The ubiquitin proteasome system and myocardial ischemia

The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several...

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Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 304; no. 3; pp. H337 - H349
Main Authors Calise, Justine, Powell, Saul R.
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.02.2013
Subjects
Animals
Autophagy
Cardiovascular disease
Heart - physiology
Humans
Ischemia
Ischemic Preconditioning
Myocardial Ischemia - pathology
Myocardial Ischemia - physiopathology
Myocardium - pathology
Oxidative Stress - physiology
Pathology
Physiology
Proteasome Endopeptidase Complex - physiology
Proteins
Reviews
Ubiquitin - physiology
Online AccessGet full text
ISSN0363-6135
1522-1539
1522-1539
DOI10.1152/ajpheart.00604.2012

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Abstract The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several pathologies such as familial and idiopathic cardiomyopathies, atherosclerosis, and myocardial ischemia. This review presents a synopsis of the literature as it relates to the role of the UPS in myocardial ischemia. Studies have shown that the UPS is dysfunctional during myocardial ischemia, and recent studies have shed some light on possible mechanisms. Other studies have defined a role for the UPS in ischemic preconditioning which is best associated with myocardial ischemia and is thus presented here. Very recent studies have started to define roles for specific proteasome subunits and components of the ubiquitination machinery in various aspects of myocardial ischemia. Lastly, despite the evidence linking myocardial ischemia and proteasome dysfunction, there are continuing suggestions that proteasome inhibitors may be useful to mitigate ischemic injury. This review presents the rationale behind this and discusses both supportive and nonsupportive studies and presents possible future directions that may help in clarifying this controversy.
AbstractList The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several pathologies such as familial and idiopathic cardiomyopathies, atherosclerosis, and myocardial ischemia. This review presents a synopsis of the literature as it relates to the role of the UPS in myocardial ischemia. Studies have shown that the UPS is dysfunctional during myocardial ischemia, and recent studies have shed some light on possible mechanisms. Other studies have defined a role for the UPS in ischemic preconditioning which is best associated with myocardial ischemia and is thus presented here. Very recent studies have started to define roles for specific proteasome subunits and components of the ubiquitination machinery in various aspects of myocardial ischemia. Lastly, despite the evidence linking myocardial ischemia and proteasome dysfunction, there are continuing suggestions that proteasome inhibitors may be useful to mitigate ischemic injury. This review presents the rationale behind this and discusses both supportive and nonsupportive studies and presents possible future directions that may help in clarifying this controversy.
The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several pathologies such as familial and idiopathic cardiomyopathies, atherosclerosis, and myocardial ischemia. This review presents a synopsis of the literature as it relates to the role of the UPS in myocardial ischemia. Studies have shown that the UPS is dysfunctional during myocardial ischemia, and recent studies have shed some light on possible mechanisms. Other studies have defined a role for the UPS in ischemic preconditioning which is best associated with myocardial ischemia and is thus presented here. Very recent studies have started to define roles for specific proteasome subunits and components of the ubiquitination machinery in various aspects of myocardial ischemia. Lastly, despite the evidence linking myocardial ischemia and proteasome dysfunction, there are continuing suggestions that proteasome inhibitors may be useful to mitigate ischemic injury. This review presents the rationale behind this and discusses both supportive and nonsupportive studies and presents possible future directions that may help in clarifying this controversy. [PUBLICATION ABSTRACT]
The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several pathologies such as familial and idiopathic cardiomyopathies, atherosclerosis, and myocardial ischemia. This review presents a synopsis of the literature as it relates to the role of the UPS in myocardial ischemia. Studies have shown that the UPS is dysfunctional during myocardial ischemia, and recent studies have shed some light on possible mechanisms. Other studies have defined a role for the UPS in ischemic preconditioning which is best associated with myocardial ischemia and is thus presented here. Very recent studies have started to define roles for specific proteasome subunits and components of the ubiquitination machinery in various aspects of myocardial ischemia. Lastly, despite the evidence linking myocardial ischemia and proteasome dysfunction, there are continuing suggestions that proteasome inhibitors may be useful to mitigate ischemic injury. This review presents the rationale behind this and discusses both supportive and nonsupportive studies and presents possible future directions that may help in clarifying this controversy.The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several pathologies such as familial and idiopathic cardiomyopathies, atherosclerosis, and myocardial ischemia. This review presents a synopsis of the literature as it relates to the role of the UPS in myocardial ischemia. Studies have shown that the UPS is dysfunctional during myocardial ischemia, and recent studies have shed some light on possible mechanisms. Other studies have defined a role for the UPS in ischemic preconditioning which is best associated with myocardial ischemia and is thus presented here. Very recent studies have started to define roles for specific proteasome subunits and components of the ubiquitination machinery in various aspects of myocardial ischemia. Lastly, despite the evidence linking myocardial ischemia and proteasome dysfunction, there are continuing suggestions that proteasome inhibitors may be useful to mitigate ischemic injury. This review presents the rationale behind this and discusses both supportive and nonsupportive studies and presents possible future directions that may help in clarifying this controversy.
Author Calise, Justine
Powell, Saul R.
