Defects of class-switch recombination - Notarangelo, Luigi D.; Lanzi, Gaetana; Peron, Sophie; Durandy, Anne (Journal of Allergy and Clinical Immunology, 2006)
Keywords: Amino acids; B-Lymphocytes - immunology; Binding sites; Biological and medical sciences; CD40 Antigens - metabolism; CD40 Ligand - genetics; Cell adhesion & migration; Chromosomes, Human, X - genetics; class-switch recombination; Cytidine Deaminase; Cytosine Deaminase - deficiency; Cytosine Deaminase - genetics; Defects; Deoxyribonucleic acid; DNA; DNA repair; Enzymes; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genes; Human subjects; Humans; Hypergammaglobulinemia - genetics; Hypergammaglobulinemia - immunology; Immune system; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunodeficiency with hyper-IgM; Immunoglobulin Class Switching; Immunoglobulin M - genetics; Immunologic Deficiency Syndromes - genetics; Immunologic Deficiency Syndromes - immunology; Immunopathology; Kinases; Lymphocytes; Medical prognosis; Medical sciences; Models, Genetic; Models, Immunological; Mutation; NF-kappa B - metabolism; Proteins; Recombination, Genetic; Signal Transduction; somatic hypermutation; Somatic Hypermutation, Immunoglobulin; Uracil-DNA Glycosidase - deficiency; Uracil-DNA Glycosidase - genetics; CD40L; CSR; D; TRAF; J; Immunodeficiency with hyper-IgM; UNG; sIg; DSB; somatic hypermutation; S; APOBEC-1; V; NF; SHM; AID; EDA-ID; NEMO; class-switch recombination; Somatic mutation; Immunopathology; Recombination; Immunology; Hyperimmunoglobulinemia M syndrome; Isotype switching; Immune deficiency; Immunodeficiency with Hyper-IgM