Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer’s disease (AD) although definitive evidence has not been presented. Whether such findings represent a causal contribution, or reflect opportunistic passengers of neurodegeneration, i...
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| Published in | Neuron (Cambridge, Mass.) Vol. 99; no. 1; pp. 64 - 82.e7 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
11.07.2018
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0896-6273 1097-4199 1097-4199 |
| DOI | 10.1016/j.neuron.2018.05.023 |
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| Abstract | Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer’s disease (AD) although definitive evidence has not been presented. Whether such findings represent a causal contribution, or reflect opportunistic passengers of neurodegeneration, is also difficult to resolve. We constructed multiscale networks of the late-onset AD-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four brain regions from human post-mortem tissue. We observed increased human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) from subjects with AD compared with controls. These results were replicated in two additional, independent and geographically dispersed cohorts. We observed regulatory relationships linking viral abundance and modulators of APP metabolism, including induction of APBB2, APPBP2, BIN1, BACE1, CLU, PICALM, and PSEN1 by HHV-6A. This study elucidates networks linking molecular, clinical, and neuropathological features with viral activity and is consistent with viral activity constituting a general feature of AD.
•Common viral species frequently detected in normal, aging brain•Increased HHV-6A and HHV-7 in brains of subjects with Alzheimer’s disease (AD)•Findings were replicated in two additional, independent cohorts•Multiscale networks reveal viral regulation of AD risk, and APP processing genes
Readhead et al. construct multiscale networks of the late-onset Alzheimer’s disease (AD)-associated virome and observe pathogenic regulation of molecular, clinical, and neuropathological networks by several common viruses, particularly human herpesvirus 6A and human herpesvirus 7. |
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| AbstractList | Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer's disease (AD) although definitive evidence has not been presented. Whether such findings represent a causal contribution, or reflect opportunistic passengers of neurodegeneration, is also difficult to resolve. We constructed multiscale networks of the late-onset AD-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four brain regions from human post-mortem tissue. We observed increased human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) from subjects with AD compared with controls. These results were replicated in two additional, independent and geographically dispersed cohorts. We observed regulatory relationships linking viral abundance and modulators of APP metabolism, including induction of APBB2, APPBP2, BIN1, BACE1, CLU, PICALM, and PSEN1 by HHV-6A. This study elucidates networks linking molecular, clinical, and neuropathological features with viral activity and is consistent with viral activity constituting a general feature of AD. Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer's disease (AD) although definitive evidence has not been presented. Whether such findings represent a causal contribution, or reflect opportunistic passengers of neurodegeneration, is also difficult to resolve. We constructed multiscale networks of the late-onset AD-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four brain regions from human post-mortem tissue. We observed increased human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) from subjects with AD compared with controls. These results were replicated in two additional, independent and geographically dispersed cohorts. We observed regulatory relationships linking viral abundance and modulators of APP metabolism, including induction of APBB2, APPBP2, BIN1, BACE1, CLU, PICALM, and PSEN1 by HHV-6A. This study elucidates networks linking molecular, clinical, and neuropathological features with viral activity and is consistent with viral activity constituting a general feature of AD.Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer's disease (AD) although definitive evidence has not been presented. Whether such findings represent a causal contribution, or reflect opportunistic passengers of neurodegeneration, is also difficult to resolve. We constructed multiscale networks of the late-onset AD-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four brain regions from human post-mortem tissue. We observed increased human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) from subjects with AD compared with controls. These results were replicated in two additional, independent and geographically dispersed cohorts. We observed regulatory relationships linking viral abundance and modulators of APP metabolism, including induction of APBB2, APPBP2, BIN1, BACE1, CLU, PICALM, and PSEN1 by HHV-6A. This study elucidates networks linking molecular, clinical, and neuropathological features with viral activity and is consistent with viral activity constituting a general feature of AD. SummaryInvestigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer’s disease (AD) although definitive evidence has not been presented. Whether such findings represent a causal contribution, or reflect opportunistic passengers of neurodegeneration, is also difficult to resolve. We constructed multiscale networks of the late-onset AD-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four brain regions from human post-mortem tissue. We observed increased human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) from subjects with AD compared with controls. These results were replicated in two additional, independent and geographically dispersed cohorts. We observed regulatory relationships linking viral abundance and modulators of APP metabolism, including induction of APBB2, APPBP2, BIN1, BACE1, CLU, PICALM, and PSEN1 by HHV-6A. This study elucidates networks linking molecular, clinical, and neuropathological features with viral activity and is consistent with viral activity constituting a general feature of AD. Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer’s disease (AD) although definitive evidence has not been presented. Whether such findings represent a causal contribution, or reflect opportunistic passengers of neurodegeneration, is also difficult to resolve. We constructed multiscale networks of the late-onset AD-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four brain regions from human post-mortem tissue. We observed increased human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) from subjects with AD compared with controls. These results were replicated in two additional, independent and geographically dispersed cohorts. We observed regulatory relationships linking viral abundance and modulators of APP metabolism, including induction of APBB2, APPBP2, BIN1, BACE1, CLU, PICALM, and PSEN1 by HHV-6A. This study elucidates networks linking molecular, clinical, and neuropathological features with viral activity and is consistent with viral activity constituting a general feature of AD. •Common viral species frequently detected in normal, aging brain•Increased HHV-6A and HHV-7 in brains of subjects with Alzheimer’s disease (AD)•Findings were replicated in two additional, independent cohorts•Multiscale networks reveal viral regulation of AD risk, and APP processing genes Readhead et al. construct multiscale networks of the late-onset Alzheimer’s disease (AD)-associated virome and observe pathogenic regulation of molecular, clinical, and neuropathological networks by several common viruses, particularly human herpesvirus 6A and human herpesvirus 7. |
| Author | Readhead, Ben Richards, Matthew A. Sano, Mary Schadt, Eric E. Gandy, Sam Liang, Winnie S. Haure-Mirande, Jean-Vianney Funk, Cory C. Shannon, Paul Reiman, Eric M. Ehrlich, Michelle E. Price, Nathan D. Beckmann, Noam D. Dudley, Joel T. Haroutunian, Vahram |
| Author_xml | – sequence: 1 givenname: Ben surname: Readhead fullname: Readhead, Ben organization: Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA – sequence: 2 givenname: Jean-Vianney surname: Haure-Mirande fullname: Haure-Mirande, Jean-Vianney organization: Department of Neurology, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA – sequence: 3 givenname: Cory C. surname: Funk fullname: Funk, Cory C. organization: Institute for Systems Biology, Seattle, WA, 98109-5263, USA – sequence: 4 givenname: Matthew A. surname: Richards fullname: Richards, Matthew A. organization: Institute for Systems Biology, Seattle, WA, 98109-5263, USA – sequence: 5 givenname: Paul surname: Shannon fullname: Shannon, Paul organization: Institute for Systems Biology, Seattle, WA, 98109-5263, USA – sequence: 6 givenname: Vahram surname: Haroutunian fullname: Haroutunian, Vahram organization: Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA – sequence: 7 givenname: Mary surname: Sano fullname: Sano, Mary organization: James J. Peters VA Medical Center, 130 West Kingsbridge Road, New York, NY 10468, USA – sequence: 8 givenname: Winnie S. surname: Liang fullname: Liang, Winnie S. organization: Arizona Alzheimer’s Consortium, Phoenix, AZ 85014, USA – sequence: 9 givenname: Noam D. surname: Beckmann fullname: Beckmann, Noam D. organization: Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA – sequence: 10 givenname: Nathan D. surname: Price fullname: Price, Nathan D. organization: Institute for Systems Biology, Seattle, WA, 98109-5263, USA – sequence: 11 givenname: Eric M. surname: Reiman fullname: Reiman, Eric M. organization: Arizona Alzheimer’s Consortium, Phoenix, AZ 85014, USA – sequence: 12 givenname: Eric E. surname: Schadt fullname: Schadt, Eric E. organization: Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA – sequence: 13 givenname: Michelle E. surname: Ehrlich fullname: Ehrlich, Michelle E. organization: Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA – sequence: 14 givenname: Sam surname: Gandy fullname: Gandy, Sam organization: Department of Neurology, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA – sequence: 15 givenname: Joel T. surname: Dudley fullname: Dudley, Joel T. email: joel.dudley@mssm.edu organization: Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29937276$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0022-2836(05)80360-2 10.1126/scitranslmed.aaf1059 10.1016/S0007-1935(17)50172-4 10.3233/JAD-150464 10.1038/nmeth.3337 10.1128/JVI.75.21.10511-10514.2001 10.1016/j.immuni.2017.08.008 10.1093/bioinformatics/btr625 10.1038/nbt.1511 10.1002/ajmg.b.30607 10.1186/1750-9378-2-18 10.1016/j.jalz.2014.04.522 