Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta

The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP-3, MMP-10), and their tissue inhibitors (TIMPs) (TIMP-1, TIMP-2) as well as transforming growth factor β (TGF-β) differ in the patients with systemic sclerosis (SSc)...

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Published inBioMed research international Vol. 2020; no. 2020; pp. 1 - 8
Main Authors Olczyk, Krystyna, Kucharz, Eugeniusz J., Kotulska-Kucharz, Anna, Jura-Półtorak, Agnieszka, Komosinska-Vassev, Katarzyna, Winsz-Szczotka, Katarzyna, Kuźnik-Trocha, Kornelia, Kotyla, Przemyslaw J.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
John Wiley & Sons, Inc
Subjects
Online AccessGet full text
ISSN2314-6133
2314-6141
2314-6141
DOI10.1155/2020/6416514

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Abstract The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP-3, MMP-10), and their tissue inhibitors (TIMPs) (TIMP-1, TIMP-2) as well as transforming growth factor β (TGF-β) differ in the patients with systemic sclerosis (SSc) in relation to the healthy subjects. Plasma samples were obtained from 106 people (64 patients with SSc and 42 healthy individuals) and measured for MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-β levels using ELISA methods. GAGs isolated from plasma samples were quantified using a hexuronic acid assay. The plasma levels of total GAGs, TIMP-1, TIMP-2, and TGF-β were significantly higher, while MMP-3 was significantly decreased in SSc patients compared to the controls. We have revealed a significant correlation between plasma GAGs and TGF-β (r=–0.47) and TIMP-2 (r=0.38), respectively. The results of this study revealed that remodeling of the extracellular matrix, reflected by quantitative changes in plasma glycosaminoglycans, occurs during systemic sclerosis. Thus, the alterations in GAG metabolism connected with SSc may lead to systemic changes in the properties of the connective tissue extracellular matrix.
AbstractList The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP-3, MMP-10), and their tissue inhibitors (TIMPs) (TIMP-1, TIMP-2) as well as transforming growth factor β (TGF-β) differ in the patients with systemic sclerosis (SSc) in relation to the healthy subjects. Plasma samples were obtained from 106 people (64 patients with SSc and 42 healthy individuals) and measured for MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-β levels using ELISA methods. GAGs isolated from plasma samples were quantified using a hexuronic acid assay. The plasma levels of total GAGs, TIMP-1, TIMP-2, and TGF-β were significantly higher, while MMP-3 was significantly decreased in SSc patients compared to the controls. We have revealed a significant correlation between plasma GAGs and TGF-β (r = -0.47) and TIMP-2 (r = 0.38), respectively. The results of this study revealed that remodeling of the extracellular matrix, reflected by quantitative changes in plasma glycosaminoglycans, occurs during systemic sclerosis. Thus, the alterations in GAG metabolism connected with SSc may lead to systemic changes in the properties of the connective tissue extracellular matrix.The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP-3, MMP-10), and their tissue inhibitors (TIMPs) (TIMP-1, TIMP-2) as well as transforming growth factor β (TGF-β) differ in the patients with systemic sclerosis (SSc) in relation to the healthy subjects. Plasma samples were obtained from 106 people (64 patients with SSc and 42 healthy individuals) and measured for MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-β levels using ELISA methods. GAGs isolated from plasma samples were quantified using a hexuronic acid assay. The plasma levels of total GAGs, TIMP-1, TIMP-2, and TGF-β were significantly higher, while MMP-3 was significantly decreased in SSc patients compared to the controls. We have revealed a significant correlation between plasma GAGs and TGF-β (r = -0.47) and TIMP-2 (r = 0.38), respectively. The results of this study revealed that remodeling of the extracellular matrix, reflected by quantitative changes in plasma glycosaminoglycans, occurs during systemic sclerosis. Thus, the alterations in GAG metabolism connected with SSc may lead to systemic changes in the properties of the connective tissue extracellular matrix.
