Efficacy and safety of Indigo naturalis extract in oil (Lindioil) in treating nail psoriasis: A randomized, observer-blind, vehicle-controlled trial

Treating nail psoriasis is notoriously difficult and lacks standardized therapeutic regimens. Indigo naturalis has been demonstrated to be safe and effective in treating skin psoriasis. This trial was conducted to evaluate the efficacy and safety of refined indigo naturalis extract in oil (Lindioil)...

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Published in	Phytomedicine (Stuttgart) Vol. 21; no. 7; pp. 1015 - 1020
Main Authors	Lin, Yin-Ku, See, Lai-Chu, Huang, Yu-Huei, Chang, Ya-Ching, Tsou, Teng-Cheng, Lin, Tung-Yi, Lin, Na-Ling
Format	Journal Article
Language	English
Published	Germany Elsevier GmbH 15.06.2014 Urban & Fischer Verlag
Subjects	Acanthaceae - chemistry Adult Aged Care and treatment Chromatography, High Pressure Liquid Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - therapeutic use Essences and essential oils Female hands Health aspects Humans indigo Indigo naturalis Indirubin Male Medicine, Chinese Traditional Middle Aged Nail diseases Nail Diseases - drug therapy Nail Diseases - pathology Nail psoriasis Nails - drug effects Nails - pathology olive oil patients Plants, Medicinal - chemistry Psoriasis Psoriasis - drug therapy Psoriasis - pathology topical application Traditional Chinese medicine Treatment Outcome Young Adult PASI AE Indirubin Psoriasis CI Traditional Chinese medicine PGA SGA mtNAPSI shNAPSI SD NAPSI Indigo naturalis Nail psoriasis
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ISSN	0944-7113 1618-095X 1618-095X
DOI	10.1016/j.phymed.2014.02.013

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Abstract	Treating nail psoriasis is notoriously difficult and lacks standardized therapeutic regimens. Indigo naturalis has been demonstrated to be safe and effective in treating skin psoriasis. This trial was conducted to evaluate the efficacy and safety of refined indigo naturalis extract in oil (Lindioil) in treating nail psoriasis. Thirty-one outpatients with symmetrically comparable psoriatic nails were enrolled. Lindioil (experimental group) or olive oil (control group) was applied topically to the same subjects’ two bilaterally symmetrical psoriatic nails twice daily for the first 12 weeks and then subjects applied Lindioil to both hands for 12 additional weeks. Outcomes were measured using Nail Psoriasis Severity Index (NAPSI) for five nails on one hand and for the single most severely affected nail from either hand. The results show a reduction of NAPSI scores for the 12-week treatment for the Lindioil group (49.8% for one hand and 59.3% for single nail) was superior to the reduction in the scores for the control group (22.9%, 16.3%, respectively). There were no adverse events during the 24 weeks of treatment. This trial demonstrates that Lindioil is a novel, safe and effective therapy for treating nail psoriasis.
AbstractList	Treating nail psoriasis is notoriously difficult and lacks standardized therapeutic regimens. Indigo naturalis has been demonstrated to be safe and effective in treating skin psoriasis. This trial was conducted to evaluate the efficacy and safety of refined indigo naturalis extract in oil (Lindioil) in treating nail psoriasis. Thirty-one outpatients with symmetrically comparable psoriatic nails were enrolled. Lindioil (experimental group) or olive oil (control group) was applied topically to the same subjects' two bilaterally symmetrical psoriatic nails twice daily for the first 12 weeks and then subjects applied Lindioil to both hands for 12 additional weeks. Outcomes were measured using Nail Psoriasis Severity Index (NAPSI) for five nails on one hand and for the single most severely affected nail from either hand. The results show a reduction of NAPSI scores for the 12-week treatment for the Lindioil group (49.8% for one hand and 59.3% for single nail) was superior to the reduction in the scores for the control group (22.9%, 16.3%, respectively). There were no adverse events during the 24 weeks of treatment. This trial demonstrates that Lindioil is a novel, safe and effective therapy for treating nail psoriasis.Treating nail psoriasis is notoriously difficult and lacks standardized therapeutic regimens. Indigo naturalis has been demonstrated to be safe and effective in treating skin psoriasis. This trial was conducted to evaluate the efficacy and safety of refined indigo naturalis extract in oil (Lindioil) in treating nail psoriasis. Thirty-one outpatients with symmetrically comparable psoriatic nails were enrolled. Lindioil (experimental group) or olive oil (control group) was applied topically to the same subjects' two bilaterally symmetrical psoriatic nails twice daily for the first 12 weeks and then subjects applied Lindioil to both hands for 12 additional weeks. Outcomes were measured using Nail Psoriasis Severity Index (NAPSI) for five nails on one hand and for the single most severely affected nail from either hand. The results show a reduction of NAPSI scores for the 12-week treatment for the Lindioil group (49.8% for one hand and 59.3% for single nail) was superior to the reduction in the scores for the control group (22.9%, 16.3%, respectively). There were no adverse events during the 24 weeks of treatment. This trial demonstrates that Lindioil is a novel, safe and effective therapy for treating nail psoriasis. Treating nail psoriasis is notoriously difficult and lacks standardized therapeutic regimens. Indigo naturalis has been demonstrated to be safe and effective in treating skin psoriasis. This trial was conducted to evaluate the efficacy and safety of refined indigo naturalis extract in oil (Lindioil) in treating nail psoriasis. Thirty-one outpatients with symmetrically comparable psoriatic nails were enrolled. Lindioil (experimental group) or olive oil (control group) was applied topically to the same subjects' two bilaterally symmetrical psoriatic nails twice daily for the first 12 weeks and then subjects applied Lindioil to both hands for 12 additional weeks. Outcomes were measured using Nail Psoriasis Severity Index (NAPSI) for five nails on one hand and for the single most severely affected nail from either hand. The results show a reduction of NAPSI scores for the 12-week treatment for the Lindioil group (49.8% for one hand and 59.3% for single nail) was superior to the reduction in the scores for the control group (22.9%, 16.3%, respectively). There were no adverse events during the 24 weeks of treatment. This trial demonstrates that Lindioil is a novel, safe and effective therapy for treating nail psoriasis.
Audience	Academic
Author	Tsou, Teng-Cheng See, Lai-Chu Chang, Ya-Ching Lin, Na-Ling Huang, Yu-Huei Lin, Yin-Ku Lin, Tung-Yi
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Keywords	PASI AE Indirubin Psoriasis CI Traditional Chinese medicine PGA SGA mtNAPSI shNAPSI SD NAPSI Indigo naturalis Nail psoriasis
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Snippet	Treating nail psoriasis is notoriously difficult and lacks standardized therapeutic regimens. Indigo naturalis has been demonstrated to be safe and effective...
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SubjectTerms	Acanthaceae - chemistry Adult Aged Care and treatment Chromatography, High Pressure Liquid Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - therapeutic use Essences and essential oils Female hands Health aspects Humans indigo Indigo naturalis Indirubin Male Medicine, Chinese Traditional Middle Aged Nail diseases Nail Diseases - drug therapy Nail Diseases - pathology Nail psoriasis Nails - drug effects Nails - pathology olive oil patients Plants, Medicinal - chemistry Psoriasis Psoriasis - drug therapy Psoriasis - pathology topical application Traditional Chinese medicine Treatment Outcome Young Adult
Title	Efficacy and safety of Indigo naturalis extract in oil (Lindioil) in treating nail psoriasis: A randomized, observer-blind, vehicle-controlled trial
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