An Essential Role of Antibodies in the Control of Chikungunya Virus Infection

In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV infection remains unclear. In this study, wild-...

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Published inThe Journal of immunology (1950) Vol. 190; no. 12; pp. 6295 - 6302
Main Authors Lum, Fok-Moon, Teo, Teck-Hui, Lee, Wendy W L, Kam, Yiu-Wing, Rénia, Laurent, Ng, Lisa F P
Format Journal Article
LanguageEnglish
Published United States AAI 15.06.2013
Subjects
Online AccessGet full text
ISSN0022-1767
1550-6606
1550-6606
DOI10.4049/jimmunol.1300304

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Abstract In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV infection remains unclear. In this study, wild-type (WT), CD4−/−, and B cell (μMT) knockout mice were infected with CHIKV. Sera were taken at different days postinfection and measured for anti-CHIKV Ab levels. Isotype and neutralizing capacity of these Abs were assessed in vitro, and specific linear epitopes were mapped. Viremia in CHIKV-infected μMT mice persisted for more than a year, indicating a direct role for B cells in mediating CHIKV clearance. These animals exhibited a more severe disease than WT mice during the acute phase. Characterization of CHIKV-specific Abs revealed that anti-CHIKV Abs were elicited early and targeted epitopes mainly at the C terminus of the virus E2 glycoprotein. Furthermore, CD4−/− mice could still control CHIKV infection despite having lower anti-CHIKV Ab levels with reduced neutralizing capacity. Lastly, pre-existing natural Abs in the sera of normal WT mice recognized CHIKV and were able to partially inhibit CHIKV. Taken together, natural and CHIKV infection–induced specific Abs are essential for controlling CHIKV infections.
AbstractList In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV infection remains unclear. In this study, wild-type (WT), CD4-/-, and B cell ( mu MT) knockout mice were infected with CHIKV. Sera were taken at different days postinfection and measured for anti-CHIKV Ab levels. Isotype and neutralizing capacity of these Abs were assessed in vitro, and specific linear epitopes were mapped. Viremia in CHIKV-infected mu MT mice persisted for more than a year, indicating a direct role for B cells in mediating CHIKV clearance. These animals exhibited a more severe disease than WT mice during the acute phase. Characterization of CHIKV-specific Abs revealed that anti-CHIKV Abs were elicited early and targeted epitopes mainly at the C terminus of the virus E2 glycoprotein. Furthermore, CD4-/- mice could still control CHIKV infection despite having lower anti-CHIKV Ab levels with reduced neutralizing capacity. Lastly, pre-existing natural Abs in the sera of normal WT mice recognized CHIKV and were able to partially inhibit CHIKV. Taken together, natural and CHIKV infection-induced specific Abs are essential for controlling CHIKV infections.
In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV infection remains unclear. In this study, wild-type (WT), CD4(-/-), and B cell (μMT) knockout mice were infected with CHIKV. Sera were taken at different days postinfection and measured for anti-CHIKV Ab levels. Isotype and neutralizing capacity of these Abs were assessed in vitro, and specific linear epitopes were mapped. Viremia in CHIKV-infected μMT mice persisted for more than a year, indicating a direct role for B cells in mediating CHIKV clearance. These animals exhibited a more severe disease than WT mice during the acute phase. Characterization of CHIKV-specific Abs revealed that anti-CHIKV Abs were elicited early and targeted epitopes mainly at the C terminus of the virus E2 glycoprotein. Furthermore, CD4(-/-) mice could still control CHIKV infection despite having lower anti-CHIKV Ab levels with reduced neutralizing capacity. Lastly, pre-existing natural Abs in the sera of normal WT mice recognized CHIKV and were able to partially inhibit CHIKV. Taken together, natural and CHIKV infection-induced specific Abs are essential for controlling CHIKV infections.In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV infection remains unclear. In this study, wild-type (WT), CD4(-/-), and B cell (μMT) knockout mice were infected with CHIKV. Sera were taken at different days postinfection and measured for anti-CHIKV Ab levels. Isotype and neutralizing capacity of these Abs were assessed in vitro, and specific linear epitopes were mapped. Viremia in CHIKV-infected μMT mice persisted for more than a year, indicating a direct role for B cells in mediating CHIKV clearance. These animals exhibited a more severe disease than WT mice during the acute phase. Characterization of CHIKV-specific Abs revealed that anti-CHIKV Abs were elicited early and targeted epitopes mainly at the C terminus of the virus E2 glycoprotein. Furthermore, CD4(-/-) mice could still control CHIKV infection despite having lower anti-CHIKV Ab levels with reduced neutralizing capacity. Lastly, pre-existing natural Abs in the sera of normal WT mice recognized CHIKV and were able to partially inhibit CHIKV. Taken together, natural and CHIKV infection-induced specific Abs are essential for controlling CHIKV infections.
