On the growth rates of human malignant tumors: Implications for medical decision making
Testicular carcinomas, pediatric tumors, and some mesenchymal tumors are examples of rapidly proliferating cell populations, for which the tumor volume doubling time (TVDT) can be counted in days. Cancers from the breast, prostate, and colon are frequently slow‐growing, displaying a TVDT of months o...
Saved in:
| Published in | Journal of surgical oncology Vol. 65; no. 4; pp. 284 - 297 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Wiley Subscription Services, Inc., A Wiley Company
01.08.1997
Wiley-Liss |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-4790 1096-9098 |
| DOI | 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2 |
Cover
| Abstract | Testicular carcinomas, pediatric tumors, and some mesenchymal tumors are examples of rapidly proliferating cell populations, for which the tumor volume doubling time (TVDT) can be counted in days. Cancers from the breast, prostate, and colon are frequently slow‐growing, displaying a TVDT of months or years. Irrespective of their growth rates, most human tumors have been found: to start from one single cell, to have a long subclinical period, to grow at constant rates for long periods of time, to start to metastasize often even before the primary is detected, and to have metastases that often grow at approximately the same rate as the primary tumor. The recognition of basic facts in tumor cell kinetics is essential in the evaluation of important present‐day strategies in oncology. Among the facts emphasized in this review are: (1) Screening programs. Most tumors are several years old when detectable by present‐day diagnostic methods. This makes the term “early detection” questionable. (2) Legal trials. The importance of so‐called doctor's delay is often discussed, but the prognostic value of “early” detection is overestimated. (3) Analyses of clinical trials. Such analysis may be differentiated depending on the growth rates of the type of tumor studied. Furthermore, uncritical analysis of survival data may be misleading if the TVDT is not taken into consideration. (4) Analyses of epidemiological data. If causes of malignant tumors in humans are searched for, the time of exposure must be extended far back in the subject's history. (5) Risk estimations by insurance companies. For the majority of human cancers, the 5‐year survival rate is not a valid measurement for cure. Thus, basic knowledge of tumor kinetics may have important implications for political health programs, legal trials, medical science, and insurance policies. J. Surg. Oncol. 1997;65:284–297. © 1997 Wiley‐Liss, Inc. |
|---|---|
| AbstractList | Testicular carcinomas, pediatric tumors, and some mesenchymal tumors are examples of rapidly proliferating cell populations, for which the tumor volume doubling time (TVDT) can be counted in days. Cancers from the breast, prostate, and colon are frequently slow-growing, displaying a TVDT of months or years. Irrespective of their growth rates, most human tumors have been found: to start from one single cell, to have a long subclinical period, to grow at constant rates for long periods of time, to start to metastasize often even before the primary is detected, and to have metastases that often grow at approximately the same rate as the primary tumor. The recognition of basic facts in tumor cell kinetics is essential in the evaluation of important present-day strategies in oncology. Among the facts emphasized in this review are: (1) Screening programs. Most tumors are several years old when detectable by present-day diagnostic methods. This makes the term "early detection" questionable. (2) Legal trials. The importance of so-called doctor's delay is often discussed, but the prognostic value of "early" detection is overestimated. (3) Analyses of clinical trials. Such analysis may be differentiated depending on the growth rates of the type of tumor studied. Furthermore, uncritical analysis of survival data may be misleading if the TVDT is not taken into consideration. (4) Analyses of epidemiological data. If causes of malignant tumors in humans are searched for, the time of exposure must be extended far back in the subject's history. (5) Risk estimations by insurance companies. For the majority of human cancers, the 5-year survival rate is not a valid measurement for cure. Thus, basic knowledge of tumor kinetics may have important implications for political health programs, legal trials, medical science, and insurance policies.Testicular carcinomas, pediatric tumors, and some mesenchymal tumors are examples of rapidly proliferating cell populations, for which the tumor volume doubling time (TVDT) can be counted in days. Cancers from the breast, prostate, and colon are frequently slow-growing, displaying a TVDT of months or years. Irrespective of their growth rates, most human tumors have been found: to start from one single cell, to have a long subclinical period, to grow at constant rates for long periods of time, to start to metastasize often even before the primary is detected, and to have metastases that often grow at approximately the same rate as the primary tumor. The recognition of basic facts in tumor cell kinetics is essential in the evaluation of important present-day strategies in oncology. Among the facts emphasized in this review are: (1) Screening programs. Most tumors are several years old when detectable by present-day diagnostic methods. This makes the term "early detection" questionable. (2) Legal trials. The importance of so-called doctor's delay is often discussed, but the prognostic value of "early" detection is overestimated. (3) Analyses of clinical trials. Such analysis may be differentiated depending on the growth rates of the type of tumor studied. Furthermore, uncritical analysis of survival data may be misleading if the TVDT is not taken into consideration. (4) Analyses of epidemiological data. If causes of malignant tumors in humans are searched for, the time of exposure must be extended far back in the subject's history. (5) Risk estimations by insurance companies. For the majority of human cancers, the 5-year survival rate is not a valid measurement for cure. Thus, basic knowledge of tumor kinetics may have important implications for political health programs, legal trials, medical science, and insurance policies. Testicular carcinomas, pediatric tumors, and some mesenchymal tumors are examples of rapidly proliferating cell populations, for which the tumor volume doubling time (TVDT) can be counted in days. Cancers from the breast, prostate, and colon are frequently slow-growing, displaying a TVDT of months or years. Irrespective of their growth rates, most human tumors have been found: to start from one single cell, to have a long subclinical period, to grow at constant rates for long periods of time, to start to metastasize often even before the primary is detected, and to have metastases that often grow at approximately the same rate as the primary tumor. The recognition of basic facts in tumor cell kinetics is essential in the evaluation of important present-day strategies in oncology. Among the facts emphasized in this review are: (1) Screening programs. Most tumors are several years old when detectable by present-day diagnostic methods. This makes the term "early detection" questionable. (2) Legal trials. The importance of so-called doctor's delay is often discussed, but the prognostic value of "early" detection is overestimated. (3) Analyses of clinical trials. Such analysis may be differentiated depending on the growth rates of the type of tumor studied. Furthermore, uncritical analysis of survival data may be misleading if the TVDT is not taken into consideration. (4) Analyses of epidemiological data. If causes of malignant tumors in humans are searched for, the time of exposure must be extended far back in the subject's history. (5) Risk estimations by insurance companies. For the majority of human cancers, the 5-year survival rate is not a valid measurement for cure. Thus, basic knowledge of tumor kinetics may have important implications for political health programs, legal trials, medical science, and insurance policies. Testicular carcinomas, pediatric tumors, and some mesenchymal tumors are examples of rapidly proliferating cell populations, for which the tumor volume doubling time (TVDT) can be counted in days. Cancers from the breast, prostate, and colon are frequently slow‐growing, displaying a TVDT of months or years. Irrespective of their growth rates, most human tumors have been found: to start from one single cell, to have a long subclinical period, to grow at constant rates for long periods of time, to start to metastasize often even before the primary is detected, and to have metastases that often grow at approximately the same rate as the primary tumor. The recognition of basic facts in tumor cell kinetics is essential in the evaluation of important present‐day strategies in oncology. Among the facts emphasized in this review are: (1) Screening programs. Most tumors are several years old when detectable by present‐day diagnostic methods. This makes the term “early detection” questionable. (2) Legal trials. The importance of so‐called doctor's delay is often discussed, but the prognostic value of “early” detection is overestimated. (3) Analyses of clinical trials. Such analysis may be differentiated depending on the growth rates of the type of tumor studied. Furthermore, uncritical analysis of survival data may be misleading if the TVDT is not taken into consideration. (4) Analyses of epidemiological data. If causes of malignant tumors in humans are searched for, the time of exposure must be extended far back in the subject's history. (5) Risk estimations by insurance companies. For the majority of human cancers, the 5‐year survival rate is not a valid measurement for cure. Thus, basic knowledge of tumor kinetics may have important implications for political health programs, legal trials, medical science, and insurance policies. J. Surg. Oncol. 1997;65:284–297. © 1997 Wiley‐Liss, Inc. |
| Author | Mattson, Stefan Friberg, Sten |
| Author_xml | – sequence: 1 givenname: Sten surname: Friberg fullname: Friberg, Sten organization: Department of General Oncology, Radiumhemmet, Karolinska Hospital, and WHO Collaborating Centre For Urologic Research, Stockholm, Sweden – sequence: 2 givenname: Stefan surname: Mattson fullname: Mattson, Stefan organization: Department of Statistics, Uppsala University, Uppsala, Sweden |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2793838$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/9274795$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkVtv0zAUgC00NLrBT0DyA0LbQzrH17hcpClAWzTRh45N4uXIS502LHGKnWjs3-MuVV9AQn6wfC6fzvF3go5c6yxCH1IyTgmhF2fLeT4_T4mWiSY6O0u1ViQ7l2LC39OMTyaX80_J1-UiTT-yMRnni3c0oc_Q6NBxhEaRQxOuNHmBTkL4SQjRWvJjdKypimExQrcLh7uNxWvfPnQb7E1nA25LvOkb43Bj6mrtjOtw1zetDxM8b7Z1VZiual3AZetxY1fxXeOVLaoQo7HnvnLrl-h5aepgX-3vU_T9y-frfJZcLabz_PIqKbiWacIpL7SSUqxWLJNSZoIozgrGC6OoFoSWmnPOhOKlZToriKTcpHeWpsJYUUp2it4O3K1vf_U2dNBUobB1bZxt-wBKU06ForHw9b6wv4szw9ZXjfGPsP-JmH-zz5sQ9ym9cXGhQxlVmmXxHPYofBuCt-WhIiWw8waw8wY7C7CzAIM3kAI4RG8A0Rs8eQMGBPIFUNiNdzNwH6raPv4F_Q_zX8ghEMHJAK5CZ38fwMbfg1RMCbj9NoWZnN38uM6XMGV_AMGXt84 |
