Rufinamide: a new antiepileptic drug treatment for Lennox-Gastaut syndrome

Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types, particularly generalized seizures, which are often resistant to antiepileptic drug medication. Rufinamide is a new antiepileptic drug approved as...

Full description

Saved in:
Bibliographic Details
Published inExpert review of neurotherapeutics Vol. 10; no. 6; pp. 851 - 860
Main Author Ferrie, Colin D
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.06.2010
Expert Reviews Ltd
Informa Healthcare
Subjects
adult
adverse effect
Anticonvulsants
Anticonvulsants - adverse effects
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Antiepileptic agents
antiepileptic drug
Child
Children
Clinical trials
Clinical Trials as Topic
Data processing
Drug therapy
efficacy
Epilepsy
Epilepsy, Generalized - drug therapy
Geriatrics
Health aspects
Humans
Lennox-Gastaut syndrome
Metabolism
pharmacodynamics
Pharmacokinetics
randomized controlled study
Reviews
rufinamide
Seizures
Side effects
Syndrome
Triazoles - adverse effects
Triazoles - pharmacology
Triazoles - therapeutic use
United Kingdom
Online AccessGet full text
ISSN1473-7175
1744-8360
1744-8360
DOI10.1586/ern.10.51

Cover

Abstract Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types, particularly generalized seizures, which are often resistant to antiepileptic drug medication. Rufinamide is a new antiepileptic drug approved as adjunctive therapy to treat seizures in Lennox-Gastaut syndrome in those 4 years of age and older. In this article, the putative mechanism of action is described, along with data relating to its pharmacokinetics and metabolism. Key findings from clinical trials are presented and discussed. Adverse effects are summarized and compared with those encountered with competitor antiepileptic drugs. Finally, the role of rufinamide in the holistic management of subjects with Lennox-Gastaut syndrome is considered.
AbstractList Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types, particularly generalized seizures, which are often resistant to antiepileptic drug medication. Rufinamide is a new antiepileptic drug approved as adjunctive therapy to treat seizures in Lennox-Gastaut syndrome in those 4 years of age and older. In this article, the putative mechanism of action is described, along with data relating to its pharmacokinetics and metabolism. Key findings from clinical trials are presented and discussed. Adverse effects are summarized and compared with those encountered with competitor antiepileptic drugs. Finally, the role of rufinamide in the holistic management of subjects with Lennox-Gastaut syndrome is considered.
Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types, particularly generalized seizures, which are often resistant to antiepileptic drug medication. Rufinamide is a new antiepileptic drug approved as adjunctive therapy to treat seizures in Lennox-Gastaut syndrome in those 4 years of age and older. In this article, the putative mechanism of action is described, along with data relating to its pharmacokinetics and metabolism. Key findings from clinical trials are presented and discussed. Adverse effects are summarized and compared with those encountered with competitor antiepileptic drugs. Finally, the role of rufinamide in the holistic management of subjects with Lennox-Gastaut syndrome is considered.Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types, particularly generalized seizures, which are often resistant to antiepileptic drug medication. Rufinamide is a new antiepileptic drug approved as adjunctive therapy to treat seizures in Lennox-Gastaut syndrome in those 4 years of age and older. In this article, the putative mechanism of action is described, along with data relating to its pharmacokinetics and metabolism. Key findings from clinical trials are presented and discussed. Adverse effects are summarized and compared with those encountered with competitor antiepileptic drugs. Finally, the role of rufinamide in the holistic management of subjects with Lennox-Gastaut syndrome is considered.
