Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19
In this study, 20% of patients with Covid-19 had a prolonged activated partial-thromboplastin time. In 90% of these cases, the cause was lupus anticoagulant, with no associated bleeding. Patients with Covid-19 are susceptible to thromboses. The presence of a prolonged aPTT should, in general, not be...
Saved in:
| Published in | The New England journal of medicine Vol. 383; no. 3; pp. 288 - 290 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Massachusetts Medical Society
16.07.2020
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0028-4793 1533-4406 1533-4406 |
| DOI | 10.1056/NEJMc2013656 |
Cover
| Abstract | In this study, 20% of patients with Covid-19 had a prolonged activated partial-thromboplastin time. In 90% of these cases, the cause was lupus anticoagulant, with no associated bleeding. Patients with Covid-19 are susceptible to thromboses. The presence of a prolonged aPTT should, in general, not be considered a contraindication to anticoagulation. |
|---|---|
| AbstractList | In this study, 20% of patients with Covid-19 had a prolonged activated partial-thromboplastin time. In 90% of these cases, the cause was lupus anticoagulant, with no associated bleeding. Patients with Covid-19 are susceptible to thromboses. The presence of a prolonged aPTT should, in general, not be considered a contraindication to anticoagulation. |
| Author | Platton, Sean Pasi, K. John Yartey, Nada Hart, Daniel P MacDonald, Vickie MacCallum, Peter Green, Laura Dave, Minal Lee, Kurtis Sivapalaratnam, Suthesh Bowles, Louise |
| Author_xml | – sequence: 1 givenname: Louise surname: Bowles fullname: Bowles, Louise email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 2 givenname: Sean surname: Platton fullname: Platton, Sean email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 3 givenname: Nada surname: Yartey fullname: Yartey, Nada email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 4 givenname: Minal surname: Dave fullname: Dave, Minal email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 5 givenname: Kurtis surname: Lee fullname: Lee, Kurtis email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 6 givenname: Daniel P surname: Hart fullname: Hart, Daniel P email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 7 givenname: Vickie surname: MacDonald fullname: MacDonald, Vickie email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 8 givenname: Laura surname: Green fullname: Green, Laura email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 9 givenname: Suthesh surname: Sivapalaratnam fullname: Sivapalaratnam, Suthesh email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 10 givenname: K. John surname: Pasi fullname: Pasi, K. John email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom – sequence: 11 givenname: Peter surname: MacCallum fullname: MacCallum, Peter email: k.j.pasi@qmul.ac.uk organization: Royal London Hospital, London, United Kingdom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32369280$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kc1v1DAQxa2qqN2W3nquIsGBAyn-TnxBWq3Kl7bAoZwtx5m0XiX2EidF_PcMbIvaCnyxPf7N03vjI7IfUwRCThk9Z1TpN58vPl16TpnQSu-RBVNClFJSvU8WlPK6lJURh-Qo5w3FxaQ5IIeCC214TRdkvZ63cy6WcQo-ueu5d3EqXGyLZRPTOLi-WO3KU0ixuII85SLE4iveIeL5R5huELkNbcnMc_Ksc32Gk7v9mHx7d3G1-lCuv7z_uFquSy9NNZWtoUZ73ygGpgGpmOzaDsBJpiqjOswiQUMFAstNU8tKKuXrzgigGM6DOCZvd7rbuRmg9ehkdL3djmFw40-bXLCPX2K4sdfp1lacVUopFHh1JzCm7zOGskPIHnpMD2nOlgtTayaoFoi-eIJu0jxGjGe55BLHbpRG6uyho79W7geNAN8Bfkw5j9BZH6Y_Q0WDobeM2t-_aR_-Jja9ftJ0r_sf_OUOH4ZsI2yGf2O_AC7oqp0 |