10.1128/JVI.02526-09 10.1073/pnas.0913586107 10.1523/JNEUROSCI.16-14-04491.1996 10.1093/nar/gkq1107 10.1017/thg.2014.79 10.2202/1544-6115.1027 10.1126/science.6474172 10.3233/JAD-160152 10.1038/nature15393 10.1186/s13059-017-1349-1 10.2174/156720512801322573 10.1016/j.neuroscience.2012.02.037 10.1212/WNL.43.11.2412-a 10.1093/bioinformatics/btt656 10.1016/S0022-3476(76)81045-1 10.1093/bioinformatics/bts635 10.1111/j.1460-9568.2004.03852.x 10.1093/nar/gkt850 10.1002/0471250953.bi1110s43 10.3389/fnagi.2015.00061 10.1177/1753425912473345 10.1038/nchembio.1479 10.1186/1471-2156-10-23 10.1073/pnas.0506580102 10.1093/biostatistics/kxs014 10.1073/pnas.080076097 10.1038/tp.2013.18 10.1016/j.neurobiolaging.2008.05.013 10.1006/viro.1999.9949 10.1016/j.jalz.2011.03.003 10.1016/S0021-9258(18)53402-5 10.1371/journal.pgen.1004033 10.1016/j.cell.2013.03.030 10.1038/nmeth.3772 10.1093/nar/gku1207 10.1126/science.1141229 10.1186/1742-4690-10-160 10.1093/nar/gkv1209 10.1128/JVI.75.11.5043-5048.2001 10.1038/tp.2016.164 10.1001/archneur.55.9.1185 10.1212/WNL.41.4.479 10.1093/bioinformatics/bts163 10.1016/j.molcel.2014.01.027 10.1093/database/bav059 10.1093/nar/gkt214 10.1093/bioinformatics/btn480 10.1038/s41467-018-03751-6 10.1016/S0140-6736(80)91490-7 10.1038/sdata.2016.89 10.1099/jgv.0.000692 10.1002/jmv.20113 10.1093/bioinformatics/btp324 10.1152/physiolgenomics.00242.2007 10.1093/bioinformatics/bti473 10.1016/j.celrep.2015.11.039 10.1186/s12864-016-2446-3 10.1093/jnen/64.2.113 10.1186/s12985-016-0672-6 10.1128/jvi.63.6.2585-2591.1989 10.1093/hmg/ddh019 10.1093/bioinformatics/btr011 10.1016/0197-4580(92)90027-U 10.1152/physiolgenomics.00208.2006 10.1016/j.neurobiolaging.2013.06.024 10.1093/nar/gkv862 10.1093/bioinformatics/btp352 10.3389/fneur.2017.00040 10.2174/156720512801322663 10.1002/anie.201605431 10.1002/path.1127 10.1093/database/baw100 10.1128/JVI.00495-12 10.1128/jvi.71.11.8087-8095.1997 10.1021/bi500945x 10.1007/s00401-006-0127-z 10.1212/WNL.44.11.2015 10.1371/journal.pgen.1000529 10.1093/nar/gkv007 10.1073/pnas.1507125112 10.1186/gb-2014-15-2-r29 10.1006/viro.1998.9305 10.1016/j.biopsych.2017.06.004 10.1038/21637 10.1523/JNEUROSCI.4790-14.2015 10.1038/ng.2802 10.1073/pnas.051633498 10.1016/S0163-7258(99)00004-2 10.1128/JVI.01166-08 10.1093/nar/gki956 10.1038/nature05992 10.1002/jcla.20379 10.1016/j.ajhg.2010.06.009 10.1093/bioinformatics/btp616 10.1016/j.jalz.2010.06.001 10.1093/bioinformatics/btq466 10.1371/journal.pgen.1004898 10.1371/journal.pone.0009505 10.1093/nar/gkn666 10.1093/nar/gkt265 10.1186/1471-2105-12-322 10.1126/science.aad6970 10.1038/35057062 10.1038/nn.4608 10.1038/tp.2015.52 10.1038/mp.2015.167 10.1016/j.jalz.2014.07.157 10.1016/j.neurobiolaging.2017.10.019 10.1007/s00430-003-0194-x 10.1002/gepi.21945 10.1097/00001756-199412000-00031 10.1534/g3.111.001198 10.3109/13550289809113493 10.3389/fnagi.2014.00202 10.1038/nmeth.1923 10.1111/j.2517-6161.1995.tb02031.x |
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| References | Sang, Tait, Scott, Creagh, Kumar, Haynes, Straus (bib108) 2014; 53 Gusmao, Allhoff, Zenke, Costa (bib38) 2016; 13 Lander, Linton, Birren, Nusbaum, Zody, Baldwin, Devon, Dewar, Doyle, FitzHugh (bib59) 2001; 409 Scholz, Vogel, Höver, Prösch, Kotchetkov, Cinatl, Koch, Doerr, Cinatl (bib109) 2004; 193 Cohain, Divaraniya, Zhu, Scarpa, Kasarskis, Zhu, Chang, Dudley, Schadt (bib26) 2017; 22 Lövheim, Gilthorpe, Johansson, Eriksson, Hallmans, Elgh (bib74) 2015; 11 Caccamo, Branca, Piras, Ferreira, Huentelman, Liang, Readhead, Dudley, Spangenberg, Green (bib18) 2017; 20 Benjamini, Hochberg (bib11) 1995; 57 Newman, Liu, Green, Gentles, Feng, Xu, Hoang, Diehn, Alizadeh (bib89) 2015; 12 Soscia, Kirby, Washicosky, Tucker, Ingelsson, Hyman, Burton, Goldstein, Duong, Tanzi, Moir (bib116) 2010; 5 Allen, Carrasquillo, Funk, Heavner, Zou, Younkin, Burgess, Chai, Crook, Eddy (bib4) 2016; 3 Zhang, Gaiteri, Bodea, Wang, McElwee, Podtelezhnikov, Zhang, Xie, Tran, Dobrin (bib135) 2013; 153 Dickson, Crystal, Mattiace, Masur, Blau, Davies, Yen, Aronson (bib29) 1992; 13 Nousiainen, Sillanpää, Jiang, Thompson, Taipale, Julkunen (bib92) 2013; 19 Braak, Alafuzoff, Arzberger, Kretzschmar, Del Tredici (bib16) 2006; 112 Yoo, Takikawa, Geraghty, Argmann, Campbell, Lin, Huang, Tu, Foronjy, Spira (bib132) 2015; 11 Krasemann, Madore, Cialic, Baufeld, Calcagno, El Fatimy, Beckers, O’Loughlin, Xu, Fanek (bib54) 2017; 47 Lövheim, Gilthorpe, Adolfsson, Nilsson, Elgh (bib73) 2015; 11 Ament, S., Shannon, P., and Richards, M. (2017). TReNA: Fit transcriptional regulatory networks using gene expression, priors, machine learning. R package version 0.99.10. Kaddurah-Daouk, Rozen, Matson, Han, Hulette, Burke, Doraiswamy, Welsh-Bohmer (bib51) 2011; 7 Howie, Donnelly, Marchini (bib43) 2009; 5 Middleton, Petric, Kozak, Rewcastle, McLachlan (bib80) 1980; 1 Hsu, Lin, Wu, Liang, Huang, Chan, Tsai, Chen, Lee, Chiu (bib45) 2011; 39 Song, Lee (bib115) 2015; 7 Liao, Smyth, Shi (bib68) 2013; 41 Rotmistrovsky, K., and Agarwala, R. (2011). BMTagger: Best Match Tagger for removing human reads from metagenomics datasets. Mak, Kleiman (bib76) 1997; 71 . Grady, Hwang, Vastag, Rabinowitz, Shenk (bib37) 2012; 86 Upton, Chan (bib124) 2014; 54 Van der Auwera, Carneiro, Hartl, Poplin, Del Angel, Levy-Moonshine, Jordan, Shakir, Roazen, Thibault (bib125) 2013; 43 Pearl, Bergey, Funk, Basu, Oshone, Shannon, Hood, Price, Colantuoni, Ament (bib96) 2017 Chen, Simmons, Perry, Wiener, Harrell, Go (bib24) 2008; 147 Sigurðsson (bib112) 1954; 110 Woodbury, Freilich, Cheng, Asai, Ikezu, Boucher, Slack, Ikezu (bib130) 2015; 35 Howie, Marchini, Stephens (bib44) 2011; 1 Madeira, Lourenco, Vargas-Lopes, Suemoto, Brandão, Reis, Leite, Laks, Jacob-Filho, Pasqualucci (bib75) 2015; 5 Shugar (bib111) 1999; 82 Cox, Mann (bib27) 2008; 26 Mastroeni, Nolz, Sekar, Delvaux, Serrano, Cuyugan, Liang, Beach, Rogers, Coleman (bib78) 2018; 63 Boyle, Guinney, Crawford, Furey (bib15) 2008; 24 Hauw, Daniel, Dickson, Horoupian, Jellinger, Lantos, McKee, Tabaton, Litvan (bib42) 1994; 44 Rouillard, Gundersen, Fernandez, Wang, Monteiro, McDermott, Ma’ayan (bib107) 2016; 2016 Artusi, Perrone, Lago, Raffa, Di Iorio, Palù, Richter (bib9) 2016; 44 Sjogren, Sjogren, Lindgren (bib113) 1952; 82 Auton, Brooks, Durbin, Garrison, Kang, Korbel, Marchini, McCarthy, McVean, Abecasis (bib1) 2015; 526 Franzén, Ermel, Cohain, Akers, Di Narzo, Talukdar, Foroughi-Asl, Giambartolomei, Fullard, Sukhavasi (bib32) 2016; 353 Ritchie, Phipson, Wu, Hu, Law, Shi, Smyth (bib103) 2015; 43 Garant, Luce, Scott, Perreault (bib33) 2015; 2015 Gatto, Rossi, Rossi, Kroening, Bonatti, Mallardo (bib34) 2008; 36 Zhao, Yao, Xu, Lambeth, Smith, Kgosana, Wang, Nair (bib136) 2009; 83 Aran, Hu, Butte (bib7) 2017; 18 Cen, Khorchid, Javanbakht, Gabor, Stello, Shiba, Musier-Forsyth, Kleiman (bib22) 2001; 75 Itzhaki (bib48) 2014; 6 Miller, Cai, Langfelder, Geschwind, Kurian, Salomon, Horvath (bib81) 2011; 12 Zhang, de Bolle, Aquaro, van Lommel, De Clercq, Schols (bib134) 2001; 75 Dobin, Davis, Schlesinger, Drenkow, Zaleski, Jha, Batut, Chaisson, Gingeras (bib30) 2013; 29 Bennett, Schneider, Buchman, Barnes, Boyle, Wilson (bib13) 2012; 9 Papadopoulou, Guilbaud, Schiavone, Sale (bib94) 2015; 13 Liang, Dunckley, Beach, Grover, Mastroeni, Walker, Caselli, Kukull, McKeel, Morris (bib65) 2007; 28 Bernier, Cleret-Buhot, Zhang, Goulet, Monteiro, Gosselin, DaFonseca, Wacleche, Jenabian, Routy (bib14) 2013; 10 Vidal, Frangione, Rostagno, Mead, Révész, Plant, Ghiso (bib126) 1999; 399 Westman, Blomberg, Yun, Lannfelt, Ingelsson, Eriksson (bib128) 2017; 8 Caselli, D’Accolti, Soffritti, Zatelli, Rossi, Degli Uberti, Di Luca (bib21) 2017; 14 Harrich, Garcia, Wu, Mitsuyasu, Gonazalez, Gaynor (bib41) 1989; 63 Nygaard (bib93) 2018; 83 Epel, Puterman, Lin, Blackburn, Lum, Beckmann, Zhu, Lee, Gilbert, Rissman (bib31) 2016; 6 Zaharia, M., Bolosky, W.J., Curtis, K., Fox, A., Patterson, D., Shenker, S., Stoica, I., Karp, R.M., and Sittler, T. (2011). Faster and more accurate sequence alignment with SNAP. arXiv, arXiv:1111.5572 Cartharius, Frech, Grote, Klocke, Haltmeier, Klingenhoff, Frisch, Bayerlein, Werner (bib20) 2005; 21 Prusty, Gulve, Rasa, Murovska, Hernandez, Ablashi (bib99) 2017; 98 Lee, Wu, Lin (bib62) 2012; 13 Liang, Dunckley, Beach, Grover, Mastroeni, Ramsey, Caselli, Kukull, McKeel, Morris (bib67) 2010; 31 Lin, Wozniak, Cooper, Wilcock, Itzhaki (bib70) 2002; 197 Mirra, Heyman, McKeel, Sumi, Crain, Brownlee, Vogel, Hughes, van Belle, Berg (bib83) 1991; 41 Lambert, Ibrahim-Verbaas, Harold, Naj, Sims, Bellenguez, DeStafano, Bis, Beecham, Grenier-Boley (bib58) 2013; 45 Chen, Xu, Gordonov, Lim, Perkins, Ma’ayan (bib25) 2012; 28 Li, Handsaker, Wysoker, Fennell, Ruan, Homer, Marth, Abecasis, Durbin (bib64) 2009; 25 Murat, Zhong, Lekieffre, Cowieson, Clancy, Preiss, Balasubramanian, Khanna, Tellam (bib87) 2014; 10 Mattiussi, Tempera, Matusali, Mearini, Lenti, Fratarcangeli, Mosca, D’Erme, Mattia (bib79) 2007; 2 Kersey, Allen, Armean, Boddu, Bolt, Carvalho-Silva, Christensen, Davis, Falin, Grabmueller (bib53) 2016; 44 Su, Anderson, Cummings, Cotman (bib118) 1994; 5 Marçais, Kingsford (bib77) 2011; 27 Kaddurah-Daouk, Zhu, Sharma, Bogdanov, Rozen, Matson, Oki, Motsinger-Reif, Churchill, Lei (bib52) 2013; 3 Langmead, Salzberg (bib60) 2012; 9 Brister, Ako-Adjei, Bao, Blinkova (bib17) 2015; 43 Readhead, Haure-Mirande, Zhang, Haroutunian, Gandy, Schadt, Dudley, Ehrlich (bib101) 2016; 21 Ha, Juluri, Zhou, Leung, Hermankova, Snyder (bib39) 2001; 98 Prusty, Krohne, Rudel (bib98) 2013; 9 Agostini, Mancuso, Baglio, Cabinio, Hernis, Guerini, Calabrese, Nemni, Clerici (bib2) 2016; 49 Millstein, Zhang, Zhu, Schadt (bib82) 2009; 10 Mishra, Macgregor (bib84) 2015; 18 Wu, Pankow (bib131) 2016; 40 Thai, Calado, Casola, Ansel, Xiao, Xue, Murphy, Frendewey, Valenzuela, Kutok (bib122) 2007; 316 Toribara, Roberton, Ho, Kuo, Gum, Hicks, Gum, Byrd, Siddiki, Kim (bib123) 1993; 268 Hyman, Van Hoesen, Damasio, Barnes (bib47) 1984; 225 Li, Durbin (bib63) 2009; 25 Darmanis, Sloan, Zhang, Enge, Caneda, Shuer, Hayden Gephart, Barres, Quake (bib28) 2015; 112 Lachmann, Torre, Keenan, Jagodnik, Lee, Wang, Silverstein, Ma’ayan (bib57) 2018; 9 Arbuckle, Medveczky, Luka, Hadley, Luegmayr, Ablashi, Lund, Tolar, De Meirleir, Montoya (bib8) 2010; 107 Robinson, McCarthy, Smyth (bib104) 2010; 26 Morris (bib86) 1993; 43 Beaudoin, Perreault (bib10) 2013; 41 Liu, Lin, Wu, Liu, Wang, Tsai, Lee, Tsai (bib71) 2010; 24 Vidal, Revesz, Rostagno, Kim, Holton, Bek, Bojsen-Møller, Braendgaard, Plant, Ghiso, Frangione (bib127) 2000; 97 Subramanian, Tamayo, Mootha, Mukherjee, Ebert, Gillette, Paulovich, Pomeroy, Golub, Lander, Mesirov (bib119) 2005; 102 Chang, Chung, Hong, Ichimura, Nakao, Liu (bib23) 2005; 33 Liao, Smyth, Shi (bib69) 2014; 30 Law, Chen, Shi, Smyth (bib61) 2014; 15 Rampelli, Soverini, Turroni, Quercia, Biagi, Brigidi, Candela (bib100) 2016; 17 Pearl (bib95) 2009 Nixon, Wegiel, Kumar, Yu, Peterhoff, Cataldo, Cuervo (bib91) 2005; 64 Altschul, Gish, Miller, Myers, Lipman (bib5) 1990; 215 Eimer, Kumar, Shanmugam, Rodriguez, Mitchell, Washicosky, György, Breakefield, Tanzi, Moir (bib137) 2018; 98 Gómez-Isla, Price, McKeel, Morris, Growdon, Hyman (bib35) 1996; 16 Kumar, Choi, Washicosky, Eimer, Tucker, Ghofrani, Lefkowitz, McColl, Goldstein, Tanzi, Moir (bib55) 2016; 8 Sperling, Aisen, Beckett, Bennett, Craft, Fagan, Iwatsubo, Jack, Kaye, Montine (bib117) 2011; 7 Swanson, Sherer, Malim (bib120) 2010; 84 Tanaka-Taya, Sashihara, Kurahashi, Amo, Miyagawa, Kondo, Okada, Yamanishi (bib121) 2004; 73 Murphy, Yunis (bib88) 1976; 88 Wong, Higgins, Halliday, Garner (bib129) 2012; 210 Piper, Elze, Cauchy, Cockerill, Bonifer, Ott (bib97) 2013; 41 Lachmann, Xu, Krishnan, Berger, Mazloom, Ma’ayan (bib56) 2010; 26 Rode, Endoh, Sugimoto (bib105) 2016; 55 Bennett, Schneider, Arvanitakis, Wilson (bib12) 2012; 9 Jankowsky, Fadale, Anderson, Xu, Gonzales, Jenkins, Copeland, Lee, Younkin, Wagner (bib50) 2004; 13 Gottwein, Mukherjee, Sachse, Frenzel, Majoros, Chi, Braich, Manoharan, Soutschek, Ohler, Cullen (bib36) 2007; 450 Liu, McRae, Nyholt, Medland, Wray, Brown, Hayward, Montgomery, Visscher, Martin, Macgregor (bib72) 2010; 87 Itzhaki, Lathe, Balin, Ball, Bearer, Braak, Bullido, Carter, Clerici, Cosby (bib49) 2016; 51 Smyth (bib114) 2004; 3 Nishida, Kawasaki, Fujie, Usami, Yamada (bib90) 1999; 263 Haroutunian, Perl, Purohit, Marin, Khan, Lantz, Davis, Mohs (bib40) 1998; 55 Albright, Lavi, Black, Goldberg, O’Connor, González-Scarano (bib3) 1998; 4 Carbone, Lazzarotto, Ianni, Porcellini, Forti, Masliah, Gabrielli, Licastro (bib19) 2014; 35 Rhodes, Lipps (bib102) 2015; 43 Mori, Yagi, Shimamoto, Isegawa, Sunagawa, Inagi, Kondo, Tano, Yamanishi (bib85) 1998; 249 Shabalin (bib110) 2012; 28 Liang, Dunckley, Beach, Grover, Mastroeni, Ramsey, Caselli, Kukull, McKeel, Morris (bib66) 2008; 33 Huang, Tanimukai, Liu, Iqbal, Grundke-Iqbal, Gong (bib46) 2004; 20 Middleton (10.1016/j.neuron.2018.05.023_bib80) 1980; 1 Bernier (10.1016/j.neuron.2018.05.023_bib14) 2013; 10 Kersey (10.1016/j.neuron.2018.05.023_bib53) 2016; 44 Sperling (10.1016/j.neuron.2018.05.023_bib117) 2011; 7 Lee (10.1016/j.neuron.2018.05.023_bib62) 2012; 13 Shugar (10.1016/j.neuron.2018.05.023_bib111) 1999; 82 Sigurðsson (10.1016/j.neuron.2018.05.023_bib112) 1954; 110 Agostini (10.1016/j.neuron.2018.05.023_bib2) 2016; 49 Caccamo (10.1016/j.neuron.2018.05.023_bib18) 2017; 20 Piper (10.1016/j.neuron.2018.05.023_bib97) 2013; 41 Haroutunian (10.1016/j.neuron.2018.05.023_bib40) 1998; 55 Bennett (10.1016/j.neuron.2018.05.023_bib13) 2012; 9 Mori (10.1016/j.neuron.2018.05.023_bib85) 1998; 249 Franzén (10.1016/j.neuron.2018.05.023_bib32) 2016; 353 Aran (10.1016/j.neuron.2018.05.023_bib7) 2017; 18 Epel (10.1016/j.neuron.2018.05.023_bib31) 2016; 6 Garant (10.1016/j.neuron.2018.05.023_bib33) 2015; 2015 Nixon (10.1016/j.neuron.2018.05.023_bib91) 2005; 64 Rode (10.1016/j.neuron.2018.05.023_bib105) 2016; 55 Toribara (10.1016/j.neuron.2018.05.023_bib123) 1993; 268 Rampelli (10.1016/j.neuron.2018.05.023_bib100) 2016; 17 Liang (10.1016/j.neuron.2018.05.023_bib67) 2010; 31 Prusty (10.1016/j.neuron.2018.05.023_bib99) 2017; 98 Gottwein (10.1016/j.neuron.2018.05.023_bib36) 2007; 450 Bennett (10.1016/j.neuron.2018.05.023_bib12) 2012; 9 Kaddurah-Daouk (10.1016/j.neuron.2018.05.023_bib52) 2013; 3 10.1016/j.neuron.2018.05.023_bib6 Su (10.1016/j.neuron.2018.05.023_bib118) 1994; 5 Li (10.1016/j.neuron.2018.05.023_bib63) 2009; 25 Itzhaki (10.1016/j.neuron.2018.05.023_bib48) 2014; 6 Arbuckle (10.1016/j.neuron.2018.05.023_bib8) 2010; 107 Sang (10.1016/j.neuron.2018.05.023_bib108) 2014; 53 Chen (10.1016/j.neuron.2018.05.023_bib25) 2012; 28 Allen (10.1016/j.neuron.2018.05.023_bib4) 2016; 3 Prusty (10.1016/j.neuron.2018.05.023_bib98) 2013; 9 Lander (10.1016/j.neuron.2018.05.023_bib59) 2001; 409 Law (10.1016/j.neuron.2018.05.023_bib61) 2014; 15 Brister (10.1016/j.neuron.2018.05.023_bib17) 2015; 43 Tanaka-Taya (10.1016/j.neuron.2018.05.023_bib121) 2004; 73 Scholz (10.1016/j.neuron.2018.05.023_bib109) 2004; 193 Van der Auwera (10.1016/j.neuron.2018.05.023_bib125) 2013; 43 Itzhaki (10.1016/j.neuron.2018.05.023_bib49) 2016; 51 Mattiussi (10.1016/j.neuron.2018.05.023_bib79) 2007; 2 Eimer (10.1016/j.neuron.2018.05.023_bib137) 2018; 98 Chen (10.1016/j.neuron.2018.05.023_bib24) 2008; 147 Grady (10.1016/j.neuron.2018.05.023_bib37) 2012; 86 Krasemann (10.1016/j.neuron.2018.05.023_bib54) 2017; 47 Murphy (10.1016/j.neuron.2018.05.023_bib88) 1976; 88 Wu (10.1016/j.neuron.2018.05.023_bib131) 2016; 40 Liu (10.1016/j.neuron.2018.05.023_bib71) 2010; 24 Liao (10.1016/j.neuron.2018.05.023_bib68) 2013; 41 Lambert (10.1016/j.neuron.2018.05.023_bib58) 2013; 45 Gusmao (10.1016/j.neuron.2018.05.023_bib38) 2016; 13 Lachmann (10.1016/j.neuron.2018.05.023_bib56) 2010; 26 Beaudoin (10.1016/j.neuron.2018.05.023_bib10) 2013; 41 Cox (10.1016/j.neuron.2018.05.023_bib27) 2008; 26 Shabalin (10.1016/j.neuron.2018.05.023_bib110) 2012; 28 Song (10.1016/j.neuron.2018.05.023_bib115) 2015; 7 Zhang (10.1016/j.neuron.2018.05.023_bib135) 2013; 153 Lövheim (10.1016/j.neuron.2018.05.023_bib74) 2015; 11 Dickson (10.1016/j.neuron.2018.05.023_bib29) 1992; 13 Liao (10.1016/j.neuron.2018.05.023_bib69) 2014; 30 Lin (10.1016/j.neuron.2018.05.023_bib70) 2002; 197 Murat (10.1016/j.neuron.2018.05.023_bib87) 2014; 10 Cen (10.1016/j.neuron.2018.05.023_bib22) 2001; 75 Rouillard (10.1016/j.neuron.2018.05.023_bib107) 2016; 2016 Westman (10.1016/j.neuron.2018.05.023_bib128) 2017; 8 Lachmann (10.1016/j.neuron.2018.05.023_bib57) 2018; 9 Auton (10.1016/j.neuron.2018.05.023_bib1) 2015; 526 Upton (10.1016/j.neuron.2018.05.023_bib124) 2014; 54 Boyle (10.1016/j.neuron.2018.05.023_bib15) 2008; 24 Millstein (10.1016/j.neuron.2018.05.023_bib82) 2009; 10 Readhead (10.1016/j.neuron.2018.05.023_bib101) 2016; 21 Thai (10.1016/j.neuron.2018.05.023_bib122) 2007; 316 Liu (10.1016/j.neuron.2018.05.023_bib72) 2010; 87 Zhang (10.1016/j.neuron.2018.05.023_bib134) 2001; 75 Cohain (10.1016/j.neuron.2018.05.023_bib26) 2017; 22 Mak (10.1016/j.neuron.2018.05.023_bib76) 1997; 71 Hauw (10.1016/j.neuron.2018.05.023_bib42) 1994; 44 Braak (10.1016/j.neuron.2018.05.023_bib16) 2006; 112 10.1016/j.neuron.2018.05.023_bib106 Subramanian (10.1016/j.neuron.2018.05.023_bib119) 2005; 102 Jankowsky (10.1016/j.neuron.2018.05.023_bib50) 2004; 13 Wong (10.1016/j.neuron.2018.05.023_bib129) 2012; 210 Albright (10.1016/j.neuron.2018.05.023_bib3) 1998; 4 Marçais (10.1016/j.neuron.2018.05.023_bib77) 2011; 27 Cartharius (10.1016/j.neuron.2018.05.023_bib20) 2005; 21 Kumar (10.1016/j.neuron.2018.05.023_bib55) 2016; 8 Zhao (10.1016/j.neuron.2018.05.023_bib136) 2009; 83 Smyth (10.1016/j.neuron.2018.05.023_bib114) 2004; 3 Artusi (10.1016/j.neuron.2018.05.023_bib9) 2016; 44 Rhodes (10.1016/j.neuron.2018.05.023_bib102) 2015; 43 Pearl (10.1016/j.neuron.2018.05.023_bib95) 2009 Dobin (10.1016/j.neuron.2018.05.023_bib30) 2013; 29 Liang (10.1016/j.neuron.2018.05.023_bib66) 2008; 33 Mishra (10.1016/j.neuron.2018.05.023_bib84) 2015; 18 Robinson (10.1016/j.neuron.2018.05.023_bib104) 2010; 26 Benjamini (10.1016/j.neuron.2018.05.023_bib11) 1995; 57 Sjogren (10.1016/j.neuron.2018.05.023_bib113) 1952; 82 10.1016/j.neuron.2018.05.023_bib133 Nousiainen (10.1016/j.neuron.2018.05.023_bib92) 2013; 19 Nishida (10.1016/j.neuron.2018.05.023_bib90) 1999; 263 Liang (10.1016/j.neuron.2018.05.023_bib65) 2007; 28 Ha (10.1016/j.neuron.2018.05.023_bib39) 2001; 98 Darmanis (10.1016/j.neuron.2018.05.023_bib28) 2015; 112 Papadopoulou (10.1016/j.neuron.2018.05.023_bib94) 2015; 13 Gatto (10.1016/j.neuron.2018.05.023_bib34) 2008; 36 Li (10.1016/j.neuron.2018.05.023_bib64) 2009; 25 Lövheim (10.1016/j.neuron.2018.05.023_bib73) 2015; 11 Chang (10.1016/j.neuron.2018.05.023_bib23) 2005; 33 Madeira (10.1016/j.neuron.2018.05.023_bib75) 2015; 5 Morris (10.1016/j.neuron.2018.05.023_bib86) 1993; 43 Carbone (10.1016/j.neuron.2018.05.023_bib19) 2014; 35 Ritchie (10.1016/j.neuron.2018.05.023_bib103) 2015; 43 Nygaard (10.1016/j.neuron.2018.05.023_bib93) 2018; 83 Soscia (10.1016/j.neuron.2018.05.023_bib116) 2010; 5 Langmead (10.1016/j.neuron.2018.05.023_bib60) 2012; 9 Kaddurah-Daouk (10.1016/j.neuron.2018.05.023_bib51) 2011; 7 Miller (10.1016/j.neuron.2018.05.023_bib81) 2011; 12 Swanson (10.1016/j.neuron.2018.05.023_bib120) 2010; 84 Huang (10.1016/j.neuron.2018.05.023_bib46) 2004; 20 Hyman (10.1016/j.neuron.2018.05.023_bib47) 1984; 225 Newman (10.1016/j.neuron.2018.05.023_bib89) 2015; 12 Pearl (10.1016/j.neuron.2018.05.023_bib96) 2017 Vidal (10.1016/j.neuron.2018.05.023_bib127) 2000; 97 Altschul (10.1016/j.neuron.2018.05.023_bib5) 1990; 215 Vidal (10.1016/j.neuron.2018.05.023_bib126) 1999; 399 Yoo (10.1016/j.neuron.2018.05.023_bib132) 2015; 11 Mirra (10.1016/j.neuron.2018.05.023_bib83) 1991; 41 Woodbury (10.1016/j.neuron.2018.05.023_bib130) 2015; 35 Gómez-Isla (10.1016/j.neuron.2018.05.023_bib35) 1996; 16 Harrich (10.1016/j.neuron.2018.05.023_bib41) 1989; 63 Caselli (10.1016/j.neuron.2018.05.023_bib21) 2017; 14 Howie (10.1016/j.neuron.2018.05.023_bib43) 2009; 5 Howie (10.1016/j.neuron.2018.05.023_bib44) 2011; 1 Hsu (10.1016/j.neuron.2018.05.023_bib45) 2011; 39 Mastroeni (10.1016/j.neuron.2018.05.023_bib78) 2018; 63 32336252 - J Bioinform Comput Biol. 2020 Feb;18(1):2050012 30033181 - Trends Neurosci. 2018 Sep;41(9):570-573 31855626 - Neuron. 2019 Dec 18;104(6):1034-1035 30294260 - Front Mol Neurosci. 2018 Sep 20;11:340 31855627 - Neuron. 2019 Dec 18;104(6):1036-1037 |
