Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice

In order to elucidate novel actions of degalactosylated whey protein (D-WP) in comparison with intact whey protein (WP), the effects of oral intake of D-WP on peripheral blood telomere length and telomerase were examined in young and aged mice. In young mice, peripheral blood telomere length was sig...

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Published inScientific reports Vol. 14; no. 1; pp. 30859 - 9
Main Authors Inui, Toshio, Kawamura, Namiko, Yamamura, Masahiro, Kubo, Kentaro, Yamakage, Hajime, Satoh-Asahara, Noriko, Ogawa, Yoshihiro, Katsuura, Goro
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 28.12.2024
Nature Publishing Group
Nature Portfolio
Subjects
631/154
692/1537
Administration, Oral
Aging
Animals
Blood levels
Degalactosylation
Drinking water
Gene expression
Humanities and Social Sciences
Male
Mice
multidisciplinary
Peripheral blood
Peripheral blood telomere length
Proteins
RNA - genetics
RNA - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA-directed DNA polymerase
Science
Science (multidisciplinary)
Telomerase
Telomerase - genetics
Telomerase - metabolism
Telomerase reverse transcriptase
Telomere - genetics
Telomere - metabolism
Telomere Homeostasis - drug effects
Telomeres
Whey protein
Whey Proteins - administration & dosage
Aging
Peripheral blood telomere length
Mice
Degalactosylation
Whey protein
Telomerase
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-024-81597-3