| CitedBy_id | crossref_primary_10_7759_cureus_10137 crossref_primary_10_1111_1756_185X_13909 crossref_primary_10_1038_s41569_020_00469_1 crossref_primary_10_1038_s41584_020_0474_5 crossref_primary_10_1016_j_rcreue_2024_08_005 crossref_primary_10_1056_NEJMoa2102968 crossref_primary_10_1371_journal_pone_0269466 crossref_primary_10_1016_j_beha_2022_101402 crossref_primary_10_1177_10600280211036151 crossref_primary_10_1002_jha2_228 crossref_primary_10_3390_vaccines9080903 crossref_primary_10_1038_s41598_021_95397_6 crossref_primary_10_1097_CCM_0000000000004545 crossref_primary_10_1016_j_jhep_2021_04_003 crossref_primary_10_1016_j_autrev_2021_102754 crossref_primary_10_1016_j_autrev_2020_102597 crossref_primary_10_1093_ndt_gfad170 crossref_primary_10_1016_j_autrev_2022_103206 crossref_primary_10_1038_s41598_021_84776_8 crossref_primary_10_1002_micr_30930 crossref_primary_10_1186_s12959_020_00236_9 crossref_primary_10_1002_art_41634 crossref_primary_10_1136_postgradmedj_2021_139923 crossref_primary_10_3389_fmed_2022_934270 crossref_primary_10_3390_jcm9092935 crossref_primary_10_1016_j_jpeds_2020_07_032 crossref_primary_10_1080_10408363_2023_2232010 crossref_primary_10_1111_ijlh_13543 crossref_primary_10_2144_fsoa_2022_0011 crossref_primary_10_1111_all_14657 crossref_primary_10_1001_jamanetworkopen_2020_17539 crossref_primary_10_1038_s41590_021_01104_y crossref_primary_10_1186_s43054_023_00161_2 crossref_primary_10_1002_rth2_12470 crossref_primary_10_1111_ijlh_13547 crossref_primary_10_1186_s13054_020_03077_0 crossref_primary_10_3389_fimmu_2020_01962 crossref_primary_10_1093_rap_rkaa081 crossref_primary_10_18621_eurj_830973 crossref_primary_10_1016_j_jaut_2024_103299 crossref_primary_10_1055_a_1701_2809 crossref_primary_10_1371_journal_pone_0267605 crossref_primary_10_1097_MBC_0000000000000996 crossref_primary_10_7554_eLife_91329 crossref_primary_10_7554_eLife_91329_3 crossref_primary_10_3389_fimmu_2020_584241 crossref_primary_10_1007_s40139_021_00228_y crossref_primary_10_7759_cureus_10233 crossref_primary_10_1136_annrheumdis_2021_220520 crossref_primary_10_3390_vaccines10122023 crossref_primary_10_1016_j_sjbs_2021_09_065 crossref_primary_10_1007_s11926_021_01041_7 crossref_primary_10_1016_j_rpth_2023_100041 crossref_primary_10_1111_jon_12770 crossref_primary_10_1080_00325481_2021_1974212 crossref_primary_10_1097_MD_0000000000021380 crossref_primary_10_1097_MRM_0000000000000336 crossref_primary_10_1136_bcr_2020_240981 crossref_primary_10_3389_fimmu_2022_807934 crossref_primary_10_1016_j_ijid_2020_10_032 crossref_primary_10_1016_j_thromres_2020_08_017 crossref_primary_10_1093_ehjqcco_qcad048 crossref_primary_10_1097_CCE_0000000000000427 crossref_primary_10_5858_arpa_2020_0324_SA crossref_primary_10_1002_jmv_26467 crossref_primary_10_3389_fmed_2020_562142 crossref_primary_10_1016_j_amsu_2020_06_035 crossref_primary_10_1002_rth2_12809 crossref_primary_10_7759_cureus_12529 crossref_primary_10_1007_s11239_021_02485_5 crossref_primary_10_1053_j_jvca_2020_10_039 crossref_primary_10_1186_s13000_024_01445_w crossref_primary_10_2478_inmed_2021_0151 crossref_primary_10_3390_ph14080751 crossref_primary_10_1590_1677_5449_200234 crossref_primary_10_1016_j_jaut_2020_102506 crossref_primary_10_1111_hae_14191 crossref_primary_10_1136_annrheumdis_2020_218157 crossref_primary_10_1186_s43166_021_00105_x crossref_primary_10_2147_JIR_S465127 crossref_primary_10_1002_biof_1696 crossref_primary_10_1111_ijlh_13320 crossref_primary_10_2957_kanzo_63_491 crossref_primary_10_1093_eurheartj_ehac076 crossref_primary_10_17827_aktd_1000224 crossref_primary_10_61186_mlj_17_4_1 crossref_primary_10_3390_ijms22031283 crossref_primary_10_1016_j_thromres_2020_06_040 crossref_primary_10_5758_vsi_210039 crossref_primary_10_1136_bcr_2020_241027 crossref_primary_10_3390_jcm12196365 