Pharmacokinetics of Terazosin Enantiomers in Healthy Chinese Male Subjects
ABSTRACT The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2‐mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma...
Saved in:
| Published in | Chirality (New York, N.Y.) Vol. 24; no. 12; pp. 1047 - 1050 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.12.2012
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0899-0042 1520-636X 1520-636X |
| DOI | 10.1002/chir.22095 |
Cover
| Abstract | ABSTRACT
The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2‐mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma concentrations of (+)‐(R)‐terazosin at all time points were higher than those of (−)‐(S)‐terazosin. The area under the plasma concentration–time curve (AUC0–∞) and maximum plasma concentration of (+)‐(R)‐terazosin were significantly greater than those of the (−)‐(S)‐terazosin (P < 0.01, respectively). The R/S ratio of AUC0–∞ of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects. Chirality 24:1047–1050, 2012. © 2012 Wiley Periodicals, Inc. |
|---|---|
| AbstractList | The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2‐mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma concentrations of (+)‐( R )‐terazosin at all time points were higher than those of (−)‐( S )‐terazosin. The area under the plasma concentration–time curve (AUC 0–∞ ) and maximum plasma concentration of (+)‐( R )‐terazosin were significantly greater than those of the (−)‐( S )‐terazosin ( P < 0.01, respectively). The R / S ratio of AUC 0–∞ of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects. Chirality 24:1047–1050, 2012 . © 2012 Wiley Periodicals, Inc. ABSTRACT The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2‐mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma concentrations of (+)‐(R)‐terazosin at all time points were higher than those of (−)‐(S)‐terazosin. The area under the plasma concentration–time curve (AUC0–∞) and maximum plasma concentration of (+)‐(R)‐terazosin were significantly greater than those of the (−)‐(S)‐terazosin (P < 0.01, respectively). The R/S ratio of AUC0–∞ of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects. Chirality 24:1047–1050, 2012. © 2012 Wiley Periodicals, Inc. The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48h in 12 healthy subjects. The plasma concentrations of (+)-(R)-terazosin at all time points were higher than those of (-)-(S)-terazosin. The area under the plasma concentration-time curve (AUC0-[infin]) and maximum plasma concentration of (+)-(R)-terazosin were significantly greater than those of the (-)-(S)-terazosin (P<0.01, respectively). The R/S ratio of AUC0-[infin] of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects. Chirality 24:1047-1050, 2012. © 2012 Wiley Periodicals, Inc. [PUBLICATION ABSTRACT] The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48h in 12 healthy subjects. The plasma concentrations of (+)-(R)-terazosin at all time points were higher than those of (-)-(S)-terazosin. The area under the plasma concentration-time curve (AUC sub(0-[infin])) and maximum plasma concentration of (+)-(R)-terazosin were significantly greater than those of the (-)-(S)-terazosin (P<0.01, respectively). The R/S ratio of AUC sub(0-[infin]) of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects. Chirality 24:1047-1050, 2012. [copy 2012 Wiley