Effects of Lactobacillus gasseri OLL2809 and α-lactalbumin on university-student athletes: a randomized, double-blind, placebo-controlled clinical trial

Strenuous exercise reduces immune cell function and increases the risk of respiratory and gastrointestinal infections. In addition, it affects mood state and causes physical fatigue. Athletes require both mental and physical conditioning to execute good performance. In this study, we conducted a ran...

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Published inApplied physiology, nutrition, and metabolism Vol. 38; no. 12; pp. 1228 - 1235
Main Authors Sashihara, Toshihiro, Nagata, Masashi, Mori, Takeshi, Ikegami, Shuji, Gotoh, Minoru, Okubo, Kimihiro, Uchida, Masayuki, Itoh, Hiroyuki
Format Journal Article
LanguageEnglish
Published Canada NRC Research Press 01.12.2013
Subjects
activité NK
Athletes
blood sampling
blood serum
clinical trials
College athletes
college students
Dietary supplements
Double-Blind Method
emotions
exercice physique
Exercise
fatigue
Food and nutrition
gastrointestinal system
Health aspects
Humans
ingestion
Lactalbumin
Lactobacillus
Lactobacillus gasseri
metabolism
natural killer cells
NK activity
nutritional intervention
placebos
questionnaires
reactive oxygen species
risk
stress
Students
transforming growth factors
Universities
α-lactalbumin
α-lactalbumine
Japan
Online AccessGet full text
ISSN1715-5312
1715-5320
1715-5320
DOI10.1139/apnm-2012-0490

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Abstract Strenuous exercise reduces immune cell function and increases the risk of respiratory and gastrointestinal infections. In addition, it affects mood state and causes physical fatigue. Athletes require both mental and physical conditioning to execute good performance. In this study, we conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the immunopotentiation and fatigue-alleviation effects of Lactobacillus gasseri OLL2809 (LG2809) and α-lactalbumin (αLA) in university-student athletes after strenuous exercise. A total of 44 university students who performed strenuous exercise daily were separated into 3 groups to receive a 4-week course of placebo, 100 mg LG2809, or 100 mg LG2809 in combination with 900 mg αLA, respectively. Before and after each dietary treatment, the subjects performed strenuous cycle ergometer exercise for 1 h. Before and after each exercise session, blood samples and visual analogue scale scores for fatigue were obtained. In addition, the mood of each subject before and after the dietary treatment was evaluated using the Profile of Mood States (POMS) questionnaire. LG2809 ingestion was effective in preventing reduced natural killer cell activity due to strenuous exercise and elevating mood from a depressed state. In addition, LG2809 + αLA was found to alleviate minor resting fatigue, which was supported objectively by the significant reduction in the serum reactive oxygen metabolites and transforming growth factor β1 levels. These effects could be helpful for athletes to maintain mental and physical condition.
AbstractList Strenuous exercise reduces immune cell function and increases the risk of respiratory and gastrointestinal infections. In addition, it affects mood state and causes physical fatigue. Athletes require both mental and physical conditioning to execute good performance. In this study, we conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the immunopotentiation and fatigue-alleviation effects of Lactobacillus gasseri OLL2809 (LG2809) and α-lactalbumin (αLA) in university-student athletes after strenuous exercise. A total of 44 university students who performed strenuous exercise daily were separated into 3 groups to receive a 4-week course of placebo, 100 mg LG2809, or 100 mg LG2809 in combination with 900 mg αLA, respectively. Before and after each dietary treatment, the subjects performed strenuous cycle ergometer exercise for 1 h. Before and after each exercise session, blood samples and visual analogue scale scores for fatigue were obtained. In addition, the mood of each subject before and after the dietary treatment was evaluated using the Profile of Mood States (POMS) questionnaire. LG2809 ingestion was effective in preventing reduced natural killer cell activity due to strenuous exercise and elevating mood from a depressed state. In addition, LG2809 + αLA was found to alleviate minor resting fatigue, which was supported objectively by the significant reduction in the serum reactive oxygen metabolites and transforming growth factor β1 levels. These effects could be helpful for athletes to maintain mental and physical condition.
