Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways - Scholz, Carsten C.; Cavadas, Miguel A. S.; Tambuwala, Murtaza M.; Hams, Emily; Rodríguez, Javier; von Kriegsheim, Alex; Cotter, Philip; Bruning, Ulrike; Fallon, Padraic G.; Cheong, Alex; Cummins, Eoin P.; Taylor, Cormac T. (Proceedings of the National Academy of Sciences - PNAS, 2013)
Keywords: Analysis of Variance; animal models; Antiinflammatories; B lymphocytes; Biological Sciences; Blotting, Western; Enzymes; gene expression; Gene expression regulation; Gene Expression Regulation - physiology; HeLa Cells; Humans; Hydroxylation; Hypoxia; Hypoxia - metabolism; Hypoxia - physiopathology; Immunoprecipitation; Inflammation; Inflammation - metabolism; Inflammation - physiopathology; interleukin-1beta; Interleukin-1beta - metabolism; Luciferases; Mass Spectrometry; Mixed Function Oxygenases - metabolism; NF-kappa B - metabolism; Oxygen; Plasmids; procollagen-proline dioxygenase; Prolyl Hydroxylases - metabolism; Protein isoforms; signal transduction; Signal Transduction - physiology; tissues; transcription (genetics); transcription factor NF-kappa B; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism; tumor necrosis factors; inflammatory disease; UBC13; oxygen; OTUB1