| CODEN | JSONAU |
| Cites_doi | 10.1016/S0022-5347(17)54359-1 10.1098/rstl.1825.0026 10.1002/1097-0142(195807/08)11:4<726::AID-CNCR2820110408>3.0.CO;2-2 10.1016/S0022-5223(19)40835-0 10.1038/nm0295-149 10.1002/1097-0142(19900915)66:14+<1351::AID-CNCR2820661410>3.0.CO;2-E 10.1002/1097-0142(197610)38:4<1826::AID-CNCR2820380460>3.0.CO;2-L 10.1111/j.1442-2042.1995.tb00427.x 10.1007/BF00177837 10.1016/S0140-6736(95)92655-0 10.1002/1097-0142(197905)43:5<1888::AID-CNCR2820430545>3.0.CO;2-M 10.1136/bmj.2.5753.67 10.1111/j.1365-2141.1969.tb00441.x 10.1227/00006123-199504000-00008 10.1038/bjc.1966.9 10.1002/jso.2930600216 10.1016/S0033-8389(22)02367-3 10.3109/02841867309131092 10.1016/S0003-4975(10)65234-4 10.1038/bjc.1993.351 10.1172/JCI106327 10.1136/bmj.2.6039.781 10.1002/1097-0142(19850201)55:3<658::AID-CNCR2820550331>3.0.CO;2-P 10.1056/NEJM199203123261104 10.1002/(SICI)1096-9098(199706)65:2<73::AID-JSO1>3.0.CO;2-K 10.3171/jns.1988.68.1.0041 10.7326/0003-4819-111-3-232 10.1016/S0140-6736(94)90235-6 10.1002/1097-0142(195801/02)11:1<89::AID-CNCR2820110118>3.0.CO;2-Y 10.1002/1097-0142(197903)43:3<857::AID-CNCR2820430312>3.0.CO;2-Y 10.1002/1097-0142(197710)40:4<1722::AID-CNCR2820400448>3.0.CO;2-2 10.1016/B978-1-4831-9930-6.50011-3 10.1016/S0022-5347(17)41175-X 10.7326/0003-4819-87-3-293 10.1200/JCO.1995.13.1.62 10.1016/0014-2964(66)90009-0 10.1177/030089168106700410 10.1016/0014-2964(77)90139-6 10.1002/1097-0142(19840415)53:8<1793::AID-CNCR2820530832>3.0.CO;2-Y 10.9783/9781512802900 10.1097/00000658-196402000-00001 10.1002/1097-0142(196308)16:8<961::AID-CNCR2820160802>3.0.CO;2-B 10.1016/0014-2964(67)90049-7 10.1002/1097-0142(196111/12)14:6<1272::AID-CNCR2820140618>3.0.CO;2-H 10.1073/pnas.18.1.1 10.1016/0014-2964(80)90034-1 10.1016/0014-2964(71)90073-9 10.1002/1097-0142(19840101)53:1<96::AID-CNCR2820530117>3.0.CO;2-A 10.1111/j.1349-7006.1990.tb02591.x 10.1111/j.1365-2605.1987.tb00161.x 10.1002/1097-0142(19940801)74:3<872::AID-CNCR2820740313>3.0.CO;2-P 10.1073/pnas.88.15.6848 10.1002/jso.2930300307 10.1093/oxfordjournals.bmb.a072473 10.1016/0014-2964(66)90008-9 10.1002/1097-0142(197508)36:2<471::AID-CNCR2820360225>3.0.CO;2-4 10.3109/02841868709091429 10.1001/jama.1966.03110250060019 10.7326/0003-4819-89-1-107 10.1002/1097-0142(197208)30:2<594::AID-CNCR2820300241>3.0.CO;2-2 10.1002/1097-0142(19930601)71:11<3547::AID-CNCR2820711114>3.0.CO;2-C 10.1002/1097-0142(19800415)45:8<2198::AID-CNCR2820450832>3.0.CO;2-7 10.1002/1097-0142(197812)42:6<2880::AID-CNCR2820420650>3.0.CO;2-X 10.1016/0014-2964(67)90022-9 10.1002/1097-0142(196306)16:6<687::AID-CNCR2820160602>3.0.CO;2-E 10.1002/1096-9098(199601)61:1<68::AID-JSO2930610102>3.0.CO;2-E 10.1001/archsurg.1963.01310080107024 10.1002/1097-0142(19921001)70:7<1928::AID-CNCR2820700720>3.0.CO;2-R 10.1016/S0022-5223(19)42271-X 10.1002/1097-0142(196306)16:6<694::AID-CNCR2820160603>3.0.CO;2-J 10.1038/bjc.1967.1 10.1093/jnci/40.2.389 10.1378/chest.65.1.3 10.1056/NEJM197407042910109 10.1016/0014-2964(69)90012-7 10.1200/JCO.1994.12.3.447 10.1002/1097-0142(196501)18:1<14::AID-CNCR2820180105>3.0.CO;2-T |
| ContentType | Journal Article |
| Copyright | Copyright © 1997 Wiley‐Liss, Inc. 1997 INIST-CNRS |
| Copyright_xml | – notice: Copyright © 1997 Wiley‐Liss, Inc. – notice: 1997 INIST-CNRS |
| DBID | BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2 |
| DatabaseName | Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1096-9098 |
| EndPage | 297 |
| ExternalDocumentID | 9274795 2793838 10_1002__SICI_1096_9098_199708_65_4_284__AID_JSO11_3_0_CO_2_2 JSO11 ark_67375_WNG_H6HVZTCS_G |
| Genre | reviewArticle Research Support, Non-U.S. Gov't Journal Article Review |
| GrantInformation_xml | – fundername: S. and R. Fredriksson Foundation |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 3O- 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAMMB AAMNL AANHP AANLZ AAONW AAQQT AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEGXH AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFFNX AFFPM AFGKR AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHMBA AIACR AIAGR AIDQK AIDYY AIQQE AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE FUBAC G-S G.N GLUZI GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IH2 IX1 J0M JPC KBYEO KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M6P MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RX1 RYL SAMSI SUPJJ SV3 TEORI UB1 V2E V8K W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WVDHM WXI WXSBR X7M XG1 XPP XV2 ZGI ZXP ZZTAW ~IA ~WT AAHHS AAYXX ACCFJ AEEZP AEQDE AIWBW AJBDE CITATION IQODW AEUQT AFPWT CGR CUY CVF ECM EIF GNP NPM RWI WRC WUP WWO 7X8 |
| ID | FETCH-LOGICAL-c4961-424c97665dd38666850743c34ca729502f94443574fe398c0624a1be215ae5f63 |
| IEDL.DBID | DR2 |
| ISSN | 0022-4790 |
| IngestDate | Fri Jul 11 01:51:20 EDT 2025 Wed Feb 19 02:36:16 EST 2025 Mon Jul 21 09:17:22 EDT 2025 Tue Jul 01 04:22:09 EDT 2025 Wed Aug 20 07:25:29 EDT 2025 Sun Sep 21 06:24:54 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Human Growth rate Doubling time Review Malignant tumor Epidemiology Quality of life Cancerology Health policy Risk factor Decision criterion Diagnosis Public health |
| Language | English |
| License | http://doi.wiley.com/10.1002/tdm_license_1.1 CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4961-424c97665dd38666850743c34ca729502f94443574fe398c0624a1be215ae5f63 |
| Notes | istex:CC974072C816A47038D5941BD24532E293B2F352 S. and R. Fredriksson Foundation ark:/67375/WNG-H6HVZTCS-G ArticleID:JSO11 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 9274795 |
| PQID | 79242572 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | proquest_miscellaneous_79242572 pubmed_primary_9274795 pascalfrancis_primary_2793838 crossref_primary_10_1002__SICI_1096_9098_199708_65_4_284__AID_JSO11_3_0_CO_2_2 wiley_primary_10_1002_SICI_1096_9098_199708_65_4_284_AID_JSO11_3_0_CO_2_2_JSO11 istex_primary_ark_67375_WNG_H6HVZTCS_G |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | August 1997 |
| PublicationDateYYYYMMDD | 1997-08-01 |
| PublicationDate_xml | – month: 08 year: 1997 text: August 1997 |
| PublicationDecade | 1990 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: New York, NY – name: United States |
| PublicationTitle | Journal of surgical oncology |
| PublicationTitleAlternate | J. Surg. Oncol |
| PublicationYear | 1997 |
| Publisher | Wiley Subscription Services, Inc., A Wiley Company Wiley-Liss |
| Publisher_xml | – name: Wiley Subscription Services, Inc., A Wiley Company – name: Wiley-Liss |
| References | Spratt JS, Ackerman LV: The growth of a colonic adenocarcinoma. Am Surg 1961; 27: 23-28. Combes PF, Douchez J, Carton M, Naja A: Etude de la croissance des métastases pulmonaires humaines comme argument objectif d'evaluation du pronostic et des effets thérapiques. J Radiologie et d'Electrologie 1968; 49: 893-902. Heuser LS, Spratt JS, Kuhns JG, et al.: The association of pathologic and mammographic characteristics of primary human breast cancers with "slow" and "fast" growth rates and with axillary lymph node metastases. Cancer 1984; 53: 96-98. Spratt JS, Ter-Pogossian M, Long RTL: The detection and growth of intrathoracic neoplasms. Arch Surg 1963; 86: 283-288. Rutqvist LE, Wallgren A: Long-term survival of 458 young breast cancer patients. Cancer 1985; 55: 658-665. Refsum SB, Berdal P: Cell loss in malignant tumours in man. (Letter to the Editor). Europ J Cancer 1967; 3: 235-236. Waldenström J: Hypergammaglobulinemia as a clinical hematologic problem: A study in the gammopathies. Progr Haematol 1962; 3: 266-293. Buchanan JB, Spratt JS, Heuser LS: Tumor growth, doubling times and the inability of the radiobiologist to diagnose certain cancers. Radiol Clin N Am 1983; 21: 115-126. Blomqvist C, Wiklund T, Tarkkanen M, et al.: Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma. Brit J Cancer 1993; 68: 414-417. Spratt JS, Greenberg RA, Heuser LS: Geometry, growth rates and duration of cancer and carcinoma in situ of the breast before detection by screening. Cancer Res 1986; 46: 970-974. Borge N, Fosså SD, Stenwig AE: Metastatic testicular cancer and extragonadal germ cell tumor presenting with neurological symptoms. J Neurooncol 1990; 8: 145-148. Joensuu H, Toikkanen S: Cured of breast cancer? J Clin Oncol 1995; 13: 62-69. Galante E, Guzzon A, Gallus G, et al.: Prognostic significance of the growth rate of breast cancer: preliminary evaluation on the follow-up of 196 breast cancers. Tumori 1981; 67: 333-340. Spratt JS, Spjut HJ, Roper CL: The frequency distribution of the rates of growth and the estimated duration of primary pulmonary carcinomas. Cancer 1963; 16: 687-693. Holmgren L, O'Reilly M, Folkman J: Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Medicine 1995; 1: 149-153. Collins VP, Loeffler RK, Tivey H: Observations on growth rates of human tumors. Am J Roentgen 1956; 76: 988-1000. Sidransky DS, Frost P, von Eschenbach A, et al.: Clonal origin of bladder cancer. N Engl J Med 1991; 326: 737-740. Steel GG: "Growth Kinetics of Tumours: Cell Population Kinetics in Relation to the Growth and Treatment of Cancer". Oxford: Clarendon Press, 1977. Wright CJ, Mueller CB: Screening mammography and public health policy: The need for perspective. Lancet 1995; 346: 29-32. McNichols D, Segura J, DeWeerd J: Renal cell carcinoma: Long-term survival and late recurrence. J Urol 1981; 126: 17-23. Ingleby H, Gershon-Cohen J: "Comparative Anatomy, Pathology and Roentgenology of the Breast." Philadelphia: University of Pennsylvania Press, 1960. Heuser L, Spratt JS, Polk HC, Buchanan J: Relation between mammary cancer growth kinetics and the interval between screenings. Cancer 1979; 43: 857-862. Breur K: Growth rate and radiosensitivity of human tumours-II. Eur J Cancer 1966; 2: 173-188. Pearlman AW: Growth rate investigation and tumor lethal dose in Ewing's sarcoma. Acta Radiol 1973; 12: 57-70. Garland LH, Coulson W, Wollin E: The rate of growth and apparent duration of untreated primary bronchial carcinoma. Cancer 1963; 16: 694-707. Chaganti RSK, Rodriguez E, Mathew S: Origin of adult male mediastinal germ-cell tumors. Lancet 1994; 343: 1130-1132. Friberg S: The 5-year cure rate: Yet another myth. J Surg Oncol 1997; 65: 73-75. Schwartz M: A biomathematical approach to clinical tumor growth. Cancer 