Moving Toward Multicenter Therapeutic Trials in Amyotrophic Lateral Sclerosis: Feasibility of Data Pooling Using Different Translocator Protein PET Radioligands - Van Weehaeghe, Donatienne; Babu, Suma; De Vocht, Joke; Zürcher, Nicole R.; Chew, Sheena; Tseng, Chieh-En J.; Loggia, Marco L.; Koole, Michel; Rezaei, Ahmadreza; Schramm, Georg; Van Damme, Philip; Hooker, Jacob M.; et al. (Journal of Nuclear Medicine, 2020)
Keywords: Acetamides - pharmacokinetics; Adult; Aged; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - diagnostic imaging; Amyotrophic Lateral Sclerosis - drug therapy; Biomarkers; Carbon Radioisotopes - pharmacokinetics; Cerebellum; Clinical trials; Clinical Trials as Topic; Clusters; Feasibility; Feasibility Studies; Female; Fluorine isotopes; Fluorine Radioisotopes - pharmacokinetics; Humans; Inflammation; Injection; Magnetic resonance imaging; Male; Mathematical analysis; Medical imaging; Middle Aged; Neurology; Occipital lobe; Pharmacodynamics; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Proteins; Pyrazoles - pharmacokinetics; Pyridines - pharmacokinetics; Pyrimidines - pharmacokinetics; Radioisotopes; Receptors, GABA - metabolism; Tomography; Tracers; Belgium; United States--US; 11C-PBR28; 18F-DPA714; translocator protein; amyotrophic lateral sclerosis; multicenter