Strenuous exercise reduces immune cell function and increases the risk of respiratory and gastrointestinal infections. In addition, it affects mood state and causes physical fatigue. Athletes require both mental and physical conditioning to execute good performance. In this study, we conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the immunopotentiation and fatigue-alleviation effects of Lactobacillus gasseri OLL2809 (LG2809) and α-lactalbumin (αLA) in university-student athletes after strenuous exercise. A total of 44 university students who performed strenuous exercise daily were separated into 3 groups to receive a 4-week course of placebo, 100 mg LG2809, or 100 mg LG2809 in combination with 900 mg αLA, respectively. Before and after each dietary treatment, the subjects performed strenuous cycle ergometer exercise for 1 h. Before and after each exercise session, blood samples and visual analogue scale scores for fatigue were obtained. In addition, the mood of each subject before and after the dietary treatment was evaluated using the Profile of Mood States (POMS) questionnaire. LG2809 ingestion was effective in preventing reduced natural killer cell activity due to strenuous exercise and elevating mood from a depressed state. In addition, LG2809 + αLA was found to alleviate minor resting fatigue, which was supported objectively by the significant reduction in the serum reactive oxygen metabolites and transforming growth factor β1 levels. These effects could be helpful for athletes to maintain mental and physical condition.Strenuous exercise reduces immune cell function and increases the risk of respiratory and gastrointestinal infections. In addition, it affects mood state and causes physical fatigue. Athletes require both mental and physical conditioning to execute good performance. In this study, we conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the immunopotentiation and fatigue-alleviation effects of Lactobacillus gasseri OLL2809 (LG2809) and α-lactalbumin (αLA) in university-student athletes after strenuous exercise. A total of 44 university students who performed strenuous exercise daily were separated into 3 groups to receive a 4-week course of placebo, 100 mg LG2809, or 100 mg LG2809 in combination with 900 mg αLA, respectively. Before and after each dietary treatment, the subjects performed strenuous cycle ergometer exercise for 1 h. Before and after each exercise session, blood samples and visual analogue scale scores for fatigue were obtained. In addition, the mood of each subject before and after the dietary treatment was evaluated using the Profile of Mood States (POMS) questionnaire. LG2809 ingestion was effective in preventing reduced natural killer cell activity due to strenuous exercise and elevating mood from a depressed state. In addition, LG2809 + αLA was found to alleviate minor resting fatigue, which was supported objectively by the significant reduction in the serum reactive oxygen metabolites and transforming growth factor β1 levels. These effects could be helpful for athletes to maintain mental and physical condition.
Strenuous exercise reduces immune cell function and increases the risk of respiratory and gastrointestinal infections. In addition, it affects mood state and causes physical fatigue. Athletes require both mental and physical conditioning to execute good performance. In this study, we conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the immunopotentiation and fatigue-alleviation effects of Lactobacillus gasseri OLL2809 (LG2809) and α-lactalbumin (αLA) in university-student athletes after strenuous exercise. A total of 44 university students who performed strenuous exercise daily were separated into 3 groups to receive a 4-week course of placebo, 100 mg LG2809, or 100 mg LG2809 in combination with 900 mg αLA, respectively. Before and after each dietary treatment, the subjects performed strenuous cycle ergometer exercise for 1 h. Before and after each exercise session, blood samples and visual analogue scale scores for fatigue were obtained. In addition, the mood of each subject before and after the dietary treatment was evaluated using the Profile of Mood States (POMS) questionnaire. LG2809 ingestion was effective in preventing reduced natural killer cell activity due to strenuous exercise and elevating mood from a depressed state. In addition, LG2809 + αLA was found to alleviate minor resting fatigue, which was supported objectively by the significant reduction in the serum reactive oxygen metabolites and transforming growth factor β1 levels. These effects could be helpful for athletes to maintain mental and physical condition. Key words: lactobacillus, α-lactalbumin, NK activity, fatigue, stress, exercise. L'exercice intense amenuise la fonction immunitaire et accroit le risque d'infections respiratoires et gastrointestinales. En outre, il affecte l'humeur et suscite la fatigue physique. Les athletes doivent etre en bonne condition physique et mentale pour effectuer une performance acceptable. Dans cette etude, des etudiants-athletes a l'universite participent a un essai clinique aleatoire a double insu avec groupe de controle pour evaluer les effets du Lactobacillus gasseri OLL2809 (LG2809) et de l'a-lactalbumine (αLA) sur l'immunopotentialisation et l'attenuation de la fatigue apres un exercice intense. Au total, 44 etudiants universitaires s'exercant intensement tous les jours sont repartis dans 3 groupes recevant durant 4 semaines un placebo, 100 mg de LG2809 ou 100 mg de LG2809 combine a 900 mg d'αLA, respectivement. Avant et apres chaque traitement alimentaire, les sujets effectuent durant 1h un effort intense sur un cycloergometre. Avant et apres chaque seance d'exercice, on preleve des echantillons de sang et on demande aux sujets de coter leur fatigue sur une echelle visuelle analogue. De plus, on evalue l'humeur de chaque sujet avant et apres chaque traitement alimentaire au moyen du questionnaire sur le profil des humeurs (<<Profile of Mood State>>, POMS). L'apport de LG2809 est efficace pour prevenir la diminution de l'activite des cellules NK causee par l'exercice intense et pour rehausser l'humeur abaissee par l'exercice. De plus, le LG2809 combine a l'αLA allege la fatigue mineure de repos, ce qui est appuye objectivement par la diminution significative de la concentration serique des metabolites reactifs de l'oxygene et du facteur de croissance transformant β1. Ces effets pourraient etre utiles au maintien d'une bonne condition physique et mentale chez les athletes. [Traduit par la Redaction] Mots-cles: lactobacillus, α-lactalbumine, activite NK, fatigue, stress, exercice physique.
Strenuous exercise reduces immune cell function and increases the risk of respiratory and gastrointestinal infections. In addition, it affects mood state and causes physical fatigue. Athletes require both mental and physical conditioning to execute good performance. In this study, we conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the immunopotentiation and fatigue-alleviation effects of Lactobacillus gasseri OLL2809 (LG2809) and alpha -lactalbumin ( alpha LA) in university-student athletes after strenuous exercise. A total of 44 university students who performed strenuous exercise daily were separated into 3 groups to receive a 4-week course of placebo, 100 mg LG2809, or 100 mg LG2809 in combination with 900 mg alpha LA, respectively. Before and after each dietary treatment, the subjects performed strenuous cycle ergometer exercise for 1 h. Before and after each exercise session, blood samples and visual analogue scale scores for fatigue were obtained. In addition, the mood of each subject before and after the dietary treatment was evaluated using the Profile of Mood States (POMS) questionnaire. LG2809 ingestion was effective in preventing reduced natural killer cell activity due to strenuous exercise and elevating mood from a depressed state. In addition, LG2809 + alpha LA was found to alleviate minor resting fatigue, which was supported objectively by the significant reduction in the serum reactive oxygen metabolites and transforming growth factor beta 1 levels. These effects could be helpful for athletes to maintain mental and physical condition.Original Abstract: L'exercice intense amenuise la fonction immunitaire et accroit le risque d'infections respiratoires et gastro-intestinales. En outre, il affecte l'humeur et suscite la fatigue physique. Les athletes doivent etre en bonne condition physique et mentale pour effectuer une performance acceptable. Dans cette etude, des etudiants-athletes a l'universite participent a un essai clinique aleatoire a double insu avec groupe de controle pour evaluer les effets du Lactobacillus gasseri OLL2809 (LG2809) et de l' alpha -lactalbumine ( alpha LA) sur l'immunopotentialisation et l'attenuation de la fatigue apres un exercice intense. Au total, 44 etudiants universitaires s'exercant intensement tous les jours sont repartis dans 3 groupes recevant durant 4 semaines un placebo, 100 mg de LG2809 ou 100 mg de LG2809 combine a 900 mg d' alpha LA, respectivement. Avant et apres chaque traitement alimentaire, les sujets effectuent durant 1 h un effort intense sur un cycloergometre. Avant et apres chaque seance d'exercice, on preleve des echantillons de sang et on demande aux sujets de coter leur fatigue sur une echelle visuelle analogue. De plus, on evalue l'humeur de chaque sujet avant et apres chaque traitement alimentaire au moyen du questionnaire sur le profil des humeurs ( Profile of Mood State , POMS). L'apport de LG2809 est efficace pour prevenir la diminution de l'activite des cellules NK causee par l'exercice intense et pour rehausser l'humeur abaissee par l'exercice. De plus, le LG2809 combine a l' alpha LA allege la fatigue mineure de repos, ce qui est appuye objectivement par la diminution significative de la concentration serique des metabolites reactifs de l'oxygene et du facteur de croissance transformant beta 1. Ces effets pourraient etre utiles au maintien d'une bonne condition physique et mentale chez les athletes. [Traduit par la Redaction]
Abstract_FL L’exercice intense amenuise la fonction immunitaire et accroît le risque d’infections respiratoires et gastro-intestinales. En outre, il affecte l’humeur et suscite la fatigue physique. Les athlètes doivent être en bonne condition physique et mentale pour effectuer une performance acceptable. Dans cette étude, des étudiants-athlètes à l’université participent à un essai clinique aléatoire à double insu avec groupe de contrôle pour évaluer les effets du Lactobacillus gasseri OLL2809 (LG2809) et de l’α-lactalbumine (αLA) sur l’immunopotentialisation et l’atténuation de la fatigue après un exercice intense. Au total, 44 étudiants universitaires s’exerçant intensément tous les jours sont répartis dans 3 groupes recevant durant 4 semaines un placebo, 100 mg de LG2809 ou 100 mg de LG2809 combiné à 900 mg d’αLA, respectivement. Avant et après chaque traitement alimentaire, les sujets effectuent durant 1 h un effort intense sur un cycloergomètre. Avant et après chaque séance d’exercice, on prélève des échantillons de sang et on demande aux sujets de coter leur fatigue sur une échelle visuelle analogue. De plus, on évalue l’humeur de chaque sujet avant et après chaque traitement alimentaire au moyen du questionnaire sur le profil des humeurs (≪ Profile of Mood State ≫, POMS). L’apport de LG2809 est efficace pour prévenir la diminution de l’activité des cellules NK causée par l’exercice intense et pour rehausser l’humeur abaissée par l’exercice. De plus, le LG2809 combiné à l’αLA allège la fatigue mineure de repos, ce qui est appuyé objectivement par la diminution significative de la concentration sérique des métabolites réactifs de l’oxygène et du facteur de croissance transformant β1. Ces effets pourraient être utiles au maintien d’une bonne condition physique et mentale chez les athletes. [Traduit par la Rédaction]
Audience Academic
Author Okubo, Kimihiro
Uchida, Masayuki
Nagata, Masashi
Mori, Takeshi
Gotoh, Minoru
Sashihara, Toshihiro
Itoh, Hiroyuki
Ikegami, Shuji
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Snippet Strenuous exercise reduces immune cell function and increases the risk of respiratory and gastrointestinal infections. In addition, it affects mood state and...
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SubjectTerms activité NK
Athletes
blood sampling
blood serum
clinical trials
College athletes
college students
Dietary supplements
Double-Blind Method
emotions
exercice physique
Exercise
fatigue
Food and nutrition
gastrointestinal system
Health aspects
Humans
ingestion
Lactalbumin
Lactobacillus
Lactobacillus gasseri
metabolism
natural killer cells
NK activity
nutritional intervention
placebos
questionnaires
reactive oxygen species
risk
stress
Students
transforming growth factors
Universities
α-lactalbumin
α-lactalbumine
Title Effects of Lactobacillus gasseri OLL2809 and α-lactalbumin on university-student athletes: a randomized, double-blind, placebo-controlled clinical trial
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