In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV infection remains unclear. In this study, wild-type (WT), CD4(-/-), and B cell (μMT) knockout mice were infected with CHIKV. Sera were taken at different days postinfection and measured for anti-CHIKV Ab levels. Isotype and neutralizing capacity of these Abs were assessed in vitro, and specific linear epitopes were mapped. Viremia in CHIKV-infected μMT mice persisted for more than a year, indicating a direct role for B cells in mediating CHIKV clearance. These animals exhibited a more severe disease than WT mice during the acute phase. Characterization of CHIKV-specific Abs revealed that anti-CHIKV Abs were elicited early and targeted epitopes mainly at the C terminus of the virus E2 glycoprotein. Furthermore, CD4(-/-) mice could still control CHIKV infection despite having lower anti-CHIKV Ab levels with reduced neutralizing capacity. Lastly, pre-existing natural Abs in the sera of normal WT mice recognized CHIKV and were able to partially inhibit CHIKV. Taken together, natural and CHIKV infection-induced specific Abs are essential for controlling CHIKV infections.
In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV infection remains unclear. In this study, wild-type (WT), CD4−/−, and B cell (μMT) knockout mice were infected with CHIKV. Sera were taken at different days postinfection and measured for anti-CHIKV Ab levels. Isotype and neutralizing capacity of these Abs were assessed in vitro, and specific linear epitopes were mapped. Viremia in CHIKV-infected μMT mice persisted for more than a year, indicating a direct role for B cells in mediating CHIKV clearance. These animals exhibited a more severe disease than WT mice during the acute phase. Characterization of CHIKV-specific Abs revealed that anti-CHIKV Abs were elicited early and targeted epitopes mainly at the C terminus of the virus E2 glycoprotein. Furthermore, CD4−/− mice could still control CHIKV infection despite having lower anti-CHIKV Ab levels with reduced neutralizing capacity. Lastly, pre-existing natural Abs in the sera of normal WT mice recognized CHIKV and were able to partially inhibit CHIKV. Taken together, natural and CHIKV infection–induced specific Abs are essential for controlling CHIKV infections.
Author Ng, Lisa F P
Lum, Fok-Moon
Teo, Teck-Hui
Rénia, Laurent
Lee, Wendy W L
Kam, Yiu-Wing
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Cites_doi 10.1128/JVI.01780-12
10.1172/JCI40104
10.1038/350423a0
10.1186/1471-2334-9-200
10.1099/vir.0.82858-0
10.1038/nprot.2010.5
10.4269/ajtmh.2007.76.1189
10.1007/s12026-012-8266-x
10.1128/JVI.00956-12
10.1016/j.medmal.2011.12.002
10.4049/jimmunol.0904181
10.1084/jem.20090851
10.1371/journal.ppat.0040029
10.1086/529444
10.4049/jimmunol.1202177
10.1086/600381
10.1128/JVI.02603-09
10.1097/QAD.0b013e328354622a
10.1172/JCI117892
10.1016/S0255-0857(21)02403-8
10.1016/S0022-1759(98)00015-5
10.4103/0028-3886.51289
10.3174/ajnr.A1133
10.1016/j.micinf.2009.09.004
10.1371/journal.ppat.1002322
10.4049/jimmunol.0803706
10.4269/ajtmh.2012.11-0393
10.1002/jcc.20084
10.4103/0971-5916.92618
10.1016/0167-5699(93)90063-Q
10.1002/emmm.201200213
10.1016/j.virol.2011.12.020
10.1093/infdis/jis033
10.1172/JCI63120
10.1371/journal.pntd.0000623
10.1016/S0167-5699(00)01754-0
10.1016/0035-9203(55)90080-8
10.1371/journal.ppat.1002390
10.1086/517537
10.1038/nri3152
10.1016/S0065-2776(08)60692-6
10.1126/science.286.5447.2156
10.1073/pnas.70.2.416
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F.-M.L. and T.-H.T. contributed equally to this work.
