Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition - Shi, Xiangguo; Li, Minhua; Liu, Zian; Tiessen, Jonathan; Li, Yuan; Zhou, Jing; Zhu, Yudan; Mahesula, Swetha; Ding, Qing; Tan, Lin; Feng, Mengdie; Kageyama, Yuki; et al. (Nature communications, 2025)
Keywords: 13/100; 13/31; 13/44; 631/67/1990/283/1897; 631/67/2327; 631/67/71; 64/60; Acute myeloid leukemia; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Biosynthesis; Cell Line, Tumor; Chromatin; Complex formation; Differentiation; Guanine; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Humanities and Social Sciences; Humans; IMP Dehydrogenase - antagonists & inhibitors; IMP Dehydrogenase - genetics; IMP Dehydrogenase - metabolism; Inhibitors; Inosine monophosphate; Leukemia; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - metabolism; Leukemia, Myeloid, Acute - pathology; Mice; multidisciplinary; Myeloid-Lymphoid Leukemia Protein - genetics; Myeloid-Lymphoid Leukemia Protein - metabolism; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Nucleotides; Proto-Oncogene Proteins - antagonists & inhibitors; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; rRNA; Science; Science (multidisciplinary); Stem cells; Transcription Factors - genetics; Transcription Factors - metabolism