Dexmedetomidine and remifentanil in the perioperative management of an adolescent undergoing resection of pheochromocytoma -A case report

• Published in: Korean journal of anesthesiology Vol. 63; no. 6; pp. 555 - 558
• Main Authors: Jung, Jae-Wook, Park, Jung Kyu, Jeon, Sang Yoon, Kim, Yong Han, Nam, So-Hyun, Choi, Young-Gyun, Bang, Si Ra
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Anesthesiologists 01.12.2012; Korean Society of Anesthesiologists; 대한마취통증의학회
• Subjects: Case Report; catecholamine; dexmedetomidine; pheochromocytoma; remifentanil; 마취과학; Pheochromocytoma; Catecholamine; Remifentanil; Dexmedetomidine
• ISSN: 2005-6419; 2005-7563; 2005-7563
• DOI: 10.4097/kjae.2012.63.6.555

A 15-year-old adolescent with unilateral multiple adrenal pheochromocytoma had an episode of subcortical intracerebral hemorrhage and seizure 6 weeks before the surgery. He was pretreated with terazosin, losartan, atenolol and levetiracetam for 2 weeks. Dexmedetomidine was started in the preoperative waiting area, and a combination of dexmedetomidine and remifentanil was continuously infused for most of anesthetic time. To control blood pressure, bolus injection of remifentanil and low-dose infusion of sodium nitroprusside, nicardipine, and esmolol were administered during three adrenergic crises. There was minimal post-resection hypotension, and his trachea was extubated safely 20 min after the surgery. He was discharged without noticeable complication. His catecholamine levels showed the steadily decreasing pattern during the operation in this case. Though a combination of dexmedetomidine and remifentanil may not prevent the hemodynamic instability impeccably during the tumor manipulation, this combination seems to be the way of interrupting release of catecholamines and minimizing hemodynamic fluctuations.