Periodicals, Inc. The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma concentrations of (+)-(R)-terazosin at all time points were higher than those of (-)-(S)-terazosin. The area under the plasma concentration-time curve (AUC(0-∞) ) and maximum plasma concentration of (+)-(R)-terazosin were significantly greater than those of the (-)-(S)-terazosin (P < 0.01, respectively). The R/S ratio of AUC(0-∞) of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects.The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma concentrations of (+)-(R)-terazosin at all time points were higher than those of (-)-(S)-terazosin. The area under the plasma concentration-time curve (AUC(0-∞) ) and maximum plasma concentration of (+)-(R)-terazosin were significantly greater than those of the (-)-(S)-terazosin (P < 0.01, respectively). The R/S ratio of AUC(0-∞) of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects. The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma concentrations of (+)-(R)-terazosin at all time points were higher than those of (-)-(S)-terazosin. The area under the plasma concentration-time curve (AUC(0-∞) ) and maximum plasma concentration of (+)-(R)-terazosin were significantly greater than those of the (-)-(S)-terazosin (P < 0.01, respectively). The R/S ratio of AUC(0-∞) of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects. |
| Author | Zhang, Yanan Liu, Man Wang, Xiaolin Zhao, Ting Han, Jing Zhang, Dan Yang, Man Liu, Huichen |
| Author_xml | – sequence: 1 givenname: Man surname: Liu fullname: Liu, Man organization: Department of Clinical Pharmacology, Aerospace Center Hospital, Beijing, People's Republic of China – sequence: 2 givenname: Dan surname: Zhang fullname: Zhang, Dan organization: Department of Clinical Pharmacology, Aerospace Center Hospital, Beijing, People's Republic of China – sequence: 3 givenname: Man surname: Yang fullname: Yang, Man organization: Department of Clinical Pharmacology, Aerospace Center Hospital, Beijing, People's Republic of China – sequence: 4 givenname: Ting surname: Zhao fullname: Zhao, Ting organization: Department of Clinical Pharmacology, Aerospace Center Hospital, Beijing, People's Republic of China – sequence: 5 givenname: Xiaolin surname: Wang fullname: Wang, Xiaolin organization: Department of Clinical Pharmacology, Aerospace Center Hospital, Beijing, People's Republic of China – sequence: 6 givenname: Yanan surname: Zhang fullname: Zhang, Yanan organization: Department of Clinical Pharmacology, Aerospace Center Hospital, Beijing, People's Republic of China – sequence: 7 givenname: Jing surname: Han fullname: Han, Jing organization: Department of Clinical Pharmacology, Aerospace Center Hospital, Beijing, People's Republic of China – sequence: 8 givenname: Huichen surname: Liu fullname: Liu, Huichen email: huichenliu@163.com organization: Department of Clinical Pharmacology, Aerospace Center Hospital, Beijing, People's Republic of China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22887707$$D View this record in MEDLINE/PubMed |
| BookMark | eNqF0V1rFDEUBuAgFbttvfEHyIA3Upiar0kml7K03dbVSq1UvAmZ7Amb7cykJjPU9debddteFNGrcOB5D-S8e2inDz0g9IrgI4IxfWeXPh5RilX1DE1IRXEpmPi2gya4VqrEmNNdtJfSCmOsBOMv0C6ldS0llhN0_nlpYmdsuPE9DN6mIrjiCqL5FZLvi-Pe9IMPHcRU5HEGph2W62K6zDpB8dG0UHwZmxXYIR2g5860CV7ev_vo68nx1XRWzi9Oz6bv56XlilflwnEGjEvhhG2cYGCZA-McN8pVeeKNkpV0vGaCkLqpKytY4xhQYWlN3YLto7fbvbcx_BghDbrzyULbmh7CmDSRnAtVy4r9n1JKCMNK1pm-eUJXYYx9_shGYZH3SZrV63s1Nh0s9G30nYlr_XDQDA63wMaQUgT3SAjWm7b0pi39p62M8RNs_WDyvfshGt_-PUK2kTvfwvofy_V0dnb5kCm3GZ8G-PmYMfFGC8lkpa8_nerLazo7_zA_0d_Zby2RtTA |