crossref_primary_10_1055_s_0043_1771268 crossref_primary_10_7759_cureus_13065 crossref_primary_10_1186_s40545_020_00274_8 crossref_primary_10_3390_bacteria3040022 crossref_primary_10_1136_bcr_2021_246698 crossref_primary_10_1155_2020_8880143 crossref_primary_10_17116_jnevro20211211025 crossref_primary_10_23736_S2532_1285_21_00087_2 crossref_primary_10_3389_fimmu_2020_589474 crossref_primary_10_1097_MBC_0000000000001007 crossref_primary_10_1016_j_amjcard_2020_07_056 crossref_primary_10_1136_annrheumdis_2020_218145 crossref_primary_10_1016_j_autrev_2021_103012 crossref_primary_10_1111_joim_13149 crossref_primary_10_1007_s00296_021_04875_7 crossref_primary_10_1007_s00277_023_05234_1 crossref_primary_10_1002_path_5642 crossref_primary_10_1007_s11926_021_01029_3 crossref_primary_10_1186_s12950_023_00333_2 crossref_primary_10_2217_fvl_2022_0055 crossref_primary_10_1007_s12185_020_03029_y crossref_primary_10_1016_j_thromres_2024_02_026 crossref_primary_10_1097_MCG_0000000000001459 crossref_primary_10_3389_fimmu_2023_1188786 crossref_primary_10_1093_ajcp_aqab052 crossref_primary_10_1007_s11356_022_20984_7 crossref_primary_10_1007_s11926_020_00973_w crossref_primary_10_3389_fcimb_2024_1489936 crossref_primary_10_52420_2071_5943_2021_20_6_63_68 crossref_primary_10_1016_j_avsurg_2022_100082 crossref_primary_10_1038_s41586_022_05273_0 crossref_primary_10_5662_wjm_v12_i5_331 crossref_primary_10_1111_1744_9987_13599 crossref_primary_10_1093_rheumatology_keac224 crossref_primary_10_3390_life14080953 crossref_primary_10_1007_s11739_020_02443_8 crossref_primary_10_1055_s_0040_1722612 crossref_primary_10_1002_rth2_12396 crossref_primary_10_1007_s10067_021_05724_5 crossref_primary_10_3389_fimmu_2021_645013 crossref_primary_10_1002_ajh_25982 crossref_primary_10_2478_jccm_2020_0033 crossref_primary_10_4103_mamcjms_mamcjms_83_21 crossref_primary_10_3389_fimmu_2022_977443 crossref_primary_10_1007_s00277_020_04366_y crossref_primary_10_1177_20587384211042115 crossref_primary_10_1007_s11239_021_02593_2 crossref_primary_10_1097_MJT_0000000000001515 crossref_primary_10_4103_VIT_VIT_19_20 crossref_primary_10_1021_acs_jproteome_1c00475 crossref_primary_10_26442_00403660_2020_11_000887 crossref_primary_10_31631_20733046_2022_21_5_138_146 crossref_primary_10_1016_j_ad_2020_11_013 crossref_primary_10_1007_s10875_021_00994_9 crossref_primary_10_1016_j_autrev_2021_102822 crossref_primary_10_1590_1806_9282_20210720 crossref_primary_10_3390_jcm10040825 crossref_primary_10_1177_08971900211000705 crossref_primary_10_1007_s11739_020_02432_x crossref_primary_10_1002_art_41409 crossref_primary_10_1016_j_jbior_2020_100735 crossref_primary_10_1177_0961203320961848 crossref_primary_10_1111_crj_13438 crossref_primary_10_1111_joim_13166 crossref_primary_10_1177_1941874420985983 crossref_primary_10_1017_S0950268822001480 crossref_primary_10_2491_jjsth_34_29 crossref_primary_10_1080_09537104_2020_1768523 crossref_primary_10_3390_cells11233882 crossref_primary_10_1371_journal_pcbi_1009892 crossref_primary_10_2196_25442 crossref_primary_10_1002_ajh_25979 crossref_primary_10_3389_fneur_2023_1338593 crossref_primary_10_3389_fimmu_2024_1509289 crossref_primary_10_1016_j_intimp_2021_107995 crossref_primary_10_7759_cureus_14887 crossref_primary_10_1002_joa3_12569 crossref_primary_10_1097_MBC_0000000000000963 crossref_primary_10_1007_s42399_021_00992_3 crossref_primary_10_1177_1179544120978667 crossref_primary_10_14423_SMJ_0000000000001337 crossref_primary_10_3390_v13081484 crossref_primary_10_47360_1995_4484_2022_271_275 crossref_primary_10_1016_j_chest_2023_06_032 crossref_primary_10_1080_10255842_2022_2124858 crossref_primary_10_15690_vramn1551 crossref_primary_10_1111_ene_15008 