Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production

The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of tissues. Overexpression of hyaluronan plays pivotal roles in inflammation and cancer, and markedly high serum and tis...

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Published inMatrix biology Vol. 78-79; pp. 100 - 117
Main Authors Heldin, Paraskevi, Lin, Chun-Yu, Kolliopoulos, Constantinos, Chen, Yen-Hsu, Skandalis, Spyros S.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.05.2019
Elsevier Science Ltd
Subjects
Biosynthesis
Breast carcinoma
Gene regulation
Homeostasis
Hyaluronic acid
Lymphocytes B
Metabolic disorders
Transcription
Online AccessGet full text
ISSN0945-053X
1569-1802
1569-1802
DOI10.1016/j.matbio.2018.01.017

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Abstract The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of tissues. Overexpression of hyaluronan plays pivotal roles in inflammation and cancer, and markedly high serum and tissue levels of hyaluronan are noted under such pathological conditions. This review focuses on the complexity of the regulation at transcriptional and posttranslational level of hyaluronan synthetic enzymes, and the outcome of their aberrant expression and accumulation of hyaluronan in clinical conditions, such as systemic B-cell cancers, aggressive breast carcinomas, metabolic diseases and virus infection. •Mechanisms that regulate hyaluronan biosynthesis at transcriptional and posttranslational levels.•Consequences of hyaluronan deficiency.•Functional implications of overproduction of HAS1, HAS2 and HAS3 in cancer, metabolic diseases and infection.
AbstractList The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of tissues. Overexpression of hyaluronan plays pivotal roles in inflammation and cancer, and markedly high serum and tissue levels of hyaluronan are noted under such pathological conditions. This review focuses on the complexity of the regulation at transcriptional and posttranslational level of hyaluronan synthetic enzymes, and the outcome of their aberrant expression and accumulation of hyaluronan in clinical conditions, such as systemic B-cell cancers, aggressive breast carcinomas, metabolic diseases and virus infection.The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of tissues. Overexpression of hyaluronan plays pivotal roles in inflammation and cancer, and markedly high serum and tissue levels of hyaluronan are noted under such pathological conditions. This review focuses on the complexity of the regulation at transcriptional and posttranslational level of hyaluronan synthetic enzymes, and the outcome of their aberrant expression and accumulation of hyaluronan in clinical conditions, such as systemic B-cell cancers, aggressive breast carcinomas, metabolic diseases and virus infection.
The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of tissues. Overexpression of hyaluronan plays pivotal roles in inflammation and cancer, and markedly high serum and tissue levels of hyaluronan are noted under such pathological conditions. This review focuses on the complexity of the regulation at transcriptional and posttranslational level of hyaluronan synthetic enzymes, and the outcome of their aberrant expression and accumulation of hyaluronan in clinical conditions, such as systemic B-cell cancers, aggressive breast carcinomas, metabolic diseases and virus infection.
The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of tissues. Overexpression of hyaluronan plays pivotal roles in inflammation and cancer, and markedly high serum and tissue levels of hyaluronan are noted under such pathological conditions. This review focuses on the complexity of the regulation at transcriptional and posttranslational level of hyaluronan synthetic enzymes, and the outcome of their aberrant expression and accumulation of hyaluronan in clinical conditions, such as systemic B-cell cancers, aggressive breast carcinomas, metabolic diseases and virus infection. •Mechanisms that regulate hyaluronan biosynthesis at transcriptional and posttranslational levels.•Consequences of hyaluronan deficiency.•Functional implications of overproduction of HAS1, HAS2 and HAS3 in cancer, metabolic diseases and infection.
Author Skandalis, Spyros S.
Lin, Chun-Yu
Chen, Yen-Hsu
Heldin, Paraskevi
Kolliopoulos, Constantinos
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  givenname: Chun-Yu
  surname: Lin
  fullname: Lin, Chun-Yu
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  givenname: Constantinos
  surname: Kolliopoulos
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  givenname: Yen-Hsu
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  organization: Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110 Patras, Greece
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Snippet The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial...
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SubjectTerms Biosynthesis
Breast carcinoma
Gene regulation
Homeostasis
Hyaluronic acid
Lymphocytes B
Metabolic disorders
Transcription
Title Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production
URI https://dx.doi.org/10.1016/j.matbio.2018.01.017
https://www.ncbi.nlm.nih.gov/pubmed/29374576
https://www.proquest.com/docview/2246256868
https://www.proquest.com/docview/1993018998
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-386169
Volume 78-79
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