L.R. and L.F.P.N. directed this work equally.
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References Teo (2025032407074148000_r20) 2013; 190
Swain (2025032407074148000_r33) 2012; 12
Roederer (2025032407074148000_r44) 1995; 95
Powers (2025032407074148000_r7) 2007; 88
Her (2025032407074148000_r13) 2010; 184
Pettersen (2025032407074148000_r28) 2004; 25
Borgherini (2025032407074148000_r3) 2007; 44
Teo (2025032407074148000_r19) 2012; 53
Malvy (2025032407074148000_r34) 2009; 9
Kam (2025032407074148000_r26) 2012; 205
Ochsenbein (2025032407074148000_r37) 1999; 286
Andersson (2025032407074148000_r30) 1973; 70
Herzenberg (2025032407074148000_r36) 1993; 14
Lakshmi (2025032407074148000_r4) 2008; 46
Labadie (2025032407074148000_r14) 2010; 120
Couderc (2025032407074148000_r16) 2008; 4
Kitamura (2025032407074148000_r23) 1991; 350
Her (2025032407074148000_r1) 2009; 11
Werneke (2025032407074148000_r12) 2011; 7
Hertz (2025032407074148000_r43) 2012; 86
Barr (2025032407074148000_r31) 2009; 183
Lee (2025032407074148000_r22) 2011; 7
De Cock (2025032407074148000_r39) 2012; 26
Vitetta (2025032407074148000_r32) 1989; 45
Chandak (2025032407074148000_r5) 2009; 57
Ganesan (2025032407074148000_r6) 2008; 29
Rudd (2025032407074148000_r17) 2012; 86
Ochsenbein (2025032407074148000_r35) 2000; 21
Robinson (2025032407074148000_r2) 1955; 49
Gardner (2025032407074148000_r11) 2012; 425
Kam (2025032407074148000_r24) 2012; 4
Kam (2025032407074148000_r25) 2012; 86
Mayer (2025032407074148000_r38) 2011; 134
Schilte (2025032407074148000_r15) 2010; 207
Renault (2025032407074148000_r8) 2012; 42
Thiboutot (2025032407074148000_r40) 2010; 4
Roy (2025032407074148000_r29) 2010; 5
Gardner (2025032407074148000_r10) 2010; 84
Martin (2025032407074148000_r27) 1998; 212
Chua (2025032407074148000_r9) 2010; 65
Teng (2025032407074148000_r18) 2012; 122
Sergon (2025032407074148000_r42) 2007; 76
Ravi (2025032407074148000_r41) 2006; 24
Couderc (2025032407074148000_r21) 2009; 200
22706007 - AIDS. 2012 Jun 19;26(10):1205-13
18282093 - PLoS Pathog. 2008 Feb 8;4(2):e29
18566010 - AJNR Am J Neuroradiol. 2008 Oct;29(9):1636-7
19572805 - J Infect Dis. 2009 Aug 15;200(4):516-23
10591647 - Science. 1999 Dec 10;286(5447):2156-9
18419449 - Clin Infect Dis. 2008 May 1;46(9):1436-42
20404274 - J Immunol. 2010 May 15;184(10):5903-13
20179353 - J Clin Invest. 2010 Mar;120(3):894-906
9672206 - J Immunol Methods. 1998 Mar 15;212(2):187-92
16687855 - Indian J Med Microbiol. 2006 Apr;24(2):83-4
20436958 - PLoS Negl Trop Dis. 2010;4(4):e623
22028657 - PLoS Pathog. 2011 Oct;7(10):e1002322
22761364 - J Virol. 2012 Sep;86(18):9888-98
20360767 - Nat Protoc. 2010 Apr;5(4):725-38
7738173 - J Clin Invest. 1995 May;95(5):2061-6
21901945 - Med J Malaysia. 2010 Dec;65(4):277-82
22389226 - J Infect Dis. 2012 Apr 1;205(7):1147-54
20123960 - J Exp Med. 2010 Feb 15;207(2):429-42
23160199 - J Clin Invest. 2012 Dec;122(12):4447-60
19747979 - Microbes Infect. 2009 Dec;11(14-15):1165-76
20519386 - J Virol. 2010 Aug;84(16):8021-32
