Neutrophil-to-Lymphocyte Ratio and Intratumoral CD45RO-Positive T Cells as Predictive Factors for Longer Survival of Patients with Colorectal Liver Metastasis after Hepatectomy
Colorectal cancer is the fourth most common malignancy across the world, and over 50% of patients had colorectal liver metastases (CLM). Activated neutrophils and tumor-infiltrating lymphocytes (TILs) are considered to interrupt progression of primary colorectal cancer; however, immunological host r...
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| Published in | The Tohoku Journal of Experimental Medicine Vol. 251; no. 4; pp. 303 - 311 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tohoku University Medical Press
2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0040-8727 1349-3329 1349-3329 |
| DOI | 10.1620/tjem.251.303 |
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| Abstract | Colorectal cancer is the fourth most common malignancy across the world, and over 50% of patients had colorectal liver metastases (CLM). Activated neutrophils and tumor-infiltrating lymphocytes (TILs) are considered to interrupt progression of primary colorectal cancer; however, immunological host reactions to CLM have not been fully elucidated. We thus aimed to explore the prognostic implication of neutrophil-to-lymphocyte ratio (NLR) in peripheral blood and TILs in resected metastatic cancer tissues of 29 patients with CLM who underwent hepatectomy. To evaluate local immunological responses in CLM, we examined the infiltration of CD66b+ neutrophils and TILs, such as CD8+ T cells, CD45RO+ T cells, and forkhead box P3+ (FOXP3+) T cells. The presence of fewer than 4 tumors (p = 0.0005), the absence of distant metastasis (p = 0.018), adjuvant anti-cancer chemotherapy (p = 0.0013), and elevated NLR over 4.1 (p = 0.026) were found to be significant parameters related to longer survival after hepatectomy. Further, high numbers of infiltrated CD45RO+ T cells in CLM were significantly associated with longer patient survival (p = 0.020). The numbers of CD45RO+ T cells were correlated with those of CD8+ T cells (p = 0.008). The numbers of peripheral blood neutrophils were negatively correlated with those of CD45RO+ T cells (p = 0.038) and of CD66b+ neutrophils (p = 0.008) in CLM. The present data indicate that elevated peripheral blood NLR and high numbers of intratumoral CD45RO+ T cells are predictive of longer CLM patient survival after hepatectomy among current biomarkers. |
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| AbstractList | Colorectal cancer is the fourth most common malignancy across the world, and over 50% of patients had colorectal liver metastases (CLM). Activated neutrophils and tumor-infiltrating lymphocytes (TILs) are considered to interrupt progression of primary colorectal cancer; however, immunological host reactions to CLM have not been fully elucidated. We thus aimed to explore the prognostic implication of neutrophil-to-lymphocyte ratio (NLR) in peripheral blood and TILs in resected metastatic cancer tissues of 29 patients with CLM who underwent hepatectomy. To evaluate local immunological responses in CLM, we examined the infiltration of CD66b+ neutrophils and TILs, such as CD8+ T cells, CD45RO+ T cells, and forkhead box P3+ (FOXP3+) T cells. The presence of fewer than 4 tumors (p = 0.0005), the absence of distant metastasis (p = 0.018), adjuvant anti-cancer chemotherapy (p = 0.0013), and elevated NLR over 4.1 (p = 0.026) were found to be significant parameters related to longer survival after hepatectomy. Further, high numbers of infiltrated CD45RO+ T cells in CLM were significantly associated with longer patient survival (p = 0.020). The numbers of CD45RO+ T cells were correlated with those of CD8+ T cells (p = 0.008). The numbers of peripheral blood neutrophils were negatively correlated with those of CD45RO+ T cells (p = 0.038) and of CD66b+ neutrophils (p = 0.008) in CLM. The