| CitedBy_id | crossref_primary_10_1111_bcpt_14090 crossref_primary_10_1016_j_saa_2020_118624 crossref_primary_10_1038_aps_2013_78 crossref_primary_10_1002_adsc_202400777 crossref_primary_10_1002_chir_22505 crossref_primary_10_1246_cl_160004 |
| Cites_doi | 10.1208/aapsj0901011 10.1016/S0014-2999(97)89681-1 10.1177/009127009203200605 10.1016/S0378-4347(00)00313-3 10.1016/j.chroma.2009.05.034 10.1016/S0378-4347(98)00120-0 10.1016/S0026-895X(25)09946-8 10.1002/(SICI)1097-0045(19990215)38:3<216::AID-PROS6>3.0.CO;2-0 10.1016/S0021-9673(97)00892-3 10.1016/S0026-895X(25)10156-9 10.3109/10799899509049862 |
| ContentType | Journal Article |
| Copyright | Copyright © 2012 Wiley Periodicals, Inc Copyright © 2012 Wiley Periodicals, Inc. |
| Copyright_xml | – notice: Copyright © 2012 Wiley Periodicals, Inc – notice: Copyright © 2012 Wiley Periodicals, Inc. |
| DBID | BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QO 7QR 7U7 8FD C1K FR3 P64 7X8 7SR 7U5 8BQ JG9 L7M |
| DOI | 10.1002/chir.22095 |
| DatabaseName | Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Biotechnology Research Abstracts Chemoreception Abstracts Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic Engineered Materials Abstracts Solid State and Superconductivity Abstracts METADEX Materials Research Database Advanced Technologies Database with Aerospace |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Biotechnology Research Abstracts Technology Research Database Toxicology Abstracts Chemoreception Abstracts Engineering Research Database Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic Materials Research Database Engineered Materials Abstracts Solid State and Superconductivity Abstracts Advanced Technologies Database with Aerospace METADEX |
| DatabaseTitleList | CrossRef Biotechnology Research Abstracts Materials Research Database MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1520-636X |
| EndPage | 1050 |
| ExternalDocumentID | 2827860001 22887707 10_1002_chir_22095 CHIR22095 ark_67375_WNG_RW2HJKLF_Z |
| Genre | article Clinical Trial Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: This work was supported by the Daicel Chiral Technologies (China) Co., Ltd |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 29B 31~ 33P 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHQN AAMMB AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABDBF ABEML ABIJN ABOCM ABPVW ACAHQ ACBWZ ACCZN ACGFS ACIWK ACPOU ACPRK ACRPL ACSCC ACUHS ACXBN ACXQS ACYXJ ADBBV ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEGXH AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFFPM AFGKR AFRAH AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AI. AIDQK AIDYY AIQQE AITYG AIURR AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AUFTA AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BSCLL BTSUX BY8 CS3 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRSTM DU5 EBD EBS EJD F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA H.T H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M21 MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG P2W P2X P4D PALCI Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RX1 RYL SAMSI SUPJJ TUS UB1 UPT V2E V8K VH1 W8V W99 WBFHL WBKPD WIB WIH WIK WJL WOHZO WQJ WXSBR WYISQ XG1 XV2 ZZTAW ~02 ~IA ~WT AAHHS ACCFJ ADZOD AEEZP AEQDE AEUQT AFPWT AIWBW AJBDE RWI RWK WRC YCJ AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QO 7QR 7U7 8FD C1K FR3 P64 7X8 7SR 7U5 8BQ JG9 L7M |
