such as high lactic acid (LA) levels, hypoxia and nutrient competition, hampers T cell functions such as glycolysis, lipid metabolism and amino acid metabolism, leading to impaired T cell proliferation and antitumor response. Metabolic waste products, including LA and adenosine, further contribute to the immunosuppressive environment. T cell exhaustion, induced by nutrient deprivation and metabolic dysregulation, serves a key role in the failure of immune responses. Moreover, strategies to modulate T cell metabolism, such as targeting glycolysis and fatty acid oxidation, show promise in enhancing immunotherapy outcomes. The current review also highlights emerging technologies, such as single-cell metabolomics and CRISPR screening, which are critical for identifying metabolic targets and advancing personalized therapies. Despite challenges in translating these findings to clinical settings, understanding T cell metabolism in the AML TME offers new therapeutic avenues for improving patient outcomes. Key words: immunization, T cells, tumor immunology |
| ArticleNumber | 455 |
| Audience | Academic |
| Author | Zhao, Xueya Luo, Jie Yang, Min Luo, Yanhong |
| AuthorAffiliation | 2 Bishan Hospital of Chongqing Medical University, Chongqing 402760, P.R. China 1 Department of Hematology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China 3 Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, P.R. China |
| AuthorAffiliation_xml | – name: 3 Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, P.R. China – name: 2 Bishan Hospital of Chongqing Medical University, Chongqing 402760, P.R. China – name: 1 Department of Hematology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China |
| Author_xml | – sequence: 1 givenname: Yanhong surname: Luo fullname: Luo, Yanhong organization: 1Department of Hematology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China – sequence: 2 givenname: Jie surname: Luo fullname: Luo, Jie organization: 2Bishan Hospital of Chongqing Medical University, Chongqing 402760, P.R. China – sequence: 3 givenname: Min surname: Yang fullname: Yang, Min organization: 1Department of Hematology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China – sequence: 4 givenname: Xueya surname: Zhao fullname: Zhao, Xueya organization: 3Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, P.R. China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40762019$$D View this record in MEDLINE/PubMed |
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| Snippet | Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is often resistant to conventional therapies. The present narrative review... |
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| SubjectTerms | Amino acids Biosynthesis Bone marrow Cancer Cell growth Cells Chemokines Chemotherapy Cytokines Cytotoxicity Fatty acids Fibroblasts Glucose Glucose metabolism Health aspects Hypoxia Immune response immunization Immunotherapy Kinases Lactic acid Leukemia Ligands Lipids Lymphocytes Medical prognosis Metabolism Nutrients Oncology, Experimental Review T cells tumor immunology Tumors |
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| Title | Mechanisms of T-cell metabolic reprogramming in the microenvironment of acute myeloid leukemia and its therapeutic potential (Review) |
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