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Cites_doi 10.1586/14779072.5.1.119
10.1074/mcp.M800058-MCP200
10.1093/cvr/cvp247
10.1097/00004647-200010000-00008
10.1006/bbrc.2002.6476
10.1016/S0021-9258(18)48021-0
10.1089/ars.2010.3488
10.1016/j.jmb.2006.08.073
10.1152/ajpheart.00714.2003
10.1016/j.molcel.2010.12.020
10.1161/CIRCRESAHA.111.244707
10.1097/00001756-199206000-00016
10.1161/CIRCULATIONAHA.108.842252
10.1016/j.cell.2010.07.036
10.1038/sj.embor.7400380
10.1093/cvr/cvp287
10.1016/0197-0186(95)00071-2
10.1016/S0065-2776(02)80012-8
10.1016/j.tcm.2012.05.015
10.1074/jbc.M110.133777
10.1161/01.RES.0000195656.52760.30
10.1073/pnas.76.7.3107
10.1152/ajpheart.1991.260.5.H1395
10.1074/mcp.M700187-MCP200
10.1161/CIRCRESAHA.112.270983
10.1021/bi952540s
10.1159/000468693
10.1161/01.ATV.0000232501.08576.73
10.1177/107424840400900104
10.1016/j.athoracsur.2007.10.049
10.1038/nrm2673
10.1146/annurev-arplant-042809-112256
10.1006/abbi.2000.2036
10.1161/CIRCRESAHA.110.219485
10.1042/BJ20100985
10.1016/S0021-9258(18)48020-9
10.1016/j.yjmcc.2008.11.001
10.1002/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO;2-Q
10.1074/jbc.M301032200
10.1002/pro.750
10.1161/01.STR.0000125721.10606.dc
10.1007/BF03033160
10.1021/bi001815n
10.1089/ars.2007.1689
10.1111/j.1365-2141.2007.06659.x
10.1093/cvr/cvp333
10.1038/nrm3143
10.4049/jimmunol.0903182
10.4161/auto.5638
10.1196/annals.1341.018
10.1096/fj.10-160895
10.1161/CIRCRESAHA.108.187427
10.1093/emboj/cdf333
10.1016/j.tcm.2008.01.004
10.1038/nrm2690
10.1021/bi990056+
10.1038/sj.jcbfm.9600019
10.1016/j.freeradbiomed.2004.04.017
10.1172/JCI28804
10.1161/01.RES.0000237386.98506.f7
10.1038/cr.2010.123
10.1016/j.tibs.2008.01.005
10.4161/auto.5.5.8510
10.1042/BJ20100878
10.1016/j.yjmcc.2006.10.010
10.1007/s11906-009-0069-7
10.1006/jmcc.1998.0880
10.1074/mcp.M110.006122
10.1016/j.tcm.2005.04.005
10.4161/auto.7.4.14395
10.1016/j.pbb.2005.03.011
10.1093/cvr/cvr358
10.1161/CIRCRESAHA.109.208801
10.1016/S0955-0674(97)80079-8
10.1152/ajpheart.00851.2002
10.1093/cvr/cvp334
10.1038/nrm2731
10.1006/abbi.2000.1717
10.1161/01.RES.0000237389.40000.02
10.1074/jbc.272.44.27994
10.1023/A:1006957802028
10.1186/gb-2011-12-4-220
10.1038/35040607
10.1515/BC.1999.040
10.1096/fj.09-136259
10.1074/jbc.274.53.38211
10.1021/jm801329v
10.2741/3980
10.1161/CIRCULATIONAHA.109.904557
10.1161/01.RES.84.9.973
10.1158/1078-0432.CCR-10-1950
10.1016/j.freeradbiomed.2006.03.003
10.1093/cvr/cvp321
10.1152/ajpheart.00765.2007
10.1074/mcp.M800064-MCP200
10.1152/ajpheart.00328.2005
10.1002/pmic.200800387
10.1089/ars.2005.7.538
10.1016/j.sbi.2010.08.010
10.1146/annurev.biochem.78.101807.093809
10.1007/s00018-012-0938-0
10.1073/pnas.91.20.9213
10.1152/physrev.00027.2001
10.1172/JCI45709
10.1074/jbc.M512138200
10.1161/01.RES.0000239412.40685.61
10.1016/S0076-6879(05)98024-5
10.1016/j.bbrc.2009.10.067
10.1016/0891-5849(90)90116-Z
10.1186/1471-2407-6-129
10.1161/STROKEAHA.107.487108
10.1042/bj20031122
10.1681/ASN.2009050479
10.1046/j.1432-1327.2000.01706.x
10.1038/sj.onc.1207973
10.1002/art.33333
10.1016/j.yjmcc.2008.01.010
10.1007/BF00990974
10.1152/ajpheart.00712.2006
10.1016/j.cellsig.2011.10.009
10.1152/ajpheart.00714.2011
10.1161/CIRCRESAHA.110.222364
10.1016/j.jtcvs.2008.07.041
10.1074/jbc.M702846200
10.1016/j.neuroscience.2005.03.036
10.1016/S1357-2725(02)00390-4
10.1161/STROKEAHA.112.650416
10.1016/S1357-2725(02)00385-0
10.1038/nri3084
10.1038/nrm1552
10.1007/s12185-008-0139-7
10.1074/jbc.M100142200
10.1002/pmic.200600574
10.1097/00000658-200101000-00003
10.2174/138920312802430626
10.1042/bj3350637
10.1161/01.RES.0000252342.61447.a2
10.1096/fj.08-105940
10.1016/j.freeradbiomed.2005.09.022
10.1007/s00109-003-0422-2
10.4161/auto.5655
10.1007/s10571-012-9854-y
10.1016/S0891-5849(01)00514-7
10.1073/pnas.0803145105
10.1038/sj.cdd.4400384
10.4161/auto.5190
10.1016/j.yjmcc.2007.12.009
10.1038/nrm731
10.1016/j.molcel.2008.03.004
10.1007/s12185-010-0586-9
10.1161/CIRCULATIONAHA.109.928242
10.1016/j.coi.2012.01.005
10.1152/ajpheart.00189.2012
10.1038/nm.1978
10.1074/jbc.M702439200
10.1016/j.yjmcc.2007.10.005
10.1097/00004647-200206000-00009
10.1161/CIRCRESAHA.110.217554
10.1016/j.cell.2011.12.030
10.1016/j.yjmcc.2011.10.023
10.1161/01.CIR.0000101682.24138.36
10.1016/j.abb.2012.04.018
10.1016/j.abb.2006.02.003
10.1002/med.20111
10.1093/cvr/cvn289
10.1016/j.yjmcc.2010.12.015
10.1038/381166a0
10.1177/1074248411407769
10.1161/01.RES.0000069215.36389.8D
10.1074/jbc.M805935200
10.1073/pnas.052713199
10.1021/bi051336u
10.1097/01.WCB.0000039285.37737.C2
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B21
B22
B23
B26
B27
B28
B29
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B159
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B157
B154
B155
B152
B153
B150
B151
Davies KJ (B25) 1987; 262
B30
B31
B32
B33
B34
B35
B36
B37
B38
B39
B169
B167
Zheng Q (B173) 2010; 52
B1
B168
B2
B165
B3
B166
B4
B163
B5
B164
B6
B161
B7
B162
B8
B9
B160
B40
B41
B43
B44
B45
B46
B47
B48
B49
B176
B177
B174
B175
B170
B171
B50
B51
B52
B53
B54
B55
B56
B57
B58
B59
B109
B107
B108
B105
B106
B103
B104