Audience Academic
Author Ferrie, Colin D
Author_xml – sequence: 1
  givenname: Colin D
  surname: Ferrie
  fullname: Ferrie, Colin D
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20518600$$D View this record in MEDLINE/PubMed
BookMark eNp9kk9v1DAQxS3Uiv6BA18ARXAADtnasR0n3KoKSquVKiE4W5N4XLlK7MV2VPbb49W2B0qFfPAcfu_Z82ZOyIEPHgl5w-iKya49w-hXpZbsBTlmSoi64y09KLVQvFZMySNyktIdpVz0UrwkRw2VrGspPSbX3xfrPMzO4OcKKo_3FfjscOMm3GQ3ViYut1WOCHlGnysbYrVG78Pv-hJShiVXaetNDDO-IocWpoSvH-5T8vPrlx8X3-r1zeXVxfm6HiWluW7tMHaDHCSyvqessXxgXLCBozWNAisMgjIMu2awSOlAQTWdpdAzBWKglp-SD3vfTQy_FkxZzy6NOE3gMSxJK84ZV43khfz4X5JRpnrZNUwW9N0T9C4s0Zc-NG9bzlQJr0Dv99AtTKidtyFHGHee-rxpqRSipX2hVs9Q5Ric3VgmZ0u2fwvePry9DDMavYluhrjVj1MqwNkeGGNIKaLVo8uQXfDF2U2lD73bA132YFdLVhSfnigeTZ9jxZ7dfTXOcB_iZHSG7RSijeBHVzL4V_YHAMzDBA
CitedBy_id crossref_primary_10_2515_therapie_2012013
crossref_primary_10_1097_FTD_0b013e31820fa9ad
crossref_primary_10_1111_ane_12086
crossref_primary_10_1007_s40262_013_0067_4
crossref_primary_10_1111_j_1365_2885_2011_01353_x
Cites_doi 10.1016/S0920-1211(00)00185-6
10.1016/j.ejpn.2008.12.005
10.1002/9781444316667.ch44
10.1517/13543784.9.4.829
10.1111/j.1528-1157.1997.tb00065.x
10.1111/j.0013-9580.2005.35504.x
10.1111/j.1528-1167.2006.00589.x
10.1177/08830738050200010101
10.1002/9781444316667.ch2
10.1684/epd.2007.0144
10.1016/S1474-4422(08)70292-8
10.1212/WNL.52.9.1882
10.1111/j.1528-1157.1996.tb06020.x
10.1056/NEJM199712183372504
10.1016/S0920-1211(98)00108-9
10.1016/j.eplepsyres.2006.02.004
10.1212/01.wnl.0000303813.95800.0d
10.1016/S1474-4422(08)70092-9
10.1111/j.1528-1167.2005.00341.x
10.1002/9781444316667.ch54
10.1002/9781444316667.ch51
10.1056/NEJM199301073280105
10.1002/9781444316667.ch57
10.1016/j.yebeh.2008.12.013
10.1111/j.1528-1157.1998.tb05118.x
10.1111/j.1528-1167.2008.01665.x
10.1111/j.1528-1167.2008.01552.x
ContentType Journal Article
Copyright Expert Reviews Ltd 2010
COPYRIGHT 2010 Expert Reviews Ltd.
2010 Expert Reviews Ltd
Copyright_xml – notice: Expert Reviews Ltd 2010
– notice: COPYRIGHT 2010 Expert Reviews Ltd.
– notice: 2010 Expert Reviews Ltd
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
88G
8AO
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
K9.
M0S
M1P
M2M
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
PSYQQ
Q9U
7QO
7TK
8FD
FR3
P64
7X8
DOI 10.1586/ern.10.51
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
ProQuest Pharma Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
Psychology Database
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Psychology
ProQuest Central Basic
Biotechnology Research Abstracts
Neurosciences Abstracts
Technology Research Database
Engineering Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest One Psychology
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Psychology Journals (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest Psychology Journals
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
Engineering Research Database
Biotechnology Research Abstracts
Technology Research Database
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList MEDLINE
ProQuest One Psychology
Engineering Research Database
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central (New) (NC LIVE)
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1744-8360
EndPage 860
ExternalDocumentID 2054616141
A260544609
20518600
10_1586_ern_10_51
11212545
Genre Article
Journal Article
Review
GeographicLocations United Kingdom
GeographicLocations_xml – name: United Kingdom
GroupedDBID ---
0BK
0R~
29G
3V.