| References_xml | – volume: 44 start-page: 2015 year: 1994 end-page: 2019 ident: bib42 article-title: Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy) publication-title: Neurology – volume: 26 start-page: 2438 year: 2010 end-page: 2444 ident: bib56 article-title: ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments publication-title: Bioinformatics – volume: 20 start-page: 3489 year: 2004 end-page: 3497 ident: bib46 article-title: Elevation of the level and activity of acid ceramidase in Alzheimer’s disease brain publication-title: Eur. J. Neurosci. – volume: 40 start-page: 91 year: 2016 end-page: 100 ident: bib131 article-title: Sequence kernel association test of multiple continuous phenotypes publication-title: Genet. Epidemiol. – volume: 107 start-page: 5563 year: 2010 end-page: 5568 ident: bib8 article-title: The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro publication-title: Proc. Natl. Acad. Sci. USA – volume: 41 start-page: 5898 year: 2013 end-page: 5911 ident: bib10 article-title: Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening publication-title: Nucleic Acids Res. – volume: 353 start-page: 827 year: 2016 end-page: 830 ident: bib32 article-title: Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases publication-title: Science – volume: 87 start-page: 139 year: 2010 end-page: 145 ident: bib72 article-title: A versatile gene-based test for genome-wide association studies publication-title: Am. J. Hum. Genet. – volume: 13 start-page: 179 year: 1992 end-page: 189 ident: bib29 article-title: Identification of normal and pathological aging in prospectively studied nondemented elderly humans publication-title: Neurobiol. Aging – volume: 13 start-page: 2491 year: 2015 end-page: 2503 ident: bib94 article-title: Nucleotide pool depletion induces G-quadruplex-dependent perturbation of gene expression publication-title: Cell Rep. – volume: 53 start-page: 6092 year: 2014 end-page: 6102 ident: bib108 article-title: Probing the interaction between U24 and the SH3 domain of Fyn tyrosine kinase publication-title: Biochemistry – volume: 33 start-page: 6528 year: 2005 end-page: 6539 ident: bib23 article-title: Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1 publication-title: Nucleic Acids Res. – volume: 147 start-page: 363 year: 2008 end-page: 369 ident: bib24 article-title: Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer’s disease publication-title: Am. J. Med. Genet. B. Neuropsychiatr. Genet. – volume: 73 start-page: 465 year: 2004 end-page: 473 ident: bib121 article-title: Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA publication-title: J. Med. Virol. – volume: 13 start-page: 159 year: 2004 end-page: 170 ident: bib50 article-title: Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase publication-title: Hum. Mol. Genet. – volume: 98 start-page: 266 year: 2017 end-page: 274 ident: bib99 article-title: Possible chromosomal and germline integration of human herpesvirus 7 publication-title: J. Gen. Virol. – volume: 102 start-page: 15545 year: 2005 end-page: 15550 ident: bib119 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc. Natl. Acad. Sci. USA – volume: 55 start-page: 1185 year: 1998 end-page: 1191 ident: bib40 article-title: Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease publication-title: Arch. Neurol. – volume: 12 start-page: 453 year: 2015 end-page: 457 ident: bib89 article-title: Robust enumeration of cell subsets from tissue expression profiles publication-title: Nat. Methods – volume: 36 start-page: 6608 year: 2008 end-page: 6619 ident: bib34 article-title: Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway publication-title: Nucleic Acids Res. – volume: 197 start-page: 395 year: 2002 end-page: 402 ident: bib70 article-title: Herpesviruses in brain and Alzheimer’s disease publication-title: J. Pathol. – volume: 83 start-page: 489 year: 2009 end-page: 492 ident: bib136 article-title: A functional MicroRNA-155 ortholog encoded by the oncogenic Marek’s disease virus publication-title: J. Virol. – volume: 8 start-page: 340ra72 year: 2016 ident: bib55 article-title: Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease publication-title: Sci. Transl. Med. – volume: 25 start-page: 1754 year: 2009 end-page: 1760 ident: bib63 article-title: Fast and accurate short read alignment with Burrows-Wheeler transform publication-title: Bioinformatics – reference: Ament, S., Shannon, P., and Richards, M. (2017). TReNA: Fit transcriptional regulatory networks using gene expression, priors, machine learning. R package version 0.99.10. – volume: 82 start-page: 1 year: 1952 end-page: 152 ident: bib113 article-title: Morbus Alzheimer and morbus Pick; a genetic, clinical and patho-anatomical study publication-title: Acta Psychiatr. Neurol. Scand., Suppl. – volume: 112 start-page: 389 year: 2006 end-page: 404 ident: bib16 article-title: Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry publication-title: Acta Neuropathol. – volume: 27 start-page: 764 year: 2011 end-page: 770 ident: bib77 article-title: A fast, lock-free approach for efficient parallel counting of occurrences of k-mers publication-title: Bioinformatics – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: bib60 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods – volume: 15 start-page: R29 year: 2014 ident: bib61 article-title: voom: Precision weights unlock linear model analysis tools for RNA-seq read counts publication-title: Genome Biol. – volume: 86 start-page: 8259 year: 2012 end-page: 8268 ident: bib37 article-title: Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase publication-title: J. Virol. – volume: 5 start-page: 2529 year: 1994 end-page: 2533 ident: bib118 article-title: Immunohistochemical evidence for apoptosis in Alzheimer’s disease publication-title: Neuroreport – volume: 51 start-page: 979 year: 2016 end-page: 984 ident: bib49 article-title: Microbes and Alzheimer’s Disease publication-title: J. Alzheimers Dis. – volume: 2016 start-page: 2016 year: 2016 ident: bib107 article-title: The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins publication-title: Database (Oxford) – volume: 268 start-page: 5879 year: 1993 end-page: 5885 ident: bib123 article-title: Human gastric mucin. Identification of a unique species by expression cloning publication-title: J. Biol. Chem. – volume: 4 start-page: 486 year: 1998 end-page: 494 ident: bib3 article-title: The effect of human herpesvirus-6 (HHV-6) on cultured human neural cells: oligodendrocytes and microglia publication-title: J. Neurovirol. – volume: 47 start-page: 566 year: 2017 end-page: 581 e9 ident: bib54 article-title: The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases publication-title: Immunity – volume: 24 start-page: 2537 year: 2008 end-page: 2538 ident: bib15 article-title: F-Seq: a feature density estimator for high-throughput sequence tags publication-title: Bioinformatics – volume: 17 start-page: 165 year: 2016 ident: bib100 article-title: ViromeScan: a new tool for metagenomic viral community profiling publication-title: BMC Genomics – volume: 263 start-page: 220 year: 1999 end-page: 229 ident: bib90 article-title: Aminoacylation of tRNAs encoded by Chlorella virus CVK2 publication-title: Virology – volume: 43 start-page: e47 year: 2015 ident: bib103 article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies publication-title: Nucleic Acids Res. – volume: 19 start-page: 516 year: 2013 end-page: 530 ident: bib92 article-title: Human kinome analysis reveals novel kinases contributing to virus infection and retinoic-acid inducible gene I-induced type I and type III IFN gene expression publication-title: Innate Immun. – volume: 9 start-page: 1366 year: 2018 ident: bib57 article-title: Massive mining of publicly available RNA-seq data from human and mouse publication-title: Nat. Commun. – volume: 45 start-page: 1452 year: 2013 end-page: 1458 ident: bib58 article-title: Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease publication-title: Nat. Genet. – volume: 28 start-page: 105 year: 2012 end-page: 111 ident: bib25 article-title: Expression2Kinases: mRNA profiling linked to multiple upstream regulatory layers publication-title: Bioinformatics – volume: 13 start-page: 303 year: 2016 end-page: 309 ident: bib38 article-title: Analysis of computational footprinting methods for DNase sequencing experiments publication-title: Nat. Methods – volume: 316 start-page: 604 year: 2007 end-page: 608 ident: bib122 article-title: Regulation of the germinal center response by microRNA-155 publication-title: Science – volume: 526 start-page: 68 year: 2015 end-page: 74 ident: bib1 article-title: A global reference for human genetic variation publication-title: Nature – volume: 55 start-page: 14315 year: 2016 end-page: 14319 ident: bib105 article-title: tRNA shifts the G-quadruplex-hairpin conformational equilibrium in RNA towards the hairpin conformer publication-title: Angew. Chem. Int. Ed. Engl. – volume: 44 start-page: D574 year: 2016 end-page: D580 ident: bib53 article-title: Ensembl Genomes 2016: more genomes, more complexity publication-title: Nucleic Acids Res. – volume: 98 year: 2018 ident: bib137 article-title: Alzheimer’s disease-associated β-amyloid is rapidly seeded by publication-title: Neuron – volume: 5 start-page: e9505 year: 2010 ident: bib116 article-title: The Alzheimer’s disease-associated amyloid beta-protein is an antimicrobial peptide publication-title: PLoS ONE – volume: 44 start-page: 10343 year: 2016 end-page: 10353 ident: bib9 article-title: Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells publication-title: Nucleic Acids Res. – volume: 2 start-page: 18 year: 2007 ident: bib79 article-title: Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression publication-title: Infect. Agent. Cancer – reference: Zaharia, M., Bolosky, W.J., Curtis, K., Fox, A., Patterson, D., Shenker, S., Stoica, I., Karp, R.M., and Sittler, T. (2011). Faster and more accurate sequence alignment with SNAP. arXiv, arXiv:1111.5572, – volume: 5 start-page: e1000529 year: 2009 ident: bib43 article-title: A flexible and accurate genotype imputation method for the next generation of genome-wide association studies publication-title: PLoS Genet. – volume: 11 start-page: 587 year: 2015 end-page: 592 ident: bib74 article-title: Herpes simplex infection and the risk of Alzheimer’s disease: A nested case-control study publication-title: Alzheimers Dement. – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: bib104 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics – volume: 28 start-page: 1353 year: 2012 end-page: 1358 ident: bib110 article-title: Matrix eQTL: ultra fast eQTL analysis via large matrix operations publication-title: Bioinformatics – volume: 6 start-page: e880 year: 2016 ident: bib31 article-title: Meditation and vacation effects have an impact on disease-associated molecular phenotypes publication-title: Transl. Psychiatry – volume: 21 start-page: 2933 year: 2005 end-page: 2942 ident: bib20 article-title: MatInspector and beyond: promoter analysis based on transcription factor binding sites publication-title: Bioinformatics – volume: 82 start-page: 315 year: 1999 end-page: 335 ident: bib111 article-title: Viral and host-cell protein kinases: enticing antiviral targets and relevance of nucleoside, and viral thymidine, kinases publication-title: Pharmacol. Ther. – volume: 41 start-page: e201 year: 2013 ident: bib97 article-title: Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data publication-title: Nucleic Acids Res. – volume: 215 start-page: 403 year: 1990 end-page: 410 ident: bib5 article-title: Basic local alignment search tool publication-title: J. Mol. Biol. – volume: 112 start-page: 7285 year: 2015 end-page: 7290 ident: bib28 article-title: A survey of human brain transcriptome diversity at the single cell level publication-title: Proc. Natl. Acad. Sci. USA – volume: 12 start-page: 322 year: 2011 ident: bib81 article-title: Strategies for aggregating gene expression data: the collapseRows R function publication-title: BMC Bioinformatics – volume: 10 start-page: 23 year: 2009 ident: bib82 article-title: Disentangling molecular relationships with a causal inference test publication-title: BMC Genet. – year: 2009 ident: bib95 article-title: Causality – volume: 210 start-page: 363 