| ID | FETCH-LOGICAL-c4945-df43e3476f6cbf63ec3feaff4a9f53ec4b9757f4836118b85c63bf3e26c282fd3 |
| IEDL.DBID | DR2 |
| ISSN | 0899-0042 1520-636X |
| IngestDate | Thu Jul 10 23:02:43 EDT 2025 Thu Jul 10 21:27:13 EDT 2025 Sun Jul 13 04:16:25 EDT 2025 Wed Feb 19 01:51:42 EST 2025 Tue Jul 01 05:14:54 EDT 2025 Thu Apr 24 23:03:34 EDT 2025 Wed Jan 22 16:33:20 EST 2025 Sun Sep 21 06:20:01 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor Copyright © 2012 Wiley Periodicals, Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4945-df43e3476f6cbf63ec3feaff4a9f53ec4b9757f4836118b85c63bf3e26c282fd3 |
| Notes | This work was supported by the Daicel Chiral Technologies (China) Co., Ltd ark:/67375/WNG-RW2HJKLF-Z ArticleID:CHIR22095 istex:1CEE97B8DE9D45FBA52ED7313F85083212081769 ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Feature-2 |
| PMID | 22887707 |
| PQID | 1220687572 |
| PQPubID | 986330 |
| PageCount | 4 |
| ParticipantIDs | proquest_miscellaneous_1744698753 proquest_miscellaneous_1221130978 proquest_journals_1220687572 pubmed_primary_22887707 crossref_primary_10_1002_chir_22095 crossref_citationtrail_10_1002_chir_22095 wiley_primary_10_1002_chir_22095_CHIR22095 istex_primary_ark_67375_WNG_RW2HJKLF_Z |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | December 2012 |
| PublicationDateYYYYMMDD | 2012-12-01 |
| PublicationDate_xml | – month: 12 year: 2012 text: December 2012 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Chichester |
| PublicationTitle | Chirality (New York, N.Y.) |
| PublicationTitleAlternate | Chirality |
| PublicationYear | 2012 |
| Publisher | Blackwell Publishing Ltd Wiley Subscription Services, Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Wiley Subscription Services, Inc |
| References | Forray C, Bard JA, Wetzel JM, Chiu G, Shapiro E, Tang R, Lepor H, Hartig PR, Weinshank RL, Branchek TA. The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Mol Pharmacol 1994;45:703-708. Bansal S, DeStefano A. Key elements of bioanalytical method validation for small molecules. AAPS J 2007;9:E109-E114. Ferretti R, Gallinella B, La Torre F, Zanitti L, Turchetto L, Mosca A, Cirilli R. Direct high-performance liquid chromatography enantioseparation of terazosin on an immobilised polysaccharide-based chiral stationary phase under polar organic and reversed-phase conditions. J Chromatogr A 2009;1216:5385-5390. Achari R, Laddu A. Terazosin: a new alpha adrenoceptor blocking drug. J Clin Pharmacol 1992;32:520-523. Liu M, Zhang D, Han J, Liu H. Enantiomeric separation of terazosin by NP-HPLC. Chin J Pharm 2012;43:53-56. Ireland LM, Cain JC, Rotert G, Thomas S, Shoghi S, Hancock AA, Kerwin JF Jr. [3H]R-terazosin binds selectively to alpha1-adrenoceptors over alpha2-adrenoceptors - comparison with racemic [3H]terazosin and [3H]prazosin. Eur J Pharmacol 1997;327:79-86. Sekhar EC, Rao TR, Sekhar KR, Naidu MU, Shobha JC, Rani PU, Kumar TV, Kumar VP. Determination of terazosin in human plasma, using high-performance liquid chromatography with fluorescence detection. J Chromatogr B 1998;710:137-142. Zavitsanos AP, Alebic-Kolbah T. Enantioselective determination of terazosin in human plasma by normal phase high-performance liquid chromatography-electrospray mass spectrometry. J Chromatogr A 1998;794:45-56. Hancock AA, Buckner SA, Ireland LM, Knepper SM, Kerwin JF Jr. Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro. J Recept Signal Transduct Res 1995;15:863-885. Bu Y, Chen D, Zhao C. Studies on pharmacokinetics and bioequivalence of terazosin hydrochloride tablets. Chin J Pharm Anal 2007;27:1361-1363. Chen J, Lu W, Gao K, Shi Z, Jiang X, Rong Z, Chen H. Studies on the bioequivalence of domestic terazosin tablet in healthy volunteers. Chin Pharm J 2003;38:446-448. Nakaki T, Nakayama M, Yamamoto S, Kato R. Alpha 1-adrenergic stimulation and beta 2-adrenergic inhibition of DNA synthesis in vascular smooth muscle cells. Mol Pharmacol 1990;37:30-36. Cheah PY, Yuen KH, Liong ML. Improved high-performance liquid chromatographic analysis of terazosin in human plasma. J Chromatogr B 2000;745:439-443. Smith P, Rhodes NP, Ke Y, Foster CS. Influence of the alpha1-adrenergic antagonist, doxazosin, on noradrenaline-induced modulation of cytoskeletal proteins in cultured hyperplastic prostatic stromal cells. Prostate 1999;38:216-227. 2009; 1216 1997; 327 1990; 37 1995; 15 1999; 38 2000; 745 1994; 45 2007; 9 2003; 38 1998; 710 1992; 32 1998; 794 2012; 43 2007; 27 e_1_2_5_15_1 e_1_2_5_14_1 e_1_2_5_16_1 e_1_2_5_11_1 e_1_2_5_7_1 e_1_2_5_10_1 e_1_2_5_6_1 e_1_2_5_5_1 e_1_2_5_12_1 e_1_2_5_4_1 Nakaki T (e_1_2_5_3_1) 1990; 37 Bu Y (e_1_2_5_8_1) 2007; 27 Liu M (e_1_2_5_13_1) 2012; 43 Chen J (e_1_2_5_9_1) 2003; 38 Forray C (e_1_2_5_2_1) 1994; 45 |
| References_xml | – reference: Ireland LM, Cain JC, Rotert G, Thomas S, Shoghi S, Hancock AA, Kerwin JF Jr. [3H]R-terazosin binds selectively to alpha1-adrenoceptors over alpha2-adrenoceptors - comparison with racemic [3H]terazosin and [3H]prazosin. Eur J Pharmacol 1997;327:79-86. – reference: Bansal S, DeStefano A. Key elements of bioanalytical method validation for small molecules. AAPS J 2007;9:E109-E114. – reference: Forray C, Bard JA, Wetzel JM, Chiu G, Shapiro E, Tang R, Lepor H, Hartig PR, Weinshank RL, Branchek TA. The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Mol Pharmacol 1994;45:703-708. – reference: Sekhar EC, Rao TR, Sekhar KR, Naidu MU, Shobha JC, Rani PU, Kumar TV, Kumar VP. Determination of terazosin in human plasma, using high-performance liquid chromatography with fluorescence detection. J Chromatogr B 1998;710:137-142. – reference: Cheah PY, Yuen KH, Liong ML. Improved high-performance liquid chromatographic analysis of terazosin in human plasma. J Chromatogr B 2000;745:439-443. – reference: Hancock AA, Buckner SA, Ireland LM, Knepper SM, Kerwin JF Jr. Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro. J Recept Signal Transduct Res 1995;15:863-885. – reference: Liu M, Zhang D, Han J, Liu H. Enantiomeric separation of terazosin by NP-HPLC. Chin J Pharm 2012;43:53-56. – reference: Achari R, Laddu A. Terazosin: a new alpha adrenoceptor blocking drug. J Clin Pharmacol 1992;32:520-523. – reference: Chen J, Lu W, Gao K, Shi Z, Jiang X, Rong Z, Chen H. Studies on the bioequivalence of domestic terazosin tablet in healthy volunteers. Chin Pharm J 2003;38:446-448. – reference: Zavitsanos AP, Alebic-Kolbah T. Enantioselective determination of terazosin in human plasma by