Chemical generation of bispecific antibodies - Doppalapudi, Venkata R.; Huang, Jie; Liu, Dingguo; Jin, Ping; Liu, Bin; Li, Lingna; Desharnais, Joel; Hagen, Crystal; Levin, Nancy J.; Shields, Michael J.; Parish, Michelle; Murphy, Robert E.; et al. (Proceedings of the National Academy of Sciences - PNAS, 2010)
Keywords: Amino Acid Sequence; Angiogenesis; angiopoietin-2; Angiopoietin-2 - chemistry; Angiopoietin-2 - immunology; Angiopoietin-2 - metabolism; Animals; Antibodies; Antibodies, Bispecific - immunology; Antibodies, Bispecific - metabolism; Antibodies, Bispecific - pharmacology; Antibody Specificity; Antigens; antineoplastic activity; Antineoplastic Agents - immunology; Antineoplastic Agents - pharmacology; Azetidines - chemistry; Binding sites; Biological Sciences; Bispecific antibodies; Cancer; Cell Line, Tumor; clinical trials; drug therapy; Enzyme-Linked Immunosorbent Assay; half life; Heterologous transplantation; Humans; Immunoglobulins; Immunologic Factors - immunology; Immunologic Factors - metabolism; Immunologic Factors - pharmacokinetics; Macaca fascicularis; Male; manufacturing; Medical treatment; Mice; Mice, Nude; Molecular Sequence Data; Molecules; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - pathology; Peptides; Pharmaceutical technology; Pharmacokinetics; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Scaffolds; Surface Plasmon Resonance; Tumor Burden - drug effects; Tumors; Vascular Endothelial Growth Factor A - chemistry; Vascular Endothelial Growth Factor A - immunology; Vascular Endothelial Growth Factor A - metabolism; Vascular Endothelial Growth Factor Receptor-2 - metabolism; vascular endothelial growth factors; Xenograft Model Antitumor Assays