Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: Role of the Akt pathway and the ERK/Bim axis - Matsumoto, Takumi; Nagase, Yuichi; Iwasawa, Mitsuyasu; Yasui, Tetsuro; Masuda, Hironari; Kadono, Yuho; Nakamura, Kozo; Tanaka, Sakae (Arthritis & rheumatology (Hoboken, N.J.), 2011)
Keywords: AKT protein; AKT1 protein; Animals; Apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Apoptosis Regulatory Proteins - deficiency; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - physiology; Bcl-2-Like Protein 11; BIM protein; Bisphosphonates; Bone density; Bone Density - drug effects; Bone Density - physiology; Bone Density Conservation Agents - pharmacology; Bone marrow; Bone mineral density; Bone resorption; Bone Resorption - physiopathology; Cells, Cultured; Etidronic Acid - analogs & derivatives; Etidronic Acid - pharmacology; Extracellular signal-regulated kinase; Extracellular Signal-Regulated MAP Kinases - physiology; Gene Deletion; In Vitro Techniques; Macrophages; Male; MAP Kinase Kinase 1 - physiology; Membrane Proteins - deficiency; Membrane Proteins - genetics; Membrane Proteins - physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondria - drug effects; Mitochondria - physiology; Models, Animal; Osteoclasts; Osteoclasts - drug effects; Osteoclasts - physiology; Osteoporosis; Proto-Oncogene Proteins - deficiency; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - physiology; Proto-Oncogene Proteins c-akt - physiology; Risedronate Sodium; Risedronic acid; Signal Transduction - drug effects; Signal Transduction - physiology