Screening of single nucleotide polymorphisms among fuchs’ endothelial corneal dystrophy subjects in Malaysia
Background The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic predisposition being reported as the single best predictor of the disease. Genetic studies have shown that several genes in various loci such a...
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| Published in | Egyptian Journal of Medical Human Genetics Vol. 22; no. 1; pp. 73 - 11 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
15.09.2021
Springer Springer Nature B.V SpringerOpen |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1110-8630 2090-2441 |
| DOI | 10.1186/s43042-021-00193-6 |
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| Abstract | Background
The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic predisposition being reported as the single best predictor of the disease. Genetic studies have shown that several genes in various loci such as
COL8A2, SLC4A11, TCF8/ZEB1
and
TCF4
are associated with FECD in different populations and ethnicities. A case–control study was conducted to determine the association between genetic variants and FECD in a tertiary care setting in Malaysia. A total number of 12 patients with clinically diagnosed FECD and 12 age, gender and race matched control subjects were recruited. Extracted genomic DNA were genotyped using Infinium Global Screening Array (GSA)-24 version 1.0 BeadChip with iScan high-throughput system. Illumina GenomeStudio 2.0 Data Analysis and PLINK version 1.9 software were used to perform association tests and determine the distribution of obtained variants among the cases and controls.
Results
A significant novel genetic variant,
rs11626651
, a variant of the
LOC105370676
gene or known as the
LINC02320
gene, located at chromosome 14, has been identified as a suggestive association with FECD (
p
< 5 × 10
−6
). Further analysis in this study suggested that candidate genes such as
COL8A2, ZEB1/TCF8, TCF4
and
SLC4A11
had no significant associations with FECD.
Conclusions
The discovery of a novel variant may influence the underlying pathogenic basis of FECD in Malaysia. The current study is the first genetic study on FECD to use Infinium GSA. It is the first comprehensive report in Malaysia to provide genetic information of potential relevance to FECD, which may pave the way for new therapeutic strategies in the future. A detailed analysis with a larger sample size is recommended for further evaluation. |
|---|---|
| AbstractList | The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic predisposition being reported as the single best predictor of the disease. Genetic studies have shown that several genes in various loci such as COL8A2, SLC4A11, TCF8/ZEB1 and TCF4 are associated with FECD in different populations and ethnicities. A case-control study was conducted to determine the association between genetic variants and FECD in a tertiary care setting in Malaysia. A total number of 12 patients with clinically diagnosed FECD and 12 age, gender and race matched control subjects were recruited. Extracted genomic DNA were genotyped using Infinium Global Screening Array (GSA)-24 version 1.0 BeadChip with iScan high-throughput system. Illumina GenomeStudio 2.0 Data Analysis and PLINK version 1.9 software were used to perform association tests and determine the distribution of obtained variants among the cases and controls. A significant novel genetic variant, rs11626651, a variant of the LOC105370676 gene or known as the LINC02320 gene, located at chromosome 14, has been identified as a suggestive association with FECD (p < 5 x 10.sup.