8447936 - Immunol Today. 1993 Feb;14(2):79-83; discussion 88-90
19542370 - J Immunol. 2009 Jul 15;183(2):1005-12
22389221 - EMBO Mol Med. 2012 Apr;4(4):330-43
22418724 - Immunol Res. 2012 Sep;53(1-3):136-47
23209328 - J Immunol. 2013 Jan 1;190(1):259-69
20003320 - BMC Infect Dis. 2009;9:200
15264254 - J Comput Chem. 2004 Oct;25(13):1605-12
22305131 - Virology. 2012 Apr 10;425(2):103-12
2665437 - Adv Immunol. 1989;45:1-105
17698645 - J Gen Virol. 2007 Sep;88(Pt 9):2363-77
22280563 - Med Mal Infect. 2012 Mar;42(3):93-101
4568727 - Proc Natl Acad Sci U S A. 1973 Feb;70(2):416-20
17479933 - Clin Infect Dis. 2007 Jun 1;44(11):1401-7
22310809 - Indian J Med Res. 2011 Dec;134(6):739-41
11114423 - Immunol Today. 2000 Dec;21(12):624-30
19439849 - Neurol India. 2009 Mar-Apr;57(2):177-80
22144891 - PLoS Pathog. 2011 Dec;7(12):e1002390
23015702 - J Virol. 2012 Dec;86(23):13005-15
14373834 - Trans R Soc Trop Med Hyg. 1955 Jan;49(1):28-32
22232469 - Am J Trop Med Hyg. 2012 Jan;86(1):171-7
17556634 - Am J Trop Med Hyg. 2007 Jun;76(6):1189-93
22266691 - Nat Rev Immunol. 2012 Feb;12(2):136-48
1901381 - Nature. 1991 Apr 4;350(6317):423-6
References_xml – volume: 86
  start-page: 13005
  year: 2012
  ident: 2025032407074148000_r25
  article-title: Longitudinal analysis of the human antibody response to Chikungunya virus infection: implications for serodiagnosis and vaccine development
  publication-title: J. Virol.
  doi: 10.1128/JVI.01780-12
– volume: 120
  start-page: 894
  year: 2010
  ident: 2025032407074148000_r14
  article-title: Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI40104
– volume: 350
  start-page: 423
  year: 1991
  ident: 2025032407074148000_r23
  article-title: A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
  publication-title: Nature
  doi: 10.1038/350423a0
– volume: 9
  start-page: 200
  year: 2009
  ident: 2025032407074148000_r34
  article-title: Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
  publication-title: BMC Infect. Dis.
  doi: 10.1186/1471-2334-9-200
– volume: 88
  start-page: 2363
  year: 2007
  ident: 2025032407074148000_r7
  article-title: Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus
  publication-title: J. Gen. Virol.
  doi: 10.1099/vir.0.82858-0
– volume: 5
  start-page: 725
  year: 2010
  ident: 2025032407074148000_r29
  article-title: I-TASSER: a unified platform for automated protein structure and function prediction
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2010.5
– volume: 76
  start-page: 1189
  year: 2007
  ident: 2025032407074148000_r42
  article-title: Seroprevalence of Chikungunya virus infection on Grande Comore Island, union of the Comoros, 2005
  publication-title: Am. J. Trop. Med. Hyg.
  doi: 10.4269/ajtmh.2007.76.1189
– volume: 53
  start-page: 136
  year: 2012
  ident: 2025032407074148000_r19
  article-title: Mouse models for Chikungunya virus: deciphering immune mechanisms responsible for disease and pathology
  publication-title: Immunol. Res.