year: 2012 end-page: 374 ident: bib129 article-title: Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer’s disease publication-title: Neuroscience – volume: 43 start-page: 1 year: 2013 end-page: 33 ident: bib125 article-title: From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline publication-title: Curr. Protoc. Bioinformatics – volume: 64 start-page: 113 year: 2005 end-page: 122 ident: bib91 article-title: Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study publication-title: J. Neuropathol. Exp. Neurol. – volume: 20 start-page: 1236 year: 2017 end-page: 1246 ident: bib18 article-title: Necroptosis activation in Alzheimer’s disease publication-title: Nat. Neurosci. – volume: 97 start-page: 4920 year: 2000 end-page: 4925 ident: bib127 article-title: A decamer duplication in the 3′ region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred publication-title: Proc. Natl. Acad. Sci. USA – volume: 54 start-page: 273 year: 2014 end-page: 280 ident: bib124 article-title: Staying alive: cell death in antiviral immunity publication-title: Mol. Cell – year: 2017 ident: bib96 article-title: Genome-scale transcriptional regulatory network models of psychiatric and neurodegenerative disorders publication-title: bioRxiv – volume: 110 start-page: 341 year: 1954 end-page: 344 ident: bib112 article-title: Rida, a chronic encephalitis of sheep: with general remarks on infections which develop slowly and some of their special characteristics publication-title: Brit. Vet. J. – volume: 153 start-page: 707 year: 2013 end-page: 720 ident: bib135 article-title: Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease publication-title: Cell – volume: 14 start-page: 3 year: 2017 ident: bib21 article-title: HHV-6A in vitro infection of thyrocytes and T cells alters the expression of miRNA associated to autoimmune thyroiditis publication-title: Virol. J. – volume: 6 start-page: 202 year: 2014 ident: bib48 article-title: Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus publication-title: Front. Aging Neurosci. – volume: 2015 start-page: bav059 year: 2015 ident: bib33 article-title: G4RNA: an RNA G-quadruplex database publication-title: Database (Oxford) – volume: 9 start-page: e1004033 year: 2013 ident: bib98 article-title: Reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation publication-title: PLoS Genet. – volume: 10 start-page: 160 year: 2013 ident: bib14 article-title: Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication publication-title: Retrovirology – volume: 84 start-page: 6748 year: 2010 end-page: 6759 ident: bib120 article-title: SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA publication-title: J. Virol. – volume: 43 start-page: D571 year: 2015 end-page: D577 ident: bib17 article-title: NCBI viral genomes resource publication-title: Nucleic Acids Res. – volume: 83 start-page: 369 year: 2018 end-page: 376 ident: bib93 article-title: Targeting Fyn Kinase in Alzheimer’s Disease publication-title: Biol. Psychiatry – volume: 3 start-page: e244 year: 2013 ident: bib52 article-title: Alterations in metabolic pathways and networks in Alzheimer’s disease publication-title: Transl. Psychiatry – volume: 249 start-page: 129 year: 1998 end-page: 139 ident: bib85 article-title: Analysis of human herpesvirus 6 U3 gene, which is a positional homolog of human cytomegalovirus UL 24 gene publication-title: Virology – volume: 26 start-page: 1367 year: 2008 end-page: 1372 ident: bib27 article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification publication-title: Nat. Biotechnol. – volume: 28 start-page: 311 year: 2007 end-page: 322 ident: bib65 article-title: Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain publication-title: Physiol. Genomics – volume: 16 start-page: 4491 year: 1996 end-page: 4500 ident: bib35 article-title: Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease publication-title: J. Neurosci. – volume: 30 start-page: 923 year: 2014 end-page: 930 ident: bib69 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics – volume: 35 start-page: 122 year: 2014 end-page: 129 ident: bib19 article-title: Herpes virus in Alzheimer’s disease: relation to progression of the disease publication-title: Neurobiol. Aging – reference: Rotmistrovsky, K., and Agarwala, R. (2011). BMTagger: Best Match Tagger for removing human reads from metagenomics datasets. – volume: 7 start-page: 280 year: 2011 end-page: 292 ident: bib117 article-title: Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease publication-title: Alzheimers Dement. – volume: 25 start-page: 2078 year: 2009 end-page: 2079 ident: bib64 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics – volume: 11 start-page: 593 year: 2015 end-page: 599 ident: bib73 article-title: Reactivated herpes simplex infection increases the risk of Alzheimer’s disease publication-title: Alzheimers Dement. – volume: 31 start-page: 549 year: 2010 end-page: 566 ident: bib67 article-title: Neuronal gene expression in non-demented individuals with intermediate Alzheimer’s Disease neuropathology publication-title: Neurobiol. Aging – volume: 399 start-page: 776 year: 1999 end-page: 781 ident: bib126 article-title: A stop-codon mutation in the BRI gene associated with familial British dementia publication-title: Nature – volume: 8 start-page: 40 year: 2017 ident: bib128 article-title: Decreased HHV-6 IgG in Alzheimer’s disease publication-title: Front. Neurol. – volume: 1 start-page: 1038 year: 1980 ident: bib80 article-title: Herpes-simplex viral genome and senile and presenile dementias of Alzheimer and Pick publication-title: Lancet – volume: 3 start-page: 160089 year: 2016 ident: bib4 article-title: Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases publication-title: Sci. Data – volume: 1 start-page: 457 year: 2011 end-page: 470 ident: bib44 article-title: Genotype imputation with thousands of genomes publication-title: G3 (Bethesda) – volume: 22 start-page: 120 year: 2017 end-page: 131 ident: bib26 article-title: Exploring the reproducibility of probabilistic causal molecular network models publication-title: Pac. Symp. Biocomput. – volume: 24 start-page: 182 year: 2010 end-page: 186 ident: bib71 article-title: Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer’s disease publication-title: J. Clin. Lab. Anal. – volume: 88 start-page: 937 year: 1976 end-page: 942 ident: bib88 article-title: Encephalopathy following measles infection in children with chronic illness publication-title: J. Pediatr. – volume: 225 start-page: 1168 year: 1984 end-page: 1170 ident: bib47 article-title: Alzheimer’s disease: cell-specific pathology isolates the hippocampal formation publication-title: Science – volume: 33 start-page: 240 year: 2008 end-page: 256 ident: bib66 article-title: Altered neuronal gene expression in brain regions differentially affected by Alzheimer’s disease: a reference data set publication-title: Physiol. Genomics – volume: 11 start-page: e1004898 year: 2015 ident: bib132 article-title: Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD publication-title: PLoS Genet. – volume: 71 start-page: 8087 year: 1997 end-page: 8095 ident: bib76 article-title: Primer tRNAs for reverse transcription publication-title: J. Virol. – volume: 18 start-page: 86 year: 2015 end-page: 91 ident: bib84 article-title: VEGAS2: Software for More Flexible Gene-Based Testing publication-title: Twin Res. Hum. Genet. – volume: 3 start-page: e3 year: 2004 ident: bib114 article-title: Linear models and empirical bayes methods for assessing differential expression in microarray experiments publication-title: Stat. Appl. Genet. Mol. Biol. – volume: 409 start-page: 860 year: 2001 end-page: 921 ident: bib59 article-title: Initial sequencing and analysis of the human genome publication-title: Nature – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib11 article-title: Controlling the false discovery rate - a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. B – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: bib30 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics – volume: 35 start-page: 9764 year: 2015 end-page: 9781 ident: bib130 article-title: miR-155 is essential for inflammation-induced hippocampal neurogenic dysfunction publication-title: J. Neurosci. – volume: 49 start-page: 229 year: 2016 end-page: 235 ident: bib2 article-title: Lack of evidence for a role of HHV-6 in the pathogenesis of Alzheimer’s disease publication-title: J. Alzheimers Dis. – volume: 9 start-page: 628 year: 2012 end-page: 645 ident: bib12 article-title: Overview and findings from the religious orders study publication-title: Curr. Alzheimer Res. – volume: 10 start-page: 358 year: 2014 end-page: 364 ident: bib87 article-title: G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation publication-title: Nat. Chem. Biol. – volume: 63 start-page: 12 year: 2018 end-page: 21 ident: bib78 article-title: Laser-captured microglia in the Alzheimer’s and Parkinson’s brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer’s brain publication-title: Neurobiol. Aging – volume: 9 start-page: 646 year: 2012 end-page: 663 ident: bib13 article-title: Overview and findings from the rush Memory and Aging Project publication-title: Curr. Alzheimer Res. – volume: 98 start-page: 3364 year: 2001 end-page: 3368 ident: bib39 article-title: Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration publication-title: Proc. Natl. Acad. Sci. USA – volume: 18 start-page: 220 year: 2017 ident: bib7 article-title: xCell: digitally portraying the tissue cellular heterogeneity landscape publication-title: Genome Biol. – volume: 43 start-page: 8627 year: 2015 end-page: 8637 ident: bib102 article-title: G-quadruplexes and their regulatory roles in biology publication-title: Nucleic Acids Res. – volume: 450 start-page: 1096 year: 2007 end-page: 1099 ident: bib36 article-title: A viral microRNA functions as an orthologue of cellular miR-155 publication-title: Nature – volume: 63 start-page: 2585 year: 1989 end-page: 2591 ident: bib41 article-title: Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat publication-title: J. Virol. – volume: 75 start-page: 10511 year: 2001 end-page: 10514 ident: bib134 article-title: Productive infection of primary macrophages with human herpesvirus 7 publication-title: J. Virol. – volume: 75 start-page: 5043 year: 2001 end-page: 5048 ident: bib22 article-title: Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1 publication-title: J. Virol. – volume: 7 start-page: 309 year: 2011 end-page: 317 ident: bib51 article-title: Metabolomic changes in autopsy-confirmed Alzheimer’s disease publication-title: Alzheimers Dement. – volume: 41 start-page: e108 year: 2013 ident: bib68 article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote publication-title: Nucleic Acids Res. – volume: 21 start-page: 1099 year: 2016 end-page: 1111 ident: bib101 