The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP‐3, MMP‐10), and their tissue inhibitors (TIMPs) (TIMP‐1, TIMP‐2) as well as transforming growth factor β (TGF‐ β ) differ in the patients with systemic sclerosis (SSc) in relation to the healthy subjects. Plasma samples were obtained from 106 people (64 patients with SSc and 42 healthy individuals) and measured for MMP‐3, MMP‐10, TIMP‐1, TIMP‐2, and TGF‐ β levels using ELISA methods. GAGs isolated from plasma samples were quantified using a hexuronic acid assay. The plasma levels of total GAGs, TIMP‐1, TIMP‐2, and TGF‐ β were significantly higher, while MMP‐3 was significantly decreased in SSc patients compared to the controls. We have revealed a significant correlation between plasma GAGs and TGF‐ β ( r = –0.47) and TIMP‐2 ( r = 0.38), respectively. The results of this study revealed that remodeling of the extracellular matrix, reflected by quantitative changes in plasma glycosaminoglycans, occurs during systemic sclerosis. Thus, the alterations in GAG metabolism connected with SSc may lead to systemic changes in the properties of the connective tissue extracellular matrix.
The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP-3, MMP-10), and their tissue inhibitors (TIMPs) (TIMP-1, TIMP-2) as well as transforming growth factor (TGF- ) differ in the patients with systemic sclerosis (SSc) in relation to the healthy subjects. Plasma samples were obtained from 106 people (64 patients with SSc and 42 healthy individuals) and measured for MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF- levels using ELISA methods. GAGs isolated from plasma samples were quantified using a hexuronic acid assay. The plasma levels of total GAGs, TIMP-1, TIMP-2, and TGF- were significantly higher, while MMP-3 was significantly decreased in SSc patients compared to the controls. We have revealed a significant correlation between plasma GAGs and TGF- ( = -0.47) and TIMP-2 ( = 0.38), respectively. The results of this study revealed that remodeling of the extracellular matrix, reflected by quantitative changes in plasma glycosaminoglycans, occurs during systemic sclerosis. Thus, the alterations in GAG metabolism connected with SSc may lead to systemic changes in the properties of the connective tissue extracellular matrix.
The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP-3, MMP-10), and their tissue inhibitors (TIMPs) (TIMP-1, TIMP-2) as well as transforming growth factor β (TGF-β) differ in the patients with systemic sclerosis (SSc) in relation to the healthy subjects. Plasma samples were obtained from 106 people (64 patients with SSc and 42 healthy individuals) and measured for MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-β levels using ELISA methods. GAGs isolated from plasma samples were quantified using a hexuronic acid assay. The plasma levels of total GAGs, TIMP-1, TIMP-2, and TGF-β were significantly higher, while MMP-3 was significantly decreased in SSc patients compared to the controls. We have revealed a significant correlation between plasma GAGs and TGF-β (r=–0.47) and TIMP-2 (r=0.38), respectively. The results of this study revealed that remodeling of the extracellular matrix, reflected by quantitative changes in plasma glycosaminoglycans, occurs during systemic sclerosis. Thus, the alterations in GAG metabolism connected with SSc may lead to systemic changes in the properties of the connective tissue extracellular matrix.
Audience Academic
Author Kotulska-Kucharz, Anna
Winsz-Szczotka, Katarzyna
Jura-Półtorak, Agnieszka
Komosinska-Vassev, Katarzyna
Kuźnik-Trocha, Kornelia
Kotyla, Przemyslaw J.
Kucharz, Eugeniusz J.
