Optical Microbubble Resonators with High Refractive Index Inner Coating for Bio-Sensing Applications: An Analytical Approach
The design of Whispering Gallery Mode Resonators (WGMRs) used as an optical transducer for biosensing represents the first and crucial step towards the optimization of the final device performance in terms of sensitivity and Limit of Detection (LoD). Here, we propose an analytical method for the des...
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| Published in | Sensors (Basel, Switzerland) Vol. 16; no. 12; p. 1992 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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MDPI AG
25.11.2016
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| ISSN | 1424-8220 1424-8220 |
| DOI | 10.3390/s16121992 |
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| Abstract | The design of Whispering Gallery Mode Resonators (WGMRs) used as an optical transducer for biosensing represents the first and crucial step towards the optimization of the final device performance in terms of sensitivity and Limit of Detection (LoD). Here, we propose an analytical method for the design of an optical microbubble resonator (OMBR)-based biosensor. In order to enhance the OMBR sensing performance, we consider a polymeric layer of high refractive index as an inner coating for the OMBR. The effect of this layer and other optical/geometrical parameters on the mode field distribution, sensitivity and LoD of the OMBR is assessed and discussed, both for transverse electric (TE) and transverse magnetic (TM) polarization. The obtained results do provide physical insights for the development of OMBR-based biosensor. |
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| AbstractList | The design of Whispering Gallery Mode Resonators (WGMRs) used as an optical transducer for biosensing represents the first and crucial step towards the optimization of the final device performance in terms of sensitivity and Limit of Detection (LoD). Here, we propose an analytical method for the design of an optical microbubble resonator (OMBR)-based biosensor. In order to enhance the OMBR sensing performance, we consider a polymeric layer of high refractive index as an inner coating for the OMBR. The effect of this layer and other optical/geometrical parameters on the mode field distribution, sensitivity and LoD of the OMBR is assessed and discussed, both for transverse electric (TE) and transverse magnetic (TM) polarization. The obtained results do provide physical insights for the development of OMBR-based biosensor. The design of Whispering Gallery Mode Resonators (WGMRs) used as an optical transducer for biosensing represents the first and crucial step towards the optimization of the final device performance in terms of sensitivity and Limit of Detection (LoD). Here, we propose an analytical method for the design of an optical microbubble resonator (OMBR)-based biosensor. In order to enhance the OMBR sensing performance, we consider a polymeric layer of high refractive index as an inner coating for the OMBR. The effect of this layer and other optical/geometrical parameters on the mode field distribution, sensitivity and LoD of the OMBR is assessed and discussed, both for transverse electric (TE) and transverse magnetic (TM) polarization. The obtained results do provide physical insights for the development of OMBR-based biosensor.The design of Whispering Gallery Mode Resonators (WGMRs) used as an optical transducer for biosensing represents the first and crucial step towards the optimization of the final device performance in terms of sensitivity and Limit of Detection (LoD). Here, we propose an analytical method for the design of an optical microbubble resonator (OMBR)-based biosensor. In order to enhance the OMBR sensing performance, we consider a polymeric layer of high refractive index as an inner coating for the OMBR. The effect of this layer and other optical/geometrical parameters on the mode field distribution, sensitivity and LoD of the OMBR is assessed and discussed, both for transverse electric (TE) and transverse magnetic (TM) polarization. The obtained results do provide physical insights for the development of OMBR-based biosensor. |
| Author | Farnesi, Daniele Barucci, Andrea Berneschi, Simone Baldini, Francesco Pelli, Stefano Soria, Silvia Righini, Giancarlo Nunzi Conti, Gualtiero Giannetti, Ambra Cosci, Alessandro |
| AuthorAffiliation | 1 Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy; a.barucci@ifac.cnr.it (A.B.); s.berneschi@ifac.cnr.it (S.B.); a.giannetti@ifac.cnr.it (A.G.); f.baldini@ifac.cnr.it (F.B.); a.cosci@ifac.cnr.it (A.C.); s.pelli@ifac.cnr.it (S.P.); d.farnesi@ifac.cnr.it (D.F.); giancarlo.righini@centrofermi.it (G.C.R.); g.nunziconti@ifac.cnr.it (G.N.C.) 2 Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy |
| AuthorAffiliation_xml | – name: 1 Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy; a.barucci@ifac.cnr.it (A.B.); s.berneschi@ifac.cnr.it (S.B.); a.giannetti@ifac.cnr.it (A.G.); f.baldini@ifac.cnr.it (F.B.); a.cosci@ifac.cnr.it (A.C.); s.pelli@ifac.cnr.it (S.P.); d.farnesi@ifac.cnr.it (D.F.); giancarlo.righini@centrofermi.it (G.C.R.); g.nunziconti@ifac.cnr.it (G.N.C.) – name: 2 Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy |
| Author_xml | – sequence: 1 givenname: Andrea orcidid: 0000-0002-3759-7512 surname: Barucci fullname: Barucci, Andrea – sequence: 2 givenname: Simone surname: Berneschi fullname: Berneschi, Simone – sequence: 3 givenname: Ambra orcidid: 0000-0002-0002-2977 surname: Giannetti fullname: Giannetti, Ambra – sequence: 4 givenname: Francesco orcidid: 0000-0002-2689-5952 surname: Baldini fullname: Baldini, Francesco – sequence: 5 givenname: Alessandro surname: Cosci fullname: Cosci, Alessandro – sequence: 6 givenname: Stefano surname: Pelli fullname: Pelli, Stefano – sequence: 7 givenname: Daniele surname: Farnesi fullname: Farnesi, Daniele – sequence: 8 givenname: Giancarlo orcidid: 0000-0002-6081-6971 surname: Righini fullname: Righini, Giancarlo – sequence: 9 givenname: Silvia orcidid: 0000-0002-4838-2197 surname: Soria fullname: Soria, Silvia – sequence: 10 givenname: Gualtiero orcidid: 0000-0002-2239-7622 surname: Nunzi Conti fullname: Nunzi Conti, Gualtiero |
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| SubjectTerms | Biosensing Techniques - methods Biosensors Coating Design analysis high refractive index polymer Limit of Detection Mathematical analysis Microbubbles optical microbubble resonator optical modeling Polymers - chemistry Refractive index Refractivity Refractometry Resonators Transducers whispering gallery mode resonators |
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| Title | Optical Microbubble Resonators with High Refractive Index Inner Coating for Bio-Sensing Applications: An Analytical Approach |
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