Retrovirus-based pseudotyped virus neutralisation assays overestimate neutralising activity in sera from participants receiving integrase inhibitors - McCormack, Mhairi J.; Asamaphan, Patawee; Hughes, Ellen C.; Banda, Louis; Kasenda, Stephen; Davis, Chris; Szemiel, Agnieszka M.; Crampin, Amelia; Amoah, Abena S.; Thomson, Emma C.; Ho, Antonia; Willett, Brian J. (Scientific reports, 2025)
Keywords: 631/1647; 631/250; 631/326/596; Adult; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antiretroviral agents; Confidence intervals; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - immunology; COVID-19 - virology; Female; Glycoproteins; Hepacivirus - immunology; Hepatitis C; Hepatitis C - immunology; HIV; HIV Infections - blood; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; Human immunodeficiency virus; Humanities and Social Sciences; Humans; Immunity; Immunoglobulin G; Inhibitors; Integrase; Integrase inhibitors; Integrase Inhibitors - therapeutic use; Interference; Leukemia; Male; Mann-Whitney U test; Middle Aged; multidisciplinary; Neutralization Tests - methods; Pseudovirus assay; Pyridones; Retroviridae - immunology; SARS-CoV-2 - immunology; Science; Science (multidisciplinary); Serology; Severe acute respiratory syndrome coronavirus 2; Statistical significance; Stomatitis; United Kingdom--UK; Malawi; Pseudovirus assay; HIV; Integrase inhibitors; Interference