article-title: Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer’s brain molecular pathology publication-title: Mol. Psychiatry – volume: 7 start-page: 61 year: 2015 ident: bib115 article-title: miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function publication-title: Front. Aging Neurosci. – volume: 39 start-page: D163 year: 2011 end-page: D169 ident: bib45 article-title: miRTarBase: a database curates experimentally validated microRNA-target interactions publication-title: Nucleic Acids Res. – reference: . – volume: 41 start-page: 479 year: 1991 end-page: 486 ident: bib83 article-title: The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease publication-title: Neurology – volume: 5 start-page: e561 year: 2015 ident: bib75 article-title: d-serine levels in Alzheimer’s disease: implications for novel biomarker development publication-title: Transl. Psychiatry – volume: 13 start-page: 762 year: 2012 end-page: 775 ident: bib62 article-title: Optimal tests for rare variant effects in sequencing association studies publication-title: Biostatistics – volume: 43 start-page: 2412 year: 1993 end-page: 2414 ident: bib86 article-title: The Clinical Dementia Rating (CDR): current version and scoring rules publication-title: Neurology – volume: 193 start-page: 195 year: 2004 end-page: 203 ident: bib109 article-title: Thrombin induces Sp1-mediated antiviral effects in cytomegalovirus-infected human retinal pigment epithelial cells publication-title: Med. Microbiol. Immunol. (Berl.) – volume: 215 start-page: 403 year: 1990 ident: 10.1016/j.neuron.2018.05.023_bib5 article-title: Basic local alignment search tool publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(05)80360-2 – volume: 8 start-page: 340ra72 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib55 article-title: Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaf1059 – year: 2009 ident: 10.1016/j.neuron.2018.05.023_bib95 – ident: 10.1016/j.neuron.2018.05.023_bib106 – volume: 110 start-page: 341 year: 1954 ident: 10.1016/j.neuron.2018.05.023_bib112 article-title: Rida, a chronic encephalitis of sheep: with general remarks on infections which develop slowly and some of their special characteristics publication-title: Brit. Vet. J. doi: 10.1016/S0007-1935(17)50172-4 – volume: 49 start-page: 229 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib2 article-title: Lack of evidence for a role of HHV-6 in the pathogenesis of Alzheimer’s disease publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-150464 – volume: 12 start-page: 453 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib89 article-title: Robust enumeration of cell subsets from tissue expression profiles publication-title: Nat. Methods doi: 10.1038/nmeth.3337 – volume: 75 start-page: 10511 year: 2001 ident: 10.1016/j.neuron.2018.05.023_bib134 article-title: Productive infection of primary macrophages with human herpesvirus 7 publication-title: J. Virol. doi: 10.1128/JVI.75.21.10511-10514.2001 – volume: 47 start-page: 566 year: 2017 ident: 10.1016/j.neuron.2018.05.023_bib54 article-title: The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases publication-title: Immunity doi: 10.1016/j.immuni.2017.08.008 – volume: 28 start-page: 105 year: 2012 ident: 10.1016/j.neuron.2018.05.023_bib25 article-title: Expression2Kinases: mRNA profiling linked to multiple upstream regulatory layers publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr625 – volume: 26 start-page: 1367 year: 2008 ident: 10.1016/j.neuron.2018.05.023_bib27 article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1511 – volume: 147 start-page: 363 year: 2008 ident: 10.1016/j.neuron.2018.05.023_bib24 article-title: Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer’s disease publication-title: Am. J. Med. Genet. B. Neuropsychiatr. Genet. doi: 10.1002/ajmg.b.30607 – year: 2017 ident: 10.1016/j.neuron.2018.05.023_bib96 article-title: Genome-scale transcriptional regulatory network models of psychiatric and neurodegenerative disorders publication-title: bioRxiv – volume: 2 start-page: 18 year: 2007 ident: 10.1016/j.neuron.2018.05.023_bib79 article-title: Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression publication-title: Infect. Agent. Cancer doi: 10.1186/1750-9378-2-18 – volume: 11 start-page: 593 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib73 article-title: Reactivated herpes simplex infection increases the risk of Alzheimer’s disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2014.04.522 – volume: 84 start-page: 6748 year: 2010 ident: 10.1016/j.neuron.2018.05.023_bib120 article-title: SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA publication-title: J. Virol. doi: 10.1128/JVI.02526-09 – volume: 107 start-page: 5563 year: 2010 ident: 10.1016/j.neuron.2018.05.023_bib8 article-title: The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0913586107 – volume: 16 start-page: 4491 year: 1996 ident: 10.1016/j.neuron.2018.05.023_bib35 article-title: Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.16-14-04491.1996 – volume: 39 start-page: D163 year: 2011 ident: 10.1016/j.neuron.2018.05.023_bib45 article-title: miRTarBase: a database curates experimentally validated microRNA-target interactions publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq1107 – volume: 18 start-page: 86 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib84 article-title: VEGAS2: Software for More Flexible Gene-Based Testing publication-title: Twin Res. Hum. Genet. doi: 10.1017/thg.2014.79 – volume: 3 start-page: e3 year: 2004 ident: 10.1016/j.neuron.2018.05.023_bib114 article-title: Linear models and empirical bayes methods for assessing differential expression in microarray experiments publication-title: Stat. Appl. Genet. Mol. Biol. doi: 10.2202/1544-6115.1027 – volume: 225 start-page: 1168 year: 1984 ident: 10.1016/j.neuron.2018.05.023_bib47 article-title: Alzheimer’s disease: cell-specific pathology isolates the hippocampal formation publication-title: Science doi: 10.1126/science.6474172 – volume: 51 start-page: 979 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib49 article-title: Microbes and Alzheimer’s Disease publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-160152 – volume: 526 start-page: 68 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib1 article-title: A global reference for human genetic variation publication-title: Nature doi: 10.1038/nature15393 – volume: 18 start-page: 220 year: 2017 ident: 10.1016/j.neuron.2018.05.023_bib7 article-title: xCell: digitally portraying the tissue cellular heterogeneity landscape publication-title: Genome Biol. doi: 10.1186/s13059-017-1349-1 – volume: 9 start-page: 628 year: 2012 ident: 10.1016/j.neuron.2018.05.023_bib12 article-title: Overview and findings from the religious orders study publication-title: Curr. Alzheimer Res. doi: 10.2174/156720512801322573 – volume: 210 start-page: 363 year: 2012 ident: 10.1016/j.neuron.2018.05.023_bib129 article-title: Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer’s disease publication-title: Neuroscience doi: 10.1016/j.neuroscience.2012.02.037 – volume: 43 start-page: 2412 year: 1993 ident: 10.1016/j.neuron.2018.05.023_bib86 article-title: The Clinical Dementia Rating (CDR): current version and scoring rules publication-title: Neurology doi: 10.1212/WNL.43.11.2412-a – volume: 30 start-page: 923 year: 2014 ident: 10.1016/j.neuron.2018.05.023_bib69 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt656 – volume: 88 start-page: 937 year: 1976 ident: 10.1016/j.neuron.2018.05.023_bib88 article-title: Encephalopathy following measles infection in children with chronic illness publication-title: J. Pediatr. doi: 10.1016/S0022-3476(76)81045-1 – volume: 29 start-page: 15 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib30 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 20 start-page: 3489 year: 2004 ident: 10.1016/j.neuron.2018.05.023_bib46 article-title: Elevation of the level and activity of acid ceramidase in Alzheimer’s disease brain publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2004.03852.x – volume: 41 start-page: e201 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib97 article-title: Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt850 – volume: 43 start-page: 1 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib125 article-title: From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline publication-title: Curr. Protoc. Bioinformatics doi: 10.1002/0471250953.bi1110s43 – volume: 7 start-page: 61 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib115 article-title: miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2015.00061 – volume: 19 start-page: 516 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib92 article-title: Human kinome analysis reveals novel kinases contributing to virus infection and retinoic-acid inducible gene I-induced type I and type III IFN gene expression publication-title: Innate Immun. doi: 10.1177/1753425912473345 – volume: 10 start-page: 358 year: 2014 ident: 10.1016/j.neuron.2018.05.023_bib87 article-title: G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.1479 – volume: 44 start-page: 10343 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib9 article-title: Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells publication-title: Nucleic Acids Res. – volume: 10 start-page: 23 year: 2009 ident: 10.1016/j.neuron.2018.05.023_bib82 article-title: Disentangling molecular relationships with a causal inference test publication-title: BMC Genet. doi: 10.1186/1471-2156-10-23 – volume: 102 start-page: 15545 year: 2005 ident: 10.1016/j.neuron.2018.05.023_bib119 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0506580102 – volume: 13 start-page: 762 year: 2012 ident: 10.1016/j.neuron.2018.05.023_bib62 article-title: Optimal tests for rare variant effects in sequencing association studies publication-title: Biostatistics doi: 10.1093/biostatistics/kxs014 – volume: 97 start-page: 4920 year: 2000 ident: 10.1016/j.neuron.2018.05.023_bib127 article-title: A decamer duplication in the 3′ region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.080076097 – volume: 3 start-page: e244 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib52 article-title: Alterations in metabolic pathways and networks in Alzheimer’s disease publication-title: Transl. Psychiatry doi: 10.1038/tp.2013.18 – volume: 31 start-page: 549 year: 2010 ident: 10.1016/j.neuron.2018.05.023_bib67 article-title: Neuronal gene expression in non-demented individuals with intermediate Alzheimer’s Disease neuropathology publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2008.05.013 – volume: 263 start-page: 220 year: 1999 ident: 10.1016/j.neuron.2018.05.023_bib90 article-title: Aminoacylation of tRNAs encoded by Chlorella virus CVK2 publication-title: Virology doi: 10.1006/viro.1999.9949 – volume: 7 start-page: 280 year: 2011 ident: 