Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture - Trimmer, Patricia A.; Keeney, Paula M.; Borland, M.Kate; Simon, Frederic A.; Almeida, Jatanna; Swerdlow, Russell H.; Parks, Janice P.; Parker, W.Davis; Bennett, James P. (Neurobiology of disease, 2004)
Keywords: Aged; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Bioenergetic phenotype; Cell Line; Cybrids; DNA Replication - physiology; DNA, Mitochondrial - biosynthesis; Electron Transport Complex IV - metabolism; Energy Metabolism - physiology; Gene Expression Regulation - physiology; Humans; Hybrid Cells - metabolism; Hybrid Cells - pathology; Hybrid Cells - ultrastructure; Inclusion Bodies - genetics; Inclusion Bodies - metabolism; Inclusion Bodies - pathology; Intracellular Membranes - metabolism; Intracellular Membranes - pathology; Intracellular Membranes - ultrastructure; Microscopy, Electron; Middle Aged; Mitochondria - metabolism; Mitochondria - pathology; Mitochondria - ultrastructure; Models, Biological; mtDNA; Replicative advantage; Cybrids; Replicative advantage; mtDNA; Bioenergetic phenotype; Alzheimer's disease