1961; 14: 1271-1294. Steel GG, Lamerton LF: The growth rate of human tumours. Br J Cancer 1966; 20: 74-86. Weiss W, Boucot KR, Cooper DA: Growth rate in the detection and prognosis of bronchogenic carcinoma. JAMA 1966; 198: 108-114. Steele JD, Buell P: Asymptomatic solitary pulmonary nodules. Host survival, tumor size and growth rate. J Thorac Cardiovasc Surg 1973; 65: 140-151. Joseph WL, Morton DL, Adkins PC: Prognostic significance of tumor doubling time in evaluating operability in pulmonary metastatic disease. J Thor Cardiovasc Surg 1971; 61: 23-32. Einhorn LH, Donohue J: Cis-diamminedichloroplatinum, vinblastine and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Int Med 1977; 87: 293-298. Eddy DM: Screening for lung cancer. Ann Int Med 1989; 111: 232-237. Spratt JS: The rates of growth of skeletal sarcomas. Cancer 1965; 18: 14-24. Pollock WF, Hastings N, Snyder WH: The Collins "period of risk" formula for malignant tumors in children, with particular reference to Wilms' tumor and neuroblastoma. Surgery 1960; 48: 606-609. Arnerlöv C, Emdin SO, Lundgren B, et al.: Breast carcinoma growth rate described by mammographic doubling time and S-phase fraction. Cancer 1992; 70: 1928-1934. Heuser L, Spratt JS, Polk HC: Growth rates of primary breast cancers. Cancer 1979; 43: 1888-1894. Kuroishi T, Tominaga S, Morimoto T, et al.: Tumor growth rate and prognosis of breast cancer mainly by mass screening. Jpn J Cancer Res 1990; 81: 454-462. McKinnon NE: Cancer of the breast: The invalid evidence for faith in early treatment. Canad J Publ Health 1951; 42: 218-223. Spratt JS, Meyer JS, Spratt JA: Rates of growth of human solid neoplasms: Part I. J Surg Oncol 1995; 60: 137-146. Band PR, Kocandrle C: Growth rate of pulmonary metastases in human sarcomas. Cancer 1975; 36: 471-474. Charbit A, Malaise EP, Tubiana M: Relation between the pathological nature and the growth rate of human tumors. Europ J Cancer 1971; 7: 307-315. Peer P, van Dijk J, Hendriks J, et al.: Age-dependent growth rate of primary breast cancer. Cancer 1993; 71: 3547-3551. Rambert PE, Malaise E, Laugier A, et al.: Données sur la vitesse de croissance de tumeurs humaines. Bulletin du Cancer 1968; 55: 323-342. Breur K: Growth rate and radiosensitivity of human tumours-I. Eur J Cancer 1966; 2: 157-171. Weiss W: Tumor doubling time and survival of men with bronchogenic carcinoma. Chest 1974; 65: 3-8. Spratt JS, Kaltenbach ML, Spratt J: Cytokinetic definition of acute and chronic breast cancer. Cancer Res 1977; 37: 226-230. Oeser HV: "Krebsbekämpfung: Hoffnung und Realität." Stuttgart: Georg Thieme Verlag, 1974. Frei E, Freireich EJ: Progress and perspectives in the chemotherapy of acute leukemia. Adv Chemother 1965; 2: 269-298. Mattson K, Holsti LR: Prognostic value of doubling time in lung cancer. Strahlentherapie 1980; 156: 632-636. Gilliland DG, Blanchard KL, Levy J, et al.: Clonality in myeloproliferative disorders: Analysis by means of the polymerase chain reaction. Proc Natl Acad Sci USA 1991; 88: 6848-6852. Hobbs JR: Immunocytoma o' mice an' men. Br Med J 1971; 2: 67-72. Brenner MW, Holsti LR, Perttala, Y: The study by graphical analysis of the growth of human tumours and metastases of the lung. Br J Cancer 1967; XXI: 1-13. Kusama S, Spratt JS, Donegan WL, et al.: The gross rates of growth of human mammary carcinoma. Cancer 1972; 30: 594-599. Noguchi S, Aihara T, Koyama H, et al.: Discrimination between multicentric and multifocal carcinomas of the breast through clonal analysis. Cancer 1994; 74: 872-877. Brigham BA, Bunn PA, Minna JD, et al.: Growth rates of small cell bronchogenic carcinomas. Cancer 1978; 42: 2880-2886. Brown WD, Tavaré CJ, Sobel EL, Gilles FH: Medulloblastoma and Collins' law: A critical review of the concept of a period of risk for tumor recurrence and patient survival. Neurosurgery 1995; 36: 691-697. Fournier DV, Weber E, Hoeffken W, et al.: Growth rate of 147 mammary carcinomas. Cancer 1980; 45: 2198-2207. Gershon-Cohen J, Berger SM, Klickstein HS: Roentgenography of breast cancer moderating concept of "biologic predeterminism". Cancer 1963; 16: 961-964. Knox WE, Pillers EMK: Time of recurrence or cure of tumours in childhood. Lancet 1958; 188-191. Bauer W, Igot JP, Le Gal Y: Chronologie du cancer mammaire utilisant un modèle de croissance de Gompertz. Annales d'Anatomie patologique 1980; 25: 39-56. Mueller CB: Stage II breast cancer is not simply a late stage. I. Surgery 1988; 104: 631-638. Virchow R: "Vorlesungen über Pathologie". Berlin: A Hirchwald Verlag, 1862, p 1. Fujimoto N, Sugita A, Terasawa Y, Kato M: Observations on the growth rate of renal cell carcinoma. Int J Urol 1995; 2: 71-76. Collins VP: The treatment of Wilms's tumor. Cancer 1958; 11: 89-94. Spratt JS, Chang AFC, Heuser LS, et al.: Acute carcinoma of the breast. Surg Gynecol Obstet 1983; 157: 220-222. Wang N, Perkins KL, Bronson DL, Fraley EE: Cytogenetic evidence for premeiotic transformation of human testicular cancers. Cancer Res 1981; 41: 2135-2140. Pearlman AW: Fibrosarcoma: The biomathematical approach to late metastases-a case report. Mount Sinai J Med 1979; 46: 255-260. Meyer JA: The concept and significance of growth rates in human pulmonary tumors. Ann Thorac Surg 1972; 14: 309-322. Demicheli R: Growth of testicular neoplasm lung metastases: Tumor-specific relation between two Gompertzian Parameters. Eur J Cancer 1980; 16: 1603-1608. Tubiana M, Chauvel P, Renaud A, Malaise EP: Vitesse de croissance et histoire naturelle du cancer du sein. Bulletin du Cancer 1975; 62: 341-358. Duncan W, Kerr GR: The curability of breast cancer. Br Med J 1976; 2: 781-783. Rööser B, Petterson H, Alvegård T: Growth rate of pulmonary metastases from soft tissue sarcoma. Acta Oncol 1987; 26: 189-192. Shackney SE, McGormack GW, Cuchural GJ: Growth rate patterns of solid tumors and their relation to responsiveness to therapy. Ann Int Med 1978; 89: 107-121. Cuzick J, Stewart H, Rutqvist L, et al.: Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol 1994; 12: 447-453. Stamey TA, Kabalin JN, McNeal JE, et al.: Prostate specific antigen in the diagnosis and treatment of 1966; 198 1993; 68 1963; 86 1983; 157 1973; 12 1995; 36 1932; 18 1980; 45 1958; 11 1989; 111 1976 1974 1971 1981; 41 1965; 18 1977 1988; 104 1994; 343 1965; 2 1984; 53 1971; 7 1995; 60 1991; 47 1977; 37 1960; 48 1993; 71 1991; 88 1989; 141 1969; 5 1986; 46 1996; 61 1983; 21 1985 1862 1971; 2 1972; 14 1985; 55 1976; 38 1994; 74 1974; 291 1968; 55 1966; 20 1966; 2 1980; 25 1987; 10 1968; 49 1971; 61 1997; 65 1981; 126 1962; 3 1956; 76 1995; 13 1977; 40 1976; 2 1975; 36 1969; 16 1825; 115 1977; 87 1995; 2 1995; 1 1968; 40 1961; 14 1951; 42 1964; 159 1990; 81 1980; 156 1981; 67 1980; 16 1963; 16 1992; 70 1979; 46 1990; 66 1974; 65 1978; 89 1973; 65 1978; 42 1967; 3 1967; XXI 1994; 12 1988; 68 1995; 346 1960 1985; 30 1958; 188–191 1972; 30 1977; 13 1991; 326 1975; 62 1979; 43 1990; 8 1970; 49 1961; 27 1987; 26 1966 Fialkow (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB4) 1974; 291 Weiss (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB63) 1974; 65 Steele (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB27) 1973; 65 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB17) 1963; 86 Gompertz (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB35) 1825; 115 Kuroishi (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB49) 1990; 81 Cuzick (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB87) 1994; 12 Demicheli (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB44) 1980; 16 Wang (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB10) 1981; 41 Heuser (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB57) 1979; 43 Rutqvist (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB84) 1984; 53 Eddy (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB96) 1989; 111 Gershon-Cohen (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB53) 1963; 16 Austin (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB80) 1988; 68 Joseph (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB71) 1971; 61 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB19) 1963; 16 Steel (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB37) 1966; 20 Breur (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB23) 1966; 2 Gilliland (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB7) 1991; 88 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB58) 1983; 157 Buchanan (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB59) 1983; 21 Fournier (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB32) 1980; 45 Breur (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB22) 1966; 2 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB72) 1965; 18 Galante (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB62) 1981; 67 Ingleby (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB51) 1958; 11 Salmon (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB92) 1970; 49 Schwartz (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB16) 1961; 14 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB90) 1996; 61 Rööser (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB33) 1987; 26 Refsum (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB14) 1967; 3 Dethlefsen (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB38) 1968; 40 Skakkebaekk (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB11) 1987; 10 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB20) 1964; 159 Mattson (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB66) 1980; 156 Tubiana (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB74) 1975; 62 Heuser (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB56) 1979; 43 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB61) 1985; 30 Brown (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB81) 1995; 36 Mueller (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB100) 1988; 104 Virchow (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB2) 1862 Knutson (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB68) 1971 Joensuu (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB86) 1995; 13 Borge (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB88) 1990; 8 Duncan (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB83) 1976; 2 Meyer (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB26) 1972; 14 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB89) 1995; 60 Wright (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB95) 1995; 346 Einhorn (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB93) 1977; 87 Collins (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB15) 1956; 76 Blomqvist (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB34) 1993; 68 Allan (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB82) 1977; 13 Noguchi (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB9) 1994; 74 Pearlman (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB29) 1976; 38 Arnerlöv (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB50) 1992; 70 Ingleby (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB52) 1960 Pollock (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB31) 1960; 48 Heuser (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB60) 1984; 53 Hobbs (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB6) 1971; 2 Charbit (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB64) 1971; 7 Chaganti (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB12) 1994; 343 Pearlman (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB30) 1979; 46 Fujimoto (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB46) 1995; 2 Fournier (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB75) 1985 Haybittle (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB77) 1991; 47 Holmgren (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB1) 1995; 1 Lundgren (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB55) 1977; 40 Friberg (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB101) 1997; 65 Band (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB70) 1975; 36 Rutqvist (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB85) 1985; 55 McKinnon (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB94) 1951; 42 Combes (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB69) 1968; 49 Brigham (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB67) 1978; 42 Brenner (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB24) 1967 Garland (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB18) 1963; 16 Winsor (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB36) 1932; 18 Hobbs (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB5) 1969; 16 Oeser (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB91) 1974 Sidransky (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB8) 1991; 326 Weiss (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB21) 1966; 198 Bauer (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB76) 1980; 25 Stamey (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB40) 1989; 141 Waldenström (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB3) 1962; 3 Collins (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB78) 1958; 11 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB45) 1961; 27 Chahinian (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB65) 1969; 5 Peer (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB48) 1993; 71 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB54) 1977; 37 Kusama (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB47) 1972; 30 Frei (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB43) 1965; 2 Pearlman (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB28) 1973; 12 Shackney (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB42) 1978; 89 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB98) 1990; 66 Steel (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB39) 1977 MacDonald (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB73) 1966 Rambert (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB25) 1968; 55 Steel (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB13) 1967; 3 McNichols (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB99) 1981; 126 Zelen (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB97) 1976 Knox (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB79) 1958; 188–191 Spratt (10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB41) 1986; 46 |
| References_xml | – reference: Spratt JS, Ter-Pogossian M, Long RTL: The detection and growth of intrathoracic neoplasms. Arch Surg 1963; 86: 283-288. – reference: Buchanan JB, Spratt JS, Heuser LS: Tumor growth, doubling times and the inability of the radiobiologist to diagnose certain cancers. Radiol Clin N Am 1983; 21: 115-126. – reference: Refsum SB, Berdal P: Cell loss in malignant tumours in man. (Letter to the Editor). Europ J Cancer 1967; 3: 235-236. – reference: Spratt JS, Ackerman LV: The growth of a colonic adenocarcinoma. Am Surg 1961; 27: 23-28. – reference: Spratt JS, Spratt JA: What is breast cancer doing before we can detect it? J Surg Oncol 1985; 30: 156-160. – reference: Collins VP, Loeffler RK, Tivey H: Observations on growth rates of human tumors. Am J Roentgen 1956; 76: 988-1000. – reference: Pearlman AW: Fibrosarcoma: The biomathematical approach to late metastases-a case report. Mount Sinai J Med 1979; 46: 255-260. – reference: Charbit A, Malaise EP, Tubiana M: Relation between the pathological nature and the growth rate of human tumors. Europ J Cancer 1971; 7: 307-315. – reference: Waldenström J: Hypergammaglobulinemia as a clinical hematologic problem: A study in the gammopathies. Progr Haematol 1962; 3: 266-293. – reference: Pearlman AW: Breast cancer: Influence of growth rate on prognosis and treatment evaluation. Cancer 1976; 38: 1826-1833. – reference: McKinnon NE: Cancer of the breast: The invalid evidence for faith in early treatment. Canad J Publ Health 1951; 42: 218-223. – reference: Frei E, Freireich EJ: Progress and perspectives in the chemotherapy of acute leukemia. Adv Chemother 1965; 2: 269-298. – reference: Hobbs JR: Growth rates and responses to treatment in human myelomatosis. Brit J Haemat 1969; 16: 607-617. – reference: Joensuu H, Toikkanen S: Cured of breast cancer? J Clin Oncol 1995; 13: 62-69. – reference: Kusama S, Spratt JS, Donegan WL, et al.: The gross rates of growth of human mammary carcinoma. Cancer 1972; 30: 594-599. – reference: Combes PF, Douchez J, Carton M, Naja A: Etude de la croissance des métastases pulmonaires humaines comme argument objectif d'evaluation du pronostic et des effets thérapiques. J Radiologie et d'Electrologie 1968; 49: 893-902. – reference: Steel GG: "Growth Kinetics of Tumours: Cell Population Kinetics in Relation to the Growth and Treatment of Cancer". Oxford: Clarendon Press, 1977. – reference: Weiss W: Tumor doubling time and survival of men with bronchogenic carcinoma. Chest 1974; 65: 3-8. – reference: Friberg S: The 5-year cure rate: Yet another myth. J Surg Oncol 1997; 65: 73-75. – reference: Haybittle JL: Curability of breast cancer. Br Med Bull 1991; 47: 319-323. – reference: Skakkebaekk NE, Berthelsen JU, Giwerman A, et al.: Carcinoma-in-situ of the testis: Possible origin from gonocytes and precursors of all types of germ cell tumors except spermatocytoma. Int J Androl 1987; 10: 19-28. – reference: Spratt JS, Chang AFC, Heuser LS, et al.: Acute carcinoma of the breast. Surg Gynecol Obstet 1983; 157: 220-222. – reference: Spratt JS, Meyer JS, Spratt JA: Rates of growth of human solid neoplasms: Part I. J Surg Oncol 1995; 60: 137-146. – reference: Rööser B, Petterson H, Alvegård T: Growth rate of pulmonary metastases from soft tissue sarcoma. Acta Oncol 1987; 26: 189-192. – reference: Chaganti RSK, Rodriguez E, Mathew S: Origin of adult male mediastinal germ-cell tumors. Lancet 1994; 343: 1130-1132. – reference: Shackney SE, McGormack GW, Cuchural GJ: Growth rate patterns of solid tumors and their relation to responsiveness to therapy. Ann Int Med 1978; 89: 107-121. – reference: Galante E, Guzzon A, Gallus G, et al.: Prognostic significance of the growth rate of breast cancer: preliminary evaluation on the follow-up of 196 breast cancers. Tumori 1981; 67: 333-340. – reference: Gompertz B: On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. Phil Trans Roy Soc London 1825; 115: 513-583. – reference: Pollock WF, Hastings N, Snyder WH: The Collins "period of risk" formula for malignant tumors in children, with particular reference to Wilms' tumor and neuroblastoma. Surgery 1960; 48: 606-609. – reference: Meyer JA: The concept and significance of growth rates in human pulmonary tumors. Ann Thorac Surg 1972; 14: 309-322. – reference: Mueller CB: Stage II breast cancer is not simply a late stage. I. Surgery 1988; 104: 631-638. – reference: Fialkow PJ: The origin and development of human tumors studied with cell markers. N Engl J Med 1974; 291: 26-34. – reference: Tubiana M, Chauvel P, Renaud A, Malaise EP: Vitesse de croissance et histoire naturelle du cancer du sein. Bulletin du Cancer 1975; 62: 341-358. – reference: Lundgren B: Observations on growth rate of breast carcinomas and its possible implications for lead time. Cancer 1977; 40: 1722-1725. – reference: Mattson K, Holsti LR: Prognostic value of doubling time in lung cancer. Strahlentherapie 1980; 156: 632-636. – reference: Virchow R: "Vorlesungen über Pathologie". Berlin: A Hirchwald Verlag, 1862, p 1. – reference: Spratt JS, Greenberg RA, Heuser LS: Geometry, growth rates and duration of cancer and carcinoma in situ of the breast before detection by screening. Cancer Res 1986; 46: 970-974. – reference: Wright CJ, Mueller CB: Screening mammography and public health policy: The need for perspective. Lancet 1995; 346: 29-32. – reference: Brenner MW, Holsti LR, Perttala, Y: The study by graphical analysis of the growth of human tumours and metastases of the lung. Br J Cancer 1967; XXI: 1-13. – reference: Borge N, Fosså SD, Stenwig AE: Metastatic testicular cancer and extragonadal germ cell tumor presenting with neurological symptoms. J Neurooncol 1990; 8: 145-148. – reference: Spratt JS, Meyer JS, Spratt JA: Rates of growth of human solid neoplasms: Part II. J Surg Oncol 1996; 61: 68-83. – reference: Knox WE, Pillers EMK: Time of recurrence or cure of tumours in childhood. Lancet 1958; 188-191. – reference: Schwartz M: A biomathematical approach to clinical tumor growth. Cancer 1961; 14: 1271-1294. – reference: Spratt JS, Kaltenbach ML, Spratt J: Cytokinetic definition of acute and chronic breast cancer. Cancer Res 1977; 37: 226-230. – reference: Fujimoto N, Sugita A, Terasawa Y, Kato M: Observations on the growth rate of renal cell carcinoma. Int J Urol 1995; 2: 71-76. – reference: Kuroishi T, Tominaga S, Morimoto T, et al.: Tumor growth rate and prognosis of breast cancer mainly by mass screening. Jpn J Cancer Res 1990; 81: 454-462. – reference: Allan E: Breast cancer: The long latent interval. Eur J Cancer 1977; 13: 839-845. – reference: Rutqvist LE, Wallgren A: Long-term survival of 458 young breast cancer patients. Cancer 1985; 55: 658-665. – reference: Hobbs JR: Immunocytoma o' mice an' men. Br Med J 1971; 2: 67-72. – reference: Eddy DM: Screening for lung cancer. Ann Int Med 1989; 111: 232-237. – reference: Fournier DV, Weber E, Hoeffken W, et al.: Growth rate of 147 mammary carcinomas. Cancer 1980; 45: 2198-2207. – reference: Einhorn LH, Donohue J: Cis-diamminedichloroplatinum, vinblastine and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Int Med 1977; 87: 293-298. – reference: Chahinian P, Israel L: Survival gain and volume gain: Mathematical tools in evaluating treatments. Europ J Cancer 1969; 5: 625-629. – reference: Steel GG, Lamerton LF: The growth rate of human tumours. Br J Cancer 1966; 20: 74-86. – reference: Heuser LS, Spratt JS, Kuhns JG, et al.: The association of pathologic and mammographic characteristics of primary human breast cancers with "slow" and "fast" growth rates and with axillary lymph node metastases. Cancer 1984; 53: 96-98. – reference: Rambert PE, Malaise E, Laugier A, et al.: Données sur la vitesse de croissance de tumeurs humaines. Bulletin du Cancer 1968; 55: 323-342. – reference: Austin EJ, Alvord EC: Recurrences of cerebellar astrocytomas: A violation of Collins' law. J Neurosurg 1988; 68: 41-47. – reference: Garland LH, Coulson W, Wollin E: The rate of growth and apparent duration of untreated primary bronchial carcinoma. Cancer 1963; 16: 694-707. – reference: Spratt JS, Spratt SW: Medical and legal implications of screening and follow-up procedures for breast cancer. Cancer 1990; 66: 1351-1362. – reference: Salmon SE, Smith BA: Immunoglobulin synthesis and total body tumor cell number in IgG multiple myeloma. J Clin Invest 1970; 49: 1114-1121. – reference: Spratt JS, Spratt TL: Rates of growth of pulmonary metastases and host survival. Ann Surg 1964; 159: 161-171. – reference: Arnerlöv C, Emdin SO, Lundgren B, et al.: Breast carcinoma growth rate described by mammographic doubling time and S-phase fraction. Cancer 1992; 70: 1928-1934. – reference: Holmgren L, O'Reilly M, Folkman J: Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Medicine 1995; 1: 149-153. – reference: Duncan W, Kerr GR: The curability of breast cancer. Br Med J 1976; 2: 781-783. – reference: Breur K: Growth rate and radiosensitivity of human tumours-I. Eur J Cancer 1966; 2: 157-171. – reference: Brown WD, Tavaré CJ, Sobel EL, Gilles FH: Medulloblastoma and Collins' law: A critical review of the concept of a period of risk for tumor recurrence and patient survival. Neurosurgery 1995; 36: 691-697. – reference: McNichols D, Segura J, DeWeerd J: Renal cell carcinoma: Long-term survival and late recurrence. J Urol 1981; 126: 17-23. – reference: Oeser HV: "Krebsbekämpfung: Hoffnung und Realität." Stuttgart: Georg Thieme Verlag, 1974. – reference: Wang N, Perkins KL, Bronson DL, Fraley EE: Cytogenetic evidence for premeiotic transformation of human testicular cancers. Cancer Res 1981; 41: 2135-2140. – reference: Gilliland DG, Blanchard KL, Levy J, et al.: Clonality in myeloproliferative disorders: Analysis by means of the polymerase chain reaction. Proc Natl Acad Sci USA 1991; 88: 6848-6852. – reference: Weiss W, Boucot KR, Cooper DA: Growth rate in the detection and prognosis of bronchogenic carcinoma. JAMA 1966; 198: 108-114. – reference: Stamey TA, Kabalin JN, McNeal JE, et al.: Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. II: Radical prostatectomy treated patients. J Urol 1989; 141: 1076-1083. – reference: Band PR, Kocandrle C: Growth rate of pulmonary metastases in human sarcomas. Cancer 1975; 36: 471-474. – reference: Brigham BA, Bunn PA, Minna JD, et al.: Growth rates of small cell bronchogenic carcinomas. Cancer 1978; 42: 2880-2886. – reference: Winsor CP: The Gompertz curve as a growth curve. Proc Nat Acad Sci 1932; 18: 1-8. – reference: Sidransky DS, Frost P, von Eschenbach A, et al.: Clonal origin of bladder cancer. N Engl J Med 1991; 326: 737-740. – reference: Collins VP: The treatment of Wilms's tumor. Cancer 1958; 11: 89-94. – reference: Steele JD, Buell P: Asymptomatic solitary pulmonary nodules. Host survival, tumor size and growth rate. J Thorac Cardiovasc Surg 1973; 65: 140-151. – reference: Heuser L, Spratt JS, Polk HC: Growth rates of primary breast cancers. Cancer 1979; 43: 1888-1894. – reference: Peer P, van Dijk J, Hendriks J, et al.: Age-dependent growth rate of primary breast cancer. Cancer 1993; 71: 3547-3551. – reference: Blomqvist C, Wiklund T, Tarkkanen M, et al.: Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma. Brit J Cancer 1993; 68: 414-417. – reference: Gershon-Cohen J, Berger SM, Klickstein HS: Roentgenography of breast cancer moderating concept of "biologic predeterminism". Cancer 1963; 16: 961-964. – reference: Heuser L, Spratt JS, Polk HC, Buchanan J: Relation between mammary cancer growth kinetics and the interval between screenings. Cancer 1979; 43: 857-862. – reference: Joseph WL, Morton DL, Adkins PC: Prognostic significance of tumor doubling time in evaluating operability in pulmonary metastatic disease. J Thor Cardiovasc Surg 1971; 61: 23-32. – reference: Cuzick J, Stewart H, Rutqvist L, et al.: Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol 1994; 12: 447-453. – reference: Spratt JS: The rates of growth of skeletal sarcomas. Cancer 1965; 18: 14-24. – reference: Dethlefsen LA, Prewitt JMS, Mendelsohn ML: Analysis of tumor growth curves. J Natl Cancer Inst 1968; 40: 389-405. – reference: Pearlman AW: Growth rate investigation and tumor lethal dose in Ewing's sarcoma. Acta Radiol 1973; 12: 57-70. – reference: Steel GG: Cell loss as a factor in the growth rate of human tumours. Eur J Cancer 1967; 3: 381-387. – reference: Breur K: Growth rate and radiosensitivity of human tumours-II. Eur J Cancer 1966; 2: 173-188. – reference: Bauer W, Igot JP, Le Gal Y: Chronologie du cancer mammaire utilisant un modèle de croissance de Gompertz. Annales d'Anatomie patologique 1980; 25: 39-56. – reference: Demicheli R: Growth of testicular neoplasm lung metastases: Tumor-specific relation between two Gompertzian Parameters. Eur J Cancer 1980; 16: 1603-1608. – reference: Rutqvist LE, Wallgren A, Nilsson B: Is breast cancer a curable disease? Cancer 1984; 53: 1793-1800. – reference: Spratt JS, Spjut HJ, Roper CL: The frequency distribution of the rates of growth and the estimated duration of primary pulmonary carcinomas. Cancer 1963; 16: 687-693. – reference: Ingleby H, Gershon-Cohen J: "Comparative Anatomy, Pathology and Roentgenology of the Breast." Philadelphia: University of Pennsylvania Press, 1960. – reference: Ingleby H, Moore L, Gershon-Cohen J: A roentgenographic study of the growth rate of 6 "early" cancers of the breast. Cancer 1958; 11: 726-730. – reference: Noguchi S, Aihara T, Koyama H, et al.: Discrimination between multicentric and multifocal carcinomas of the breast through clonal analysis. Cancer 1994; 74: 872-877. – volume: 30 start-page: 594 year: 1972 end-page: 599 article-title: The gross rates of growth of human mammary carcinoma publication-title: Cancer – volume: 87 start-page: 293 year: 1977 end-page: 298 article-title: Cis‐diamminedichloroplatinum, vinblastine and bleomycin combination chemotherapy in disseminated testicular cancer publication-title: Ann Int Med – volume: 55 start-page: 323 year: 1968 end-page: 342 article-title: Données sur la vitesse de croissance de tumeurs humaines publication-title: Bulletin du Cancer – volume: 37 start-page: 226 year: 1977 end-page: 230 article-title: Cytokinetic definition of acute and chronic breast cancer publication-title: Cancer Res – volume: 7 start-page: 307 year: 1971 end-page: 315 article-title: Relation between the pathological nature and the growth rate of human tumors publication-title: Europ J Cancer – volume: 104 start-page: 631 year: 1988 end-page: 638 article-title: Stage II breast cancer is not simply a late stage. I publication-title: Surgery – volume: 12 start-page: 57 year: 1973 end-page: 70 article-title: Growth rate investigation and tumor lethal dose in Ewing's sarcoma publication-title: Acta Radiol – volume: 65 start-page: 73 year: 1997 end-page: 75 article-title: The 5‐year cure rate: Yet another myth publication-title: J Surg Oncol – volume: 141 start-page: 1076 year: 1989 end-page: 1083 article-title: Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. II: Radical prostatectomy treated patients publication-title: J Urol – volume: 18 start-page: 14 year: 1965 end-page: 24 article-title: The rates of growth of skeletal sarcomas publication-title: Cancer – start-page: 287 year: 1976 end-page: 300 – volume: 16 start-page: 1603 year: 1980 end-page: 1608 article-title: Growth of testicular neoplasm lung metastases: Tumor‐specific relation between two Gompertzian Parameters publication-title: Eur J Cancer – start-page: 11 year: 1966 end-page: 34 – volume: 326 start-page: 737 year: 1991 end-page: 740 article-title: Clonal origin of bladder cancer publication-title: N Engl J Med – volume: 14 start-page: 309 year: 1972 end-page: 322 article-title: The concept and significance of growth rates in human pulmonary tumors publication-title: Ann Thorac Surg – volume: 38 start-page: 1826 year: 1976 end-page: 1833 article-title: Breast cancer: Influence of growth rate on prognosis and treatment evaluation publication-title: Cancer – volume: 49 start-page: 1114 year: 1970 end-page: 1121 article-title: Immunoglobulin synthesis and total body tumor cell number in IgG multiple myeloma publication-title: J Clin Invest – volume: 88 start-page: 6848 year: 1991 end-page: 6852 article-title: Clonality in myeloproliferative disorders: Analysis by means of the polymerase chain reaction publication-title: Proc Natl Acad Sci USA – volume: 53 start-page: 96 year: 1984 end-page: 98 article-title: The association of pathologic and mammographic characteristics of primary human breast cancers with “slow” and “fast” growth rates and with axillary lymph node metastases publication-title: Cancer – volume: 159 start-page: 161 year: 1964 end-page: 171 article-title: Rates of growth of pulmonary metastases and host survival publication-title: Ann Surg – volume: 65 start-page: 3 year: 1974 end-page: 8 article-title: Tumor doubling time and survival of men with bronchogenic carcinoma publication-title: Chest – volume: 71 start-page: 3547 year: 1993 end-page: 3551 article-title: Age‐dependent growth rate of primary breast cancer publication-title: Cancer – volume: 49 start-page: 893 year: 1968 end-page: 902 article-title: Etude de la croissance des métastases pulmonaires humaines comme argument objectif d'evaluation du pronostic et des effets thérapiques publication-title: J Radiologie et d'Electrologie – volume: 16 start-page: 694 year: 1963 end-page: 707 article-title: The rate of growth and apparent duration of untreated primary bronchial carcinoma publication-title: Cancer – volume: 2 start-page: 269 year: 1965 end-page: 298 article-title: Progress and perspectives in the chemotherapy of acute leukemia publication-title: Adv Chemother – volume: 13 start-page: 839 year: 1977 end-page: 845 article-title: Breast cancer: The long latent interval publication-title: Eur J Cancer – volume: 42 start-page: 218 year: 1951 end-page: 223 article-title: Cancer of the breast: The invalid evidence for faith in