Grape polyphenols decrease circulating branched chain amino acids in overfed adults
Dietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resistance in humans, and thus represents a suitable model of the metab...
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Published in | Frontiers in nutrition (Lausanne) Vol. 9; p. 998044 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
26.10.2022
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Online Access | Get full text |
ISSN | 2296-861X 2296-861X |
DOI | 10.3389/fnut.2022.998044 |
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Abstract | Dietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resistance in humans, and thus represents a suitable model of the metabolic complications resulting from obesity. We studied the effects of a polyphenol-rich grape extract supplementation on the plasma metabolome during an overfeeding intervention in adults, in two randomized parallel controlled clinical trials.
Blood plasma samples from 40 normal weight to overweight male adults, submitted to a 31-day overfeeding (additional 50% of energy requirement by a high calorie-high fructose diet), given either 2 g/day grape polyphenol extract or a placebo at 0, 15, 21, and 31 days were analyzed (Lyon study). Samples from a similarly designed trial on females (20 subjects) were collected in parallel (Lausanne study). Nuclear magnetic resonance (NMR)-based metabolomics was conducted to characterize metabolome changes induced by overfeeding and associated effects from polyphenol supplementation. The clinical trials are registered under the numbers NCT02145780 and NCT02225457 at ClinicalTrials.gov.
Changes in plasma levels of many metabolic markers, including branched chain amino acids (BCAA), ketone bodies and glucose in both placebo as well as upon polyphenol intervention were identified in the Lyon study. Polyphenol supplementation counterbalanced levels of BCAA found to be induced by overfeeding. These results were further corroborated in the Lausanne female study.
Administration of grape polyphenol-rich extract over 1 month period was associated with a protective metabolic effect against overfeeding in adults. |
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AbstractList | Dietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resistance in humans, and thus represents a suitable model of the metabolic complications resulting from obesity. We studied the effects of a polyphenol-rich grape extract supplementation on the plasma metabolome during an overfeeding intervention in adults, in two randomized parallel controlled clinical trials.
Blood plasma samples from 40 normal weight to overweight male adults, submitted to a 31-day overfeeding (additional 50% of energy requirement by a high calorie-high fructose diet), given either 2 g/day grape polyphenol extract or a placebo at 0, 15, 21, and 31 days were analyzed (Lyon study). Samples from a similarly designed trial on females (20 subjects) were collected in parallel (Lausanne study). Nuclear magnetic resonance (NMR)-based metabolomics was conducted to characterize metabolome changes induced by overfeeding and associated effects from polyphenol supplementation. The clinical trials are registered under the numbers NCT02145780 and NCT02225457 at ClinicalTrials.gov.
Changes in plasma levels of many metabolic markers, including branched chain amino acids (BCAA), ketone bodies and glucose in both placebo as well as upon polyphenol intervention were identified in the Lyon study. Polyphenol supplementation counterbalanced levels of BCAA found to be induced by overfeeding. These results were further corroborated in the Lausanne female study.
Administration of grape polyphenol-rich extract over 1 month period was associated with a protective metabolic effect against overfeeding in adults. Introduction and aimsDietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resistance in humans, and thus represents a suitable model of the metabolic complications resulting from obesity. We studied the effects of a polyphenol-rich grape extract supplementation on the plasma metabolome during an overfeeding intervention in adults, in two randomized parallel controlled clinical trials.MethodsBlood plasma samples from 40 normal weight to overweight male adults, submitted to a 31-day overfeeding (additional 50% of energy requirement by a high calorie-high fructose diet), given either 2 g/day grape polyphenol extract or a placebo at 0, 15, 21, and 31 days were analyzed (Lyon study). Samples from a similarly designed trial on females (20 subjects) were collected in parallel (Lausanne study). Nuclear magnetic resonance (NMR)-based metabolomics was conducted to characterize metabolome changes induced by overfeeding and associated effects from polyphenol supplementation. The clinical trials are registered under the numbers NCT02145780 and NCT02225457 at ClinicalTrials.gov.ResultsChanges in plasma levels of many metabolic markers, including branched chain amino acids (BCAA), ketone bodies