Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts - Moiani, Arianna; Paleari, Ylenia; Sartori, Daniela; Mezzadra, Riccardo; Miccio, Annarita; Cattoglio, Claudia; Cocchiarella, Fabienne; Lidonnici, Maria Rosa; Ferrari, Giuliana; Mavilio, Fulvio (The Journal of clinical investigation, 2012)
Keywords: Alternative Splicing; Base Sequence; Biomedical research; Cells, Cultured; Cloning; Gene expression; Genes, Reporter; Genetic aspects; Genetic transcription; Genome, Human; Green Fluorescent Proteins - biosynthesis; Green Fluorescent Proteins - genetics; Host-Pathogen Interactions; Humans; Introns; Lentivirus; Lentivirus - genetics; Lentivirus - physiology; Lentivirus Infections - genetics; Microbial genetic engineering; Molecular Sequence Data; Mutant Chimeric Proteins - genetics; Mutant Chimeric Proteins - metabolism; Primary Cell Culture; Protein Isoforms - genetics; Protein Isoforms - metabolism; Real-Time Polymerase Chain Reaction; RNA Splice Sites; RNA Stability; RNA, Messenger - genetics; RNA, Messenger - metabolism; Transgenes; Virus Integration; Virus-vector relationships