Accumulation of saturated intramyocellular lipid is associated with insulin resistance[S]
Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs...
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| Published in | Journal of lipid research Vol. 60; no. 7; pp. 1323 - 1332 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.07.2019
The American Society for Biochemistry and Molecular Biology Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-2275 1539-7262 1539-7262 |
| DOI | 10.1194/jlr.M091942 |
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| Abstract | Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs is unknown in these states. 1H magnetic resonance spectroscopy (MRS) can be used to overcome this problem. Thus, we used a recently validated 1H MRS method to compare the compositional saturation index (CH2:CH3) and concentration independent of the composition (CH3) of IMCLs in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes (n = 14) and healthy controls (n = 41). The IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic subjects compared with controls but was similar in athletes and controls. IMCL CH2:CH3 was dependent on the IMCL concentration in the controls and, after adjusting the compositional index for quantity (CH2:CH3adj), could distinguish lipodystrophics from athletes. This CH2:CH3adj marker had a stronger relationship with insulin resistance than IMCL concentration alone and was inversely related to VO2max. The association of insulin resistance with the accumulation of saturated IMCLs is consistent with a potential pathogenic role for saturated fat and the reported benefits of exercise and diet in insulin-resistant states. |
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| AbstractList | Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs is unknown in these states.
1
H magnetic resonance spectroscopy (MRS) can be used to overcome this problem. Thus, we used a recently validated
1
H MRS method to compare the compositional saturation index (CH
2
:CH
3
) and concentration independent of the composition (CH
3
) of IMCLs in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes (
n
= 14) and healthy controls (
n
= 41). The IMCL CH
2
:CH
3
ratio was significantly higher in both muscles of the lipodystrophic subjects compared with controls but was similar in athletes and controls. IMCL CH
2
:CH
3
was dependent on the IMCL concentration in the controls and, after adjusting the compositional index for quantity (CH
2
:CH
3adj
), could distinguish lipodystrophics from athletes. This CH
2
:CH
3adj
marker had a stronger relationship with insulin resistance than IMCL concentration alone and was inversely related to VO
2max
. The association of insulin resistance with the accumulation of saturated IMCLs is consistent with a potential pathogenic role for saturated fat and the reported benefits of exercise and diet in insulin-resistant states. Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs is unknown in these states. 1H magnetic resonance spectroscopy (MRS) can be used to overcome this problem. Thus, we used a recently validated 1H MRS method to compare the compositional saturation index (CH2:CH3) and concentration independent of the composition (CH3) of IMCLs in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes (n = 14) and healthy controls (n = 41). The IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic subjects compared with controls but was similar in athletes and controls. IMCL CH2:CH3 was dependent on the IMCL concentration in the controls and, after adjusting the compositional index for quantity (CH2:CH3adj), could distinguish lipodystrophics from athletes. This CH2:CH3adj marker had a stronger relationship with insulin resistance than IMCL concentration alone and was inversely related to VO2max. The association of insulin resistance with the accumulation of saturated IMCLs is consistent with a potential pathogenic role for saturated fat and the reported benefits of exercise and diet in insulin-resistant states. Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs is unknown in these states. 1H magnetic resonance spectroscopy (MRS) can be used to overcome this problem. Thus, we used a recently validated 1H MRS method to compare the compositional saturation index (CH2:CH3) and concentration independent of the composition (CH3) of IMCLs in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes (n = 14) and healthy controls (n = 41). The IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic subjects compared with controls but was similar in athletes and controls. IMCL CH2:CH3 was dependent on the IMCL concentration in the controls and, after adjusting the compositional index for quantity (CH2:CH3adj), could distinguish lipodystrophics from athletes. This CH2:CH3adj marker had a stronger relationship with insulin resistance than IMCL concentration alone and was inversely related to VO2max The association of insulin resistance with the accumulation of saturated IMCLs is consistent with a potential pathogenic role for saturated fat and the reported benefits of exercise and diet in insulin-resistant states.Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs is unknown in these states. 