Olczyk, Krystyna
AuthorAffiliation 1 Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland
2 Department of Internal Medicine, Rheumatology and Clinical Immunology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
AuthorAffiliation_xml – name: 2 Department of Internal Medicine, Rheumatology and Clinical Immunology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
– name: 1 Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland
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CitedBy_id crossref_primary_10_1186_s12967_024_05411_4
crossref_primary_10_5114_reum_2020_102004
crossref_primary_10_1093_rheumatology_keab580
crossref_primary_10_17650_1818_8338_2022_16_4_K658
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Cites_doi 10.1016/s0190-9622(00)90011-2
10.1016/S0928-4680(97)00170-3
10.1111/j.1432-1033.1992.tb16778.x
10.2147/btt.s2806
10.1016/S0021-9258(18)99267-7
10.1016/j.cardiores.2005.12.002
10.1016/0304-4165(94)00123-f
10.1186/s13075-015-0591-8
10.1080/14397595.2016.1206510
10.1007/s004030050224
10.1016/0003-2697(73)90377-1
10.1007/s11010-006-9230-7
10.1371/journal.pone.0115596
10.1002/jcla.21864
10.1111/j.1600-0625.2009.00999.x
10.1093/rheumatology/ken481
10.1016/0009-8981(94)90255-0
10.1136/annrheumdis-2012-201958
10.5604/17322693.1196355
10.1080/1354750X.2018.1548032
10.1093/rheumatology/kes090
10.1136/annrheumdis-2013-204424
10.1111/j.1365-2133.1992.tb08399.x
10.1136/ard.2006.066530
10.1172/JCI12020
10.4161/self.2.1.14058
10.1007/s004030050225
10.1007/s00403-009-0996-9
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Copyright Copyright © 2020 Kornelia Kuźnik-Trocha et al.
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Copyright © 2020 Kornelia Kuźnik-Trocha et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0
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References e_1_2_9_30_2
e_1_2_9_10_2
e_1_2_9_33_2
e_1_2_9_12_2
e_1_2_9_31_2
e_1_2_9_11_2
e_1_2_9_32_2
Kniazev I. A. (e_1_2_9_18_2) 1986; 3
Ieremia G. (e_1_2_9_16_2) 2007; 48
e_1_2_9_14_2
e_1_2_9_13_2
e_1_2_9_15_2
Kuźnik-Trocha K. (e_1_2_9_9_2) 2008; 3
e_1_2_9_21_2
e_1_2_9_20_2
e_1_2_9_23_2
e_1_2_9_22_2
e_1_2_9_7_2
e_1_2_9_6_2
e_1_2_9_5_2
e_1_2_9_4_2
e_1_2_9_3_2
e_1_2_9_2_2
e_1_2_9_1_2
Fuzailov O. R. (e_1_2_9_17_2) 1984; 56
e_1_2_9_8_2
e_1_2_9_25_2
e_1_2_9_24_2
e_1_2_9_27_2
Herrmann K. (e_1_2_9_19_2) 1982; 168
e_1_2_9_26_2
e_1_2_9_29_2
e_1_2_9_28_2
References_xml – ident: e_1_2_9_27_2
  doi: 10.1016/s0190-9622(00)90011-2
– ident: e_1_2_9_13_2
  doi: 10.1016/S0928-4680(97)00170-3
– ident: e_1_2_9_22_2
  doi: 10.1111/j.1432-1033.1992.tb16778.x
– ident: e_1_2_9_3_2
  doi: 10.2147/btt.s2806
– ident: e_1_2_9_21_2
  doi: 10.1016/S0021-9258(18)99267-7
– ident: e_1_2_9_25_2
  doi: 10.1016/j.cardiores.2005.12.002
– ident: e_1_2_9_12_2
  doi: 10.1016/0304-4165(94)00123-f
– volume: 168
  start-page: 761
  year: 1982
  ident: e_1_2_9_19_2
  article-title: Glycosaminoglycans in progressive scleroderma
  publication-title: Dermatologische Monatschrift
– ident: e_1_2_9_33_2
  doi: 10.1186/s13075-015-0591-8
– ident: e_1_2_9_8_2
  doi: 10.1080/14397595.2016.1206510
– volume: 3
  start-page: 10
  year: 2008
  ident: e_1_2_9_9_2
  article-title: Serum lysosomal glycosidases in patiens with systemic sclerosis
  publication-title: Farm. Przegl. Nauk.
