High-precision prostate cancer irradiation by clinical application of an offline patient setup verification procedure, using portal imaging

• Published in: International journal of radiation oncology, biology, physics Vol. 35; no. 2; pp. 321 - 332
• Main Authors: Bel, Arjan, Vos, Pieter H., Rodrigus, Patrick T.R., Creutzberg, Carien L., Visser, Andries G., Stroom, Joep C., Lebesque, Joos V.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1996; Elsevier
• Subjects: Biological and medical sciences; Computerized, statistical medical data processing and models in biomedicine; Decision rules; Feasibility Studies; Humans; Male; Medical management aid. Diagnosis aid; Medical sciences; Portal imaging; Prostate cancer; Prostatic Neoplasms - radiotherapy; Radiotherapy Planning, Computer-Assisted - methods; Setup accuracy; Decision rules; Setup accuracy; Portal imaging; Prostate cancer; Human; Electronic equipment; Urinary system disease; Prostate disease; Image processing; High precision; Verification; Malignant tumor; Radiotherapy; Decision rule; Biomedical data processing; Cancerology; Treatment; Diagnostic aid; Male genital diseases; Prostate
• ISSN: 0360-3016; 1879-355X
• DOI: 10.1016/0360-3016(95)02395-X

Purpose : To investigate in three institutions, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis [AvL]), Dr. Daniel den Hoed Cancer Center (DDHC), and Dr, Bernard Verbeeten Institute (BVI). how much the patient setup accuracy for irradiation of prostate cancer can be improved by an offline setup verification and correction procedure, using portal imaging. Methods and Materials : The verification procedure consisted of two stages. During the first stage, setup deviation were measured during a number ( max) of consecutive initial treatment sessions. The length of the average three dimensional (3D) setup deviation vector was compared with an action level for corrections, which shrunk with the number of setup measurements. After a correction was applied, N max measurements had to be performed again. Each institution chose different values for the initial action level (6, 9, and 10 mm) and N max (2 and 4). The choice of these parameters was based on a simlation of the procedure, using as input preestimated values of random and systematic deviations in each institution. During the second stage of the procedure, with weekly setup measurements, the AvL used a different criterion (“outlier detection”) for corrective actions than the DDHC and the BVI (“sliding average”). After each correction the first stage of the procedure was restarted. The procedure was tested for 151 patients (62 in AvL, 47 in DDHC, and 42 in BVI) treated for prostate carcinoma. Treatment techniques and portal image acquisition and analysis were different in each institution. Results : The actual distribution of random and systemic deviations without corrections were estimated by eliminating the effect of the corrections. The percentage of mean (systematic) 3D deviations larger than 5mm was 26% for the AvL and the DDHC, and 36% for the BVI. The setup accuracy after application of the procedure was considerably improved (percentage of mean 3D deviations larger than 5 mm was 1.6% in the AvL and 0% in the DDHC and BVI), in agreement with the results of the simulation. The number of corrections (about 0.7 on the average per patient) was not larger than predicted. Conclusion : The verification procedure appeared to be feasible in the three institutions and enable a significance reduction of mean 3D setup deviations. The computer simulation of the procedure proved to be a useful tool, because it enable an accurate prediction of the setup accuracy and the required number of corrections.