B101
B102
B100
B60
B61
B62
B63
B64
B65
B66
B67
B68
B69
B118
B119
B116
B117
B114
B115
B112
B113
B110
B111
Tisdale MJ (B147) 2003; 1
B70
B71
B72
B73
B74
B75
B76
B77
B78
B79
B129
B127
B128
B125
Zheng Q (B172) 2011; 1
B126
B123
B124
B121
B122
B120
B80
B81
B82
B83
B84
B85
B86
B87
B88
B89
B138
B139
B136
B137
B134
B135
B132
Davies KJ (B24) 1987; 262
B133
B130
B131
B90
B91
B92
B93
B94
B95
B96
B97
B10
B98
B11
B99
B12
B13
B14
B15
B16
B17
B18
B19
B149
B148
B145
B146
B143
B144
B141
B142
B140
15183190 - Free Radic Biol Med. 2004 Jul 1;37(1):1-9
2035661 - Am J Physiol. 1991 May;260(5 Pt 2):H1395-405
2172099 - Free Radic Biol Med. 1990;9(2):133-41
7937744 - Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9213-7
8610016 - Nature. 1996 May 9;381(6578):166-8
17140599 - J Mol Cell Cardiol. 2007 Jan;42(1):265-9
19959714 - J Am Soc Nephrol. 2010 Feb;21(2):316-26
15647744 - J Cereb Blood Flow Metab. 2005 Feb;25(2):193-203
18845680 - Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16165-70
11148024 - Biochemistry. 2001 Jan 16;40(2):314-9
20458563 - Int J Hematol. 2010 Jun;91(5):903-6
11855822 - Biochem Biophys Res Commun. 2002 Mar 1;291(3):542-9
18227645 - Autophagy. 2008 May;4(4):409-15
12424098 - Am J Physiol Heart Circ Physiol. 2003 Mar;284(3):H919-26
22812529 - Curr Protein Pept Sci. 2012 Aug;13(5):413
19793765 - Cardiovasc Res. 2010 Jan 15;85(2):303-11
16337889 - Free Radic Biol Med. 2006 Jan 1;40(1):156-64
12672454 - Int J Biochem Cell Biol. 2003 May;35(5):617-28
19398895 - Autophagy. 2009 Jul;5(5):709-12
3036877 - J Biol Chem. 1987 Jul 15;262(20):9908-13
20595653 - Circ Res. 2010 Sep 3;107(5):642-9
22740087 - Circ Res. 2012 Aug 17;111(5):532-42
22033037 - Cell Signal. 2012 Feb;24(2):410-21
11012676 - Eur J Biochem. 2000 Oct;267(20):6221-30
17158347 - Circ Res. 2006 Dec 8;99(12):1315-28
17390294 - Proteomics. 2007 Apr;7(7):1047-58
11375979 - J Biol Chem. 2001 Aug 10;276(32):30057-63
17986870 - Autophagy. 2008 Feb;4(2):141-50
9794805 - Biochem J. 1998 Nov 1;335 ( Pt 3):637-42
20228723 - Panminerva Med. 2010 Mar;52(1):9-25
20431057 - Circ Res. 2010 Jun 25;106(12):1829-38
16229478 - Biochemistry. 2005 Oct 25;44(42):13893-901
22523251 - Am J Physiol Heart Circ Physiol. 2012 Jul;303(1):H9-18
19944202 - Biochem Biophys Res Commun. 2009 Dec 25;390(4):1136-41
15060320 - Stroke. 2004 May;35(5):1186-91
12663490 - Circ Res. 2003 May 2;92(8):873-80
10775442 - Arch Biochem Biophys. 2000 May 1;377(1):65-8
12500093 - J Cereb Blood Flow Metab. 2003 Jan;23(1):75-87
20525886 - J Immunol. 2010 Jul 1;185(1):634-41
21370976 - Annu Rev Plant Biol. 2011;62:299-334
19489725 - Annu Rev Biochem. 2009;78:399-434
21841311 - J Clin Invest. 2011 Sep;121(9):3689-700
14715434 - Neurotox Res. 2003;5(7):505-14
7565668 - Mol Biol Rep. 1995;21(1):71-3
22341445 - Cell. 2012 Feb 17;148(4):727-38
19179668 - Circ Res. 2009 Jan 30;104(2):150-8
19895750 - Curr Hypertens Rep. 2009 Dec;11(6):396-405
19815565 - Cardiovasc Res. 2010 Jan 15;85(2):291-302
18253087 - Autophagy. 2008 May;4(4):416-21
17627477 - Antioxid Redox Signal. 2007 Sep;9(9):1373-81
16997324 - J Mol Biol. 2006 Oct 27;363(3):660-72
21554755 - Genome Biol. 2011;12(4):220
11836513 - Nat Rev Mol Cell Biol. 2002 Feb;3(2):112-21
21098724 - FASEB J. 2011 Mar;25(3):883-93
21158740 - Biochem J. 2011 Jan 1;433(1):31-42
18353358 - J Mol Cell Cardiol. 2008 Apr;44(4):654-61
19940261 - FASEB J. 2010 Apr;24(4):981-93
15894077 - Pharmacol Biochem Behav. 2005 May;81(1):182-9
14766672 - Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H870-7
18192226 - Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1298-303
19752367 - Circulation. 2009 Sep 15;120(11 Suppl):S191-7
19436320 - Nat Rev Mol Cell Biol. 2009 Jun;10(6):398-409
17975104 - Stroke. 2007 Dec;38(12):3230-6
16431916 - J Biol Chem. 2006 Mar 17;281(11):7429-36
22564544 - Arch Biochem Biophys. 2012 Jul 15;523(2):181-90
15809659 - EMBO Rep. 2005 Apr;6(4):321-6
18436147 - Trends Cardiovasc Med. 2008 Apr;18(3):93-8
11917093 - Physiol Rev. 2002 Apr;82(2):373-428
22076556 - Nat Rev Immunol. 2011 Dec;11(12):823-36
22201797 - Front Biosci (Landmark Ed). 2012;17:1184-200
22296715 - Curr Opin Immunol. 2012 Feb;24(1):77-83
21697901 - Nat Rev Mol Cell Biol. 2011 Jul;12(7):439-52
19820255 - Cardiovasc Res. 2010 Jan 15;85(2):385-94
16530722 - Arch Biochem Biophys. 2006 Sep 1;453(1):135-42
17880010 - Med Res Rev. 2008 Mar;28(2):309-27
10325234 - Circ Res. 1999 May 14;84(9):973-9
22700531 - Stroke. 2012 Aug;43(8):2229-35
18308332 - J Mol Cell Cardiol. 2008 Mar;44(3):618-21
12700891 - J Mol Med (Berl). 2003 Apr;81(4):235-45
21211719 - Mol Cell. 2011 Jan 7;41(1):8-19
9425343 - Curr Opin Cell Biol. 1997 Dec;9(6):788-99
19348473 - J Med Chem. 2009 May 14;52(9):3028-38
10200512 - Cell Death Differ. 1998 Jul;5(7):577-83
19026814 - J Thorac Cardiovasc Surg. 2008 Nov;136(5):1274-9
18078953 - J Mol Cell Cardiol. 2008 Feb;44(2):419-28
20805844 - Cell Res. 2010 Dec;20(12):1372-85
19003867 - Proteomics. 2008 Dec;8(23-24):5025-37
16857966 - Circ Res. 2006 Aug 18;99(4):362-71
19626045 - Nat Rev Mol Cell Biol. 2009 Aug;10(8):550-63