normal phase high-performance liquid chromatography-electrospray mass spectrometry. J Chromatogr A 1998;794:45-56. – reference: Nakaki T, Nakayama M, Yamamoto S, Kato R. Alpha 1-adrenergic stimulation and beta 2-adrenergic inhibition of DNA synthesis in vascular smooth muscle cells. Mol Pharmacol 1990;37:30-36. – reference: Bu Y, Chen D, Zhao C. Studies on pharmacokinetics and bioequivalence of terazosin hydrochloride tablets. Chin J Pharm Anal 2007;27:1361-1363. – reference: Ferretti R, Gallinella B, La Torre F, Zanitti L, Turchetto L, Mosca A, Cirilli R. Direct high-performance liquid chromatography enantioseparation of terazosin on an immobilised polysaccharide-based chiral stationary phase under polar organic and reversed-phase conditions. J Chromatogr A 2009;1216:5385-5390. – reference: Smith P, Rhodes NP, Ke Y, Foster CS. Influence of the alpha1-adrenergic antagonist, doxazosin, on noradrenaline-induced modulation of cytoskeletal proteins in cultured hyperplastic prostatic stromal cells. Prostate 1999;38:216-227. – volume: 27 start-page: 1361 year: 2007 end-page: 1363 article-title: Studies on pharmacokinetics and bioequivalence of terazosin hydrochloride tablets publication-title: Chin J Pharm Anal – volume: 38 start-page: 446 year: 2003 end-page: 448 article-title: Studies on the bioequivalence of domestic terazosin tablet in healthy volunteers publication-title: Chin Pharm J – volume: 794 start-page: 45 year: 1998 end-page: 56 article-title: Enantioselective determination of terazosin in human plasma by normal phase high‐performance liquid chromatography–electrospray mass spectrometry publication-title: J Chromatogr A – volume: 1216 start-page: 5385 year: 2009 end-page: 5390 article-title: Direct high‐performance liquid chromatography enantioseparation of terazosin on an immobilised polysaccharide‐based chiral stationary phase under polar organic and reversed‐phase conditions publication-title: J Chromatogr A – volume: 32 start-page: 520 year: 1992 end-page: 523 article-title: Terazosin: a new alpha adrenoceptor blocking drug publication-title: J Clin Pharmacol – volume: 37 start-page: 30 year: 1990 end-page: 36 article-title: Alpha 1‐adrenergic stimulation and beta 2‐adrenergic inhibition of DNA synthesis in vascular smooth muscle cells publication-title: Mol Pharmacol – volume: 710 start-page: 137 year: 1998 end-page: 142 article-title: Determination of terazosin in human plasma, using high‐performance liquid chromatography with fluorescence detection publication-title: J Chromatogr B – volume: 45 start-page: 703 year: 1994 end-page: 708 article-title: The alpha 1‐adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype publication-title: Mol Pharmacol – volume: 15 start-page: 863 year: 1995 end-page: 885 article-title: Actions of terazosin and its enantiomers at subtypes of alpha 1‐ and alpha 2‐adrenoceptors in vitro publication-title: J Recept Signal Transduct Res – volume: 38 start-page: 216 year: 1999 end-page: 227 article-title: Influence of the alpha1‐adrenergic antagonist, doxazosin, on noradrenaline‐induced modulation of cytoskeletal proteins in cultured hyperplastic prostatic stromal cells publication-title: Prostate – volume: 43 start-page: 53 year: 2012 end-page: 56 article-title: Enantiomeric separation of terazosin by NP‐HPLC publication-title: Chin J Pharm – volume: 9 start-page: E109 