crossref_primary_10_1016_j_thromres_2020_11_030 crossref_primary_10_1177_10760296211053315 crossref_primary_10_1016_j_blre_2020_100761 crossref_primary_10_1016_j_hrtlng_2021_01_011 crossref_primary_10_1097_CCM_0000000000004504 crossref_primary_10_3390_vaccines9080815 crossref_primary_10_1016_j_radcr_2021_04_078 crossref_primary_10_1016_j_tru_2022_100110 crossref_primary_10_1089_dna_2022_0293 crossref_primary_10_1016_j_jaut_2021_102682 crossref_primary_10_36303_JMLSTSA_2020_2_2_48 crossref_primary_10_1055_a_1581_6899 crossref_primary_10_1177_1179547620980381 crossref_primary_10_3390_ijms23094946 crossref_primary_10_1016_j_hrthm_2020_06_009 crossref_primary_10_1097_MD_0000000000026532 crossref_primary_10_1080_22221751_2020_1785336 crossref_primary_10_3389_fcvm_2021_779073 crossref_primary_10_1152_physiol_00019_2020 crossref_primary_10_1055_s_0043_1768475 crossref_primary_10_1097_MJT_0000000000001282 crossref_primary_10_1515_cclm_2020_0722 crossref_primary_10_1634_theoncologist_2020_0682 crossref_primary_10_1515_revneuro_2020_0136 crossref_primary_10_1016_j_rcreu_2021_02_013 crossref_primary_10_3390_biomedicines9080899 crossref_primary_10_5507_bp_2020_037 crossref_primary_10_12998_wjcc_v8_i17_3669 crossref_primary_10_1016_j_xkme_2020_07_010 crossref_primary_10_1177_00469580221093442 crossref_primary_10_4103_0028_3886_344623 crossref_primary_10_1186_s13045_020_01003_z crossref_primary_10_1080_14397595_2021_1892257 crossref_primary_10_1016_j_hrtlng_2020_10_009 crossref_primary_10_1093_jscr_rjaa204 crossref_primary_10_1093_brain_awab302 crossref_primary_10_3390_diagnostics11061114 crossref_primary_10_1002_biof_1877 crossref_primary_10_1182_hematology_2021000298 crossref_primary_10_1016_j_sjbs_2021_03_027 crossref_primary_10_1055_s_0040_1718415 crossref_primary_10_3390_ijms241814133 crossref_primary_10_1016_j_adengl_2021_01_024 crossref_primary_10_1016_j_intimp_2022_109183 crossref_primary_10_2174_1573403X18666220512142019 crossref_primary_10_1016_S1773_035X_22_00218_0 crossref_primary_10_1056_NEJMcpc2004975 crossref_primary_10_1080_00015458_2021_1911751 crossref_primary_10_3238_arztebl_2020_0561 crossref_primary_10_1111_jth_14994 crossref_primary_10_2174_1573397116666201005122603 crossref_primary_10_1002_ccr3_3527 crossref_primary_10_1007_s11239_021_02457_9 crossref_primary_10_1186_s12959_020_00229_8 crossref_primary_10_1016_j_radcr_2022_08_017 crossref_primary_10_1016_j_chest_2020_06_024 crossref_primary_10_1016_j_mayocp_2021_01_009 crossref_primary_10_1111_bjh_16906 crossref_primary_10_24969_hvt_2022_329 crossref_primary_10_3390_microorganisms11102458 crossref_primary_10_1016_j_ijcard_2021_10_156 crossref_primary_10_3390_ijms25094941 crossref_primary_10_1111_ijlh_14003 crossref_primary_10_1016_j_ancard_2020_09_027 crossref_primary_10_3389_fcvm_2022_794092 crossref_primary_10_1002_rth2_12521 crossref_primary_10_1111_bjh_17664 crossref_primary_10_4103_jcsr_jcsr_39_21 crossref_primary_10_1111_ene_14466 crossref_primary_10_1177_20503121211049931 crossref_primary_10_1007_s11033_021_06333_w crossref_primary_10_1007_s11739_020_02394_0 crossref_primary_10_3389_fimmu_2024_1354349 crossref_primary_10_1016_j_transci_2020_102858 crossref_primary_10_3389_fcvm_2020_598400 crossref_primary_10_1016_j_jaut_2020_102592 crossref_primary_10_1080_00325481_2021_1891788 crossref_primary_10_52586_5043 crossref_primary_10_17116_jnevro202212212226 crossref_primary_10_1007_s00277_020_04182_4 crossref_primary_10_32345_2664_4738_1_2024_04 crossref_primary_10_1097_MBC_0000000000001235 crossref_primary_10_1159_000512007 crossref_primary_10_3389_fmed_2021_725226 crossref_primary_10_1007_s10787_022_01047_2 crossref_primary_10_1007_s11239_020_02210_8 crossref_primary_10_1093_rheumatology_keac400 