4.4
5GY
7X7
88E
8AO
8FI
8FJ
AAGSP
AAOUU
ABEIZ
ABIVO
ABJNI
ABJXJ
ABLKL
ABUWG
ABXYU
ACGFS
ACNPW
ADBBV
AECIN
AENEX
AEOZL
AESAV
AFKRA
AGDLA
AGMLL
AHMBA
AIJEM
AIYSM
AKBVH
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALQZU
AZQEC
BENPR
BLEHA
BPHCQ
BVXVI
CCCUG
CCPQU
CS3
DWQXO
EBS
EJD
F5P
FYUFA
GNUQQ
H13
HMCUK
HZ~
IAO
IEA
IGS
IHR
IPY
ITC
KSSTO
KYCEM
M1P
M2M
MV1
O9-
OVD
PQQKQ
PROAC
PSQYO
PSYQQ
RFE
RNANH
SJN
TBQAZ
TCNNB
TDBHL
TEORI
TFL
TFW
TUROJ
UKHRP
53G
AAHJP
AANCX
AAYXX
ABKMU
ACFRI
ACLQP
ADTKB
AFRVT
AIRBT
CBZEQ
CITATION
DDEWX
DGYZD
EMOBN
LJTGL
PHGZM
PHGZT
PJZUB
PPXIY
PUEGO
TASJS
CGR
CUY
CVF
ECM
EIF
NPM
AMPGV
PMFND
7XB
8FK
K9.
PKEHL
PQEST
PQUKI
PRINS
Q9U
7QO
7TK
8FD
FR3
P64
7X8
ID FETCH-LOGICAL-c500t-6fbc8b5b5e199012f3b1341b3efd27af4dea7d1e82bfe00b0a728f0a917a4b0f3
IEDL.DBID 7X7
ISSN 1473-7175
1744-8360
IngestDate Thu Sep 04 18:50:35 EDT 2025
Fri Sep 05 06:56:01 EDT 2025
Fri Jul 25 05:44:06 EDT 2025
Tue Jun 17 21:27:25 EDT 2025
Tue Jun 10 20:44:53 EDT 2025
Mon Jul 21 05:39:22 EDT 2025
Wed Oct 01 06:51:29 EDT 2025
Thu Apr 24 23:04:00 EDT 2025
Wed Dec 25 09:04:25 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c500t-6fbc8b5b5e199012f3b1341b3efd27af4dea7d1e82bfe00b0a728f0a917a4b0f3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
content type line 23
ObjectType-Review-3
PMID 20518600
PQID 366317003
PQPubID 54578
PageCount 10
ParticipantIDs gale_infotracacademiconefile_A260544609
crossref_citationtrail_10_1586_ern_10_51
pubmed_primary_20518600
proquest_miscellaneous_733137253
informaworld_taylorfrancis_310_1586_ern_10_51
proquest_miscellaneous_1017958215
gale_infotracmisc_A260544609
proquest_journals_366317003
crossref_primary_10_1586_ern_10_51
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 6/1/2010
2010-06-00
2010-Jun
20100601
PublicationDateYYYYMMDD 2010-06-01
PublicationDate_xml – month: 06
  year: 2010
  text: 6/1/2010
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Expert review of neurotherapeutics
PublicationTitleAlternate Expert Rev Neurother
PublicationYear 2010
Publisher Taylor & Francis
Expert Reviews Ltd
Informa Healthcare
Publisher_xml – name: Taylor & Francis
– name: Expert Reviews Ltd
– name: Informa Healthcare
References Trevathan (CIT0006) 1997; 38
Jain (CIT0015) 2000; 9
Chang (CIT0022) 1998; 39
Kapeghian (CIT0020) 1996; 37
CIT0034
Wheless (CIT0008) 2005; 20
Arroyo (CIT0021) 2005; 46
Fuseau (CIT0024) 2005; 46
Hancock (CIT0010) 2009; 3
Neal (CIT0043) 2008; 7
Motte (CIT0036) 1997; 337
CIT0016
CIT0037
White (CIT0013) 2008; 49
CIT0039
Glauser (CIT0029) 2008; 70
Critchley (CIT0018) 2005; 46
Kluger (CIT0032) 2009; 14
CIT0041
Krauss (CIT0033) 2005; 46
CIT0040
CIT0042
CIT0001
CIT0023
Wheless (CIT0009) 2007; 9
Perucca (CIT0017) 2008; 49
Elger (CIT0027) 2005; 46
(CIT0035) 1993; 328
Schmutz (CIT0014) 1993; 32
Ferrie (CIT0007) 2009; 13
Biton (CIT0030) 2005; 46
Svendsen (CIT0025) 1998; 39
Bialer (CIT0012) 1999; 34
Arzimanoglou (CIT0004) 2009; 8
CIT0003
CIT0002
CIT0005
Todorov (CIT0028) 2005; 46
Sachdeo (CIT0038) 1999; 52
CIT0026
Kluger (CIT0031) 2006; 47
Waldmeier (CIT0019) 1996; 37
McLean (CIT0011) 2005; 46
References_xml – volume: 46
  start-page: 296
  year: 2005
  ident: CIT0011
  publication-title: Epilepsia
– ident: CIT0026
  doi: 10.1016/S0920-1211(00)00185-6
– volume: 13
  start-page: 493
  year: 2009
  ident: CIT0007
  publication-title: Eur. J. Paed. Neurol.