11043909 - J Cereb Blood Flow Metab. 2000 Oct;20(10):1467-73
15378130 - J Cardiovasc Pharmacol Ther. 2004 Sep;9 Suppl 1:S31-45
20812860 - Antioxid Redox Signal. 2011 Jun;14(11):2179-90
18353650 - Trends Biochem Sci. 2008 May;33(5):230-7
12672453 - Int J Biochem Cell Biol. 2003 May;35(5):606-16
17565987 - J Biol Chem. 2007 Aug 3;282(31):22460-71
16039971 - Trends Cardiovasc Med. 2005 Apr;15(3):110-8
18633693 - Int J Hematol. 2008 Sep;88(2):219-22
20880695 - Curr Opin Struct Biol. 2010 Dec;20(6):714-21
290989 - Proc Natl Acad Sci U S A. 1979 Jul;76(7):3107-10
16917100 - Circ Res. 2006 Aug 18;99(4):342-5
20167943 - Circ Res. 2010 Feb 19;106(3):463-78
20837911 - Circulation. 2010 Sep 14;122(11 Suppl):S179-84
10220354 - Biochemistry. 1999 Apr 27;38(17):5651-8
8719710 - Neurochem Int. 1996 Feb;28(2):209-12
11867760 - Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3312-7
22215722 - Cardiovasc Res. 2012 May 1;94(2):197-205
11097171 - Arch Biochem Biophys. 2000 Nov 1;383(1):1-16
21357515 - Mol Cell Proteomics. 2011 May;10(5):M110.006122
15889999 - Antioxid Redox Signal. 2005 May-Jun;7(5-6):538-46
22902070 - Trends Cardiovasc Med. 2011 Nov;21(8):224-8
10363641 - Mol Biol Rep. 1999 Apr;26(1-2):15-9
3036878 - J Biol Chem. 1987 Jul 15;262(20):9914-20
18471981 - Mol Cell. 2008 May 9;30(3):360-8
17187463 - Expert Rev Cardiovasc Ther. 2007 Jan;5(1):119-24
18796432 - J Biol Chem. 2008 Nov 14;283(46):31813-22
18355575 - Ann Thorac Surg. 2008 Apr;85(4):1503-4; author reply 1504
16778122 - Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2132-9
10093058 - J Mol Cell Cardiol. 1999 Feb;31(2):467-76
22614955 - Cell Mol Neurobiol. 2012 Aug;32(6):965-70
1327267 - Neuroreport. 1992 Jun;3(6):519-20
18579562 - Mol Cell Proteomics. 2008 Nov;7(11):2073-89
12078479 - Adv Immunol. 2002;80:1-70
14583091 - Biochem J. 2004 Feb 15;378(Pt 1):177-84
19696071 - Cardiovasc Res. 2010 Jan 15;85(2):253-62
22382925 - Cell Mol Life Sci. 2012 Aug;69(15):2543-58
19352404 - Nat Rev Mol Cell Biol. 2009 May;10(5):319-31
8619999 - Biochemistry. 1996 Mar 26;35(12):3782-9
16093497 - Ann N Y Acad Sci. 2005 Jun;1047:197-207
9346951 - J Biol Chem. 1997 Oct 31;272(44):27994-8000
7697133 - Enzyme Protein. 1993;47(4-6):354-69
22081794 - Am J Cardiovasc Dis. 2011;1(3):214-26
15939539 - Neuroscience. 2005;134(1):69-80
20919990 - Biochem J. 2010 Dec 15;432(3):585-94
17553803 - J Biol Chem. 2007 Aug 3;282(31):22921-9
16785037 - Free Radic Biol Med. 2006 Jun 15;40(12):2232-41
10223331 - Biol Chem. 1999 Mar;380(3):293-7
21821522 - J Cardiovasc Pharmacol Ther. 2011 Sep-Dec;16(3-4):239-43
20814020 - Circ Res. 2010 Oct 29;107(9):1094-101
18974044 - Cardiovasc Res. 2009 Feb 15;81(3):439-48
12045669 - J Cereb Blood Flow Metab. 2002 Jun;22(6):705-10
19059265 - J Mol Cell Cardiol. 2009 Apr;46(4):452-62
19617224 - Cardiovasc Res. 2010 Jan 15;85(2):330-8
21187719 - Autophagy. 2011 Apr;7(4):432-3
11081519 - Nature. 2000 Nov 2;408(6808):115-20
18728217 - FASEB J. 2008 Dec;22(12):4248-57
12676932 - J Biol Chem. 2003 Jun 13;278(24):21517-25
12093752 - EMBO J. 2002 Jul 1;21(13):3516-25
11141219 - Ann Surg. 2001 Jan;233(1):9-17
15688069 - Nat Rev Mol Cell Biol. 2005 Jan;6(1):79-87
21364033 - Clin Cancer Res. 2011 May 1;17(9):2734-43
18931337 - Mol Cell Proteomics. 2009 Feb;8(2):302-15
16963615 - Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H19-27
20843792 - J Biol Chem. 2010 Nov 19;285(47):36434-46
20723761 - Cell. 2010 Aug 20;142(4):613-24
14597593 - Circulation. 2003 Nov 11;108(19):2304-7
11369508 - Free Radic Biol Med. 2001 May 15;30(10):1171-6
16275337 - Methods Enzymol. 2005;398:295-306
16284183 - Circ Res. 2005 Dec 9;97(12):1351-9
15678131 - Oncogene. 2005 Jan 13;24(3):314-25
10608895 - J Biol Chem. 1999 Dec 31;274(53):38211-5
21949118 - Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2207-19
22085703 - J Mol Cell Cardiol. 2012 Mar;52(3):526-37
10797484 - Bioessays. 2000 May;22(5):442-51
20159828 - Circulation. 2010 Mar 2;121(8):997-1004
21195082 - J Mol Cell Cardiol. 2011 Apr;50(4):652-61
17561972 - Br J Haematol. 2007 Aug;138(3):396-7
22012881 - Protein Sci. 2011 Dec;20(12):1941-54
16689991 - BMC Cancer. 2006;6:129
21659648 - Circ Res. 2011 Jul 22;109(3):296-308
21905015 - Arthritis Rheum. 2012 Feb;64(2):493-503
15334872 - J Support Oncol. 2003 Sep-Oct;1(3):159-68
17660509 - Mol Cell Proteomics. 2007 Nov;6(11):2021-31
17124531 - J Clin Invest. 2006 Dec;116(12):3195-203
16857963 - Circ Res. 2006 Aug 18;99(4):372-80
19525961 - Nat Med. 2009 Jul;15(7):781-7
15994860 - Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1960-7
References_xml – ident: B141
  doi: 10.1586/14779072.5.1.119
– ident: B45
  doi: 10.1074/mcp.M800058-MCP200
– ident: B17
  doi: 10.1093/cvr/cvp247
– ident: B79
  doi: 10.1097/00004647-200010000-00008
– ident: B136
  doi: 10.1006/bbrc.2002.6476
– volume: 262
  start-page: 9914
  year: 1987
  ident: B25
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)48021-0
– ident: B60
  doi: 10.1089/ars.2010.3488
– ident: B93
  doi: 10.1016/j.jmb.2006.08.073
– ident: B16
  doi: 10.1152/ajpheart.00714.2003