crossref_primary_10_1111_dth_13686 crossref_primary_10_4103_mj_mj_39_23 crossref_primary_10_7759_cureus_27862 crossref_primary_10_1055_s_0041_1729856 crossref_primary_10_2174_1871525720666220405124021 crossref_primary_10_1016_j_jaut_2021_102644 crossref_primary_10_1080_1744666X_2021_1905526 crossref_primary_10_1016_j_clinthera_2020_08_006 crossref_primary_10_1080_17476348_2020_1802191 crossref_primary_10_1182_blood_2024025010 crossref_primary_10_3390_covid3030026 crossref_primary_10_21518_1995_1477_2020_3_4 crossref_primary_10_3389_fimmu_2022_831849 crossref_primary_10_3390_jcm11102695 crossref_primary_10_14423_SMJ_0000000000001371 crossref_primary_10_1111_jth_15261 crossref_primary_10_1007_s10557_021_07207_w crossref_primary_10_1007_s11239_021_02470_y crossref_primary_10_1002_micr_30744 crossref_primary_10_3390_vaccines10020333 crossref_primary_10_1016_S2213_2600_21_00455_0 crossref_primary_10_1111_apt_15823 crossref_primary_10_1186_s12959_020_00230_1 crossref_primary_10_5045_br_2023_2022200 crossref_primary_10_1111_ijlh_13334 crossref_primary_10_1016_j_thromres_2021_10_017 crossref_primary_10_1038_s41419_020_03333_9 crossref_primary_10_1016_j_ijcha_2020_100670 crossref_primary_10_1177_09612033211062523 crossref_primary_10_1055_s_0041_1722992 crossref_primary_10_1161_JAHA_120_017773 crossref_primary_10_1016_j_jhep_2021_07_005 crossref_primary_10_23736_S1825_859X_21_00104_3 crossref_primary_10_1590_0074_02760200552 crossref_primary_10_1038_s41598_021_81166_y crossref_primary_10_21518_1995_1477_2020_3_4_36_51 crossref_primary_10_1093_ehjcr_ytaa448 crossref_primary_10_3174_ajnr_A6864 crossref_primary_10_1016_j_immuni_2022_09_006 crossref_primary_10_1111_imr_13115 crossref_primary_10_1007_s11055_022_01287_3 crossref_primary_10_1016_j_xcrm_2021_100288 crossref_primary_10_4103_bc_bc_65_21 crossref_primary_10_5005_jp_journals_10071_24575 crossref_primary_10_1016_j_autrev_2021_102798 crossref_primary_10_1136_bmjno_2020_000084 crossref_primary_10_1016_j_tcm_2020_12_004 crossref_primary_10_1016_j_avsg_2020_12_006 crossref_primary_10_1038_s41584_021_00608_z crossref_primary_10_3390_life12111918 crossref_primary_10_1016_j_clinre_2021_101635 crossref_primary_10_1038_s41598_024_75514_x crossref_primary_10_1016_j_autrev_2024_103543 crossref_primary_10_1159_000512503 crossref_primary_10_1016_j_scib_2021_07_033 crossref_primary_10_1186_s13054_020_03304_8 crossref_primary_10_1186_s41927_020_00165_0 crossref_primary_10_1016_j_autrev_2021_102792 crossref_primary_10_1016_j_thromres_2021_04_012 crossref_primary_10_1097_SHK_0000000000001680 crossref_primary_10_1016_j_rcreu_2023_08_001 crossref_primary_10_2174_1871529X21666211201110007 crossref_primary_10_1177_10760296221074353 crossref_primary_10_3390_jcm10102045 crossref_primary_10_1016_j_tcm_2022_04_004 crossref_primary_10_2478_inmed_2021_0146 crossref_primary_10_1007_s11684_023_1041_7 crossref_primary_10_1111_jth_15004 crossref_primary_10_1111_ejh_13491 crossref_primary_10_1016_j_ahj_2020_06_009 crossref_primary_10_1016_j_jiph_2022_05_003 crossref_primary_10_1016_j_htct_2021_06_017 crossref_primary_10_1053_j_jvca_2020_06_059 crossref_primary_10_1056_NEJMc2027508 crossref_primary_10_1093_labmed_lmae053 crossref_primary_10_1155_2023_7753631 crossref_primary_10_1016_j_trsl_2020_12_007 crossref_primary_10_3389_fimmu_2021_730710 crossref_primary_10_3389_fmed_2021_682843 crossref_primary_10_1016_j_avsg_2020_08_084 crossref_primary_10_1016_j_susoc_2021_04_003 crossref_primary_10_1177_1076029620959457 crossref_primary_10_4103_jdmimsu_jdmimsu_475_20 crossref_primary_10_1055_s_0040_1715841 crossref_primary_10_2491_jjsth_31_604 crossref_primary_10_3390_life12101658 crossref_primary_10_1155_2020_8835627 