year: 2007 end-page: E114 article-title: Key elements of bioanalytical method validation for small molecules publication-title: AAPS J – volume: 327 start-page: 79 year: 1997 end-page: 86 article-title: [3H]R‐terazosin binds selectively to alpha1‐adrenoceptors over alpha2‐adrenoceptors ‐ comparison with racemic [3 ]terazosin and [3 ]prazosin publication-title: Eur J Pharmacol – volume: 745 start-page: 439 year: 2000 end-page: 443 article-title: Improved high‐performance liquid chromatographic analysis of terazosin in human plasma publication-title: J Chromatogr B – ident: e_1_2_5_15_1 doi: 10.1208/aapsj0901011 – ident: e_1_2_5_5_1 doi: 10.1016/S0014-2999(97)89681-1 – ident: e_1_2_5_16_1 doi: 10.1177/009127009203200605 – ident: e_1_2_5_10_1 doi: 10.1016/S0378-4347(00)00313-3 – ident: e_1_2_5_12_1 doi: 10.1016/j.chroma.2009.05.034 – ident: e_1_2_5_11_1 doi: 10.1016/S0378-4347(98)00120-0 – volume: 27 start-page: 1361 year: 2007 ident: e_1_2_5_8_1 article-title: Studies on pharmacokinetics and bioequivalence of terazosin hydrochloride tablets publication-title: Chin J Pharm Anal – volume: 43 start-page: 53 year: 2012 ident: e_1_2_5_13_1 article-title: Enantiomeric separation of terazosin by NP‐HPLC publication-title: Chin J Pharm – volume: 37 start-page: 30 year: 1990 ident: e_1_2_5_3_1 article-title: Alpha 1‐adrenergic stimulation and beta 2‐adrenergic inhibition of DNA synthesis in vascular smooth muscle cells publication-title: Mol Pharmacol doi: 10.1016/S0026-895X(25)09946-8 – ident: e_1_2_5_4_1 doi: 10.1002/(SICI)1097-0045(19990215)38:3<216::AID-PROS6>3.0.CO;2-0 – ident: e_1_2_5_14_1 doi: 10.1016/S0021-9673(97)00892-3 – volume: 38 start-page: 446 year: 2003 ident: e_1_2_5_9_1 article-title: Studies on the bioequivalence of domestic terazosin tablet in healthy volunteers publication-title: Chin Pharm J – volume: 45 start-page: 703 year: 1994 ident: e_1_2_5_2_1 article-title: The alpha 1‐adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype publication-title: Mol Pharmacol doi: 10.1016/S0026-895X(25)10156-9 – ident: e_1_2_5_7_1 – ident: e_1_2_5_6_1 doi: 10.3109/10799899509049862 |
| SSID | ssj0009634 |
| Score | 2.0167677 |
| Snippet | ABSTRACT
The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of... The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2‐mg... The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg... |
| SourceID | proquest pubmed crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1047 |
| SubjectTerms | Adult Asian Continental Ancestry Group Blood Chemical Analysis - methods Chirality Chromatography, High Pressure Liquid determination enantiomer Enantiomers Health HPLC-FD Humans Male Males Pharmacokinetics plasma Prazosin - analogs & derivatives Prazosin - blood Prazosin - chemistry Prazosin - pharmacokinetics Spectrometry, Fluorescence Stereoisomerism terazosin Young Adult |
| Title | Pharmacokinetics of Terazosin Enantiomers in Healthy Chinese Male Subjects |
| URI | https://api.istex.fr/ark:/67375/WNG-RW2HJKLF-Z/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fchir.22095 https://www.ncbi.nlm.nih.gov/pubmed/22887707 https://www.proquest.com/docview/1220687572 https://www.proquest.com/docview/1221130978 https://www.proquest.com/docview/1744698753 |