– ident: B135
  doi: 10.1016/j.molcel.2010.12.020
– ident: B171
  doi: 10.1161/CIRCRESAHA.111.244707
– ident: B62
  doi: 10.1097/00001756-199206000-00016
– ident: B78
  doi: 10.1161/CIRCULATIONAHA.108.842252
– ident: B133
  doi: 10.1016/j.cell.2010.07.036
– ident: B84
  doi: 10.1038/sj.embor.7400380
– ident: B139
  doi: 10.1093/cvr/cvp287
– ident: B77
  doi: 10.1016/0197-0186(95)00071-2
– ident: B124
  doi: 10.1016/S0065-2776(02)80012-8
– ident: B140
  doi: 10.1016/j.tcm.2012.05.015
– ident: B148
  doi: 10.1074/jbc.M110.133777
– ident: B13
  doi: 10.1161/01.RES.0000195656.52760.30
– ident: B65
  doi: 10.1073/pnas.76.7.3107
– ident: B103
  doi: 10.1152/ajpheart.1991.260.5.H1395
– ident: B32
  doi: 10.1074/mcp.M700187-MCP200
– ident: B146
  doi: 10.1161/CIRCRESAHA.112.270983
– ident: B18
  doi: 10.1021/bi952540s
– ident: B38
  doi: 10.1159/000468693
– ident: B151
  doi: 10.1161/01.ATV.0000232501.08576.73
– ident: B137
  doi: 10.1177/107424840400900104
– ident: B108
  doi: 10.1016/j.athoracsur.2007.10.049
– ident: B131
  doi: 10.1038/nrm2673
– ident: B69
  doi: 10.1146/annurev-arplant-042809-112256
– ident: B102
  doi: 10.1006/abbi.2000.2036
– ident: B29
  doi: 10.1161/CIRCRESAHA.110.219485
– ident: B158
  doi: 10.1042/BJ20100985
– volume: 262
  start-page: 9908
  year: 1987
  ident: B24
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)48020-9
– ident: B3
  doi: 10.1016/j.yjmcc.2008.11.001
– ident: B22
  doi: 10.1002/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO;2-Q
– ident: B94
  doi: 10.1074/jbc.M301032200
– ident: B130
  doi: 10.1002/pro.750
– ident: B160
  doi: 10.1161/01.STR.0000125721.10606.dc
– ident: B7
  doi: 10.1007/BF03033160
– ident: B129
  doi: 10.1021/bi001815n
– ident: B143
  doi: 10.1089/ars.2007.1689
– ident: B36
  doi: 10.1111/j.1365-2141.2007.06659.x
– ident: B63
  doi: 10.1093/cvr/cvp333
– ident: B154
  doi: 10.1038/nrm3143
– ident: B6
  doi: 10.4049/jimmunol.0903182
– ident: B92
  doi: 10.4161/auto.5638
– ident: B46
  doi: 10.1196/annals.1341.018
– ident: B87
  doi: 10.1096/fj.10-160895
– ident: B57
  doi: 10.1161/CIRCRESAHA.108.187427
– ident: B149
  doi: 10.1093/emboj/cdf333
– ident: B166
  doi: 10.1016/j.tcm.2008.01.004
– ident: B126
  doi: 10.1038/nrm2690
– ident: B170
  doi: 10.1021/bi990056+
– ident: B115
  doi: 10.1038/sj.jcbfm.9600019
– ident: B80
  doi: 10.1016/j.freeradbiomed.2004.04.017
– ident: B152
  doi: 10.1172/JCI28804
– ident: B47
  doi: 10.1161/01.RES.0000237386.98506.f7
– ident: B70
  doi: 10.1038/cr.2010.123
– ident: B50
  doi: 10.1016/j.tibs.2008.01.005
– ident: B165
  doi: 10.4161/auto.5.5.8510
– ident: B105
  doi: 10.1042/BJ20100878
– ident: B109
  doi: 10.1016/j.yjmcc.2006.10.010
– ident: B125
  doi: 10.1007/s11906-009-0069-7
– ident: B15
  doi: 10.1006/jmcc.1998.0880
– ident: B155
  doi: 10.1074/mcp.M110.006122
– ident: B167
  doi: 10.1016/j.tcm.2005.04.005
– ident: B119
  doi: 10.4161/auto.7.4.14395
– ident: B162
  doi: 10.1016/j.pbb.2005.03.011
– ident: B118
  doi: 10.1093/cvr/cvr358
– ident: B164
  doi: 10.1161/CIRCRESAHA.109.208801
– ident: B64
  doi: 10.1016/S0955-0674(97)80079-8
– ident: B120
  doi: 10.1152/ajpheart.00851.2002
– ident: B20
  doi: 10.1093/cvr/cvp334
– ident: B82
  doi: 10.1038/nrm2731
– ident: B123
  doi: 10.1006/abbi.2000.1717
– ident: B176
  doi: 10.1161/01.RES.0000237389.40000.02
– ident: B134
  doi: 10.1074/jbc.272.44.27994
– ident: B49
  doi: 10.1023/A:1006957802028
– ident: B128
  doi: 10.1186/gb-2011-12-4-220
– ident: B159
  doi: 10.1038/35040607
– ident: B81
  doi: 10.1515/BC.1999.040
– ident: B150
  doi: 10.1096/fj.09-136259
– ident: B100
  doi: 10.1074/jbc.274.53.38211
– ident: B174
  doi: 10.1021/jm801329v
– ident: B12
  doi: 10.2741/3980
– ident: B116
  doi: 10.1161/CIRCULATIONAHA.109.904557
– ident: B53
  doi: 10.1161/01.RES.84.9.973
– ident: B1
  doi: 10.1158/1078-0432.CCR-10-1950
– ident: B95
  doi: 10.1016/j.freeradbiomed.2006.03.003
– ident: B110
  doi: 10.1093/cvr/cvp321
– ident: B71
  doi: 10.1152/ajpheart.00765.2007
– ident: B90
  doi: 10.1074/mcp.M800064-MCP200
– ident: B168
  doi: 10.1152/ajpheart.00328.2005
– ident: B177
  doi: 10.1002/pmic.200800387
– ident: B114
  doi: 10.1089/ars.2005.7.538
– ident: B175
  doi: 10.1016/j.sbi.2010.08.010
– volume: 1
  start-page: 159
  year: 2003
  ident: B147
  publication-title: J Support Oncol
– ident: B27
  doi: 10.1146/annurev.biochem.78.101807.093809
– ident: B34
  doi: 10.1007/s00018-012-0938-0
– ident: B39
  doi: 10.1073/pnas.91.20.9213
– ident: B44
  doi: 10.1152/physrev.00027.2001
– ident: B86
  doi: 10.1172/JCI45709
– ident: B97
  doi: 10.1074/jbc.M512138200
– ident: B107
  doi: 10.1161/01.RES.0000239412.40685.61
– volume: 1
  start-page: 214
  year: 2011
  ident: B172
  publication-title: Am J Cardiovasc Dis
– ident: B26
  doi: 10.1016/S0076-6879(05)98024-5
– ident: B41
  doi: 10.1016/j.bbrc.2009.10.067
– ident: B112
  doi: 10.1016/0891-5849(90)90116-Z
– ident: B153
  doi: 10.1186/1471-2407-6-129
– ident: B40
  doi: 10.1161/STROKEAHA.107.487108
– ident: B10
  doi: 10.1042/bj20031122
– ident: B48