crossref_primary_10_1007_s42399_020_00598_1 crossref_primary_10_1055_a_2211_5052 crossref_primary_10_1111_jth_14937 crossref_primary_10_1159_000516641 crossref_primary_10_1177_10760296221127276 crossref_primary_10_1371_journal_pone_0275832 crossref_primary_10_11622_smedj_2020174 crossref_primary_10_1007_s11239_020_02335_w crossref_primary_10_2491_jjsth_32_628 crossref_primary_10_17749_2313_7347_ob_gyn_rep_2021_247 crossref_primary_10_3389_fmed_2025_1530411 crossref_primary_10_1007_s10557_020_07037_2 crossref_primary_10_1016_j_cca_2020_06_024 crossref_primary_10_3389_fphys_2020_575600 crossref_primary_10_1016_j_clindermatol_2020_12_013 crossref_primary_10_1093_jalm_jfab114 crossref_primary_10_1016_j_ipej_2020_08_006 |
| Cites_doi | 10.1111/jth.14768 10.1111/jth.14869 10.1007/s00134-020-06062-x |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 Massachusetts Medical Society. All rights reserved. Copyright © 2020 Massachusetts Medical Society. All rights reserved. 2020 Massachusetts Medical Society |
| Copyright_xml | – notice: Copyright © 2020 Massachusetts Medical Society. All rights reserved. – notice: Copyright © 2020 Massachusetts Medical Society. All rights reserved. 2020 Massachusetts Medical Society |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7RV 7X7 7XB 8AO 8C1 8FE 8FH 8FI ABUWG AFKRA AN0 AZQEC BBNVY BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K0Y LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM |
| DOI | 10.1056/NEJMc2013656 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland British Nursing Database (Proquest) ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library SciTech Premium Collection New England Journal of Medicine Biological Sciences Consumer Health Database Healthcare Administration Database Medical Database Psychology Database ProQuest Research Library Science Database Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials elibrary ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing New England Journal of Medicine ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Research Library ProQuest Central (New) ProQuest Public Health ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest Family Health ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic |
| DatabaseTitleList | ProQuest One Psychology |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1533-4406 |
| EndPage | 290 |
| ExternalDocumentID | PMC7217555 32369280 10_1056_NEJMc2013656 NJ202007163830322 |
| Genre | Correspondence Letter |
| GroupedDBID | - 0R 0WA 123 186 1VV 29N 2KS 2WC 34G 39C 4 4.4 53G 55 5RE 7FN 7RV 7X7 85S 8AO 8C1 8FE 8FH 8FI AACLI AAEJM AAIKC AALRV AAPBV AAQQT AARDX AAWTL ABACO ABEHJ ABFLS ABIVO ABOCM ABPPZ ABPTK ABQIJ ABUWG ABWJO ACGFS ACGOD ACJLH ACNCT ACPRK ACRZS ADBBV ADBIT ADCBC AENEX AETEA AFFNX AFHKK AFKRA AGFXO AGNAY AHMBA AJJEV AJVPN ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI AZQEC BBAFP BBNVY BCU BENPR BES BHPHI BKEYQ BKNYI BLC BNQBC BPHCQ BVXVI C45 CJ0 CO CS3 DCD DU5 DWQXO DZ EBS ET EX3 F5P FD8 FM. FYUFA GJ GNUQQ GUQSH HCIFZ HZ I4R IH2 K-O KM KOO L7B LK8 M0R M0T M1P M2M M2O M2P M7P MVM N9A NAPCQ NEJ O9- OK1 OMK OVD P-O P-S P2P PADUT PCD PQEST PQQKQ PQUKI PRINS PROAC PSQYO QJJ RHI RWL RXW S10 S6N SJFOW SJN TAE TAF TEORI TN5 TUQ TWZ UCV UKR UMD VQA W2G WH7 WOQ WOW X X7M XJT XYN XZL YCJ YNT YRY YZZ ZA5 ZHY ZR0 --- -DZ -ET -~X .-4 .55 .CO .GJ 0R~ 36B AAMNW AAYXX ABBLC ABCQX ABDQB ABJNI ACKOT ACPFK ADRHT ADUKH AERZD AFOSN AGHSJ ALIPV BYPQX CCPQU CITATION H13 HF~ HMCUK HZ~ N4W PHGZM PHGZT PSYQQ UKHRP YFH YR2 YR5 YYP ZCA ZVN ~KM CGR CUY CVF ECM EIF NPM R.3 UIG VXZ YIF YIN Z5M 7XB BEC K0Y MBDVC PJZUB PKEHL PPXIY PQGLB Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c497t-d9096ccb51e9be4514fdfeea415795f2014e6e7e3fdfbb847455c8f93e0533ce3 |