– volume: 48
  start-page: 361
  year: 2007
  ident: e_1_2_9_16_2
  article-title: Morphologic and histochemical changes in the skin of patients with scleroderma
  publication-title: Romanian Journal of Morphology and Embryology
– ident: e_1_2_9_23_2
  doi: 10.1007/s004030050224
– ident: e_1_2_9_14_2
  doi: 10.1016/0003-2697(73)90377-1
– ident: e_1_2_9_24_2
  doi: 10.1007/s11010-006-9230-7
– ident: e_1_2_9_26_2
  doi: 10.1371/journal.pone.0115596
– ident: e_1_2_9_2_2
  doi: 10.1002/jcla.21864
– ident: e_1_2_9_30_2
  doi: 10.1111/j.1600-0625.2009.00999.x
– ident: e_1_2_9_5_2
  doi: 10.1093/rheumatology/ken481
– ident: e_1_2_9_6_2
  doi: 10.1016/0009-8981(94)90255-0
– ident: e_1_2_9_28_2
  doi: 10.1136/annrheumdis-2012-201958
– volume: 3
  start-page: 42
  year: 1986
  ident: e_1_2_9_18_2
  article-title: Serum and urinary glycosaminoglycans in various forms of scleroderma
  publication-title: Revmatologiia
– ident: e_1_2_9_7_2
  doi: 10.5604/17322693.1196355
– ident: e_1_2_9_1_2
  doi: 10.1080/1354750X.2018.1548032
– ident: e_1_2_9_4_2
  doi: 10.1093/rheumatology/kes090
– ident: e_1_2_9_10_2
  doi: 10.1136/annrheumdis-2013-204424
– ident: e_1_2_9_15_2
  doi: 10.1111/j.1365-2133.1992.tb08399.x
– ident: e_1_2_9_11_2
  doi: 10.1136/ard.2006.066530
– ident: e_1_2_9_29_2
  doi: 10.1172/JCI12020
– ident: e_1_2_9_31_2
  doi: 10.4161/self.2.1.14058
– volume: 56
  start-page: 45
  year: 1984
  ident: e_1_2_9_17_2
  article-title: Clinical evaluation of the determination of blood serum and urinary glycosaminoglycans in systemic scleroderma
  publication-title: Terapevticheskiĭ Arkhiv
– ident: e_1_2_9_20_2
  doi: 10.1007/s004030050225
– ident: e_1_2_9_32_2
  doi: 10.1007/s00403-009-0996-9
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Snippet The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP-3, MMP-10), and their...
The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP‐3, MMP‐10), and their...
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SubjectTerms Adult
Biosynthesis
Bone morphogenetic proteins
Connective tissues
Disease
Enzyme-linked immunosorbent assay
Enzymes
Extracellular matrix
Female
Glycosaminoglycans
Glycosaminoglycans - blood
Growth factors
Hemoglobin
Humans
Immunoassay
Laboratories
Male
Matrix metalloproteinase
Matrix Metalloproteinase 10 - blood
Matrix Metalloproteinase 3 - blood
Matrix metalloproteinases
Metabolism
Middle Aged
Physiological aspects
Plasma
Plasma levels
Proteins
Scleroderma
Scleroderma (Disease)
Scleroderma, Systemic - blood
Skin
Stromelysin 1
Stromelysin 2
Systemic scleroderma
Systemic sclerosis
Tissue inhibitor of metalloproteinase 1
Tissue inhibitor of metalloproteinase 2
Tissue Inhibitor of Metalloproteinase-1 - blood
Tissue Inhibitor of Metalloproteinase-2 - blood
Transforming Growth Factor beta - blood
Transforming growth factor-b
Transforming growth factors
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Title Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta
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https://dx.doi.org/10.1155/2020/6416514
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