  doi: 10.1016/j.ejpn.2008.12.005
– volume: 46
  start-page: 206
  year: 2005
  ident: CIT0030
  publication-title: Epilepsia
– ident: CIT0040
  doi: 10.1002/9781444316667.ch44
– volume: 46
  start-page: 209
  year: 2005
  ident: CIT0018
  publication-title: Epilepsia
– volume: 9
  start-page: 829
  year: 2000
  ident: CIT0015
  publication-title: Exp. Opin. Invest. Drugs
  doi: 10.1517/13543784.9.4.829
– volume: 38
  start-page: 1283
  year: 1997
  ident: CIT0006
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1157.1997.tb00065.x
– volume: 3
  start-page: CD003277
  year: 2009
  ident: CIT0010
  publication-title: Cochrane Database Syst. Rev.
– volume: 46
  start-page: 193
  year: 2005
  ident: CIT0021
  publication-title: Epilepsia
  doi: 10.1111/j.0013-9580.2005.35504.x
– ident: CIT0034
  doi: 10.1111/j.1528-1167.2006.00589.x
– ident: CIT0002
– volume: 32
  start-page: 122
  year: 1993
  ident: CIT0014
  publication-title: Epilepsia
– volume: 20
  start-page: S1
  year: 2005
  ident: CIT0008
  publication-title: J. Child. Neurol.
  doi: 10.1177/08830738050200010101
– ident: CIT0001
  doi: 10.1002/9781444316667.ch2
– volume: 39
  start-page: 59
  year: 1998
  ident: CIT0022
  publication-title: Epilepsia
– volume: 9
  start-page: 353
  year: 2007
  ident: CIT0009
  publication-title: Epileptic Disord.
  doi: 10.1684/epd.2007.0144
– volume: 8
  start-page: 82
  year: 2009
  ident: CIT0004
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(08)70292-8
– volume: 37
  start-page: 167
  year: 1996
  ident: CIT0019
  publication-title: Epilepsia
– volume: 52
  start-page: 1882
  year: 1999
  ident: CIT0038
  publication-title: Neurology
  doi: 10.1212/WNL.52.9.1882
– volume: 37
  start-page: 26
  year: 1996
  ident: CIT0020
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1157.1996.tb06020.x
– volume: 337
  start-page: 1807
  year: 1997
  ident: CIT0036
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199712183372504
– volume: 34
  start-page: 1
  year: 1999
  ident: CIT0012
  publication-title: Epilepsy Res.
  doi: 10.1016/S0920-1211(98)00108-9
– ident: CIT0037
– ident: CIT0016
  doi: 10.1016/j.eplepsyres.2006.02.004
– volume: 46
  start-page: 218
  year: 2005
  ident: CIT0028
  publication-title: Epilepsia
– volume: 46
  start-page: 213
  year: 2005
  ident: CIT0033
  publication-title: Epilepsia
– volume: 46
  start-page: 210
  year: 2005
  ident: CIT0024
  publication-title: Epilepsia
– volume: 70
  start-page: 1946
  year: 2008
  ident: CIT0029
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000303813.95800.0d
– volume: 7
  start-page: 500
  year: 2008
  ident: CIT0043
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(08)70092-9
– volume: 47
  start-page: 139
  year: 2006
  ident: CIT0031
  publication-title: Epilepsia
– ident: CIT0003
– volume: 46
  start-page: 83
  year: 2005
  ident: CIT0027
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2005.00341.x
– ident: CIT0039
  doi: 10.1002/9781444316667.ch54
– ident: CIT0023
  doi: 10.1002/9781444316667.ch51
– volume: 328
  start-page: 29
  year: 1993
  ident: CIT0035
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199301073280105
– ident: CIT0005
– ident: CIT0041
  doi: 10.1002/9781444316667.ch57
– volume: 14
  start-page: 491
  year: 2009
  ident: CIT0032
  publication-title: Epilepsy Behav.