| Volume | 24 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1520-636X dateEnd: 20241001 omitProxy: true ssIdentifier: ssj0009634 issn: 0899-0042 databaseCode: ABDBF dateStart: 20120701 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVWIB databaseName: Wiley Online Library - Core collection (SURFmarket) issn: 0899-0042 databaseCode: DR2 dateStart: 19960101 customDbUrl: isFulltext: true eissn: 1520-636X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0009634 providerName: Wiley-Blackwell |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3daxQxEB9KfdAXta3a1VYiSkFhr70km92FvpSj53naIkdLiyBhk02wXLsnu3dg-9d3kv04KqWgbxt2spuPyWRmMvkNwAeVJVxTm4fapHmI0k-HSa55mOtYp1RkvG_die7RsRid8vF5dL4C--1dmBofonO4uZXh5bVb4JmqdpegofrXRdmjFFUEFMB9Fvkz2skSOwo5y2NHJe6aPbJmh01Kd5dV7-xGj9zA_rlP1byrufqtZ_gMfraNriNOpr3FXPX0zV94jv_bq-fwtNFJyUHNRGuwYop12Dgo0B6_uiY7xEeJevf7OjwetBniNmD8vcG9nuJvHdwzmVlyYsrsZlZdFOTQxdi42_1lRbBYX3i6Ji5jt6kMOcKtiaDcco6g6gWcDg9PBqOwyc0Qap7yKMwtZ4bxWFihlRXMaGZNZi3PUhthias0jmLLEybQhFFJpAVTlhkqNBp5NmcvYbWYFWYTCNbhhkeJTplwrs1U7aUqYVrkguVM6QA-tnMkdQNc7vJnXMoacplKN2jSD1oA7zva3zVcx71UO36qO5KsnLoAtziSZ8ef5eSMjsZfvw3ljwC2Wl6QzdquZB-_IVweABrAu-41Dr07askKM1t4mj5qB2iiP0ATc5e-E-3FAF7VfNY1iFIU_vFeHMAnzy0PdEYORl8m_un1vxC_gSeo-9E6MmcLVuflwmyjfjVXb_06ugUDxSCm |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdgexgvfGx8BAYYgSaBlG61HSd5nMpK1rUVqjpt4sVKHFubOlKUtBLbX8-dk6YamibBW6xcPny-s-_O598R8ilLI6GZzX1t4tyH2U_7Ua6Fn-tQx0ymomtxR3c0lsmpGJwH501uDp6FqfEh2oAbaoabr1HBMSC9v0YN1ReXZYcxsBEekk3coEO9_DpZo0eBbDn0qAgP2oNwtuikbH_97K31aBNZ-_suY_O27eoWn_6TusJq5TALMedk1lkuso6--QvR8b_79ZQ8bsxSeljL0TPywBTbZOewAJf85zXdoy5R1EXgt8lWb1UkbocMvjfQ1zP4LiI-07mlU1OmN_PqsqBHmGaDB_zLikKzPvN0TbFot6kMHcHqRGHqwlhQ9Zyc9o-mvcRvyjP4WsQi8HMruOEilFbqzEpuNLcmtVaksQ2gJbI4DEIrIi7Bi8miQEueWW6Y1ODn2Zy_IBvFvDCvCIVnhBFBpGMuMboZZwdxFnEtc8lznmmPfF4NktINdjmW0LhSNeoyU8g05ZjmkY8t7a8aseNOqj031i1JWs4wxy0M1Nn4m5qcsWRwMuyrHx7ZXQmDatS7Ul14h8RSAMwjH9rbwHrcbUkLM186mi4YCOCl30MTCqzgCS6jR17Wgtb-EGMw_4cHoUe-OHG5pzOqlxxP3NXrfyF-T7aS6WiohsfjkzfkEZiCrE7U2SUbi3Jp3oK5tcjeOaX6A_nzJMI |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ra9swED-6FrZ-2aPdw1u3aWwUVnDaSLJsw76UrFmatqGElpbBELYs0ZLNKXYCa__6neRH6CiF7ZuFT7Z0Okl3p9PvAD6lScQVNZmvdJz5uPopP8oU9zMVqpiKhHeNPdE9GonBKR-eB-dL8KW5C1PhQ7QONzsz3HptJ_hVZrYXoKHq4rLoUIoqwgNY4QLNK6sSjRfgUShaDjwqsvfsUTZbcFK6vah7aztasZz9fZeueVt1dXtP_wn8aFpdhZxMOvNZ2lE3fwE6_m-3nsLjWiklu5UUPYMlna_B-m6OBvmva7JJXJio87-vwaNekyJuHYbHNfD1BH9r8Z7J1JATXSQ30_IyJ3s2yMZe7y9KgsXqxtM1sSm7danJEe5NBBcu6wkqn8Npf--kN_Dr5Ay-4jEP_MxwphkPhREqNYJpxYxOjOFJbAIs8TQOg9DwiAm0YdIoUIKlhmkqFFp5JmMvYDmf5voVEKzDNQ8iFTNhfZtxuhOnEVMiEyxjqfLgczNGUtXI5TaBxk9ZYS5TaZkmHdM8-NjSXlV4HXdSbbqhbkmSYmIj3MJAno2-yfEZHQwPDvvyuwcbjSzIenKXsovfEDYRAPXgQ_saWW_PWpJcT-eOpovqAdro99CE3ObvRIPRg5eVnLUNohRX_3An9GDLScs9nZG9wf7YPb3-F-L38PD4a18e7o8O3sAq6oG0itLZgOVZMddvUdeape_clPoDcQcjcQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pharmacokinetics+of+Terazosin+Enantiomers+in+Healthy+Chinese+Male+Subjects&rft.jtitle=Chirality+%28New+York%2C+N.Y.%29&rft.au=Liu%2C+Man&rft.au=Zhang%2C+Dan&rft.au=Yang%2C+Man&rft.au=Zhao%2C+Ting&rft.date=2012-12-01&rft.issn=0899-0042&rft.eissn=1520-636X&rft.volume=24&rft.issue=12&rft.spage=1047&rft.epage=1050&rft_id=info:doi/10.1002%2Fchir.22095&rft.externalDBID=10.1002%252Fchir.22095&rft.externalDocID=CHIR22095 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0899-0042&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0899-0042&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0899-0042&client=summon |