| IEDL.DBID | 8C1 |
| ISSN | 0028-4793 1533-4406 |
| IngestDate | Thu Aug 21 14:32:31 EDT 2025 Thu Sep 04 22:29:46 EDT 2025 Sat Aug 16 21:24:44 EDT 2025 Wed Feb 19 02:29:55 EST 2025 Tue Jul 01 01:43:30 EDT 2025 Thu Apr 24 23:09:47 EDT 2025 Tue Dec 21 14:38:51 EST 2021 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | This article is made available via the PMC Open Access Subset for unrestricted re-use, except commercial resale, and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the Covid-19 pandemic or until revoked in writing. Upon expiration of these permissions, PMC is granted a license to make this article available via PMC and Europe PMC, subject to existing copyright protections. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c497t-d9096ccb51e9be4514fdfeea415795f2014e6e7e3fdfbb847455c8f93e0533ce3 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Correspondence-1 content type line 14 content type line 23 Drs. Bowles and Platton contributed equally to this letter. |
| ORCID | 0000-0003-3394-2099 0000-0002-5466-0448 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7217555 |
| PMID | 32369280 |
| PQID | 2424136956 |
| PQPubID | 40644 |
| PageCount | 3 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7217555 proquest_miscellaneous_2398613063 proquest_journals_2424136956 pubmed_primary_32369280 crossref_citationtrail_10_1056_NEJMc2013656 crossref_primary_10_1056_NEJMc2013656 mms_nejm_10_1056_NEJMc2013656 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-07-16 |
| PublicationDateYYYYMMDD | 2020-07-16 |
| PublicationDate_xml | – month: 07 year: 2020 text: 2020-07-16 day: 16 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Boston |
| PublicationTitle | The New England journal of medicine |
| PublicationTitleAlternate | N Engl J Med |
| PublicationYear | 2020 |
| Publisher | Massachusetts Medical Society |
| Publisher_xml | – name: Massachusetts Medical Society |
| References | Llitjos, JF, Leclerc, M, Chochois, C (r003) Tang, N, Li, D, Wang, X, Sun, Z (r004) 2020; 18 Helms, J, Tacquard, C, Severac, F (r001) 2020 Klok, FA, Kruip, MJHA, van der Meer, NJM (r002) e_1_3_4_2_2 Klok FA (e_1_3_4_3_2) 2020 e_1_3_4_5_2 e_1_3_4_4_2 33095521 - N Engl J Med. 2020 Nov 5;383(19):1893 32470207 - J Thromb Haemost. 2020 Oct;18(10):2778 |
| References_xml | – volume: 18 start-page: 844 year: 2020 end-page: 847 ident: r004 article-title: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. publication-title: J Thromb Haemost – ident: r002 article-title: Incidence of thrombotic complications in critically ill ICU patients with COVID-19. publication-title: Thromb Res – year: 2020 ident: r001 article-title: High risk of thrombosis in patients in severe SARS-CoV-2 infection: a multicentre prospective cohort study. publication-title: Intensive Care Med – ident: r003 article-title: High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. publication-title: J Thromb Haemost – ident: e_1_3_4_5_2 doi: 10.1111/jth.14768 – ident: e_1_3_4_4_2 doi: 10.1111/jth.14869 – ident: e_1_3_4_2_2 doi: 10.1007/s00134-020-06062-x – year: 2020 ident: e_1_3_4_3_2 article-title: Incidence of thrombotic complications in critically ill ICU patients with COVID-19. publication-title: Thromb Res – reference: 33095521 - N Engl J Med. 2020 Nov 5;383(19):1893 – reference: 32470207 - J Thromb Haemost. 2020 Oct;18(10):2778 |
| SSID | ssj0000149 |
| Score | 2.7041364 |
| Snippet | In this study, 20% of patients with Covid-19 had a prolonged activated partial-thromboplastin time. In 90% of these cases, the cause was lupus anticoagulant,... |
| SourceID | pubmedcentral proquest pubmed crossref mms |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 288 |