present data indicate that elevated peripheral blood NLR and high numbers of intratumoral CD45RO+ T cells are predictive of longer CLM patient survival after hepatectomy among current biomarkers.Colorectal cancer is the fourth most common malignancy across the world, and over 50% of patients had colorectal liver metastases (CLM). Activated neutrophils and tumor-infiltrating lymphocytes (TILs) are considered to interrupt progression of primary colorectal cancer; however, immunological host reactions to CLM have not been fully elucidated. We thus aimed to explore the prognostic implication of neutrophil-to-lymphocyte ratio (NLR) in peripheral blood and TILs in resected metastatic cancer tissues of 29 patients with CLM who underwent hepatectomy. To evaluate local immunological responses in CLM, we examined the infiltration of CD66b+ neutrophils and TILs, such as CD8+ T cells, CD45RO+ T cells, and forkhead box P3+ (FOXP3+) T cells. The presence of fewer than 4 tumors (p = 0.0005), the absence of distant metastasis (p = 0.018), adjuvant anti-cancer chemotherapy (p = 0.0013), and elevated NLR over 4.1 (p = 0.026) were found to be significant parameters related to longer survival after hepatectomy. Further, high numbers of infiltrated CD45RO+ T cells in CLM were significantly associated with longer patient survival (p = 0.020). The numbers of CD45RO+ T cells were correlated with those of CD8+ T cells (p = 0.008). The numbers of peripheral blood neutrophils were negatively correlated with those of CD45RO+ T cells (p = 0.038) and of CD66b+ neutrophils (p = 0.008) in CLM. The present data indicate that elevated peripheral blood NLR and high numbers of intratumoral CD45RO+ T cells are predictive of longer CLM patient survival after hepatectomy among current biomarkers. Colorectal cancer is the fourth most common malignancy across the world, and over 50% of patients had colorectal liver metastases (CLM). Activated neutrophils and tumor-infiltrating lymphocytes (TILs) are considered to interrupt progression of primary colorectal cancer; however, immunological host reactions to CLM have not been fully elucidated. We thus aimed to explore the prognostic implication of neutrophil-to-lymphocyte ratio (NLR) in peripheral blood and TILs in resected metastatic cancer tissues of 29 patients with CLM who underwent hepatectomy. To evaluate local immunological responses in CLM, we examined the infiltration of CD66b+ neutrophils and TILs, such as CD8+ T cells, CD45RO+ T cells, and forkhead box P3+ (FOXP3+) T cells. The presence of fewer than 4 tumors (p = 0.0005), the absence of distant metastasis (p = 0.018), adjuvant anti-cancer chemotherapy (p = 0.0013), and elevated NLR over 4.1 (p = 0.026) were found to be significant parameters related to longer survival after hepatectomy. Further, high numbers of infiltrated CD45RO+ T cells in CLM were significantly associated with longer patient survival (p = 0.020). The numbers of CD45RO+ T cells were correlated with those of CD8+ T cells (p = 0.008). The numbers of peripheral blood neutrophils were negatively correlated with those of CD45RO+ T cells (p = 0.038) and of CD66b+ neutrophils (p = 0.008) in CLM. The present data indicate that elevated peripheral blood NLR and high numbers of intratumoral CD45RO+ T cells are predictive of longer CLM patient survival after hepatectomy among current biomarkers. |
| Author | Haruyama, Yukihiro Nanashima, Atsushi Yano, Koichi Hamada, Takeomi Kondo, Kazuhiro Hamada, Roko Kataoka, Hiroaki Ishizaki, Hidenobu |