-6). Further analysis in this study suggested that candidate genes such as COL8A2, ZEB1/TCF8, TCF4 and SLC4A11 had no significant associations with FECD. The discovery of a novel variant may influence the underlying pathogenic basis of FECD in Malaysia. The current study is the first genetic study on FECD to use Infinium GSA. It is the first comprehensive report in Malaysia to provide genetic information of potential relevance to FECD, which may pave the way for new therapeutic strategies in the future. A detailed analysis with a larger sample size is recommended for further evaluation. Background The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic predisposition being reported as the single best predictor of the disease. Genetic studies have shown that several genes in various loci such as COL8A2, SLC4A11, TCF8/ZEB1 and TCF4 are associated with FECD in different populations and ethnicities. A case–control study was conducted to determine the association between genetic variants and FECD in a tertiary care setting in Malaysia. A total number of 12 patients with clinically diagnosed FECD and 12 age, gender and race matched control subjects were recruited. Extracted genomic DNA were genotyped using Infinium Global Screening Array (GSA)-24 version 1.0 BeadChip with iScan high-throughput system. Illumina GenomeStudio 2.0 Data Analysis and PLINK version 1.9 software were used to perform association tests and determine the distribution of obtained variants among the cases and controls. Results A significant novel genetic variant, rs11626651 , a variant of the LOC105370676 gene or known as the LINC02320 gene, located at chromosome 14, has been identified as a suggestive association with FECD ( p < 5 × 10 −6 ). Further analysis in this study suggested that candidate genes such as COL8A2, ZEB1/TCF8, TCF4 and SLC4A11 had no significant associations with FECD. Conclusions The discovery of a novel variant may influence the underlying pathogenic basis of FECD in Malaysia. The current study is the first genetic study on FECD to use Infinium GSA. It is the first comprehensive report in Malaysia to provide genetic information of potential relevance to FECD, which may pave the way for new therapeutic strategies in the future. A detailed analysis with a larger sample size is recommended for further evaluation. Background The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic predisposition being reported as the single best predictor of the disease. Genetic studies have shown that several genes in various loci such as COL8A2, SLC4A11, TCF8/ZEB1 and TCF4 are associated with FECD in different populations and ethnicities. A case-control study was conducted to determine the association between genetic variants and FECD in a tertiary care setting in Malaysia. A total number of 12 patients with clinically diagnosed FECD and 12 age, gender and race matched control subjects were recruited. Extracted genomic DNA were genotyped using Infinium Global Screening Array (GSA)-24 version 1.0 BeadChip with iScan high-throughput system. Illumina GenomeStudio 2.0 Data Analysis and PLINK version 1.9 software were used to perform association tests and determine the distribution of obtained variants among the cases and controls. Results A significant novel genetic variant, rs11626651, a variant of the LOC105370676 gene or known as the LINC02320 gene, located at chromosome 14, has been identified as a suggestive association with FECD (p < 5 x 10.sup.-6). Further analysis in this study suggested that candidate genes such as COL8A2, ZEB1/TCF8, TCF4 and SLC4A11 had no significant associations with FECD. Conclusions The discovery of a novel variant may influence the underlying pathogenic basis of FECD in Malaysia. The current study is the first genetic study on FECD to use Infinium GSA. It is the first comprehensive report in Malaysia to provide genetic information of potential relevance to FECD, which may pave the way for new therapeutic strategies in the future. A detailed analysis with a larger sample size is recommended for further evaluation. BackgroundThe pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic predisposition being reported as the single best predictor of the disease. Genetic studies have shown that several genes in various loci such as COL8A2, SLC4A11, TCF8/ZEB1 and TCF4 are associated with FECD in different populations and ethnicities. A case–control study was conducted to determine the association between genetic variants and FECD in a tertiary care setting in Malaysia. A total number of 12 patients with clinically diagnosed FECD and 12 age, gender and race matched control subjects were recruited. Extracted genomic DNA were genotyped using Infinium Global Screening Array (GSA)-24 version 1.0 BeadChip with iScan high-throughput system. Illumina GenomeStudio 2.0 Data Analysis and PLINK version 1.9 software were used to perform association tests and determine the distribution of obtained variants among the cases and controls.ResultsA significant novel genetic variant, rs11626651, a variant of the LOC105370676 gene or known as the LINC02320 gene, located at chromosome 14, has been identified as a suggestive association with FECD (p < 5 × 10−6). Further analysis in this study suggested that candidate genes such as COL8A2, ZEB1/TCF8, TCF4 and SLC4A11 had no significant associations with FECD.ConclusionsThe discovery of a novel variant may influence the underlying pathogenic basis of FECD in Malaysia. The current study is the first genetic study on FECD to use Infinium GSA. It is the first comprehensive report in Malaysia to provide genetic information of potential relevance to FECD, which may pave the way for new therapeutic strategies in the future. A detailed analysis with a larger sample size is recommended for further evaluation. Abstract Background The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic predisposition being reported as the single best predictor of the disease. Genetic studies have shown that several genes in various loci such as COL8A2, SLC4A11, TCF8/ZEB1 and TCF4 are associated with FECD in different populations and ethnicities. A case–control study was conducted to determine the association between genetic variants and FECD in a tertiary care setting in Malaysia. A total number of 12 patients with clinically diagnosed FECD and 12 age, gender and race matched control subjects were recruited. Extracted genomic DNA were genotyped using Infinium Global Screening Array (GSA)-24 version 1.0 BeadChip with iScan high-throughput system. Illumina GenomeStudio 2.0 Data Analysis and PLINK version 1.9 software were used to perform association tests and determine the distribution of obtained variants among the cases and controls. Results A significant novel genetic variant, rs11626651, a variant of the LOC105370676 gene or known as the LINC02320 gene, located at chromosome 14, has been identified as a suggestive association with FECD (p < 5 × 10−6). Further analysis in this study suggested that candidate genes such as COL8A2, ZEB1/TCF8, TCF4 and SLC4A11 had no significant associations with FECD. Conclusions The discovery of a novel variant may influence the underlying pathogenic basis of FECD in Malaysia. The current study is the first genetic study on FECD to use Infinium GSA. It is the first comprehensive report in Malaysia to provide genetic information of potential relevance to FECD, which may pave the way for new therapeutic strategies in the future. A detailed analysis with a larger sample size is recommended for further evaluation. |
| Audience | Professional Academic |
| Author | Ng, Ker Hsin Ramachandran, Vasudevan Subrayan, Visvaraja Ismail, Fazliana |
