New insights on the development of fungal vaccines: from immunity to recent challenges

Fungal infections are emerging as a major problem in part due to high mortality associated with systemic infections, especially in the case of immunocompromised patients. With the development of new treatments for diseases such as cancer and the acquired immune deficiency syndrome pandemic, the numb...

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Published inMemórias do Instituto Oswaldo Cruz Vol. 110; no. 8; pp. 966 - 973
Main Authors Medici, Natasha P, Del Poeta, Maurizio
Format Journal Article
LanguageEnglish
Published Brazil Instituto Oswaldo Cruz, Ministério da Saúde 01.12.2015
Fundação Oswaldo Cruz (FIOCRUZ)
Subjects
Adaptive Immunity - physiology
Clinical Trials as Topic
Fungal Vaccines - immunology
fungi
Host-Pathogen Interactions - immunology
Humans
immunity
Immunity, Innate - physiology
Immunocompromised Host - immunology
infection
Mycoses - prevention & control
PARASITOLOGY
Review
strategy
Technology, Pharmaceutical
TROPICAL MEDICINE
Vaccination - methods
Vaccination - trends
vaccine
yeast
vaccine
infection
immunity
strategy
fungi
yeast
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ISSN0074-0276
1678-8060
1678-8060
DOI10.1590/0074-02760150335

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Summary:Fungal infections are emerging as a major problem in part due to high mortality associated with systemic infections, especially in the case of immunocompromised patients. With the development of new treatments for diseases such as cancer and the acquired immune deficiency syndrome pandemic, the number of immunosuppressed patients has increased and, as a consequence, also the number of invasive fungal infections has increased. Several studies have proposed new strategies for the development of effective fungal vaccines. In addition, better understanding of how the immune system works against fungal pathogens has improved the further development of these new vaccination strategies. As a result, some fungal vaccines have advanced through clinical trials. However, there are still many challenges that prevent the clinical development of fungal vaccines that can efficiently immunise subjects at risk of developing invasive fungal infections. In this review, we will discuss these new vaccination strategies and the challenges that they present. In the future with proper investments, fungal vaccines may soon become a reality.
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ISSN:0074-0276
1678-8060
1678-8060
DOI:10.1590/0074-02760150335