10.1016/j.neuron.2018.05.023_bib117 article-title: Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2011.03.003 – volume: 268 start-page: 5879 year: 1993 ident: 10.1016/j.neuron.2018.05.023_bib123 article-title: Human gastric mucin. Identification of a unique species by expression cloning publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)53402-5 – volume: 9 start-page: e1004033 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib98 article-title: Reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004033 – volume: 153 start-page: 707 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib135 article-title: Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease publication-title: Cell doi: 10.1016/j.cell.2013.03.030 – volume: 13 start-page: 303 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib38 article-title: Analysis of computational footprinting methods for DNase sequencing experiments publication-title: Nat. Methods doi: 10.1038/nmeth.3772 – volume: 43 start-page: D571 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib17 article-title: NCBI viral genomes resource publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1207 – volume: 316 start-page: 604 year: 2007 ident: 10.1016/j.neuron.2018.05.023_bib122 article-title: Regulation of the germinal center response by microRNA-155 publication-title: Science doi: 10.1126/science.1141229 – volume: 10 start-page: 160 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib14 article-title: Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication publication-title: Retrovirology doi: 10.1186/1742-4690-10-160 – volume: 44 start-page: D574 issue: D1 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib53 article-title: Ensembl Genomes 2016: more genomes, more complexity publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv1209 – volume: 75 start-page: 5043 year: 2001 ident: 10.1016/j.neuron.2018.05.023_bib22 article-title: Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1 publication-title: J. Virol. doi: 10.1128/JVI.75.11.5043-5048.2001 – volume: 6 start-page: e880 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib31 article-title: Meditation and vacation effects have an impact on disease-associated molecular phenotypes publication-title: Transl. Psychiatry doi: 10.1038/tp.2016.164 – volume: 55 start-page: 1185 year: 1998 ident: 10.1016/j.neuron.2018.05.023_bib40 article-title: Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease publication-title: Arch. Neurol. doi: 10.1001/archneur.55.9.1185 – volume: 41 start-page: 479 year: 1991 ident: 10.1016/j.neuron.2018.05.023_bib83 article-title: The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease publication-title: Neurology doi: 10.1212/WNL.41.4.479 – volume: 28 start-page: 1353 year: 2012 ident: 10.1016/j.neuron.2018.05.023_bib110 article-title: Matrix eQTL: ultra fast eQTL analysis via large matrix operations publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts163 – volume: 54 start-page: 273 year: 2014 ident: 10.1016/j.neuron.2018.05.023_bib124 article-title: Staying alive: cell death in antiviral immunity publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.01.027 – volume: 2015 start-page: bav059 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib33 article-title: G4RNA: an RNA G-quadruplex database publication-title: Database (Oxford) doi: 10.1093/database/bav059 – ident: 10.1016/j.neuron.2018.05.023_bib6 – volume: 41 start-page: e108 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib68 article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt214 – volume: 24 start-page: 2537 year: 2008 ident: 10.1016/j.neuron.2018.05.023_bib15 article-title: F-Seq: a feature density estimator for high-throughput sequence tags publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn480 – volume: 9 start-page: 1366 year: 2018 ident: 10.1016/j.neuron.2018.05.023_bib57 article-title: Massive mining of publicly available RNA-seq data from human and mouse publication-title: Nat. Commun. doi: 10.1038/s41467-018-03751-6 – volume: 1 start-page: 1038 year: 1980 ident: 10.1016/j.neuron.2018.05.023_bib80 article-title: Herpes-simplex viral genome and senile and presenile dementias of Alzheimer and Pick publication-title: Lancet doi: 10.1016/S0140-6736(80)91490-7 – volume: 3 start-page: 160089 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib4 article-title: Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases publication-title: Sci. Data doi: 10.1038/sdata.2016.89 – volume: 98 start-page: 266 year: 2017 ident: 10.1016/j.neuron.2018.05.023_bib99 article-title: Possible chromosomal and germline integration of human herpesvirus 7 publication-title: J. Gen. Virol. doi: 10.1099/jgv.0.000692 – volume: 82 start-page: 1 year: 1952 ident: 10.1016/j.neuron.2018.05.023_bib113 article-title: Morbus Alzheimer and morbus Pick; a genetic, clinical and patho-anatomical study publication-title: Acta Psychiatr. Neurol. Scand., Suppl. – volume: 73 start-page: 465 year: 2004 ident: 10.1016/j.neuron.2018.05.023_bib121 article-title: Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA publication-title: J. Med. Virol. doi: 10.1002/jmv.20113 – volume: 25 start-page: 1754 year: 2009 ident: 10.1016/j.neuron.2018.05.023_bib63 article-title: Fast and accurate short read alignment with Burrows-Wheeler transform publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp324 – volume: 33 start-page: 240 year: 2008 ident: 10.1016/j.neuron.2018.05.023_bib66 article-title: Altered neuronal gene expression in brain regions differentially affected by Alzheimer’s disease: a reference data set publication-title: Physiol. Genomics doi: 10.1152/physiolgenomics.00242.2007 – volume: 21 start-page: 2933 year: 2005 ident: 10.1016/j.neuron.2018.05.023_bib20 article-title: MatInspector and beyond: promoter analysis based on transcription factor binding sites publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti473 – volume: 13 start-page: 2491 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib94 article-title: Nucleotide pool depletion induces G-quadruplex-dependent perturbation of gene expression publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.11.039 – volume: 17 start-page: 165 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib100 article-title: ViromeScan: a new tool for metagenomic viral community profiling publication-title: BMC Genomics doi: 10.1186/s12864-016-2446-3 – volume: 64 start-page: 113 year: 2005 ident: 10.1016/j.neuron.2018.05.023_bib91 article-title: Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/64.2.113 – volume: 14 start-page: 3 year: 2017 ident: 10.1016/j.neuron.2018.05.023_bib21 article-title: HHV-6A in vitro infection of thyrocytes and T cells alters the expression of miRNA associated to autoimmune thyroiditis publication-title: Virol. J. doi: 10.1186/s12985-016-0672-6 – volume: 63 start-page: 2585 year: 1989 ident: 10.1016/j.neuron.2018.05.023_bib41 article-title: Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat publication-title: J. Virol. doi: 10.1128/jvi.63.6.2585-2591.1989 – volume: 13 start-page: 159 year: 2004 ident: 10.1016/j.neuron.2018.05.023_bib50 article-title: Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddh019 – volume: 27 start-page: 764 year: 2011 ident: 10.1016/j.neuron.2018.05.023_bib77 article-title: A fast, lock-free approach for efficient parallel counting of occurrences of k-mers publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr011 – volume: 13 start-page: 179 year: 1992 ident: 10.1016/j.neuron.2018.05.023_bib29 article-title: Identification of normal and pathological aging in prospectively studied nondemented elderly humans publication-title: Neurobiol. Aging doi: 10.1016/0197-4580(92)90027-U – volume: 28 start-page: 311 year: 2007 ident: 10.1016/j.neuron.2018.05.023_bib65 article-title: Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain publication-title: Physiol. Genomics doi: 10.1152/physiolgenomics.00208.2006 – volume: 35 start-page: 122 year: 2014 ident: 10.1016/j.neuron.2018.05.023_bib19 article-title: Herpes virus in Alzheimer’s disease: relation to progression of the disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2013.06.024 – volume: 43 start-page: 8627 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib102 article-title: G-quadruplexes and their regulatory roles in biology publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv862 – volume: 25 start-page: 2078 year: 2009 ident: 10.1016/j.neuron.2018.05.023_bib64 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 8 start-page: 40 year: 2017 ident: 10.1016/j.neuron.2018.05.023_bib128 article-title: Decreased HHV-6 IgG in Alzheimer’s disease publication-title: Front. Neurol. doi: 10.3389/fneur.2017.00040 – volume: 9 start-page: 646 year: 2012 ident: 10.1016/j.neuron.2018.05.023_bib13 article-title: Overview and findings from the rush Memory and Aging Project publication-title: Curr. Alzheimer Res. doi: 10.2174/156720512801322663 – volume: 55 start-page: 14315 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib105 article-title: tRNA shifts the G-quadruplex-hairpin conformational equilibrium in RNA towards the hairpin conformer publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.201605431 – volume: 197 start-page: 395 year: 2002 ident: 10.1016/j.neuron.2018.05.023_bib70 article-title: Herpesviruses in brain and Alzheimer’s disease publication-title: J. Pathol. doi: 10.1002/path.1127 – volume: 2016 start-page: 2016 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib107 article-title: The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins publication-title: Database (Oxford) doi: 10.1093/database/baw100 – volume: 98 year: 2018 ident: 10.1016/j.neuron.2018.05.023_bib137 article-title: Alzheimer’s disease-associated β-amyloid is rapidly seeded by herpesviridae to protect against brain infection publication-title: Neuron – volume: 86 start-page: 8259 year: 2012 ident: 10.1016/j.neuron.2018.05.023_bib37 article-title: Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase publication-title: J. Virol. doi: 10.1128/JVI.00495-12 – volume: 71 start-page: 8087 year: 1997 ident: 10.1016/j.neuron.2018.05.023_bib76 article-title: Primer tRNAs for reverse transcription publication-title: J. Virol. doi: 10.1128/jvi.71.11.8087-8095.1997 – volume: 53 start-page: 6092 year: 2014 ident: 10.1016/j.neuron.2018.05.023_bib108 article-title: Probing the interaction between U24 and the SH3 domain of Fyn tyrosine kinase publication-title: Biochemistry doi: 10.1021/bi500945x – volume: 112 start-page: 389 year: 2006 ident: 10.1016/j.neuron.2018.05.023_bib16 article-title: Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry publication-title: Acta Neuropathol. doi: 10.1007/s00401-006-0127-z – volume: 44 start-page: 2015 year: 1994 ident: 10.1016/j.neuron.2018.05.023_bib42 article-title: Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy) publication-title: