CYP3A5 Contributes Significantly to CYP3A-mediated Drug Oxidations in Liver Microsomes from Japanese Subjects - Yamaori, Satoshi; Yamazaki, Hiroshi; Iwano, Shunsuke; Kiyotani, Kazuma; Matsumura, Keiko; Honda, Goro; Nakagawa, Kazuko; Ishizaki, Takashi; Kamataki, Tetsuya (DRUG METABOLISM AND PHARMACOKINETICS, 2004)
Keywords: Calcium Channel Blockers - metabolism; CYP3A5; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Dealkylation; diltiazem; Diltiazem - metabolism; DNA - genetics; DNA Primers; Escherichia coli - metabolism; GABA Modulators - metabolism; Genotype; Humans; Hydroxylation; In Vitro Techniques; Japan; Kinetics; liver; Microsomes, Liver - enzymology; midazolam; Midazolam - metabolism; NADPH-Ferrihemoprotein Reductase - genetics; NADPH-Ferrihemoprotein Reductase - metabolism; Oxidation-Reduction; Pharmaceutical Preparations - metabolism; polymorphism; Reverse Transcriptase Polymerase Chain Reaction; testosterone; Testosterone - metabolism; diltiazem; polymorphism; testosterone; liver; midazolam; CYP3A5