| SubjectTerms | Adolescent Adult Aged Aged, 80 and over Anticoagulants Anticoagulants - therapeutic use Betacoronavirus Blood Coagulation Tests Coronavirus Infections - blood Coronaviruses Correspondence COVID-19 Female Humans Lupus Lupus Coagulation Inhibitor - blood Male Middle Aged Pandemics Partial Thromboplastin Time Patients Pneumonia, Viral - blood Pulmonary embolisms SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Systemic lupus erythematosus Thromboplastin Thrombosis Thrombosis - drug therapy Young Adult |
| Title | Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19 |
| URI | https://nejm.org/doi/full/10.1056/NEJMc2013656 https://www.ncbi.nlm.nih.gov/pubmed/32369280 https://www.proquest.com/docview/2424136956 https://www.proquest.com/docview/2398613063 https://pubmed.ncbi.nlm.nih.gov/PMC7217555 |
| Volume | 383 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swED-WFsZexr7nrg0abE9DNLYsy3oaWWgpoy1ltJA3I8sSy2iUrE729-_OVrJ0rHvxg-5syzrJ97s76Q7gg0gNwfSUC-NKnjsjeD1qMl5bnSmpGz8SdN754rI4u8m_TuU0OtzauK1y80_sftTNwpKP_JiOMaSiQDj_efmTU9Uoiq7GEhoD2KczoGR8lZN0J31UhL_RgxQ3vqPOP6ZK8zajhGVUunpHJQ3m8_ZfaPPvTZM7Wuj0GTyN8JGNe3k_h0cuvIDHFzFA_hLOz9fLdcvGAekLQ2Xmw4qZ0LBxHQid3rJJ30zyYNf46pbNArvqs6u2jNyyyPJr1vBUv4Kb05PryRmPBRO4zbVa8UajQWJtLVOna5cjFvKNd86gklZaevzc3BVOOYHNdY16KZfSll4Lqg8hrBOvYS8sgnsLzEuhXOnw2hR56Y3xWWbwMW7ku0hjAp82Y1bZmE2cilrcVl1UWxbV7ggn8HHLveyzaDzAd4TDXwX3Y_4A_XAjmCqutbb6MzMSeL8l4yqh0IcJbrFGHqFLspQKkcCbXo7bjogMb87KUQLqnoS3DJSB-z4lzL53mbjRfFZSyoP_d-sdPMnISqd0nMUh7K3u1u4IocyqHsJATdWwm7VD2P9ycnn17TeLsvIF |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB61qQRcEG8MLSwSPSGr8a7Xj0OFQmmV0iSqUCr1ZtbrtUjVbFKcgPhz_DZm7HVIEeXWiw_e8UOzr29ndr8P4K0IFMH0wBfKJH5olPDzbsH9XKc8lmlRdgWddx6Oov5Z-Olcnm_Ar_YsDG2rbMfEeqAuZppi5Ht0jCEQEcL59_Mrn1SjKLvaSmgoJ61Q7NcUY-5gx4n5-QOXcNX-8Ues713Ojw7HB33fqQz4OkzjhV-kiOK1zmVg0tyECCDKojRG4cwWp7LECTI0kYmNwNt5joN5KKVOylSQqILQRuB7N2ErpABKB7Y-HI5OP68RWDkA7mJYbus9oo490rrXnCjTSDx7bVLcnE6rf-Hdv7dtrs2DRw_gvgOwrNe0uIewYewjuDN0KfrHMBgs58uK9dBNeqZI6N4umLIF6-WW8PElO2huU4tgY_x0xSaWnTb8rhWjwDCafJ8UfpA-gbNbceZT6NiZNc-BlVLEJjF4LaIwKZUqOVf4GtMt61ynB-9an2Xa8ZmTrMZlVufVZZSte9iD3ZX1vOHxuMFuB92fWXMxvaF8u62YzPX2KvvTNj14syrGfkrJF2XNbIk2Ik1orRYJD5419bj6EcHxYZ50PYiv1fDKgDjAr5fYydeaCxwX8LGU8sX_f-s13O2Ph4NscDw6eQn3OMUMiBw02obO4tvS7CCwWuSvXOtl8OW2O8xv7nU0ZA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFD7aRZp4QdwX2MBI7AlFbew4l4cJlW3VxrqqQpu0t-A4jiha3W5pQfxFfhXnJE7pEONtL3mITy46vpzPPvb3AbwTgSKYHvhCmcQPjRJ-3i24n-uUxzItyq6g885nw-j4Ivx0KS_X4Fd7Foa2VbZjYj1QF1NNa-QdOsYQiAjhfKd02yJGh_0Ps2ufFKQo09rKaSgns1Ds13Rj7pDHqfn5A6dz1f7JIdb9Huf9o_ODY98pDvg6TOO5X6SI6LXOZWDS3IQIJsqiNEZhlItTWWKwDE1kYiPwdp7jwB5KqZMyFSSwILQR-N512Iwx6uNEcPPj0XD0eYXMyoFxt57ltuEjAumQ7r3mRJ9GQtorAXJ9Mqn-hX3_3sK5EhP7j-ChA7Os17S-x7Bm7BPYOnPp-qcwGCxmi4r10E16qkj03s6ZsgXr5Zaw8hU7aG5T62Dn-OmKjS0bNVyvFaNFYjT5Pi78IH0GF_fizOewYafWbAMrpYhNYvBaRGFSKlVyrvA1plvWeU8P3rc-y7TjNieJjauszrHLKFv1sAd7S-tZw-lxh90uuj-z5tvkjvKdtmIy1_Or7E879eDtshj7LCVilDXTBdqINKF5WyQ8eNHU4_JHBMeHedL1IL5Vw0sD4gO_XWLHX2tecJzMx1LKl___rTewhR0nG5wMT1_BA07LB8QTGu3AxvxmYXYRY83z167xMvhy3_3lN3TUOKg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lupus+Anticoagulant+and+Abnormal+Coagulation+Tests+in+Patients+with+Covid-19&rft.jtitle=The+New+England+journal+of+medicine&rft.au=Bowles%2C+Louise&rft.au=Platton%2C+Sean&rft.au=Yartey%2C+Nada&rft.au=Dave%2C+Minal&rft.date=2020-07-16&rft.issn=1533-4406&rft.eissn=1533-4406&rft.volume=383&rft.issue=3&rft.spage=288&rft_id=info:doi/10.1056%2FNEJMc2013656&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-4793&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-4793&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-4793&client=summon |