Efficient Combination of Complex Chromatography, Molecular Docking and Enzyme Kinetics for Exploration of Acetylcholinesterase Inhibitors from Poria cocos - Wu, Tong; Hou, Wanchao; Liu, Chunming; Li, Sainan; Zhang, Yuchi (Molecules, 2023)
Keywords: Acetylcholinesterase; acetylcholinesterase inhibitors; Alzheimer Disease; Alzheimer's disease; Binding sites; Cholinesterase Inhibitors - analysis; Cholinesterase Inhibitors - pharmacology; Chromatography; Chromatography, High Pressure Liquid - methods; counter-current chromatography; Crystal structure; Drug development; Drug dosages; Efficiency; enzymatic reactions kinetics; Enzyme kinetics; Ethanol; Genetic algorithms; Herbal medicine; Ingredients; Ligands; Mass spectrometry; Methods; Molecular Docking Simulation; molecular docking technique; Natural products; Poria - chemistry; Poria cocos; Proteins; Retention; Scientific imaging; semi-preparative high−performance liquid chromatography; Traditional Chinese medicine; Wolfiporia - chemistry; semi-preparative high−performance liquid chromatography; acetylcholinesterase inhibitors; counter-current chromatography; enzymatic reactions kinetics; molecular docking technique; Poria cocos