early treatment publication-title: Canad J Publ Health – volume: 26 start-page: 189 year: 1987 end-page: 192 article-title: Growth rate of pulmonary metastases from soft tissue sarcoma publication-title: Acta Oncol – volume: 40 start-page: 1722 year: 1977 end-page: 1725 article-title: Observations on growth rate of breast carcinomas and its possible implications for lead time publication-title: Cancer – volume: 188–191 year: 1958 article-title: Time of recurrence or cure of tumours in childhood publication-title: Lancet – volume: 2 start-page: 157 year: 1966 end-page: 171 article-title: Growth rate and radiosensitivity of human tumours—I publication-title: Eur J Cancer – volume: 10 start-page: 19 year: 1987 end-page: 28 article-title: Carcinoma‐in‐situ of the testis: Possible origin from gonocytes and precursors of all types of germ cell tumors except spermatocytoma publication-title: Int J Androl – volume: 89 start-page: 107 year: 1978 end-page: 121 article-title: Growth rate patterns of solid tumors and their relation to responsiveness to therapy publication-title: Ann Int Med – volume: 74 start-page: 872 year: 1994 end-page: 877 article-title: Discrimination between multicentric and multifocal carcinomas of the breast through clonal analysis publication-title: Cancer – volume: 46 start-page: 970 year: 1986 end-page: 974 article-title: Geometry, growth rates and duration of cancer and carcinoma in situ of the breast before detection by screening publication-title: Cancer Res – volume: 36 start-page: 691 year: 1995 end-page: 697 article-title: Medulloblastoma and Collins' law: A critical review of the concept of a period of risk for tumor recurrence and patient survival publication-title: Neurosurgery – volume: 343 start-page: 1130 year: 1994 end-page: 1132 article-title: Origin of adult male mediastinal germ‐cell tumors publication-title: Lancet – volume: 65 start-page: 140 year: 1973 end-page: 151 article-title: Asymptomatic solitary pulmonary nodules. Host survival, tumor size and growth rate publication-title: J Thorac Cardiovasc Surg – volume: 3 start-page: 381 year: 1967 end-page: 387 article-title: Cell loss as a factor in the growth rate of human tumours publication-title: Eur J Cancer – volume: 2 start-page: 71 year: 1995 end-page: 76 article-title: Observations on the growth rate of renal cell carcinoma publication-title: Int J Urol – volume: 81 start-page: 454 year: 1990 end-page: 462 article-title: Tumor growth rate and prognosis of breast cancer mainly by mass screening publication-title: Jpn J Cancer Res – volume: 42 start-page: 2880 year: 1978 end-page: 2886 article-title: Growth rates of small cell bronchogenic carcinomas publication-title: Cancer – volume: 11 start-page: 89 year: 1958 end-page: 94 article-title: The treatment of Wilms's tumor publication-title: Cancer – volume: 2 start-page: 781 year: 1976 end-page: 783 article-title: The curability of breast cancer publication-title: Br Med J – volume: 1 start-page: 149 year: 1995 end-page: 153 article-title: Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression publication-title: Nature Medicine – volume: 5 start-page: 625 year: 1969 end-page: 629 article-title: Survival gain and volume gain: Mathematical tools in evaluating treatments publication-title: Europ J Cancer – volume: 43 start-page: 857 year: 1979 end-page: 862 article-title: Relation between mammary cancer growth kinetics and the interval between screenings publication-title: Cancer – volume: 3 start-page: 235 year: 1967 end-page: 236 article-title: Cell loss in malignant tumours in man. (Letter to the Editor) publication-title: Europ J Cancer – year: 1985 – volume: 21 start-page: 115 year: 1983 end-page: 126 article-title: Tumor growth, doubling times and the inability of the radiobiologist to diagnose certain cancers publication-title: Radiol Clin N Am – volume: 86 start-page: 283 year: 1963 end-page: 288 article-title: The detection and growth of intrathoracic neoplasms publication-title: Arch Surg – volume: 41 start-page: 2135 year: 1981 end-page: 2140 article-title: Cytogenetic evidence for premeiotic transformation of human testicular cancers publication-title: Cancer Res – volume: 3 start-page: 266 year: 1962 end-page: 293 article-title: Hypergammaglobulinemia as a clinical hematologic problem: A study in the gammopathies publication-title: Progr Haematol – volume: 68 start-page: 414 year: 1993 end-page: 417 article-title: Measurement of growth rate of lung metastases in 21 patients with bone or soft‐tissue sarcoma publication-title: Brit J Cancer – volume: 11 start-page: 726 year: 1958 end-page: 730 article-title: A roentgenographic study of the growth rate of 6 “early” cancers of the breast publication-title: Cancer – year: 1971 – volume: 61 start-page: 23 year: 1971 end-page: 32 article-title: Prognostic significance of tumor doubling time in evaluating operability in pulmonary metastatic disease publication-title: J Thor Cardiovasc Surg – volume: 25 start-page: 39 year: 1980 end-page: 56 article-title: Chronologie du cancer mammaire utilisant un modèle de croissance de Gompertz publication-title: Annales d'Anatomie patologique – volume: 2 start-page: 67 year: 1971 end-page: 72 article-title: Immunocytoma o' mice an' men publication-title: Br Med J – volume: 18 start-page: 1 year: 1932 end-page: 8 article-title: The Gompertz curve as a growth curve publication-title: Proc Nat Acad Sci – volume: 67 start-page: 333 year: 1981 end-page: 340 article-title: Prognostic significance of the growth rate of breast cancer: preliminary evaluation on the follow‐up of 196 breast cancers publication-title: Tumori – volume: 36 start-page: 471 year: 1975 end-page: 474 article-title: Growth rate of pulmonary metastases in human sarcomas publication-title: Cancer – volume: 27 start-page: 23 year: 1961 end-page: 28 article-title: The growth of a colonic adenocarcinoma publication-title: Am Surg – volume: 12 start-page: 447 year: 1994 end-page: 453 article-title: Cause‐specific mortality in long‐term survivors of breast cancer who participated in trials of radiotherapy publication-title: J Clin Oncol – volume: 126 start-page: 17 year: 1981 end-page: 23 article-title: Renal cell carcinoma: Long‐term survival and late recurrence publication-title: J Urol – volume: 157 start-page: 220 year: 1983 end-page: 222 article-title: Acute carcinoma of the breast publication-title: Surg Gynecol Obstet – volume: 156 start-page: 632 year: 1980 end-page: 636 article-title: Prognostic value of doubling time in lung cancer publication-title: Strahlentherapie – volume: 8 start-page: 145 year: 1990 end-page: 148 article-title: Metastatic testicular cancer and extragonadal germ cell tumor presenting with neurological symptoms publication-title: J Neurooncol – volume: 115 start-page: 513 year: 1825 end-page: 583 article-title: On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies publication-title: Phil Trans Roy Soc London – volume: 16 start-page: 687 year: 1963 end-page: 693 article-title: The frequency distribution of the rates of growth and the estimated duration of primary pulmonary carcinomas publication-title: Cancer – volume: 30 start-page: 156 year: 1985 end-page: 160 article-title: What is breast cancer doing before we can detect it? publication-title: J Surg Oncol – volume: 66 start-page: 1351 year: 1990 end-page: 1362 article-title: Medical and legal implications of screening and follow‐up procedures for breast cancer publication-title: Cancer – volume: 62 start-page: 341 year: 1975 end-page: 358 article-title: Vitesse de croissance et histoire naturelle du cancer du sein publication-title: Bulletin du Cancer – volume: 16 start-page: 607 year: 1969 end-page: 617 article-title: Growth rates and responses to treatment in human myelomatosis publication-title: Brit J Haemat – volume: 68 start-page: 41 year: 1988 end-page: 47 article-title: Recurrences of cerebellar astrocytomas: A violation of Collins' law publication-title: J Neurosurg – start-page: 1 year: 1862 – volume: 61 start-page: 68 year: 1996 end-page: 83 article-title: Rates of growth of human solid neoplasms: Part II publication-title: J Surg Oncol – volume: XXI start-page: 1 year: 1967 end-page: 13 article-title: The study by graphical analysis of the growth of human tumours and metastases of the lung publication-title: Br J Cancer – volume: 46 start-page: 255 year: 1979 end-page: 260 article-title: Fibrosarcoma: The biomathematical approach to late metastases—a case report publication-title: Mount Sinai J Med – year: 1960 – volume: 111 start-page: 232 year: 1989 end-page: 237 article-title: Screening for lung cancer publication-title: Ann Int Med – volume: 14 start-page: 1271 year: 1961 end-page: 1294 article-title: A biomathematical approach to clinical tumor growth publication-title: Cancer – volume: 60 start-page: 137 year: 1995 end-page: 146 article-title: Rates of growth of human solid neoplasms: Part I publication-title: J Surg Oncol – volume: 2 start-page: 173 year: 1966 end-page: 188 article-title: Growth rate and radiosensitivity of human tumours—II publication-title: Eur J Cancer – year: 1977 – volume: 16 start-page: 961 year: 1963 end-page: 964 article-title: Roentgenography of breast cancer moderating concept of “biologic predeterminism” publication-title: Cancer – volume: 198 start-page: 108 year: 1966 end-page: 114 article-title: Growth rate in the detection and prognosis of bronchogenic carcinoma publication-title: JAMA – volume: 291 start-page: 26 year: 1974 end-page: 34 article-title: The origin and development of human tumors studied with cell markers publication-title: N Engl J Med – volume: 53 start-page: 1793 year: 1984 end-page: 1800 article-title: Is breast cancer a curable disease? publication-title: Cancer – volume: 346 start-page: 29 year: 1995 end-page: 32 article-title: Screening mammography and public health policy: The need for perspective publication-title: Lancet – volume: 13 start-page: 62 year: 1995 end-page: 69 article-title: Cured of breast cancer? publication-title: J Clin Oncol – volume: 48 start-page: 606 year: 1960 end-page: 609 article-title: The Collins “period of risk” formula for malignant tumors in children, with particular reference to Wilms' tumor and neuroblastoma publication-title: Surgery – volume: 45 start-page: 2198 year: 1980 end-page: 2207 article-title: Growth rate of 147 mammary carcinomas publication-title: Cancer – volume: 55 start-page: 658 year: 1985 end-page: 665 article-title: Long‐term survival of 458 young breast cancer patients publication-title: Cancer – year: 1974 – volume: 70 start-page: 1928 year: 1992 end-page: 1934 article-title: Breast carcinoma growth rate described by mammographic doubling time and S‐phase fraction publication-title: Cancer – volume: 43 start-page: 