Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells - Rai, Prashant; Marcus Parrish; Ian Jun Jie Tay; Na Li; Shelley Ackerman; Fang He; Jimmy Kwang; Vincent T. Chow; Bevin P. Engelward (Proceedings of the National Academy of Sciences - PNAS, 2015)
Keywords: Animals; antibiotics; Apoptosis; Biological Sciences; Cells; cytotoxicity; death; Deoxyribonucleic acid; DNA; DNA Damage; DNA Repair; Epithelial Cells - pathology; Female; genes; Genotoxicity; Gram-positive bacteria; host-pathogen relationships; Hydrogen peroxide; Hydrogen Peroxide - metabolism; Ku80; Lungs; Mice; Mice, Inbred BALB C; pathogenicity; PNAS Plus; pneumonia; Pulmonary Alveoli - cytology; Pulmonary Alveoli - metabolism; Streptococcus; Streptococcus pneumoniae; Streptococcus pneumoniae - metabolism; Streptococcus pneumoniae - pathogenicity; vaccines; Virulence; Î³H2AX; Ku80; DNA damage; γH2AX; hydrogen peroxide; Streptococcus pneumoniae