| Author_xml | – sequence: 1 givenname: Ker Hsin surname: Ng fullname: Ng, Ker Hsin email: alene.khng@gmail.com organization: Department of Ophthalmology, University Malaya Medical Centre – sequence: 2 givenname: Visvaraja surname: Subrayan fullname: Subrayan, Visvaraja organization: Department of Ophthalmology, Faculty of Medicine, University of Malaya – sequence: 3 givenname: Vasudevan surname: Ramachandran fullname: Ramachandran, Vasudevan email: vasuphd@gmail.com organization: Malaysian Research Institute of Ageing, Universiti Putra Malaysia, Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research – sequence: 4 givenname: Fazliana orcidid: 0000-0002-5117-3169 surname: Ismail fullname: Ismail, Fazliana email: ifazliana@gmail.com organization: Department of Ophthalmology, Faculty of Medicine, University of Malaya |
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| Cites_doi | 10.1167/iovs.11-7568 10.1111/acer.13614 10.1016/0039-6257(93)90099-S 10.1016/0002-9394(67)93073-5 10.1093/hmg/ddm337 10.1586/eop.12.39 10.1371/journal.pgen.1002654 10.1038/ejhg.2013.72 10.1186/1471-2415-10-3 10.1016/j.ophtha.2006.10.049 10.1167/iovs.09-3764 10.1167/iovs.07-1529 10.1016/j.ophtha.2005.12.014 10.1167/iovs.04-0937 10.1038/nrm.2017.104 10.1167/iovs.07-0847 10.1016/j.ajhg.2009.12.001 10.1007/s00439-014-1512-7 10.1016/j.trecan.2015.08.010 10.1167/iovs.14-14958 10.1159/000063656 10.1038/s41598-016-0001-8 10.3390/ijms17040478 10.1371/journal.pone.0018044 10.1093/hmg/ddt156 10.1007/s10384-003-0063-6 10.2353/ajpath.2010.100279 10.1038/eye.2014.145 10.1056/NEJMoa1007064 10.1016/j.ccr.2007.07.027 10.1167/iovs.13-11918 10.1038/nrg2521 10.1167/iovs.16-19097 10.1167/iovs.05-1619 10.1167/iovs.14-15297 10.1158/0008-5472.CAN-10-2483 10.1097/ICO.0000000000000389 10.1002/ana.25216 10.1534/genetics.112.146704 10.1167/iovs.02-0268 10.1167/iovs.05-0578 10.1016/j.molcel.2015.05.004 10.1007/s11033-014-3320-5 10.1073/pnas.0904715106 10.1167/iovs.13-13221 |
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| References | Jurkunas, Bitar, Funaki, Azizi (CR6) 2010; 177 Hemadevi, Srinivasan, Arunkumar, Prajna, Sundaresan (CR13) 2010; 10 Ransohoff, Wei, Khavari (CR31) 2018; 19 Glöckle, Kohl, Mohr, Scheurenbrand, Sprecher, Weisschuh (CR22) 2014; 22 Thalamuthu, Khor, Venkataraman, Koh, Tan, Aung (CR44) 2011; 52 Lorenzetti, Uotila, Parikh, Kaufman (CR2) 1967; 64 Riazuddin, Eghrari, Al-Saif, Davey, Meadows, Katsanis (CR18) 2009; 50 Riazuddin, Zaghloul, Al-Saif, Davey, Diplas, Meadows (CR19) 2010; 86 Baratz, Tosakulwong, Ryu, Brown, Branham, Chen (CR20) 2010; 363 Sundin, Broman, Chang, Vito, Stark, Gottsch (CR17) 2006; 47 Mueller, Färber, Prüss, Melzer, Golombeck, Kümpfel (CR25) 2018; 83 Calin, Liu, Ferracin, Hyslop, Spizzo, Sevignani (CR35) 2007; 12 Wang, Handa, Green, Stark, Weinberg, Jun (CR8) 2007; 114 Gottsch, Sundin, Liu, Jun, Broman, Stark (CR15) 2005; 46 Chandra, Mitry, Wright, Campbell, Charteris (CR21) 2014; 28 Nanda, Padhy, Samal, Das, Alone (CR45) 2014; 55 Vithana, Morgan, Ramprasad, Tan, Yong, Venkataraman (CR12) 2008; 17 Sundin, Jun, Broman, Liu, Sheehan, Vito (CR16) 2006; 47 Mustafi, Kevany, Bai, Maeda, Sears, Khalil (CR37) 2013; 22 Wieben, Aleff, Eckloff, Atkinson, Baheti, Middha (CR47) 2014; 55 Xu, Li, Li, Yao, Qin, Yan (CR38) 2014; 41 Liu, Vojnovic, Kochevar, Jurkunas (CR10) 2016; 57 Gelernter, Zhou, Nuñez, Mutirangura, Malison, Kalayasiri (CR24) 2018; 42 Reuter, Spacek, Snyder (CR27) 2015; 58 Yan, Tao, Li, Zhang, Yao, Jiang (CR39) 2014; 55 Kobayashi, Fujiki, Murakami, Kato, Chen, Onoe (CR46) 2004; 48 Li, Wen, Zhang, Fan (CR33) 2016; 17 CR28 Mercer, Dinger, Mattick (CR30) 2009; 10 Iliff, Riazuddin, Gottsch (CR14) 2012; 7 CR26 Tsai, Spitale, Chang (CR32) 2011; 71 Sahu, Singhal, Chinnaiyan (CR34) 2015; 1 Li, Minear, Rimmler, Zhao, Balajonda, Hauser (CR42) 2011; 6 Mehta, Vithana, Tan, Yong, Yam, Law (CR43) 2008; 49 Kitagawa, Kojima, Sasaki, Shui, Chew, Cheng (CR4) 2002; 34 Khalil, Guttman, Huarte, Garber, Raj, Morales (CR36) 2009; 106 Adamis, Filatov, Tripathi (CR1) 1993; 38 Kaji, Amano, Usui, Oshika, Yamashiro, Ishida (CR7) 2003; 44 Jurkunas, Rawe, Bitar, Zhu, Harris, Colby (CR5) 2008; 49 Zhao, Wang, Wang, Li, Alexander, Wang (CR23) 2015; 134 Zoega, Fujisawa, Sasaki, Kubota, Sasaki, Kitagawa (CR3) 2006; 113 Tiwari, Bahr, Bähr, Fleischhauer, Zinkernagel, Winkler (CR11) 2016; 6 Wiggs, Yaspan, Hauser, Kang, Allingham, Olson (CR40) 2012; 8 Kung, Colognori, Lee (CR29) 2013; 193 Huang, Li, Liu, Zhang, Li, Wang (CR41) 2015; 34 Zhang, Igo, Fondran, Mootha, Oliva, Hammersmith (CR9) 2013; 54 |