and glucose in both placebo as well as upon polyphenol intervention were identified in the Lyon study. Polyphenol supplementation counterbalanced levels of BCAA found to be induced by overfeeding. These results were further corroborated in the Lausanne female study.ConclusionAdministration of grape polyphenol-rich extract over 1 month period was associated with a protective metabolic effect against overfeeding in adults. Introduction and aims Dietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resistance in humans, and thus represents a suitable model of the metabolic complications resulting from obesity. We studied the effects of a polyphenol-rich grape extract supplementation on the plasma metabolome during an overfeeding intervention in adults, in two randomized parallel controlled clinical trials. Methods Blood plasma samples from 40 normal weight to overweight male adults, submitted to a 31-day overfeeding (additional 50% of energy requirement by a high calorie-high fructose diet), given either 2 g/day grape polyphenol extract or a placebo at 0, 15, 21, and 31 days were analyzed (Lyon study). Samples from a similarly designed trial on females (20 subjects) were collected in parallel (Lausanne study). Nuclear magnetic resonance (NMR)-based metabolomics was conducted to characterize metabolome changes induced by overfeeding and associated effects from polyphenol supplementation. The clinical trials are registered under the numbers NCT02145780 and NCT02225457 at ClinicalTrials.gov. Results Changes in plasma levels of many metabolic markers, including branched chain amino acids (BCAA), ketone bodies and glucose in both placebo as well as upon polyphenol intervention were identified in the Lyon study. Polyphenol supplementation counterbalanced levels of BCAA found to be induced by overfeeding. These results were further corroborated in the Lausanne female study. Conclusion Administration of grape polyphenol-rich extract over 1 month period was associated with a protective metabolic effect against overfeeding in adults. Dietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resistance in humans, and thus represents a suitable model of the metabolic complications resulting from obesity. We studied the effects of a polyphenol-rich grape extract supplementation on the plasma metabolome during an overfeeding intervention in adults, in two randomized parallel controlled clinical trials.Introduction and aimsDietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resistance in humans, and thus represents a suitable model of the metabolic complications resulting from obesity. We studied the effects of a polyphenol-rich grape extract supplementation on the plasma metabolome during an overfeeding intervention in adults, in two randomized parallel controlled clinical trials.Blood plasma samples from 40 normal weight to overweight male adults, submitted to a 31-day overfeeding (additional 50% of energy requirement by a high calorie-high fructose diet), given either 2 g/day grape polyphenol extract or a placebo at 0, 15, 21, and 31 days were analyzed (Lyon study). Samples from a similarly designed trial on females (20 subjects) were collected in parallel (Lausanne study). Nuclear magnetic resonance (NMR)-based metabolomics was conducted to characterize metabolome changes induced by overfeeding and associated effects from polyphenol supplementation. The clinical trials are registered under the numbers NCT02145780 and NCT02225457 at ClinicalTrials.gov.MethodsBlood plasma samples from 40 normal weight to overweight male adults, submitted to a 31-day overfeeding (additional 50% of energy requirement by a high calorie-high fructose diet), given either 2 g/day grape polyphenol extract or a placebo at 0, 15, 21, and 31 days were analyzed (Lyon study). Samples from a similarly designed trial on females (20 subjects) were collected in parallel (Lausanne study). Nuclear magnetic resonance (NMR)-based metabolomics was conducted to characterize metabolome changes induced by overfeeding and associated effects from polyphenol supplementation. The clinical trials are registered under the numbers NCT02145780 and NCT02225457 at ClinicalTrials.gov.Changes in plasma levels of many metabolic markers, including branched chain amino acids (BCAA), ketone bodies and glucose in both placebo as well as upon polyphenol intervention were identified in the Lyon study. Polyphenol supplementation counterbalanced levels of BCAA found to be induced by overfeeding. These results were further corroborated in the Lausanne female study.ResultsChanges in plasma levels of many metabolic markers, including branched chain amino acids (BCAA), ketone bodies and glucose in both placebo as well as upon polyphenol intervention were identified in the Lyon study. Polyphenol supplementation counterbalanced levels of BCAA found to be induced by overfeeding. These results were further corroborated in the Lausanne female study.Administration of grape polyphenol-rich extract over 1 month period was associated with a protective metabolic effect against overfeeding in adults.ConclusionAdministration of grape polyphenol-rich extract over 1 month period was associated with a protective metabolic effect against overfeeding in adults. |