  doi: 10.1681/ASN.2009050479
– ident: B138
  doi: 10.1046/j.1432-1327.2000.01706.x
– ident: B19
  doi: 10.1038/sj.onc.1207973
– ident: B73
  doi: 10.1002/art.33333
– ident: B56
  doi: 10.1016/j.yjmcc.2008.01.010
– ident: B145
  doi: 10.1007/BF00990974
– ident: B9
  doi: 10.1152/ajpheart.00712.2006
– ident: B59
  doi: 10.1016/j.cellsig.2011.10.009
– ident: B156
  doi: 10.1152/ajpheart.00714.2011
– ident: B31
  doi: 10.1161/CIRCRESAHA.110.222364
– ident: B98
  doi: 10.1016/j.jtcvs.2008.07.041
– ident: B67
  doi: 10.1074/jbc.M702846200
– volume: 52
  start-page: 9
  year: 2010
  ident: B173
  publication-title: Panminerva Med
– ident: B89
  doi: 10.1016/j.neuroscience.2005.03.036
– ident: B52
  doi: 10.1016/S1357-2725(02)00390-4
– ident: B66
  doi: 10.1161/STROKEAHA.112.650416
– ident: B117
  doi: 10.1016/S1357-2725(02)00385-0
– ident: B101
  doi: 10.1038/nri3084
– ident: B21
  doi: 10.1038/nrm1552
– ident: B58
  doi: 10.1007/s12185-008-0139-7
– ident: B11
  doi: 10.1074/jbc.M100142200
– ident: B33
  doi: 10.1002/pmic.200600574
– ident: B61
  doi: 10.1097/00000658-200101000-00003
– ident: B68
  doi: 10.2174/138920312802430626
– ident: B122
  doi: 10.1042/bj3350637
– ident: B157
  doi: 10.1161/01.RES.0000252342.61447.a2
– ident: B14
  doi: 10.1096/fj.08-105940
– ident: B30
  doi: 10.1016/j.freeradbiomed.2005.09.022
– ident: B35
  doi: 10.1007/s00109-003-0422-2
– ident: B55
  doi: 10.4161/auto.5655
– ident: B91
  doi: 10.1007/s10571-012-9854-y
– ident: B111
  doi: 10.1016/S0891-5849(01)00514-7
– ident: B8
  doi: 10.1073/pnas.0803145105
– ident: B88
  doi: 10.1038/sj.cdd.4400384
– ident: B28
  doi: 10.4161/auto.5190
– ident: B113
  doi: 10.1016/j.yjmcc.2007.12.009
– ident: B76
  doi: 10.1038/nrm731
– ident: B121
  doi: 10.1016/j.molcel.2008.03.004
– ident: B144
  doi: 10.1007/s12185-010-0586-9
– ident: B127
  doi: 10.1161/CIRCULATIONAHA.109.928242
– ident: B85
  doi: 10.1016/j.coi.2012.01.005
– ident: B132
  doi: 10.1152/ajpheart.00189.2012
– ident: B99
  doi: 10.1038/nm.1978
– ident: B169
  doi: 10.1074/jbc.M702439200
– ident: B54
  doi: 10.1016/j.yjmcc.2007.10.005
– ident: B2
  doi: 10.1097/00004647-200206000-00009
– ident: B142
  doi: 10.1161/CIRCRESAHA.110.217554
– ident: B72
  doi: 10.1016/j.cell.2011.12.030
– ident: B106
  doi: 10.1016/j.yjmcc.2011.10.023
– ident: B74
  doi: 10.1161/01.CIR.0000101682.24138.36
– ident: B104
  doi: 10.1016/j.abb.2012.04.018
– ident: B37
  doi: 10.1016/j.abb.2006.02.003
– ident: B96
  doi: 10.1002/med.20111
– ident: B163
  doi: 10.1093/cvr/cvn289
– ident: B23
  doi: 10.1016/j.yjmcc.2010.12.015
– ident: B51
  doi: 10.1038/381166a0
– ident: B4
  doi: 10.1177/1074248411407769
– ident: B5
  doi: 10.1161/01.RES.0000069215.36389.8D
– ident: B43
  doi: 10.1074/jbc.M805935200
– ident: B83
  doi: 10.1073/pnas.052713199
– ident: B75
  doi: 10.1021/bi051336u
– ident: B161
  doi: 10.1097/01.WCB.0000039285.37737.C2
– reference: 17158347 - Circ Res. 2006 Dec 8;99(12):1315-28
– reference: 21187719 - Autophagy. 2011 Apr;7(4):432-3
– reference: 11148024 - Biochemistry. 2001 Jan 16;40(2):314-9
– reference: 19398895 - Autophagy. 2009 Jul;5(5):709-12
– reference: 22201797 - Front Biosci (Landmark Ed). 2012;17:1184-200
– reference: 14766672 - Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H870-7
– reference: 9794805 - Biochem J. 1998 Nov 1;335 ( Pt 3):637-42
– reference: 15889999 - Antioxid Redox Signal. 2005 May-Jun;7(5-6):538-46
– reference: 18845680 - Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16165-70
– reference: 18353358 - J Mol Cell Cardiol. 2008 Apr;44(4):654-61
– reference: 16093497 - Ann N Y Acad Sci. 2005 Jun;1047:197-207
– reference: 19944202 - Biochem Biophys Res Commun. 2009 Dec 25;390(4):1136-41
– reference: 22215722 - Cardiovasc Res. 2012 May 1;94(2):197-205
– reference: 17124531 - J Clin Invest. 2006 Dec;116(12):3195-203
– reference: 14583091 - Biochem J. 2004 Feb 15;378(Pt 1):177-84
– reference: 20812860 - Antioxid Redox Signal. 2011 Jun;14(11):2179-90
– reference: 16337889 - Free Radic Biol Med. 2006 Jan 1;40(1):156-64
– reference: 10797484 - Bioessays. 2000 May;22(5):442-51
– reference: 16857966 - Circ Res. 2006 Aug 18;99(4):362-71
– reference: 19489725 - Annu Rev Biochem. 2009;78:399-434
– reference: 15894077 - Pharmacol Biochem Behav. 2005 May;81(1):182-9
– reference: 16284183 - Circ Res. 2005 Dec 9;97(12):1351-9
– reference: 8619999 - Biochemistry. 1996 Mar 26;35(12):3782-9
– reference: 10093058 - J Mol Cell Cardiol. 1999 Feb;31(2):467-76
– reference: 3036878 - J Biol Chem. 1987 Jul 15;262(20):9914-20
– reference: 17140599 - J Mol Cell Cardiol. 2007 Jan;42(1):265-9
– reference: 22033037 - Cell Signal. 2012 Feb;24(2):410-21
– reference: 22564544 - Arch Biochem Biophys. 2012 Jul 15;523(2):181-90
– reference: 20431057 - Circ Res. 2010 Jun 25;106(12):1829-38
– reference: 15647744 - J Cereb Blood Flow Metab. 2005 Feb;25(2):193-203
– reference: 19026814 - J Thorac Cardiovasc Surg. 2008 Nov;136(5):1274-9
– reference: 2035661 - Am J Physiol. 1991 May;260(5 Pt 2):H1395-405
– reference: 12676932 - J Biol Chem. 2003 Jun 13;278(24):21517-25