  doi: 10.1007/s12026-012-8266-x
– volume: 86
  start-page: 9888
  year: 2012
  ident: 2025032407074148000_r17
  article-title: Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock
  publication-title: J. Virol.
  doi: 10.1128/JVI.00956-12
– volume: 42
  start-page: 93
  year: 2012
  ident: 2025032407074148000_r8
  article-title: Epidemiology of Chikungunya infection on Reunion Island, Mayotte, and neighboring countries
  publication-title: Med. Mal. Infect.
  doi: 10.1016/j.medmal.2011.12.002
– volume: 184
  start-page: 5903
  year: 2010
  ident: 2025032407074148000_r13
  article-title: Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0904181
– volume: 207
  start-page: 429
  year: 2010
  ident: 2025032407074148000_r15
  article-title: Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20090851
– volume: 4
  start-page: e29
  year: 2008
  ident: 2025032407074148000_r16
  article-title: A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.0040029
– volume: 46
  start-page: 1436
  year: 2008
  ident: 2025032407074148000_r4
  article-title: Clinical features and molecular diagnosis of Chikungunya fever from South India
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/529444
– volume: 190
  start-page: 259
  year: 2013
  ident: 2025032407074148000_r20
  article-title: A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1202177
– volume: 65
  start-page: 277
  year: 2010
  ident: 2025032407074148000_r9
  article-title: Epidemiology of chikungunya in Malaysia: 2006-2009
  publication-title: Med. J. Malaysia
– volume: 200
  start-page: 516
  year: 2009
  ident: 2025032407074148000_r21
  article-title: Prophylaxis and therapy for Chikungunya virus infection
  publication-title: J. Infect. Dis.
  doi: 10.1086/600381
– volume: 84
  start-page: 8021
  year: 2010
  ident: 2025032407074148000_r10
  article-title: Chikungunya virus arthritis in adult wild-type mice
  publication-title: J. Virol.
  doi: 10.1128/JVI.02603-09
– volume: 26
  start-page: 1205
  year: 2012
  ident: 2025032407074148000_r39
  article-title: The evolving epidemiology of HIV/AIDS
  publication-title: AIDS
  doi: 10.1097/QAD.0b013e328354622a
– volume: 95
  start-page: 2061
  year: 1995
  ident: 2025032407074148000_r44
  article-title: CD8 naive T cell counts decrease progressively in HIV-infected adults
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI117892
– volume: 24
  start-page: 83
  year: 2006
  ident: 2025032407074148000_r41
  article-title: Re-emergence of chikungunya virus in India
  publication-title: Indian J. Med. Microbiol.
  doi: 10.1016/S0255-0857(21)02403-8
– volume: 212
  start-page: 187
  year: 1998
  ident: 2025032407074148000_r27
  article-title: The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice
  publication-title: J. Immunol. Methods
  doi: 10.1016/S0022-1759(98)00015-5
– volume: 57
  start-page: 177
  year: 2009
  ident: 2025032407074148000_r5
  article-title: Neurological complications of Chikungunya virus infection
  publication-title: Neurol. India
  doi: 10.4103/0028-3886.51289
– volume: 29
  start-page: 1636
  year: 2008
  ident: 2025032407074148000_r6
  article-title: Chikungunya encephalomyeloradiculitis: report of 2 cases with neuroimaging and 1 case with autopsy findings
  publication-title: AJNR Am. J. Neuroradiol.
  doi: 10.3174/ajnr.A1133
– volume: 11
  start-page: 1165
  year: 2009
  ident: 2025032407074148000_r1
  article-title: Chikungunya: a bending reality
  publication-title: Microbes Infect.
  doi: 10.1016/j.micinf.2009.09.004
– volume: 7
  start-page: e1002322
  year: 2011
  ident: 2025032407074148000_r12
  article-title: ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1002322
– volume: 183
  start-page: 1005
  year: 2009
  ident: 2025032407074148000_r31
  article-title: B cell intrinsic MyD88 signals drive IFN-gamma production from T cells and control switching to IgG2c
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0803706
– volume: 86
  start-page: 171
  year: 2012
  ident: 2025032407074148000_r43
  article-title: Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania
  publication-title: Am. J. Trop. Med. Hyg.