1888 year: 1979 end-page: 1894 article-title: Growth rates of primary breast cancers publication-title: Cancer – volume: 40 start-page: 389 year: 1968 end-page: 405 article-title: Analysis of tumor growth curves publication-title: J Natl Cancer Inst – volume: 76 start-page: 988 year: 1956 end-page: 1000 article-title: Observations on growth rates of human tumors publication-title: Am J Roentgen – volume: 20 start-page: 74 year: 1966 end-page: 86 article-title: The growth rate of human tumours publication-title: Br J Cancer – volume: 47 start-page: 319 year: 1991 end-page: 323 article-title: Curability of breast cancer publication-title: Br Med Bull – volume: 126 start-page: 17 year: 1981 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB99 publication-title: J Urol doi: 10.1016/S0022-5347(17)54359-1 – volume: 115 start-page: 513 year: 1825 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB35 publication-title: Phil Trans Roy Soc London doi: 10.1098/rstl.1825.0026 – start-page: 287 volume-title: Breast Cancer: Trends in Research and Treatment year: 1976 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB97 – volume: 11 start-page: 726 year: 1958 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB51 publication-title: Cancer doi: 10.1002/1097-0142(195807/08)11:4<726::AID-CNCR2820110408>3.0.CO;2-2 – volume: 62 start-page: 341 year: 1975 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB74 publication-title: Bulletin du Cancer – volume: 65 start-page: 140 year: 1973 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB27 publication-title: J Thorac Cardiovasc Surg doi: 10.1016/S0022-5223(19)40835-0 – volume: 1 start-page: 149 year: 1995 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB1 publication-title: Nature Medicine doi: 10.1038/nm0295-149 – volume: 66 start-page: 1351 year: 1990 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB98 publication-title: Cancer doi: 10.1002/1097-0142(19900915)66:14+<1351::AID-CNCR2820661410>3.0.CO;2-E – volume-title: Early Breast Cancer year: 1985 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB75 – volume: 38 start-page: 1826 year: 1976 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB29 publication-title: Cancer doi: 10.1002/1097-0142(197610)38:4<1826::AID-CNCR2820380460>3.0.CO;2-L – volume: 2 start-page: 71 year: 1995 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB46 publication-title: Int J Urol doi: 10.1111/j.1442-2042.1995.tb00427.x – volume: 8 start-page: 145 year: 1990 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB88 publication-title: J Neurooncol doi: 10.1007/BF00177837 – volume: 346 start-page: 29 year: 1995 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB95 publication-title: Lancet doi: 10.1016/S0140-6736(95)92655-0 – volume: 43 start-page: 1888 year: 1979 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB56 publication-title: Cancer doi: 10.1002/1097-0142(197905)43:5<1888::AID-CNCR2820430545>3.0.CO;2-M – volume: 46 start-page: 255 year: 1979 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB30 publication-title: Mount Sinai J Med – volume: 41 start-page: 2135 year: 1981 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB10 publication-title: Cancer Res – volume: 2 start-page: 67 year: 1971 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB6 publication-title: Br Med J doi: 10.1136/bmj.2.5753.67 – volume: 16 start-page: 607 year: 1969 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB5 publication-title: Brit J Haemat doi: 10.1111/j.1365-2141.1969.tb00441.x – volume: 36 start-page: 691 year: 1995 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB81 publication-title: Neurosurgery doi: 10.1227/00006123-199504000-00008 – volume: 20 start-page: 74 year: 1966 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB37 publication-title: Br J Cancer doi: 10.1038/bjc.1966.9 – volume: 60 start-page: 137 year: 1995 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB89 publication-title: J Surg Oncol doi: 10.1002/jso.2930600216 – volume: 21 start-page: 115 year: 1983 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB59 publication-title: Radiol Clin N Am doi: 10.1016/S0033-8389(22)02367-3 – volume: 188–191 year: 1958 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB79 publication-title: Lancet – volume: 12 start-page: 57 year: 1973 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB28 publication-title: Acta Radiol doi: 10.3109/02841867309131092 – volume: 46 start-page: 970 year: 1986 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB41 publication-title: Cancer Res – volume: 14 start-page: 309 year: 1972 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB26 publication-title: Ann Thorac Surg doi: 10.1016/S0003-4975(10)65234-4 – volume: 68 start-page: 414 year: 1993 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB34 publication-title: Brit J Cancer doi: 10.1038/bjc.1993.351 – volume: 49 start-page: 1114 year: 1970 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB92 publication-title: J Clin Invest doi: 10.1172/JCI106327 – volume: 2 start-page: 781 year: 1976 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB83 publication-title: Br Med J doi: 10.1136/bmj.2.6039.781 – volume: 55 start-page: 658 year: 1985 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB85 publication-title: Cancer doi: 10.1002/1097-0142(19850201)55:3<658::AID-CNCR2820550331>3.0.CO;2-P – volume: 326 start-page: 737 year: 1991 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB8 publication-title: N Engl J Med doi: 10.1056/NEJM199203123261104 – volume: 65 start-page: 73 year: 1997 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB101 publication-title: J Surg Oncol doi: 10.1002/(SICI)1096-9098(199706)65:2<73::AID-JSO1>3.0.CO;2-K – year: 1971 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB68 – volume: 68 start-page: 41 year: 1988 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB80 publication-title: J Neurosurg doi: 10.3171/jns.1988.68.1.0041 – volume: 111 start-page: 232 year: 1989 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB96 publication-title: Ann Int Med doi: 10.7326/0003-4819-111-3-232 – volume: 343 start-page: 1130 year: 1994 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB12 publication-title: Lancet doi: 10.1016/S0140-6736(94)90235-6 – volume: 11 start-page: 89 year: 1958 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB78 publication-title: Cancer doi: 10.1002/1097-0142(195801/02)11:1<89::AID-CNCR2820110118>3.0.CO;2-Y – volume: 55 start-page: 323 year: 1968 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB25 publication-title: Bulletin du Cancer – volume: 43 start-page: 857 year: 1979 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB57 publication-title: Cancer doi: 10.1002/1097-0142(197903)43:3<857::AID-CNCR2820430312>3.0.CO;2-Y – volume: 40 start-page: 1722 year: 1977 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB55 publication-title: Cancer doi: 10.1002/1097-0142(197710)40:4<1722::AID-CNCR2820400448>3.0.CO;2-2 – volume: 2 start-page: 269 year: 1965 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB43 publication-title: Adv Chemother doi: 10.1016/B978-1-4831-9930-6.50011-3 – volume: 3 start-page: 266 year: 1962 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB3 publication-title: Progr Haematol – volume: 49 start-page: 893 year: 1968 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB69 publication-title: J Radiologie et d'Electrologie – volume: 141 start-page: 1076 year: 1989 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB40 publication-title: J Urol doi: 10.1016/S0022-5347(17)41175-X – volume: 157 start-page: 220 year: 1983 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB58 publication-title: Surg Gynecol Obstet – volume: 87 start-page: 293 year: 1977 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB93 publication-title: Ann Int Med doi: 10.7326/0003-4819-87-3-293 – volume: 13 start-page: 62 year: 1995 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB86 publication-title: J Clin Oncol doi: 10.1200/JCO.1995.13.1.62 – start-page: 11 volume-title: Clinical Evaluation of Breast Cancer year: 1966 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB73 – volume: 2 start-page: 173 year: 1966 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB23 publication-title: Eur J Cancer doi: 10.1016/0014-2964(66)90009-0 – volume: 67 start-page: 333 year: 1981 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB62 publication-title: Tumori doi: 10.1177/030089168106700410 – volume: 13 start-page: 839 year: 1977 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB82 publication-title: Eur J Cancer doi: 10.1016/0014-2964(77)90139-6 – volume: 53 start-page: 1793 year: 1984 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB84 publication-title: Cancer doi: 10.1002/1097-0142(19840415)53:8<1793::AID-CNCR2820530832>3.0.CO;2-Y – volume: 76 start-page: 988 year: 1956 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB15 publication-title: Am J Roentgen – volume-title: Comparative Anatomy, Pathology and Roentgenology of the Breast year: 1960 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB52 doi: 10.9783/9781512802900 – volume: 159 start-page: 161 year: 1964 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB20 publication-title: Ann Surg doi: 10.1097/00000658-196402000-00001 – volume: 16 start-page: 961 year: 1963 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB53 publication-title: Cancer doi: 10.1002/1097-0142(196308)16:8<961::AID-CNCR2820160802>3.0.CO;2-B – volume: 42 start-page: 218 year: 1951 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB94 publication-title: Canad J Publ Health – volume: 3 start-page: 235 year: 1967 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB14 publication-title: Europ J Cancer doi: 10.1016/0014-2964(67)90049-7 – volume: 14 start-page: 1271 year: 1961 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB16 publication-title: Cancer doi: 10.1002/1097-0142(196111/12)14:6<1272::AID-CNCR2820140618>3.0.CO;2-H – volume: 18 start-page: 1 year: 1932 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB36 publication-title: Proc Nat Acad Sci doi: 10.1073/pnas.18.1.1 – volume: 16 start-page: 1603 year: 1980 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB44 publication-title: Eur J Cancer doi: 10.1016/0014-2964(80)90034-1 – volume: 7 start-page: 307 year: 1971 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB64 publication-title: Europ J Cancer doi: 10.1016/0014-2964(71)90073-9 – volume-title: Growth Kinetics of Tumours: Cell Population Kinetics in Relation to the Growth and Treatment of Cancer year: 1977 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB39 – volume: 53 start-page: 96 year: 1984 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB60 