  doi: 10.1016/j.yebeh.2008.12.013
– ident: CIT0042
  doi: 10.1111/j.1528-1157.1998.tb05118.x
– volume: 49
  start-page: 1123
  year: 2008
  ident: CIT0017
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2008.01665.x
– volume: 39
  start-page: 59
  year: 1998
  ident: CIT0025
  publication-title: Epilepsia
– volume: 49
  start-page: 1213
  year: 2008
  ident: CIT0013
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2008.01552.x
SSID ssj0034954
Score 1.9157715
SecondaryResourceType review_article
Snippet Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types,...
SourceID proquest
gale
pubmed
crossref
informaworld
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 851
SubjectTerms adult
adverse effect
Anticonvulsants
Anticonvulsants - adverse effects
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Antiepileptic agents
antiepileptic drug
Child
Children
Clinical trials
Clinical Trials as Topic
Data processing
Drug therapy
efficacy
Epilepsy
Epilepsy, Generalized - drug therapy
Geriatrics
Health aspects
Humans
Lennox-Gastaut syndrome
Metabolism
pharmacodynamics
Pharmacokinetics
randomized controlled study
Reviews
rufinamide
Seizures
Side effects
Syndrome
Triazoles - adverse effects
Triazoles - pharmacology
Triazoles - therapeutic use
Title Rufinamide: a new antiepileptic drug treatment for Lennox-Gastaut syndrome
URI https://www.tandfonline.com/doi/abs/10.1586/ern.10.51
https://www.ncbi.nlm.nih.gov/pubmed/20518600
https://www.proquest.com/docview/366317003
https://www.proquest.com/docview/1017958215
https://www.proquest.com/docview/733137253
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Health & Medical Collection (ProQuest)
  customDbUrl:
  eissn: 1744-8360
  dateEnd: 20140930
  omitProxy: true
  ssIdentifier: ssj0034954
  issn: 1473-7175
  databaseCode: 7X7
  dateStart: 20010901
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central (New) (NC LIVE)
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 1744-8360
  dateEnd: 20140930
  omitProxy: true
  ssIdentifier: ssj0034954
  issn: 1473-7175
  databaseCode: BENPR
  dateStart: 20010901
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT9wwDI8GvOwF7YNtNxjKJgR7ICNtkra3l4lNfAgBOiGQ7i1K0gQhbb3bXU8a__3sNi07CfZWKVZS2Y5jx87PhOwIZUAtMsMgnuVMuia_W3hWOqmcdNaGph3QxWV2eiPPxmoca3Pmsayys4mNoS4nDu_IDwQcjYglJ75NfzNsGoXJ1dhBY4WsJeCpoFLn4z7eEuD7N0llmQsGUYuKwEKqyA78rIK49YtKlo6jaJSXMEuf9jybE-j4BVmPriM9bGX9kjzz1SuyO2qxp-_36fXDU6r5Pt2lowdU6vvX5OwKQV_Nr7vSf6WGgjdNgal3fgpmAcyGo-VscUv7unMK_0bPwQpP_rATAy7koqYdusEGuTk-uv5xymIjBeYU5zXLgnWFVVb5BNNgaRAWcdys8KFMcxNk6U1eJr5IbfCcW27ytAjcQChnpOVBvCGr1aTy7wiVcJh5USbCZZg0zSzs6DDMMN2bDp1MBuRzx0_tIso4Nrv4qTHaANZrYD1-KyD91JNOW2iNx4j2UCgaRQLzOBNfDcDfIHCVPsR4DEJaPhyQrSVK2CZuaZj9K1ZdNxcioe1eosUjC292ctdxWwNZp4QD8rEfxYWwUq3yk8VcNyYOXx-rAaFP0GCfTJGnCqZ522pUz4AUjGQBTuj7_y6_SZ63VQx4G7RFVuvZwn8A56i2280W2CZr348uR1d_ASUxD5M
