In Vivo Effect of Mutations at the PRPP Binding Site of the Bacillus subtilis Purine Repressor

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Published inJournal of Bacteriology Vol. 185; no. 22; pp. 6728 - 6731
Main Authors Rappu, Pekka, Pullinen, Terhi, Mäntsälä, Pekka
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.11.2003
Subjects
Bacillus subtilis - genetics
Bacillus subtilis - growth & development
Bacillus subtilis - metabolism
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Binding Sites
Gene Expression Regulation, Bacterial
Gene Regulation
Mutation
Phosphoribosyl Pyrophosphate - chemistry
Phosphoribosyl Pyrophosphate - metabolism
Repressor Proteins - chemistry
Repressor Proteins - genetics
Repressor Proteins - metabolism
Online AccessGet full text
ISSN0021-9193
1067-8832
1098-5530
DOI10.1128/JB.185.22.6728-6731.2003

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Abstract Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB       
AbstractList The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR.
The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA . PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR.
Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB       
The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR.The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR.
The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR. [PERIODICAL ABSTRACT]
Author Pekka Rappu
Pekka Mäntsälä
Terhi Pullinen
AuthorAffiliation Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland 1
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crossref_primary_10_3390_fermentation9070594
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crossref_primary_10_1093_nar_gkab1281
crossref_primary_10_1016_j_fbio_2024_103859
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10.1128/JB.183.21.6175-6183.2001
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10.1073/pnas.92.16.7455
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10.1073/pnas.96.23.13074
10.1128/jb.179.23.7394-7402.1997
10.1007/s002840010091
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Corresponding author. Mailing address: Department of Biochemistry and Food Chemistry, University of Turku, Vatselankatu 2, FIN-20014 Turku, Finland. Phone: 358-2 333 6856. Fax: 358-2 333 6860. E-mail: pekka.rappu@utu.fi.
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The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA . PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP...
The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP...
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SubjectTerms Bacillus subtilis - genetics
Bacillus subtilis - growth & development
Bacillus subtilis - metabolism
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Binding Sites
Gene Expression Regulation, Bacterial
Gene Regulation
Mutation
Phosphoribosyl Pyrophosphate - chemistry
Phosphoribosyl Pyrophosphate - metabolism
Repressor Proteins - chemistry
Repressor Proteins - genetics
Repressor Proteins - metabolism
Title In Vivo Effect of Mutations at the PRPP Binding Site of the Bacillus subtilis Purine Repressor
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