publication-title: Cancer doi: 10.1002/1097-0142(19840101)53:1<96::AID-CNCR2820530117>3.0.CO;2-A – volume: 81 start-page: 454 year: 1990 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB49 publication-title: Jpn J Cancer Res doi: 10.1111/j.1349-7006.1990.tb02591.x – volume: 10 start-page: 19 year: 1987 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB11 publication-title: Int J Androl doi: 10.1111/j.1365-2605.1987.tb00161.x – volume-title: Krebsbekämpfung: Hoffnung und Realität year: 1974 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB91 – volume: 74 start-page: 872 year: 1994 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB9 publication-title: Cancer doi: 10.1002/1097-0142(19940801)74:3<872::AID-CNCR2820740313>3.0.CO;2-P – volume: 88 start-page: 6848 year: 1991 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB7 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.88.15.6848 – volume: 30 start-page: 156 year: 1985 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB61 publication-title: J Surg Oncol doi: 10.1002/jso.2930300307 – volume: 47 start-page: 319 year: 1991 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB77 publication-title: Br Med Bull doi: 10.1093/oxfordjournals.bmb.a072473 – volume: 27 start-page: 23 year: 1961 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB45 publication-title: Am Surg – volume: 2 start-page: 157 year: 1966 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB22 publication-title: Eur J Cancer doi: 10.1016/0014-2964(66)90008-9 – volume: 36 start-page: 471 year: 1975 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB70 publication-title: Cancer doi: 10.1002/1097-0142(197508)36:2<471::AID-CNCR2820360225>3.0.CO;2-4 – volume: 26 start-page: 189 year: 1987 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB33 publication-title: Acta Oncol doi: 10.3109/02841868709091429 – volume: 198 start-page: 108 year: 1966 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB21 publication-title: JAMA doi: 10.1001/jama.1966.03110250060019 – volume: 89 start-page: 107 year: 1978 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB42 publication-title: Ann Int Med doi: 10.7326/0003-4819-89-1-107 – volume: 30 start-page: 594 year: 1972 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB47 publication-title: Cancer doi: 10.1002/1097-0142(197208)30:2<594::AID-CNCR2820300241>3.0.CO;2-2 – volume: 71 start-page: 3547 year: 1993 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB48 publication-title: Cancer doi: 10.1002/1097-0142(19930601)71:11<3547::AID-CNCR2820711114>3.0.CO;2-C – volume: 45 start-page: 2198 year: 1980 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB32 publication-title: Cancer doi: 10.1002/1097-0142(19800415)45:8<2198::AID-CNCR2820450832>3.0.CO;2-7 – volume: 48 start-page: 606 year: 1960 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB31 publication-title: Surgery – volume: 42 start-page: 2880 year: 1978 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB67 publication-title: Cancer doi: 10.1002/1097-0142(197812)42:6<2880::AID-CNCR2820420650>3.0.CO;2-X – volume: 3 start-page: 381 year: 1967 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB13 publication-title: Eur J Cancer doi: 10.1016/0014-2964(67)90022-9 – volume: 16 start-page: 687 year: 1963 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB19 publication-title: Cancer doi: 10.1002/1097-0142(196306)16:6<687::AID-CNCR2820160602>3.0.CO;2-E – volume: 61 start-page: 68 year: 1996 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB90 publication-title: J Surg Oncol doi: 10.1002/1096-9098(199601)61:1<68::AID-JSO2930610102>3.0.CO;2-E – volume: 86 start-page: 283 year: 1963 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB17 publication-title: Arch Surg doi: 10.1001/archsurg.1963.01310080107024 – volume: 70 start-page: 1928 year: 1992 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB50 publication-title: Cancer doi: 10.1002/1097-0142(19921001)70:7<1928::AID-CNCR2820700720>3.0.CO;2-R – volume: 61 start-page: 23 year: 1971 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB71 publication-title: J Thor Cardiovasc Surg doi: 10.1016/S0022-5223(19)42271-X – volume: 37 start-page: 226 year: 1977 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB54 publication-title: Cancer Res – volume: 16 start-page: 694 year: 1963 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB18 publication-title: Cancer doi: 10.1002/1097-0142(196306)16:6<694::AID-CNCR2820160603>3.0.CO;2-J – volume: 25 start-page: 39 year: 1980 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB76 publication-title: Annales d'Anatomie patologique – start-page: 1 year: 1967 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB24 publication-title: Br J Cancer doi: 10.1038/bjc.1967.1 – volume: 104 start-page: 631 year: 1988 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB100 publication-title: Surgery – volume: 40 start-page: 389 year: 1968 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB38 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/40.2.389 – volume: 65 start-page: 3 year: 1974 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB63 publication-title: Chest doi: 10.1378/chest.65.1.3 – start-page: 1 volume-title: Vorlesungen über Pathologie year: 1862 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB2 – volume: 291 start-page: 26 year: 1974 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB4 publication-title: N Engl J Med doi: 10.1056/NEJM197407042910109 – volume: 5 start-page: 625 year: 1969 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB65 publication-title: Europ J Cancer doi: 10.1016/0014-2964(69)90012-7 – volume: 12 start-page: 447 year: 1994 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB87 publication-title: J Clin Oncol doi: 10.1200/JCO.1994.12.3.447 – volume: 18 start-page: 14 year: 1965 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB72 publication-title: Cancer doi: 10.1002/1097-0142(196501)18:1<14::AID-CNCR2820180105>3.0.CO;2-T – volume: 156 start-page: 632 year: 1980 ident: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2-BIB66 publication-title: Strahlentherapie |
| SSID | ssj0009964 |
| Score | 1.9987035 |
| SecondaryResourceType | review_article |
| Snippet | Testicular carcinomas, pediatric tumors, and some mesenchymal tumors are examples of rapidly proliferating cell populations, for which the tumor volume... |
| SourceID | proquest pubmed pascalfrancis crossref wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 284 |
| SubjectTerms | Biological and medical sciences Breast Neoplasms - pathology Cell Division - physiology Clinical Trials as Topic Colonic Neoplasms - pathology Decision Making diagnostic level doubling time Epidemiology Female growth rate human Humans lethal burden Lung Neoplasms - secondary Male Medical sciences neoplasm Neoplasm Metastasis Neoplasms - diagnosis Neoplasms - pathology period of risk Prostatic Neoplasms - pathology Risk Survival Analysis Testicular Neoplasms - pathology Tumors |
| Title | On the growth rates of human malignant tumors: Implications for medical decision making |
| URI | https://api.istex.fr/ark:/67375/WNG-H6HVZTCS-G/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2F%28SICI%291096-9098%28199708%2965%3A4%3C284%3A%3AAID-JSO11%3E3.0.CO%3B2-2 https://www.ncbi.nlm.nih.gov/pubmed/9274795 https://www.proquest.com/docview/79242572 |
| Volume | 65 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwxV1ba9swFBalg7KX3cuyrZse1tE-OHWsi6XsAp17SQpNYOmNvRxkxe6gxBm5sLH9lf3YHVmxu2yFvQwGeQgG-UNHR0ffkY4_EfJSRCnjzJiAZQITFHThQMk4DXKpzFBxfGrcfsdxT3ZO-dGFuFgh36tvYbw-RL3h5mZGGa_dBDfpdOdaNBQJ2KCbdDFhbiEND3SolZM20jp2de1aChxivskSjL_4D3-73b3gaNDHCMH2WTNsJv1N9j4KXPxuMel09_c-XEtPYR7AK6VxHutwjbxdYO9sOdztGnXLY25L0eZvEK3drpHeeZzXiLK07t1yQ_jV1WGaKQ5F7u_QuInkLnPmctE7uEt-VObytS5XzfksbdpvvylJ_id73iN3FmSa7nrvv09WsuIBWTtelAs8JOf9giLBpZeT8ZfZJ-pUMaZ0nNPyYkI6whTk0tUB0dl8NJ5M27T7S3k9RTZPR_4Yiw4XNxFhG3e08IicHuyfJJ1gcZNEYLmW6IMRt8i7pBgOmcKETQnHnCzj1mByIcIo15wjcYx5njGtbCgjblpphnzIZCKXbJ2sFuMie0yoDm0rNTmuL0Zyo7hmXNk4tJznNswsa5BeNc7w2QuGgJeGjgCcgd2ZvwRnXvDGBSmAA5oVAE0KpUmBQQhJHyKIGuRV6S3128zkylXjxQLOe4fQkZ2zjyfJAA4bZGPJneoGEcZgxVSDvKjcCzCGuIMhU2Tj-RRiXSaeCLXuva5uqt2mhRYN0i9d548e_aVDN_XHP3jyz9_4lNz20sKuOPMZWZ1N5tkGEsZZ-ryc2T8BI21HFQ |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwxV1LbxMxELaqVipceFcEKPWBovaw6Wb9WDs8pLK0TUqTSCSlFZeR19ktUpUE5SEQ4q_wXxmvky2BSlyQkPawWskeeTwef-OZ_UzIMxGljDNjApYJDFDQhAMl4zTIpTJ9xfGrcecdrbZsnPLjc3G-Qr4v_oXx_BDlgZtbGYW_dgvcHUjvXbGGIgLrNpMmRsw1xOGBDrVy3EZax66wXUuBc8y3WYIOGN_w2W--DY67HXQR7IBVw2rS2WZvogAd-FqR33OQ6v0V-RRGAnzBNc5jHa6TV3PheztO8G4pdscL3ZWizl-iuHq9FPXaC3qBYpZ2vjU3iV9dJaaZ4GTk_haN62DuMmoutr3D2-THQmG-2uWyOpumVfvtNy7J_6XRO-TWHE_Tfb8A7pKVbHiPrLfmFQP3yVlnSBHj0ovx6Mv0E3XEGBM6ymlxNyEdYBRy4UqB6HQ2GI0nddr8pcKeIqCnA5_Jov35ZUTYxmUXHpDTw4Ne0gjml0kElmuJZhhxi9BLin6fKYzZlHDgyTJuDcYXIoxyzTlix5jnGdPKhjLippZmCIlMJnLJNsjqcDTMHhKqQ1tLTY5bjJHcKK4ZVzYOLee5DTPLKqS9mGj47DlDwLNDRwBOwS7tL8GpF7xyQQrggGoFQJVCoVJgEELSgQiiCnlemEvZmxlfuoK8WMBZ-wgasvHhYy_pwlGFbC7ZU9kgQjesmKqQrYV9AboRlxsyw2w0m0Csi9gTRW14syubanduoUWFdArb-WNEfxnQdePxHx798x63yI1Gr3UCJ832u8fkpmcadrWaT8jqdDzLNhE_TtOnxTL_CcN8SzM |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwxV1ZbxMxELaqVop44a4IUOoHitqHTTfrY-1wSGV7JIUmiPQSLyOvs1ukKkmVQyD4K_xYxutkS6ASL0hIeYhW8n7yeDz-xp79TMhzEaWMM2MClglMUNCFAyXjNMilMj3F8alx-x1Hbdk84Yfn4nyJfJ9_C-P1IcoNNzczinjtJvhVL9--Fg1FAtZtJS1MmOtIwwMdauWkjbSOXV27lgKHmG-wBOMv_sPfTms3OOx2MEKwPVYLa0lng72NAozfK1ziMusY1cdr7SlMBPhcapzHOqyQ1zPw7U0HvFXCbnrQLSka_BXCNRol1BsP9BJhFha-FTeGX10hphnjWOT-Eo2bWO4iaS5Wvf075MfcXr7Y5bI2naQ1--03Kcn_ZNC75PaMTdMd7_73yFI2uE8qR7N6gQfkrDOgyHDpxWj4ZfKZOlmMMR3mtLiZkPYxB7lwhUB0Mu0PR-MGbf1SX0-RztO-P8eivdlVRNjGnS08JCf7e8dJM5hdJRFYriU6YcQtEi8pej2mMGNTwlEny7g1mF2IMMo158gcY55nTCsbyoibepohITKZyCVbJcuD4SB7RKgObT01OS4wRnKjuGZc2Ti0nOc2zCyrkvZ8nOHKK4aA14aOAJyB3aG_BGde8MYFKYADmhUATQqFSYFBCEkHIoiq5EXhLeXbzOjSlePFAs7aB9CUzdNPx0kXDqpkbcGdygYRBmHFVJWsz90LMIi4kyEzyIbTMcS6yDwRatV7XdlUu10LLaqkU7jOHz36S4du6o9_8Pifv3GdVD7s7sP7VvvdE3LLywy7Qs2nZHkymmZrSB4n6bNikv8EbO9J4g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=On+the+growth+rates+of+human+malignant+tumors%3A+Implications+for+medical+decision+making&rft.jtitle=Journal+of+surgical+oncology&rft.au=Friberg%2C+Sten&rft.au=Mattson%2C+Stefan&rft.date=1997-08-01&rft.issn=0022-4790&rft.eissn=1096-9098&rft.volume=65&rft.issue=4&rft.spage=284&rft.epage=297&rft_id=info:doi/10.1002%2F%28SICI%291096-9098%28199708%2965%3A4%3C284%3A%3AAID-JSO11%3E3.0.CO%3B2-2&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002__SICI_1096_9098_199708_65_4_284__AID_JSO11_3_0_CO_2_2 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-4790&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-4790&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-4790&client=summon |