Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor - Ducheix, Simon; Montagner, Alexandra; Polizzi, Arnaud; Lasserre, Frédéric; Marmugi, Alice; Bertrand-Michel, Justine; Podechard, Normand; Al Saati, Talal; Chétiveaux, Maud; Baron, Silvère; Boué, Jérôme; Dietrich, Gilles; et al. (Journal of hepatology, 2013)
Keywords: Animals; Cholesterol; Cholesterol - metabolism; Deficiency Diseases - physiopathology; Dietary Fats - pharmacology; Disease Models, Animal; Fatty Acids, Essential - deficiency; Fatty Liver - physiopathology; Female; Gastroenterology and Hepatology; Gene Expression - drug effects; Gene Expression - physiology; Human health and pathology; Hépatology and Gastroenterology; Life Sciences; Lipogenesis; Lipogenesis - drug effects; Lipogenesis - genetics; Lipogenesis - physiology; Liver - metabolism; Liver X Receptors; LXR; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Orphan Nuclear Receptors - deficiency; Orphan Nuclear Receptors - genetics; Orphan Nuclear Receptors - physiology; Polyunsaturated fatty acids; Steatosis; Transcription Factors - physiology; Triglycerides - metabolism; Up-Regulation - physiology; NAFLD; EFAD; PUFA; Polyunsaturated fatty acids; HNF4α; LXR; WAT; SREBP-1c; Cholesterol; Steatosis; ChREBP; TG; PPAR; EPA; FA; DHA; Lipogenesis; TR; triglyceride; essential fatty acids deficiency; non-alcoholic fatty liver disease; white adipose tissue; polyunsaturated fatty acids; fatty acid; hepatic nuclear factor 4α; sterol responsive element binding protein 1c; thyroid receptor; docosahexaenoic acid; peroxisome proliferator-activated receptor; liver X receptor; carbohydrate response element binding protein; eicosapentaenoic acid