| References_xml | – volume: 52 start-page: 5573 issue: 8 year: 2011 end-page: 5578 ident: CR44 article-title: Association of TCF4 gene polymorphisms with Fuchs' corneal dystrophy in the Chinese publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.11-7568 – volume: 42 start-page: 861 issue: 5 year: 2018 end-page: 868 ident: CR24 article-title: Genome-wide association study of alcohol dependence and related traits in a Thai population publication-title: Alcohol Clin Exp Res doi: 10.1111/acer.13614 – volume: 38 start-page: 149 issue: 2 year: 1993 end-page: 168 ident: CR1 article-title: Fuchs' endothelial dystrophy of the cornea publication-title: Surv Ophthalmol doi: 10.1016/0039-6257(93)90099-S – volume: 64 start-page: 1155 issue: 6 year: 1967 end-page: 1158 ident: CR2 article-title: Central cornea guttata: incidence in the general population publication-title: Am J Ophthalmol doi: 10.1016/0002-9394(67)93073-5 – volume: 17 start-page: 656 issue: 5 year: 2008 end-page: 666 ident: CR12 article-title: SLC4A11 mutations in Fuchs endothelial corneal dystrophy publication-title: Hum Mol Genet doi: 10.1093/hmg/ddm337 – volume: 7 start-page: 363 issue: 4 year: 2012 end-page: 375 ident: CR14 article-title: The genetics of Fuchs’ corneal dystrophy publication-title: Exp Rev Ophthalmol doi: 10.1586/eop.12.39 – volume: 8 start-page: e1002654 issue: 4 year: 2012 ident: CR40 article-title: Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma publication-title: PLoS Genet doi: 10.1371/journal.pgen.1002654 – volume: 22 start-page: 99 issue: 1 year: 2014 end-page: 104 ident: CR22 article-title: Panel-based next generation sequencing as a reliable and efficient technique to detect mutations i- unselected patients with retinal dystrophies publication-title: Eur J Hum Genet doi: 10.1038/ejhg.2013.72 – volume: 10 start-page: 1 issue: 1 year: 2010 end-page: 6 ident: CR13 article-title: Genetic analysis of patients with Fuchs endothelial corneal dystrophy in India publication-title: BMC Ophthalmol doi: 10.1186/1471-2415-10-3 – volume: 114 start-page: 1453 issue: 8 year: 2007 end-page: 1460 ident: CR8 article-title: Advanced glycation end products and receptors in Fuchs’ dystrophy corneas undergoing Descemet’s stripping with endothelial keratoplasty publication-title: Ophthalmology doi: 10.1016/j.ophtha.2006.10.049 – volume: 50 start-page: 5667 issue: 12 year: 2009 end-page: 5671 ident: CR18 article-title: Linkage of a mild late-onset phenotype of Fuchs corneal dystrophy to a novel locus at 5q33. 1–q35. 2 publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.09-3764 – volume: 49 start-page: 2956 issue: 7 year: 2008 end-page: 2963 ident: CR5 article-title: Decreased expression of peroxiredoxins in Fuchs’ endothelial dystrophy publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.07-1529 – volume: 113 start-page: 565 issue: 4 year: 2006 end-page: 569 ident: CR3 article-title: Prevalence and risk factors for cornea guttata in the Reykjavik Eye Study publication-title: Ophthalmology doi: 10.1016/j.ophtha.2005.12.014 – volume: 46 start-page: 1934 issue: 6 year: 2005 end-page: 1939 ident: CR15 article-title: Inheritance of a novel COL8A2 mutation defines a distinct early-onset subtype of fuchs corneal dystrophy publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.04-0937 – volume: 19 start-page: 143 issue: 3 year: 2018 ident: CR31 article-title: The functions and unique features of long intergenic non-coding RNA publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm.2017.104 – volume: 49 start-page: 184 issue: 1 year: 2008 end-page: 188 ident: CR43 article-title: Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.07-0847 – volume: 86 start-page: 45 issue: 1 year: 2010 end-page: 53 ident: CR19 article-title: Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2009.12.001 – volume: 134 start-page: 217 issue: 2 year: 2015 end-page: 230 ident: CR23 article-title: Next-generation sequencing-based molecular diagnosis of 82 retinitis pigmentosa probands from Northern Ireland publication-title: Hum Genet doi: 10.1007/s00439-014-1512-7 – volume: 1 start-page: 93 issue: 2 year: 2015 end-page: 109 ident: CR34 article-title: Long noncoding RNAs in cancer: from function to translation publication-title: Trends Cancer doi: 10.1016/j.trecan.2015.08.010 – volume: 55 start-page: 6101 issue: 9 year: 2014 end-page: 6107 ident: CR47 article-title: Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.14-14958 – volume: 34 start-page: 135 issue: 3 year: 2002 end-page: 138 ident: CR4 article-title: Prevalence of primary cornea guttata and morphology of corneal endothelium in aging Japanese and Singaporean subjects publication-title: Ophthalmic Res doi: 10.1159/000063656 – volume: 6 start-page: 1 issue: 1 year: 2016 end-page: 1 ident: CR11 article-title: Next generation sequencing based identification of disease-associated mutations in Swiss patients with retinal dystrophies publication-title: Sci Rep doi: 10.1038/s41598-016-0001-8 – volume: 17 start-page: 478 issue: 4 year: 2016 ident: CR33 article-title: Novel insights into the role of long noncoding RNA in ocular diseases publication-title: Int J Mol Sci doi: 10.3390/ijms17040478 – volume: 6 start-page: e18044 issue: 4 year: 2011 ident: CR42 article-title: Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy publication-title: PLoS ONE doi: 10.1371/journal.pone.0018044 – volume: 22 start-page: 2992 issue: 15 year: 2013 end-page: 3002 ident: CR37 article-title: Evolutionarily conserved long intergenic non-coding RNAs in the eye publication-title: Hum Mol Genet doi: 10.1093/hmg/ddt156 – volume: 48 start-page: 195 issue: 3 year: 2004 end-page: 198 ident: CR46 article-title: Analysis of COL8A2 gene mutation in Japanese patients with Fuchs’ endothelial dystrophy and posterior polymorphous dystrophy publication-title: Jpn J Ophthalmol doi: 10.1007/s10384-003-0063-6 – volume: 177 start-page: 2278 issue: 5 year: 2010 end-page: 2289 ident: CR6 article-title: Evidence of oxidative stress in the pathogenesis of fuchs endothelial corneal dystrophy publication-title: Am J Clin Pathol doi: 10.2353/ajpath.2010.100279 – volume: 28 start-page: 1066 issue: 9 year: 2014 end-page: 1079 ident: CR21 article-title: Genome-wide association studies: applications and insights gained in ophthalmology publication-title: Eye doi: 10.1038/eye.2014.145 – volume: 363 start-page: 1016 issue: 11 year: 2010 end-page: 1024 ident: CR20 article-title: E2–2 protein and Fuchs's corneal dystrophy publication-title: N Engl J Med doi: 10.1056/NEJMoa1007064 – volume: 12 start-page: 215 issue: 3 year: 2007 end-page: 229 ident: CR35 article-title: Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas publication-title: Cancer Cell doi: 10.1016/j.ccr.2007.07.027 – volume: 54 start-page: 5829 issue: 8 year: 2013 end-page: 5835 ident: CR9 article-title: Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.13-11918 – volume: 10 start-page: 155 issue: 3 year: 2009 end-page: 159 ident: CR30 article-title: Long non-coding RNAs: insights into functions publication-title: Nat Rev Genet doi: 10.1038/nrg2521 – volume: 57 start-page: 2319 issue: 4 year: 2016 end-page: 2327 ident: CR10 article-title: UV-A irradiation activates Nrf2-regulated antioxidant defense and induces p53/caspase3-dependent apoptosis in corneal endothelial cells publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.16-19097 – volume: 47 start-page: 3919 issue: 9 year: 2006 end-page: 3926 ident: CR17 article-title: A common locus for late-onset Fuchs corneal dystrophy maps to 18q21. 