Author | Madrid-Gambin, Francisco Laville, Martine Vidal, Hubert Marco, Santiago Bartova, Simona Meugnier, Emmanuelle Moco, Sofia Delage, Pauline Boizot, Alexia Carayol, Jerome Hager, Jörg Vionnet, Nathalie Fernández, Luis Segrestin, Bérénice |
AuthorAffiliation | 1 Nestlé Research, EPFL Innovation Park , Lausanne , Switzerland 4 University of Lyon, CarMeN Laboratory and Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), INSERM, INRAE, Claude Bernard University Lyon 1 , Pierre-Bénite , France 5 Service d’Endocrinologie, Diabétologie et Métabolisme, CHU de Lausanne (CHUV) , Lausanne , Switzerland 3 Department of Electronics and Biomedical Engineering, Universitat de Barcelona , Barcelona , Spain 2 Signal and Information Processing for Sensing Systems, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology , Barcelona , Spain |
AuthorAffiliation_xml | – name: 2 Signal and Information Processing for Sensing Systems, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology , Barcelona , Spain – name: 4 University of Lyon, CarMeN Laboratory and Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), INSERM, INRAE, Claude Bernard University Lyon 1 , Pierre-Bénite , France – name: 1 Nestlé Research, EPFL Innovation Park , Lausanne , Switzerland – name: 3 Department of Electronics and Biomedical Engineering, Universitat de Barcelona , Barcelona , Spain – name: 5 Service d’Endocrinologie, Diabétologie et Métabolisme, CHU de Lausanne (CHUV) , Lausanne , Switzerland |
Author_xml | – sequence: 1 givenname: Simona surname: Bartova fullname: Bartova, Simona – sequence: 2 givenname: Francisco surname: Madrid-Gambin fullname: Madrid-Gambin, Francisco – sequence: 3 givenname: Luis surname: Fernández fullname: Fernández, Luis – sequence: 4 givenname: Jerome surname: Carayol fullname: Carayol, Jerome – sequence: 5 givenname: Emmanuelle surname: Meugnier fullname: Meugnier, Emmanuelle – sequence: 6 givenname: Bérénice surname: Segrestin fullname: Segrestin, Bérénice – sequence: 7 givenname: Pauline surname: Delage fullname: Delage, Pauline – sequence: 8 givenname: Nathalie surname: Vionnet fullname: Vionnet, Nathalie – sequence: 9 givenname: Alexia surname: Boizot fullname: Boizot, Alexia – sequence: 10 givenname: Martine surname: Laville fullname: Laville, Martine – sequence: 11 givenname: Hubert surname: Vidal fullname: Vidal, Hubert – sequence: 12 givenname: Santiago surname: Marco fullname: Marco, Santiago – sequence: 13 givenname: Jörg surname: Hager fullname: Hager, Jörg – sequence: 14 givenname: Sofia surname: Moco fullname: Moco, Sofia |
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Copyright | Copyright © 2022 Bartova, Madrid-Gambin, Fernández, Carayol, Meugnier, Segrestin, Delage, Vionnet, Boizot, Laville, Vidal, Marco, Hager and Moco. Attribution Copyright © 2022 Bartova, Madrid-Gambin, Fernández, Carayol, Meugnier, Segrestin, Delage, Vionnet, Boizot, Laville, Vidal, Marco, Hager and Moco. 2022 Bartova, Madrid-Gambin, Fernández, Carayol, Meugnier, Segrestin, Delage, Vionnet, Boizot, Laville, Vidal, Marco, Hager and Moco |
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Keywords | NMR grape polyphenols metabolomics human trials metabolism branched chain amino acids overfeeding obesity |
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License | Copyright © 2022 Bartova, Madrid-Gambin, Fernández, Carayol, Meugnier, Segrestin, Delage, Vionnet, Boizot, Laville, Vidal, Marco, Hager and Moco. Attribution: http://creativecommons.org/licenses/by This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. cc-by |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Martin Kussmann, Nuritas Limited, Ireland Reviewed by: Giuseppina Costabile, University of Naples Federico II, Italy; Jara Pérez-Jiménez, Institute of Science and Technology of Food and Nutrition (CSIC), Spain This article was submitted to Nutrition and Metabolism, a section of the journal Frontiers in Nutrition Present address: Francisco Madrid-Gambin, Applied Metabolomics Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Sofia Moco, Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands |
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Snippet | Dietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to... Introduction and aims Dietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases.... Introduction and aimsDietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases.... |
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SubjectTerms | branched chain amino acids Food and Nutrition grape polyphenols Life Sciences metabolomics NMR Nutrition obesity overfeeding |
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Title | Grape polyphenols decrease circulating branched chain amino acids in overfed adults |
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