| Author_xml | – sequence: 1 fullname: Ishizaki, Hidenobu organization: Department of Surgery, University of Miyazaki Faculty of Medicine – sequence: 1 fullname: Hamada, Roko organization: Department of Surgery, University of Miyazaki Faculty of Medicine – sequence: 1 fullname: Hamada, Takeomi organization: Department of Surgery, University of Miyazaki Faculty of Medicine – sequence: 1 fullname: Yano, Koichi organization: Department of Surgery, University of Miyazaki Faculty of Medicine – sequence: 1 fullname: Haruyama, Yukihiro organization: Department of Pathology, University of Miyazaki Faculty of Medicine – sequence: 1 fullname: Kondo, Kazuhiro organization: Department of Surgery, University of Miyazaki Faculty of Medicine – sequence: 1 fullname: Nanashima, Atsushi organization: Department of Surgery, University of Miyazaki Faculty of Medicine – sequence: 1 fullname: Kataoka, Hiroaki organization: Department of Pathology, University of Miyazaki Faculty of Medicine |
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| Cites_doi | 10.1016/j.ctrv.2011.09.001 10.1016/j.imbio.2013.06.003 10.1007/s00534-011-0460-z 10.1002/path.2774 10.1245/s10434-012-2752-1 10.1038/bjc.2013.508 10.1126/science.1129139 10.1097/SLA.0b013e3181a3e738 10.18632/oncotarget.4180 10.1371/journal.pone.0030806 |
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| References_xml | – reference: Pagès, F., Berger, A., Camus, M., Sanchez-Cabo, F., Costes, A., Molidor, R., Mlecnik, B., Kirilovsky, A., Nilsson, M., Damotte, D., Meatchi, T., Bruneval, P., Cugnenc, P.H., Trajanoski, Z., Fridman, W.H., et al. (2005) Effector memory T cells, early metastasis, and survival in colorectal cancer. N. Engl. J. Med., 353, 2654-2666. – reference: Malik, H.Z., Prasad, K.R., Halazun, K.J., Aldoori, A., Al-Mukhtar, A., Gomez, D., Lodge, J.P. & Toogood, G.J. (2007) Preoperative prognostic score for predicting survival after hepatic resection for colorectal liver metastases. Ann. Surg., 246, 806-814. – reference: McMillan, D.C., Crozier, J.E., Canna, K., Angerson, W.J. & McArdle, C.S. (2007) Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer. Int. J. Colorectal Dis., 22, 881-886. – reference: Roxburgh, C.S., Salmond, J.M., Horgan, P.G., Oien, K.A. & McMillan, D.C. (2009) Comparison of the prognostic value of inflammation-based pathologic and biochemical criteria in patients undergoing potentially curative resection for colorectal cancer. Ann. Surg., 249, 788-793. – reference: Mlecnik, B., Tosolini, M., Kirilovsky, A., Berger, A., Bindea, G., Meatchi, T., Bruneval, P., Trajanoski, Z., Fridman, W.H., Pagès, F. & Galon, J. (2011) Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J. Clin. Oncol., 29, 610-618. – reference: Beppu, T., Sakamoto, Y., Hasegawa, K., Honda, G., Tanaka, K., Kotera, Y., Nitta, H., Yoshidome, H., Hatano, E., Ueno, M., Takamura, H., Baba, H., Kosuge, T., Kokudo, N., Takahashi, K., et al. (2012) A nomogram predicting disease-free survival in patients with colorectal liver metastases treated with hepatic resection: multicenter data collection as a Project Study for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J. Hepatobiliary Pancreat. Sci., 19, 72-84. – reference: Hu, G. & Wang, S. (2017) Tumor-infiltrating CD45RO(+) memory T lymphocytes predict favorable clinical outcome in solid tumors. Sci. Rep., 7, 10376. – reference: Ohno, A., Yorita, K., Haruyama, Y., Kondo, K., Kato, A., Ohtomo, T., Kawaguchi, M., Marutuska, K., Chijiiwa, K. & Kataoka, H. (2014) Aberrant expression of monocarboxylate transporter 4 in tumour cells predicts an unfavourable outcome in patients with hepatocellular carcinoma. Liver Int., 34, 942-952. – reference: Okano, K., Maeba, T., Moroguchi, A., Ishimura, K., Karasawa, Y., Izuishi, K., Goda, F., Usuki, H., Wakabayashi, H. & Maeta, H. (2003) Lymphocytic infiltration surrounding liver metastases from colorectal cancer. J. Surg. Oncol., 82, 28-33. – reference: Galdiero, M.R., Bonavita, E., Barajon, I., Garlanda, C., Mantovani, A. & Jaillon, S. (2013) Tumor associated macrophages and neutrophils in cancer. 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| Title | Neutrophil-to-Lymphocyte Ratio and Intratumoral CD45RO-Positive T Cells as Predictive Factors for Longer Survival of Patients with Colorectal Liver Metastasis after Hepatectomy |
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