Neurology doi: 10.1212/WNL.44.11.2015 – volume: 5 start-page: e1000529 year: 2009 ident: 10.1016/j.neuron.2018.05.023_bib43 article-title: A flexible and accurate genotype imputation method for the next generation of genome-wide association studies publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000529 – volume: 43 start-page: e47 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib103 article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv007 – volume: 112 start-page: 7285 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib28 article-title: A survey of human brain transcriptome diversity at the single cell level publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1507125112 – volume: 15 start-page: R29 year: 2014 ident: 10.1016/j.neuron.2018.05.023_bib61 article-title: voom: Precision weights unlock linear model analysis tools for RNA-seq read counts publication-title: Genome Biol. doi: 10.1186/gb-2014-15-2-r29 – volume: 249 start-page: 129 year: 1998 ident: 10.1016/j.neuron.2018.05.023_bib85 article-title: Analysis of human herpesvirus 6 U3 gene, which is a positional homolog of human cytomegalovirus UL 24 gene publication-title: Virology doi: 10.1006/viro.1998.9305 – volume: 83 start-page: 369 year: 2018 ident: 10.1016/j.neuron.2018.05.023_bib93 article-title: Targeting Fyn Kinase in Alzheimer’s Disease publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2017.06.004 – volume: 399 start-page: 776 year: 1999 ident: 10.1016/j.neuron.2018.05.023_bib126 article-title: A stop-codon mutation in the BRI gene associated with familial British dementia publication-title: Nature doi: 10.1038/21637 – volume: 35 start-page: 9764 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib130 article-title: miR-155 is essential for inflammation-induced hippocampal neurogenic dysfunction publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4790-14.2015 – volume: 45 start-page: 1452 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib58 article-title: Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease publication-title: Nat. Genet. doi: 10.1038/ng.2802 – volume: 98 start-page: 3364 year: 2001 ident: 10.1016/j.neuron.2018.05.023_bib39 article-title: Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.051633498 – volume: 82 start-page: 315 year: 1999 ident: 10.1016/j.neuron.2018.05.023_bib111 article-title: Viral and host-cell protein kinases: enticing antiviral targets and relevance of nucleoside, and viral thymidine, kinases publication-title: Pharmacol. Ther. doi: 10.1016/S0163-7258(99)00004-2 – volume: 83 start-page: 489 year: 2009 ident: 10.1016/j.neuron.2018.05.023_bib136 article-title: A functional MicroRNA-155 ortholog encoded by the oncogenic Marek’s disease virus publication-title: J. Virol. doi: 10.1128/JVI.01166-08 – volume: 33 start-page: 6528 year: 2005 ident: 10.1016/j.neuron.2018.05.023_bib23 article-title: Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gki956 – volume: 450 start-page: 1096 year: 2007 ident: 10.1016/j.neuron.2018.05.023_bib36 article-title: A viral microRNA functions as an orthologue of cellular miR-155 publication-title: Nature doi: 10.1038/nature05992 – volume: 22 start-page: 120 year: 2017 ident: 10.1016/j.neuron.2018.05.023_bib26 article-title: Exploring the reproducibility of probabilistic causal molecular network models publication-title: Pac. Symp. Biocomput. – volume: 24 start-page: 182 year: 2010 ident: 10.1016/j.neuron.2018.05.023_bib71 article-title: Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer’s disease publication-title: J. Clin. Lab. Anal. doi: 10.1002/jcla.20379 – volume: 87 start-page: 139 year: 2010 ident: 10.1016/j.neuron.2018.05.023_bib72 article-title: A versatile gene-based test for genome-wide association studies publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2010.06.009 – volume: 26 start-page: 139 year: 2010 ident: 10.1016/j.neuron.2018.05.023_bib104 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 7 start-page: 309 year: 2011 ident: 10.1016/j.neuron.2018.05.023_bib51 article-title: Metabolomic changes in autopsy-confirmed Alzheimer’s disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2010.06.001 – volume: 26 start-page: 2438 year: 2010 ident: 10.1016/j.neuron.2018.05.023_bib56 article-title: ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq466 – volume: 11 start-page: e1004898 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib132 article-title: Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004898 – volume: 5 start-page: e9505 year: 2010 ident: 10.1016/j.neuron.2018.05.023_bib116 article-title: The Alzheimer’s disease-associated amyloid beta-protein is an antimicrobial peptide publication-title: PLoS ONE doi: 10.1371/journal.pone.0009505 – volume: 36 start-page: 6608 year: 2008 ident: 10.1016/j.neuron.2018.05.023_bib34 article-title: Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkn666 – volume: 41 start-page: 5898 year: 2013 ident: 10.1016/j.neuron.2018.05.023_bib10 article-title: Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt265 – volume: 12 start-page: 322 year: 2011 ident: 10.1016/j.neuron.2018.05.023_bib81 article-title: Strategies for aggregating gene expression data: the collapseRows R function publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-12-322 – volume: 353 start-page: 827 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib32 article-title: Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases publication-title: Science doi: 10.1126/science.aad6970 – volume: 409 start-page: 860 year: 2001 ident: 10.1016/j.neuron.2018.05.023_bib59 article-title: Initial sequencing and analysis of the human genome publication-title: Nature doi: 10.1038/35057062 – volume: 20 start-page: 1236 year: 2017 ident: 10.1016/j.neuron.2018.05.023_bib18 article-title: Necroptosis activation in Alzheimer’s disease publication-title: Nat. Neurosci. doi: 10.1038/nn.4608 – volume: 5 start-page: e561 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib75 article-title: d-serine levels in Alzheimer’s disease: implications for novel biomarker development publication-title: Transl. Psychiatry doi: 10.1038/tp.2015.52 – volume: 21 start-page: 1099 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib101 article-title: Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer’s brain molecular pathology publication-title: Mol. Psychiatry doi: 10.1038/mp.2015.167 – volume: 11 start-page: 587 year: 2015 ident: 10.1016/j.neuron.2018.05.023_bib74 article-title: Herpes simplex infection and the risk of Alzheimer’s disease: A nested case-control study publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2014.07.157 – volume: 63 start-page: 12 year: 2018 ident: 10.1016/j.neuron.2018.05.023_bib78 article-title: Laser-captured microglia in the Alzheimer’s and Parkinson’s brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer’s brain publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2017.10.019 – volume: 193 start-page: 195 year: 2004 ident: 10.1016/j.neuron.2018.05.023_bib109 article-title: Thrombin induces Sp1-mediated antiviral effects in cytomegalovirus-infected human retinal pigment epithelial cells publication-title: Med. Microbiol. Immunol. (Berl.) doi: 10.1007/s00430-003-0194-x – volume: 40 start-page: 91 year: 2016 ident: 10.1016/j.neuron.2018.05.023_bib131 article-title: Sequence kernel association test of multiple continuous phenotypes publication-title: Genet. Epidemiol. doi: 10.1002/gepi.21945 – volume: 5 start-page: 2529 year: 1994 ident: 10.1016/j.neuron.2018.05.023_bib118 article-title: Immunohistochemical evidence for apoptosis in Alzheimer’s disease publication-title: Neuroreport doi: 10.1097/00001756-199412000-00031 – volume: 1 start-page: 457 year: 2011 ident: 10.1016/j.neuron.2018.05.023_bib44 article-title: Genotype imputation with thousands of genomes publication-title: G3 (Bethesda) doi: 10.1534/g3.111.001198 – ident: 10.1016/j.neuron.2018.05.023_bib133 – volume: 4 start-page: 486 year: 1998 ident: 10.1016/j.neuron.2018.05.023_bib3 article-title: The effect of human herpesvirus-6 (HHV-6) on cultured human neural cells: oligodendrocytes and microglia publication-title: J. Neurovirol. doi: 10.3109/13550289809113493 – volume: 6 start-page: 202 year: 2014 ident: 10.1016/j.neuron.2018.05.023_bib48 article-title: Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2014.00202 – volume: 9 start-page: 357 year: 2012 ident: 10.1016/j.neuron.2018.05.023_bib60 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 – volume: 57 start-page: 289 year: 1995 ident: 10.1016/j.neuron.2018.05.023_bib11 article-title: Controlling the false discovery rate - a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. B doi: 10.1111/j.2517-6161.1995.tb02031.x – reference: 31855626 - Neuron. 2019 Dec 18;104(6):1034-1035 – reference: 32336252 - J Bioinform Comput Biol. 2020 Feb;18(1):2050012 – reference: 31855627 - Neuron. 2019 Dec 18;104(6):1036-1037 – reference: 30033181 - Trends Neurosci. 2018 Sep;41(9):570-573 – reference: 30294260 - Front Mol Neurosci. 2018 Sep 20;11:340 |
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| Snippet | Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer’s disease (AD) although definitive... Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer's disease (AD) although definitive... SummaryInvestigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer’s disease (AD) although definitive... |
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| SubjectTerms | Adaptor Proteins, Signal Transducing - genetics Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - virology Alzheimer's disease Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - genetics Animals Aspartic Acid Endopeptidases - genetics Brain - metabolism Brain - pathology Brain - virology Brain research Case-Control Studies Clusterin - genetics Cohort Studies Data collection Encephalitis, Viral - genetics Encephalitis, Viral - metabolism Encephalitis, Viral - pathology Encephalitis, Viral - virology Gene expression Gene Expression Profiling Gene Regulatory Networks Genomics Herpes viruses Herpesviridae Herpesvirus 6, Human Herpesvirus 7, Human HHV-6A HHV-6B HHV-7 human herpesvirus Humans integrative genomics Mice Mice, Knockout Mice, Transgenic Microbiota MicroRNAs - genetics Monomeric Clathrin Assembly Proteins - genetics multiscale networks network biology Neurodegeneration Neuromodulation Neuropathology Nuclear Proteins - genetics Presenilin-1 - genetics Protein turnover Proteins Proteomics Roseolovirus Roseolovirus Infections - genetics Roseolovirus Infections - metabolism Roseolovirus Infections - pathology Roseolovirus Infections - virology systems biology Tumor Suppressor Proteins - genetics Viral Load Viruses β-Site APP-cleaving enzyme 1 |
| Title | Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus |
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