– reference: 21554755 - Genome Biol. 2011;12(4):220
– reference: 18227645 - Autophagy. 2008 May;4(4):409-15
– reference: 19793765 - Cardiovasc Res. 2010 Jan 15;85(2):303-11
– reference: 9346951 - J Biol Chem. 1997 Oct 31;272(44):27994-8000
– reference: 16689991 - BMC Cancer. 2006;6:129
– reference: 16917100 - Circ Res. 2006 Aug 18;99(4):342-5
– reference: 21821522 - J Cardiovasc Pharmacol Ther. 2011 Sep-Dec;16(3-4):239-43
– reference: 22076556 - Nat Rev Immunol. 2011 Dec;11(12):823-36
– reference: 18355575 - Ann Thorac Surg. 2008 Apr;85(4):1503-4; author reply 1504
– reference: 22382925 - Cell Mol Life Sci. 2012 Aug;69(15):2543-58
– reference: 18436147 - Trends Cardiovasc Med. 2008 Apr;18(3):93-8
– reference: 22081794 - Am J Cardiovasc Dis. 2011;1(3):214-26
– reference: 12500093 - J Cereb Blood Flow Metab. 2003 Jan;23(1):75-87
– reference: 19959714 - J Am Soc Nephrol. 2010 Feb;21(2):316-26
– reference: 12093752 - EMBO J. 2002 Jul 1;21(13):3516-25
– reference: 16229478 - Biochemistry. 2005 Oct 25;44(42):13893-901
– reference: 18308332 - J Mol Cell Cardiol. 2008 Mar;44(3):618-21
– reference: 19179668 - Circ Res. 2009 Jan 30;104(2):150-8
– reference: 11097171 - Arch Biochem Biophys. 2000 Nov 1;383(1):1-16
– reference: 15939539 - Neuroscience. 2005;134(1):69-80
– reference: 21357515 - Mol Cell Proteomics. 2011 May;10(5):M110.006122
– reference: 12672453 - Int J Biochem Cell Biol. 2003 May;35(5):606-16
– reference: 2172099 - Free Radic Biol Med. 1990;9(2):133-41
– reference: 21697901 - Nat Rev Mol Cell Biol. 2011 Jul;12(7):439-52
– reference: 15183190 - Free Radic Biol Med. 2004 Jul 1;37(1):1-9
– reference: 17561972 - Br J Haematol. 2007 Aug;138(3):396-7
– reference: 19940261 - FASEB J. 2010 Apr;24(4):981-93
– reference: 20919990 - Biochem J. 2010 Dec 15;432(3):585-94
– reference: 18579562 - Mol Cell Proteomics. 2008 Nov;7(11):2073-89
– reference: 17553803 - J Biol Chem. 2007 Aug 3;282(31):22921-9
– reference: 20837911 - Circulation. 2010 Sep 14;122(11 Suppl):S179-84
– reference: 15334872 - J Support Oncol. 2003 Sep-Oct;1(3):159-68
– reference: 14597593 - Circulation. 2003 Nov 11;108(19):2304-7
– reference: 11855822 - Biochem Biophys Res Commun. 2002 Mar 1;291(3):542-9
– reference: 15378130 - J Cardiovasc Pharmacol Ther. 2004 Sep;9 Suppl 1:S31-45
– reference: 20880695 - Curr Opin Struct Biol. 2010 Dec;20(6):714-21
– reference: 18253087 - Autophagy. 2008 May;4(4):416-21
– reference: 7565668 - Mol Biol Rep. 1995;21(1):71-3
– reference: 14715434 - Neurotox Res. 2003;5(7):505-14
– reference: 18728217 - FASEB J. 2008 Dec;22(12):4248-57
– reference: 16963615 - Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H19-27
– reference: 19059265 - J Mol Cell Cardiol. 2009 Apr;46(4):452-62
– reference: 15678131 - Oncogene. 2005 Jan 13;24(3):314-25
– reference: 22341445 - Cell. 2012 Feb 17;148(4):727-38
– reference: 15809659 - EMBO Rep. 2005 Apr;6(4):321-6
– reference: 16785037 - Free Radic Biol Med. 2006 Jun 15;40(12):2232-41
– reference: 1327267 - Neuroreport. 1992 Jun;3(6):519-20
– reference: 19820255 - Cardiovasc Res. 2010 Jan 15;85(2):385-94
– reference: 15688069 - Nat Rev Mol Cell Biol. 2005 Jan;6(1):79-87
– reference: 22296715 - Curr Opin Immunol. 2012 Feb;24(1):77-83
– reference: 20814020 - Circ Res. 2010 Oct 29;107(9):1094-101
– reference: 18471981 - Mol Cell. 2008 May 9;30(3):360-8
– reference: 17627477 - Antioxid Redox Signal. 2007 Sep;9(9):1373-81
– reference: 22902070 - Trends Cardiovasc Med. 2011 Nov;21(8):224-8
– reference: 20458563 - Int J Hematol. 2010 Jun;91(5):903-6
– reference: 21098724 - FASEB J. 2011 Mar;25(3):883-93
– reference: 16857963 - Circ Res. 2006 Aug 18;99(4):372-80
– reference: 16275337 - Methods Enzymol. 2005;398:295-306
– reference: 17660509 - Mol Cell Proteomics. 2007 Nov;6(11):2021-31
– reference: 16431916 - J Biol Chem. 2006 Mar 17;281(11):7429-36
– reference: 12045669 - J Cereb Blood Flow Metab. 2002 Jun;22(6):705-10
– reference: 19525961 - Nat Med. 2009 Jul;15(7):781-7
– reference: 11043909 - J Cereb Blood Flow Metab. 2000 Oct;20(10):1467-73
– reference: 11836513 - Nat Rev Mol Cell Biol. 2002 Feb;3(2):112-21
– reference: 18633693 - Int J Hematol. 2008 Sep;88(2):219-22
– reference: 21905015 - Arthritis Rheum. 2012 Feb;64(2):493-503
– reference: 10325234 - Circ Res. 1999 May 14;84(9):973-9
– reference: 22614955 - Cell Mol Neurobiol. 2012 Aug;32(6):965-70
– reference: 7937744 - Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9213-7
– reference: 17975104 - Stroke. 2007 Dec;38(12):3230-6
– reference: 20159828 - Circulation. 2010 Mar 2;121(8):997-1004
– reference: 10363641 - Mol Biol Rep. 1999 Apr;26(1-2):15-9
– reference: 9425343 - Curr Opin Cell Biol. 1997 Dec;9(6):788-99
– reference: 10775442 - Arch Biochem Biophys. 2000 May 1;377(1):65-8
– reference: 12663490 - Circ Res. 2003 May 2;92(8):873-80
– reference: 11867760 - Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3312-7
– reference: 19617224 - Cardiovasc Res. 2010 Jan 15;85(2):330-8
– reference: 11369508 - Free Radic Biol Med. 2001 May 15;30(10):1171-6
