Finite element models can reproduce the effect of nucleotomy on the multi-axial compliance of human intervertebral discs

Finite element (FE) models can unravel the link between intervertebral disc (IVD) degeneration and its mechanical behaviour. Nucleotomy may provide the data required for model verification. Three human IVDs were scanned with MRI and tested in multiple loading scenarios, prior and post nucleotomy. Th...

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Published inComputer methods in biomechanics and biomedical engineering Vol. 23; no. 13; pp. 934 - 944
Main Authors Stadelmann, Marc A., Stocker, Roland, Maquer, Ghislain, Hoppe, Sven, Vermathen, Peter, Alkalay, Ron N., Zysset, Philippe K.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 02.10.2020
Taylor & Francis Ltd
Subjects
Adult
Calibration
Computer Simulation
Degeneration
Female
Finite Element Analysis
Finite element method
finite element modeling
Humans
Intervertebral disc
Intervertebral Disc - diagnostic imaging
Intervertebral Disc - physiopathology
Intervertebral Disc - surgery
Intervertebral discs
in vitro testing
Magnetic Resonance Imaging
Mathematical models
Mechanical properties
nucleotomy
Nucleus Pulposus - diagnostic imaging
Nucleus Pulposus - surgery
Range of Motion, Articular
finite element modeling
magnetic resonance imaging
in vitro testing
Intervertebral disc
nucleotomy
Online AccessGet full text
ISSN1025-5842
1476-8259
1476-8259
DOI10.1080/10255842.2020.1773808

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Abstract Finite element (FE) models can unravel the link between intervertebral disc (IVD) degeneration and its mechanical behaviour. Nucleotomy may provide the data required for model verification. Three human IVDs were scanned with MRI and tested in multiple loading scenarios, prior and post nucleotomy. The resulting data was used to generate, calibrate, and verify the FE models. Nucleotomy increased the experimental range of motion by 26%, a result reproduced by the FE simulation within a 5% error. This work demonstrates the ability of FE models to reproduce the mechanical compliance of human IVDs prior and post nucleotomy.
AbstractList Finite element (FE) models can unravel the link between intervertebral disc (IVD) degeneration and its mechanical behaviour. Nucleotomy may provide the data required for model verification. Three human IVDs were scanned with MRI and tested in multiple loading scenarios, prior and post nucleotomy. The resulting data was used to generate, calibrate, and verify the FE models. Nucleotomy increased the experimental range of motion by 26%, a result reproduced by the FE simulation within a 5% error. This work demonstrates the ability of FE models to reproduce the mechanical compliance of human IVDs prior and post nucleotomy.
Finite element (FE) models can unravel the link between intervertebral disc (IVD) degeneration and its mechanical behaviour. Nucleotomy may provide the data required for model verification. Three human IVDs were scanned with MRI and tested in multiple loading scenarios, prior and post nucleotomy. The resulting data was used to generate, calibrate, and verify the FE models. Nucleotomy increased the experimental range of motion by 26%, a result reproduced by the FE simulation within a 5% error. This work demonstrates the ability of FE models to reproduce the mechanical compliance of human IVDs prior and post nucleotomy.Finite element (FE) models can unravel the link between intervertebral disc (IVD) degeneration and its mechanical behaviour. Nucleotomy may provide the data required for model verification. Three human IVDs were scanned with MRI and tested in multiple loading scenarios, prior and post nucleotomy. The resulting data was used to generate, calibrate, and verify the FE models. Nucleotomy increased the experimental range of motion by 26%, a result reproduced by the FE simulation within a 5% error. This work demonstrates the ability of FE models to reproduce the mechanical compliance of human IVDs prior and post nucleotomy.
Intervertebral disc (IVD) degeneration is a cell-mediated response to progressive structural failure that is associated with chronic back pain. Due to its high socio-economic impact, numerous models have been proposed to investigate disc degeneration. In particular, finite element (FE) models have gained a considerable interest for studying the relationship between IVD degeneration and its mechanical behaviour. Mechanical data from in vitro tests are required to calibrate or validate these FE models, but IVD degeneration cannot easily be reproduced in a laboratory. However, targeted procedures such as nucleotomy can induce controlled structural changes within an IVD and thus provide the necessary data. This study aimed to develop a subject-specific IVD FE model that can predict the effect of nucleotomy on the multi-axial behavior of human IVDs. Three human IVDs were imaged in a clinical magnetic resonance imaging scanner and corresponding FE models generated. Each disc was tested in multiple loading scenarios prior and post nucleotomy. The resulting data were used to calibrate the material constants and evaluate the models performance. The FE model reproduced the experimental range of motion with an average error of 4 % for the intact and 5 % for the denucleated case. The nucleotomy caused a mean increase of 26 % in the experimental range of motion, a result reproduced by the FE simulation within a 2 % error. This work demonstrates the ability of FE models to reproduce the compliance of intact human IVDs along various loading modes and to simulate the alterations resulting from nucleotomy.
Author Stadelmann, Marc A.
Zysset, Philippe K.
Stocker, Roland
Maquer, Ghislain
Hoppe, Sven
Vermathen, Peter
Alkalay, Ron N.
AuthorAffiliation a ARTORG Center for Biomedical Engineering Research, University of Bern, Freiburgstrasse 3, 3010 Bern, Switzerland
c Department for BioMedical Research, University of Bern, Switzerland
d Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
b Department of Orthopedic Surgery, Bern University Hospital, Switzerland
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Keywords finite element modeling
magnetic resonance imaging
in vitro testing
Intervertebral disc
nucleotomy
Language English
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Snippet Finite element (FE) models can unravel the link between intervertebral disc (IVD) degeneration and its mechanical behaviour. Nucleotomy may provide the data...
Intervertebral disc (IVD) degeneration is a cell-mediated response to progressive structural failure that is associated with chronic back pain. Due to its high...
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SubjectTerms Adult
Calibration
Computer Simulation
Degeneration
Female
Finite Element Analysis
Finite element method
finite element modeling
Humans
Intervertebral disc
Intervertebral Disc - diagnostic imaging
Intervertebral Disc - physiopathology
Intervertebral Disc - surgery
Intervertebral discs
in vitro testing
Magnetic Resonance Imaging
Mathematical models
Mechanical properties
nucleotomy
Nucleus Pulposus - diagnostic imaging
Nucleus Pulposus - surgery
Range of Motion, Articular
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Title Finite element models can reproduce the effect of nucleotomy on the multi-axial compliance of human intervertebral discs
URI https://www.tandfonline.com/doi/abs/10.1080/10255842.2020.1773808
https://www.ncbi.nlm.nih.gov/pubmed/32543225
https://www.proquest.com/docview/2454089511
https://www.proquest.com/docview/2414001598
https://pubmed.ncbi.nlm.nih.gov/PMC7735477
https://www.tandfonline.com/doi/pdf/10.1080/10255842.2020.1773808?needAccess=true
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