  doi: 10.4269/ajtmh.2012.11-0393
– volume: 25
  start-page: 1605
  year: 2004
  ident: 2025032407074148000_r28
  article-title: UCSF Chimera—a visualization system for exploratory research and analysis
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20084
– volume: 134
  start-page: 739
  year: 2011
  ident: 2025032407074148000_r38
  article-title: The evolving Indian AIDS epidemic: hope & challenges of the fourth decade
  publication-title: Indian J. Med. Res.
  doi: 10.4103/0971-5916.92618
– volume: 14
  start-page: 79
  year: 1993
  ident: 2025032407074148000_r36
  article-title: B-cell lineages exist in the mouse
  publication-title: Immunol. Today
  doi: 10.1016/0167-5699(93)90063-Q
– volume: 4
  start-page: 330
  year: 2012
  ident: 2025032407074148000_r24
  article-title: Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein
  publication-title: EMBO Mol. Med.
  doi: 10.1002/emmm.201200213
– volume: 425
  start-page: 103
  year: 2012
  ident: 2025032407074148000_r11
  article-title: Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate
  publication-title: Virology
  doi: 10.1016/j.virol.2011.12.020
– volume: 205
  start-page: 1147
  year: 2012
  ident: 2025032407074148000_r26
  article-title: Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jis033
– volume: 122
  start-page: 4447
  year: 2012
  ident: 2025032407074148000_r18
  article-title: Viperin restricts chikungunya virus replication and pathology
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI63120
– volume: 4
  start-page: e623
  year: 2010
  ident: 2025032407074148000_r40
  article-title: Chikungunya: a potentially emerging epidemic?
  publication-title: PLoS Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0000623
– volume: 21
  start-page: 624
  year: 2000
  ident: 2025032407074148000_r35
  article-title: Natural antibodies and complement link innate and acquired immunity
  publication-title: Immunol. Today
  doi: 10.1016/S0167-5699(00)01754-0
– volume: 49
  start-page: 28
  year: 1955
  ident: 2025032407074148000_r2
  article-title: An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features
  publication-title: Trans. R. Soc. Trop. Med. Hyg.
  doi: 10.1016/0035-9203(55)90080-8
– volume: 7
  start-page: e1002390
  year: 2011
  ident: 2025032407074148000_r22
  article-title: Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1002390
– volume: 44
  start-page: 1401
  year: 2007
  ident: 2025032407074148000_r3
  article-title: Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/517537
– volume: 12
  start-page: 136
  year: 2012
  ident: 2025032407074148000_r33
  article-title: Expanding roles for CD4+ T cells in immunity to viruses
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3152
– volume: 45
  start-page: 1
  year: 1989
  ident: 2025032407074148000_r32
  article-title: Cellular interactions in the humoral immune response
  publication-title: Adv. Immunol.