– reference: 20228723 - Panminerva Med. 2010 Mar;52(1):9-25
– reference: 16039971 - Trends Cardiovasc Med. 2005 Apr;15(3):110-8
– reference: 16778122 - Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2132-9
– reference: 18192226 - Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1298-303
– reference: 19895750 - Curr Hypertens Rep. 2009 Dec;11(6):396-405
– reference: 19752367 - Circulation. 2009 Sep 15;120(11 Suppl):S191-7
– reference: 22523251 - Am J Physiol Heart Circ Physiol. 2012 Jul;303(1):H9-18
– reference: 17986870 - Autophagy. 2008 Feb;4(2):141-50
– reference: 10200512 - Cell Death Differ. 1998 Jul;5(7):577-83
– reference: 8719710 - Neurochem Int. 1996 Feb;28(2):209-12
– reference: 7697133 - Enzyme Protein. 1993;47(4-6):354-69
– reference: 8610016 - Nature. 1996 May 9;381(6578):166-8
– reference: 11375979 - J Biol Chem. 2001 Aug 10;276(32):30057-63
– reference: 10220354 - Biochemistry. 1999 Apr 27;38(17):5651-8
– reference: 22812529 - Curr Protein Pept Sci. 2012 Aug;13(5):413
– reference: 18974044 - Cardiovasc Res. 2009 Feb 15;81(3):439-48
– reference: 17880010 - Med Res Rev. 2008 Mar;28(2):309-27
– reference: 21195082 - J Mol Cell Cardiol. 2011 Apr;50(4):652-61
– reference: 20723761 - Cell. 2010 Aug 20;142(4):613-24
– reference: 11917093 - Physiol Rev. 2002 Apr;82(2):373-428
– reference: 12078479 - Adv Immunol. 2002;80:1-70
– reference: 19348473 - J Med Chem. 2009 May 14;52(9):3028-38
– reference: 17390294 - Proteomics. 2007 Apr;7(7):1047-58
– reference: 12672454 - Int J Biochem Cell Biol. 2003 May;35(5):617-28
– reference: 19003867 - Proteomics. 2008 Dec;8(23-24):5025-37
– reference: 15060320 - Stroke. 2004 May;35(5):1186-91
– reference: 22012881 - Protein Sci. 2011 Dec;20(12):1941-54
– reference: 21659648 - Circ Res. 2011 Jul 22;109(3):296-308
– reference: 12424098 - Am J Physiol Heart Circ Physiol. 2003 Mar;284(3):H919-26
– reference: 20805844 - Cell Res. 2010 Dec;20(12):1372-85
– reference: 19815565 - Cardiovasc Res. 2010 Jan 15;85(2):291-302
– reference: 11012676 - Eur J Biochem. 2000 Oct;267(20):6221-30
– reference: 20843792 - J Biol Chem. 2010 Nov 19;285(47):36434-46
– reference: 21841311 - J Clin Invest. 2011 Sep;121(9):3689-700
– reference: 17187463 - Expert Rev Cardiovasc Ther. 2007 Jan;5(1):119-24
– reference: 21158740 - Biochem J. 2011 Jan 1;433(1):31-42
– reference: 20595653 - Circ Res. 2010 Sep 3;107(5):642-9
– reference: 16530722 - Arch Biochem Biophys. 2006 Sep 1;453(1):135-42
– reference: 12700891 - J Mol Med (Berl). 2003 Apr;81(4):235-45
– reference: 19352404 - Nat Rev Mol Cell Biol. 2009 May;10(5):319-31
– reference: 19696071 - Cardiovasc Res. 2010 Jan 15;85(2):253-62
– reference: 3036877 - J Biol Chem. 1987 Jul 15;262(20):9908-13
– reference: 18353650 - Trends Biochem Sci. 2008 May;33(5):230-7
– reference: 10223331 - Biol Chem. 1999 Mar;380(3):293-7
– reference: 17565987 - J Biol Chem. 2007 Aug 3;282(31):22460-71
– reference: 11141219 - Ann Surg. 2001 Jan;233(1):9-17
– reference: 20167943 - Circ Res. 2010 Feb 19;106(3):463-78
– reference: 19436320 - Nat Rev Mol Cell Biol. 2009 Jun;10(6):398-409
– reference: 11081519 - Nature. 2000 Nov 2;408(6808):115-20
– reference: 18931337 - Mol Cell Proteomics. 2009 Feb;8(2):302-15
– reference: 10608895 - J Biol Chem. 1999 Dec 31;274(53):38211-5
– reference: 16997324 - J Mol Biol. 2006 Oct 27;363(3):660-72
– reference: 21949118 - Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2207-19
– reference: 21211719 - Mol Cell. 2011 Jan 7;41(1):8-19
– reference: 22740087 - Circ Res. 2012 Aug 17;111(5):532-42
– reference: 20525886 - J Immunol. 2010 Jul 1;185(1):634-41
– reference: 22085703 - J Mol Cell Cardiol. 2012 Mar;52(3):526-37
– reference: 21364033 - Clin Cancer Res. 2011 May 1;17(9):2734-43
– reference: 290989 - Proc Natl Acad Sci U S A. 1979 Jul;76(7):3107-10
– reference: 15994860 - Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1960-7
– reference: 19626045 - Nat Rev Mol Cell Biol. 2009 Aug;10(8):550-63
– reference: 21370976 - Annu Rev Plant Biol. 2011;62:299-334
– reference: 18078953 - J Mol Cell Cardiol. 2008 Feb;44(2):419-28
– reference: 22700531 - Stroke. 2012 Aug;43(8):2229-35
– reference: 18796432 - J Biol Chem. 2008 Nov 14;283(46):31813-22
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Snippet The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in...
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SubjectTerms Animals
Autophagy
Cardiovascular disease
Heart - physiology
Humans
Ischemia
Ischemic Preconditioning
Myocardial Ischemia - pathology
Myocardial Ischemia - physiopathology
Myocardium - pathology
Oxidative Stress - physiology
Pathology
Physiology
Proteasome Endopeptidase Complex - physiology
Proteins
Reviews
Ubiquitin - physiology
Title The ubiquitin proteasome system and myocardial ischemia
URI https://www.ncbi.nlm.nih.gov/pubmed/23220331
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https://www.proquest.com/docview/1284291869
https://pubmed.ncbi.nlm.nih.gov/PMC3774499
https://www.ncbi.nlm.nih.gov/pmc/articles/3774499
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