GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme - Sherpa, Dawafuti; Chrustowicz, Jakub; Qiao, Shuai; Langlois, Christine R.; Hehl, Laura A.; Gottemukkala, Karthik Varma; Hansen, Fynn M.; Karayel, Ozge; von Gronau, Susanne; Prabu, J. Rajan; Mann, Matthias; Alpi, Arno F.; et al. (Molecular cell, 2021)
Keywords: Adaptor Proteins, Signal Transducing - chemistry; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Binding Sites; Cell Adhesion Molecules - chemistry; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - metabolism; cryo-electron microscopy; cryo-EM; Cryoelectron Microscopy; CTLH; Fructose-Bisphosphatase - chemistry; Fructose-Bisphosphatase - genetics; Fructose-Bisphosphatase - metabolism; Gene Expression; GID; gluconeogenesis; Gluconeogenesis - genetics; Humans; Intracellular Signaling Peptides and Proteins - chemistry; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; K562 Cells; Kinetics; metabolic regulation; Models, Molecular; Multienzyme Complexes - chemistry; Multienzyme Complexes - genetics; Multienzyme Complexes - metabolism; mutation; Promoter Regions, Genetic; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; protein subunits; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; RING; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins - chemistry; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Sf9 Cells; Spodoptera; Structural Homology, Protein; Substrate Specificity; supramolecular assembly; ubiquitin; Ubiquitin - chemistry; Ubiquitin - genetics; Ubiquitin - metabolism; ubiquitin ligase; Ubiquitin-Conjugating Enzymes - chemistry; Ubiquitin-Conjugating Enzymes - genetics; Ubiquitin-Conjugating Enzymes - metabolism; ubiquitin-protein ligase; Ubiquitination; yeasts; ubiquitin ligase; supramolecular assembly; CTLH; GID; RING; gluconeogenesis; cryo-EM; E3; ubiquitin; metabolic regulation