2–q21. 32 publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.05-1619 – volume: 55 start-page: 7674 issue: 11 year: 2014 end-page: 7680 ident: CR45 article-title: Genetic association of TCF4 intronic polymorphisms, CTG18. 1 and rs17089887, with Fuchs' endothelial corneal dystrophy in an Indian population publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.14-15297 – volume: 71 start-page: 3 issue: 1 year: 2011 end-page: 7 ident: CR32 article-title: Long intergenic noncoding RNAs: new links in cancer progression publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-10-2483 – volume: 34 start-page: 580 issue: 5 year: 2015 end-page: 587 ident: CR41 article-title: Identification of corneal neovascularization-related long noncoding RNAs through microarray analysis publication-title: Cornea doi: 10.1097/ICO.0000000000000389 – volume: 83 start-page: 863 issue: 4 year: 2018 end-page: 869 ident: CR25 article-title: Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis publication-title: Ann Neurol doi: 10.1002/ana.25216 – volume: 193 start-page: 651 issue: 3 year: 2013 end-page: 669 ident: CR29 article-title: Long noncoding RNAs: past, present, and future publication-title: Genetics doi: 10.1534/genetics.112.146704 – volume: 44 start-page: 521 issue: 2 year: 2003 end-page: 528 ident: CR7 article-title: Expression and function of receptors for advanced glycation end products in bovine corneal endothelial cells publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.02-0268 – volume: 47 start-page: 140 issue: 1 year: 2006 end-page: 145 ident: CR16 article-title: Linkage of late-onset Fuchs corneal dystrophy to a novel locus at 13pTel-13q12. 13 publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.05-0578 – ident: CR28 – ident: CR26 – volume: 58 start-page: 586 issue: 4 year: 2015 end-page: 597 ident: CR27 article-title: High-throughput sequencing technologies publication-title: Mol cell doi: 10.1016/j.molcel.2015.05.004 – volume: 41 start-page: 4493 issue: 7 year: 2014 end-page: 4505 ident: CR38 article-title: Long non-coding RNAs: new players in ocular neovascularization publication-title: Mol Biol Rep doi: 10.1007/s11033-014-3320-5 – volume: 106 start-page: 11667 issue: 28 year: 2009 end-page: 11672 ident: CR36 article-title: Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0904715106 – volume: 55 start-page: 941 issue: 2 year: 2014 end-page: 951 ident: CR39 article-title: Aberrant expression of long noncoding RNAs in early diabetic retinopathy publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.13-13221 |
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The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic... Background The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic... The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic predisposition... BackgroundThe pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a genetic... Abstract Background The pathophysiology underlying Fuchs' Endothelial Corneal Dystrophy (FECD), especially in older individuals, remains unclear, with a... |
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| SubjectTerms | Analysis Chromosome 14 Cornea Corneal dystrophy Endothelial corneal dystrophy Endothelium Fuchs Genes Genetic aspects Genetic diversity Genetic polymorphism Health aspects Illumina Information management Medical research Medicine Medicine & Public Health Medicine, Experimental Pathophysiology Single nucleotide polymorphisms Single-nucleotide polymorphism |
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| Title | Screening of single nucleotide polymorphisms among fuchs’ endothelial corneal dystrophy subjects in Malaysia |
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