1H magnetic resonance spectroscopy (MRS) can be used to overcome this problem. Thus, we used a recently validated 1H MRS method to compare the compositional saturation index (CH2:CH3) and concentration independent of the composition (CH3) of IMCLs in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes (n = 14) and healthy controls (n = 41). The IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic subjects compared with controls but was similar in athletes and controls. IMCL CH2:CH3 was dependent on the IMCL concentration in the controls and, after adjusting the compositional index for quantity (CH2:CH3adj), could distinguish lipodystrophics from athletes. This CH2:CH3adj marker had a stronger relationship with insulin resistance than IMCL concentration alone and was inversely related to VO2max The association of insulin resistance with the accumulation of saturated IMCLs is consistent with a potential pathogenic role for saturated fat and the reported benefits of exercise and diet in insulin-resistant states. Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs is unknown in these states. H magnetic resonance spectroscopy (MRS) can be used to overcome this problem. Thus, we used a recently validated H MRS method to compare the compositional saturation index (CH :CH ) and concentration independent of the composition (CH ) of IMCLs in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes ( = 14) and healthy controls ( = 41). The IMCL CH :CH ratio was significantly higher in both muscles of the lipodystrophic subjects compared with controls but was similar in athletes and controls. IMCL CH :CH was dependent on the IMCL concentration in the controls and, after adjusting the compositional index for quantity (CH :CH ), could distinguish lipodystrophics from athletes. This CH :CH marker had a stronger relationship with insulin resistance than IMCL concentration alone and was inversely related to VO The association of insulin resistance with the accumulation of saturated IMCLs is consistent with a potential pathogenic role for saturated fat and the reported benefits of exercise and diet in insulin-resistant states. |
| Author | Kemp, Graham J. Carr, Katie Sleigh, Alison Boesch, Chris Brage, Soren Savage, David B. Watson, Laura Adams, Claire Chatterjee, Krishna K. Hodson, Leanne |
| Author_xml | – sequence: 1 givenname: David B. surname: Savage fullname: Savage, David B. organization: Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science,Cambridge Biomedical Campus, Cambridge, United Kingdom – sequence: 2 givenname: Laura surname: Watson fullname: Watson, Laura organization: National Institute for Health Research/Wellcome Trust Clinical Research Facility, Cambridge University Hospitals NHS Foundation TrustCambridge Biomedical Campus, Cambridge, United Kingdom – sequence: 3 givenname: Katie surname: Carr fullname: Carr, Katie organization: National Institute for Health Research/Wellcome Trust Clinical Research Facility, Cambridge University Hospitals NHS Foundation TrustCambridge Biomedical Campus, Cambridge, United Kingdom – sequence: 4 givenname: Claire surname: Adams fullname: Adams, Claire organization: Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science,Cambridge Biomedical Campus, Cambridge, United Kingdom – sequence: 5 givenname: Soren surname: Brage fullname: Brage, Soren organization: MRC Epidemiology UnitUniversity of Cambridge School of Clinical Medicine, Cambridge, United Kingdom – sequence: 6 givenname: Krishna K. surname: Chatterjee fullname: Chatterjee, Krishna K. organization: Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science,Cambridge Biomedical Campus, Cambridge, United Kingdom – sequence: 7 givenname: Leanne surname: Hodson fullname: Hodson, Leanne organization: Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom – sequence: 8 givenname: Chris surname: Boesch fullname: Boesch, Chris organization: Department of Clinical Research and Radiology AMSM, University Bern, Bern, Switzerland – sequence: 9 givenname: Graham J. surname: Kemp fullname: Kemp, Graham J. organization: Department of Musculoskeletal BiologyUniversity of Liverpool and MRC–Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Liverpool, United Kingdom – sequence: 10 givenname: Alison surname: Sleigh fullname: Sleigh, Alison email: as626@cam.ac.uk organization: Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science,Cambridge Biomedical Campus, Cambridge, United Kingdom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31048405$$D View this record in MEDLINE/PubMed |
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| Copyright | 2019 Copyright © 2019 Savage et al. Copyright © 2019 Savage et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. Copyright © 2019 Savage et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. 2019 Savage et al. |
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| Keywords | lipodystrophies fatty acids spectroscopy muscle exercise in vivo triglycerides lipid composition |
| Language | English |
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| SubjectTerms | Adult Choline-Phosphate Cytidylyltransferase - genetics exercise Exercise - physiology fatty acids Fatty Acids - metabolism Female Heart Rate - physiology Humans in vivo Insulin - metabolism Insulin Resistance - genetics Insulin Resistance - physiology Lamin Type A - genetics lipid composition lipodystrophies Lipodystrophy - genetics Lipodystrophy - metabolism Magnetic Resonance Spectroscopy Male muscle Muscle, Skeletal - metabolism Patient-Oriented and Epidemiological Research spectroscopy triglycerides Triglycerides - metabolism |
| Title | Accumulation of saturated intramyocellular lipid is associated with insulin resistance[S] |
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