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxELZKOcAF8W7aAgZB4VBT79re3SAhVAElbdOqQqmUm7G9NqpUNiHZCPKj-I_M7CMlUsutt5U8slcz43l47G8IeSmUAbVIDIN8ljPpqvpu5lnupHLSWRuqdkBHx0nvVB4M1XCF_GnfwuC1ytYmVoY6Hzk8I98R4BoRS058GP9k2DQKi6ttB41aKw79_BdkbNP3-59AvK_ieO_z4GOPNU0FmFOclywJ1mVWWeUjLAnFQVjENLPChzxOTZC5N2ke-Sy2wXNuuUnjLHADaY2RlgcB894gN6XgEqH60-EivxOQa1RFbJkKBlmSaoCMVJbs-EkBefJbFS25v8YJLGGkXh3pVh5v7y6504SqdLfWrXtkxRf3ydZJjXU936aDi6db0226RU8uULDnD8jBVwSZNT_Ocv-OGgrROwUhnvkxmCEwU47mk9l3urjnTuHfaB-s_ug3-2IgZJ2VtEVTeEhOr4XHj8hqMSr8GqESnKcXeSRcgkXaxIIFCd0Ey8tx18moQ960_NSuQTXH5hrnGrMbYL0G1uO3AtIXC9JxDeVxGdFrFIpGkcA8zjSvFOBvEChL72L-Byk073bI5hIlbEu3NMz-FasuqwOYUHdL0eKShTdauevGjABZq_Qd8nwxigvhzbjCj2ZTXZlUfO2sOoReQYN9OUUaK5jmca1RCwbEYJQzCHrX_7v8M3KrNzjq6_7-8eEGuV3foMCTqE2yWk5m_gkEZqV9Wm0HSr5d9_77C2orTDU
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3daxQxEA-1gvhS6mfPVo2i1YfG290ku3uCSLGe_bIc0sK9xSSblILdO-_2sPen9b9zZr_qQetb3xYyJEsm85WZ_IaQN1xqOBaxZhDPBkzYMr-bOpZZIa2wxviyHdD3o3j3ROwP5XCJXDZvYbCsstGJpaLORhbvyLscTCNiyfGur6siBjv9z-PfDBtIYaK16aZRnZADN_8D0dv0094OsPptFPW_Hn_ZZXWDAWZlEBQs9samRhrpQkwPRZ4bxDcz3PksSrQXmdNJFro0Mt4FgQl0EqU-0BDiaGECz2HeO-RuwgXHarJk2MZ6HOKOMqEtEs4gYpI1qJFM466b5BAzf5DhgimsDcICXurNXm9p_fqrZKV2W-l2dc4ekCWXPySbgwr3er5Fj6-ecU236CYdXCFizx-R_R8IOKvPzzL3kWoKnjwFhp65MagkUFmWZpPZKW1r3in8Gz0ECzC6YN80uK-zgjbICo_Jya3s8ROynI9yt0aoAEPqeBZyG2PCNjagTXwvxlRz1LMi7JD3zX4qWyOcY6ONXwojHdh6BVuP3xJIX7ek4wrW4zqid8gUhSyBeayuXyzA3yBoltrGWBDC6aDXIRsLlCCidmGY_ctWVZSXMb7qnKL4NQuvN3xXtUoBskYAOuRVO4oLYZVc7kazqSrVK758lh1Cb6DBHp08iSRM87Q6Ue0GRKCgU3CAn_13-ZfkHkieOtw7Olgn96tiCryU2iDLxWTmnoOPVpgXpTRQ8vO2xe8v2flQcA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rufinamide%3A+a+new+antiepileptic+drug+treatment+for+Lennox-Gastaut+syndrome&rft.jtitle=Expert+review+of+neurotherapeutics&rft.au=Ferrie%2C+Colin+D&rft.date=2010-06-01&rft.eissn=1744-8360&rft.volume=10&rft.issue=6&rft.spage=851&rft_id=info:doi/10.1586%2Fern.10.51&rft_id=info%3Apmid%2F20518600&rft.externalDocID=20518600
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1473-7175&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1473-7175&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1473-7175&client=summon