  doi: 10.1016/S0065-2776(08)60692-6
– volume: 286
  start-page: 2156
  year: 1999
  ident: 2025032407074148000_r37
  article-title: Control of early viral and bacterial distribution and disease by natural antibodies
  publication-title: Science
  doi: 10.1126/science.286.5447.2156
– volume: 70
  start-page: 416
  year: 1973
  ident: 2025032407074148000_r30
  article-title: Induction of immunoglobulin M synthesis and secretion in bone-marrow-derived lymphocytes by locally concentrated concanavalin A
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.70.2.416
– reference: 20404274 - J Immunol. 2010 May 15;184(10):5903-13
– reference: 22761364 - J Virol. 2012 Sep;86(18):9888-98
– reference: 22389221 - EMBO Mol Med. 2012 Apr;4(4):330-43
– reference: 8447936 - Immunol Today. 1993 Feb;14(2):79-83; discussion 88-90
– reference: 20360767 - Nat Protoc. 2010 Apr;5(4):725-38
– reference: 22310809 - Indian J Med Res. 2011 Dec;134(6):739-41
– reference: 23015702 - J Virol. 2012 Dec;86(23):13005-15
– reference: 20123960 - J Exp Med. 2010 Feb 15;207(2):429-42
– reference: 22028657 - PLoS Pathog. 2011 Oct;7(10):e1002322
– reference: 22389226 - J Infect Dis. 2012 Apr 1;205(7):1147-54
– reference: 20436958 - PLoS Negl Trop Dis. 2010;4(4):e623
– reference: 7738173 - J Clin Invest. 1995 May;95(5):2061-6
– reference: 18419449 - Clin Infect Dis. 2008 May 1;46(9):1436-42
– reference: 22266691 - Nat Rev Immunol. 2012 Feb;12(2):136-48
– reference: 22305131 - Virology. 2012 Apr 10;425(2):103-12
– reference: 20179353 - J Clin Invest. 2010 Mar;120(3):894-906
– reference: 4568727 - Proc Natl Acad Sci U S A. 1973 Feb;70(2):416-20
– reference: 22144891 - PLoS Pathog. 2011 Dec;7(12):e1002390
– reference: 20003320 - BMC Infect Dis. 2009;9:200
– reference: 17479933 - Clin Infect Dis. 2007 Jun 1;44(11):1401-7
– reference: 17698645 - J Gen Virol. 2007 Sep;88(Pt 9):2363-77
– reference: 22232469 - Am J Trop Med Hyg. 2012 Jan;86(1):171-7
– reference: 23160199 - J Clin Invest. 2012 Dec;122(12):4447-60
– reference: 18282093 - PLoS Pathog. 2008 Feb 8;4(2):e29
– reference: 19439849 - Neurol India. 2009 Mar-Apr;57(2):177-80
– reference: 1901381 - Nature. 1991 Apr 4;350(6317):423-6
– reference: 15264254 - J Comput Chem. 2004 Oct;25(13):1605-12
– reference: 11114423 - Immunol Today. 2000 Dec;21(12):624-30
– reference: 22280563 - Med Mal Infect. 2012 Mar;42(3):93-101
– reference: 19572805 - J Infect Dis. 2009 Aug 15;200(4):516-23
– reference: 22418724 - Immunol Res. 2012 Sep;53(1-3):136-47
– reference: 14373834 - Trans R Soc Trop Med Hyg. 1955 Jan;49(1):28-32
– reference: 2665437 - Adv Immunol. 1989;45:1-105
– reference: 19747979 - Microbes Infect. 2009 Dec;11(14-15):1165-76
– reference: 10591647 - Science. 1999 Dec 10;286(5447):2156-9
– reference: 18566010 - AJNR Am J Neuroradiol. 2008 Oct;29(9):1636-7
– reference: 23209328 - J Immunol. 2013 Jan 1;190(1):259-69
– reference: 20519386 - J Virol. 2010 Aug;84(16):8021-32
– reference: 19542370 - J Immunol. 2009 Jul 15;183(2):1005-12
– reference: 17556634 - Am J Trop Med Hyg. 2007 Jun;76(6):1189-93
– reference: 22706007 - AIDS. 2012 Jun 19;26(10):1205-13
– reference: 9672206 - J Immunol Methods. 1998 Mar 15;212(2):187-92
– reference: 16687855 - Indian J Med Microbiol. 2006 Apr;24(2):83-4
– reference: 21901945 - Med J Malaysia. 2010 Dec;65(4):277-82
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Snippet In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be...
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StartPage 6295
SubjectTerms Alphavirus Infections - immunology
Animals
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
B-Lymphocytes - immunology
Chikungunya Fever
Chikungunya virus
Female
Infectious Disease and Host Response
Mice
Mice, Inbred C57BL
Mice, Knockout
Title An Essential Role of Antibodies in the Control of Chikungunya Virus Infection
URI https://www.ncbi.nlm.nih.gov/pubmed/23670192
https://www.proquest.com/docview/1366577721
https://www.proquest.com/docview/1551621291
https://pubmed.ncbi.nlm.nih.gov/PMC3677171
https://www.jimmunol.org/content/jimmunol/190/12/6295.full.pdf
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