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Abstract In order to elucidate novel actions of degalactosylated whey protein (D-WP) in comparison with intact whey protein (WP), the effects of oral intake of D-WP on peripheral blood telomere length and telomerase were examined in young and aged mice. In young mice, peripheral blood telomere length was significantly elongated following oral intake of D-WP for 4 weeks. mRNA expression of both telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) was significantly increased in the peripheral blood following oral intake of D-WP for 4 weeks. In aged mice, peripheral blood telomere length was significantly decreased as compared with that of young mice, and significantly restored to the level of young mice drinking water by the oral intake of D-WP for 4 weeks. The mRNA expression of peripheral blood TERT and TERC mRNA in aged mice significantly decreased as compared with the level in young mice drinking water, and was significantly restored to the level of expression of young mice drinking water by oral intake of D-WP for 4 weeks. These results suggest that D-WP, but not WP, potently increases peripheral blood telomere length accompanied by increased mRNA expression of TERT and TERC in both young and aged mice.
AbstractList Abstract In order to elucidate novel actions of degalactosylated whey protein (D-WP) in comparison with intact whey protein (WP), the effects of oral intake of D-WP on peripheral blood telomere length and telomerase were examined in young and aged mice. In young mice, peripheral blood telomere length was significantly elongated following oral intake of D-WP for 4 weeks. mRNA expression of both telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) was significantly increased in the peripheral blood following oral intake of D-WP for 4 weeks. In aged mice, peripheral blood telomere length was significantly decreased as compared with that of young mice, and significantly restored to the level of young mice drinking water by the oral intake of D-WP for 4 weeks. The mRNA expression of peripheral blood TERT and TERC mRNA in aged mice significantly decreased as compared with the level in young mice drinking water, and was significantly restored to the level of expression of young mice drinking water by oral intake of D-WP for 4 weeks. These results suggest that D-WP, but not WP, potently increases peripheral blood telomere length accompanied by increased mRNA expression of TERT and TERC in both young and aged mice.
In order to elucidate novel actions of degalactosylated whey protein (D-WP) in comparison with intact whey protein (WP), the effects of oral intake of D-WP on peripheral blood telomere length and telomerase were examined in young and aged mice. In young mice, peripheral blood telomere length was significantly elongated following oral intake of D-WP for 4 weeks. mRNA expression of both telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) was significantly increased in the peripheral blood following oral intake of D-WP for 4 weeks. In aged mice, peripheral blood telomere length was significantly decreased as compared with that of young mice, and significantly restored to the level of young mice drinking water by the oral intake of D-WP for 4 weeks. The mRNA expression of peripheral blood TERT and TERC mRNA in aged mice significantly decreased as compared with the level in young mice drinking water, and was significantly restored to the level of expression of young mice drinking water by oral intake of D-WP for 4 weeks. These results suggest that D-WP, but not WP, potently increases peripheral blood telomere length accompanied by increased mRNA expression of TERT and TERC in both young and aged mice.
In order to elucidate novel actions of degalactosylated whey protein (D-WP) in comparison with intact whey protein (WP), the effects of oral intake of D-WP on peripheral blood telomere length and telomerase were examined in young and aged mice. In young mice, peripheral blood telomere length was significantly elongated following oral intake of D-WP for 4 weeks. mRNA expression of both telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) was significantly increased in the peripheral blood following oral intake of D-WP for 4 weeks. In aged mice, peripheral blood telomere length was significantly decreased as compared with that of young mice, and significantly restored to the level of young mice drinking water by the oral intake of D-WP for 4 weeks. The mRNA expression of peripheral blood TERT and TERC mRNA in aged mice significantly decreased as compared with the level in young mice drinking water, and was significantly restored to the level of expression of young mice drinking water by oral intake of D-WP for 4 weeks. These results suggest that D-WP, but not WP, potently increases peripheral blood telomere length accompanied by increased mRNA expression of TERT and TERC in both young and aged mice.In order to elucidate novel actions of degalactosylated whey protein (D-WP) in comparison with intact whey protein (WP), the effects of oral intake of D-WP on peripheral blood telomere length and telomerase were examined in young and aged mice. In young mice, peripheral blood telomere length was significantly elongated following oral intake of D-WP for 4 weeks. mRNA expression of both telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) was significantly increased in the peripheral blood following oral intake of D-WP for 4 weeks. In aged mice, peripheral blood telomere length was significantly decreased as compared with that of young mice, and significantly restored to the level of young mice drinking water by the oral intake of D-WP for 4 weeks. The mRNA expression of peripheral blood TERT and TERC mRNA in aged mice significantly decreased as compared with the level in young mice drinking water, and was significantly restored to the level of expression of young mice drinking water by oral intake of D-WP for 4 weeks. These results suggest that D-WP, but not WP, potently increases peripheral blood telomere length accompanied by increased mRNA expression of TERT and TERC in both young and aged mice.
ArticleNumber 30859
Author Inui, Toshio
Kubo, Kentaro
Katsuura, Goro
Kawamura, Namiko
Yamamura, Masahiro
Yamakage, Hajime
Ogawa, Yoshihiro
Satoh-Asahara, Noriko
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  givenname: Namiko
  surname: Kawamura
  fullname: Kawamura, Namiko
  organization: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
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  givenname: Masahiro
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  givenname: Goro
  surname: Katsuura
  fullname: Katsuura, Goro
  email: gorokatsuura48@gmail.com
  organization: Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center
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Issue 1
Keywords Aging
Peripheral blood telomere length
Mice
Degalactosylation
Whey protein
Telomerase
Language English
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Snippet In order to elucidate novel actions of degalactosylated whey protein (D-WP) in comparison with intact whey protein (WP), the effects of oral intake of D-WP on...
Abstract In order to elucidate novel actions of degalactosylated whey protein (D-WP) in comparison with intact whey protein (WP), the effects of oral intake of...
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SourceType Open Website
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Index Database
Publisher
StartPage 30859
SubjectTerms 631/154
692/1537
Administration, Oral
Aging
Animals
Blood levels
Degalactosylation
Drinking water
Gene expression
Humanities and Social Sciences
Male
Mice
multidisciplinary
Peripheral blood
Peripheral blood telomere length
Proteins
RNA - genetics
RNA - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA-directed DNA polymerase
Science
Science (multidisciplinary)
Telomerase
Telomerase - genetics
Telomerase - metabolism
Telomerase reverse transcriptase
Telomere - genetics
Telomere - metabolism
Telomere Homeostasis - drug effects
Telomeres
Whey protein
Whey Proteins - administration & dosage
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Title Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice
URI https://link.springer.com/article/10.1038/s41598-024-81597-3
https://www.ncbi.nlm.nih.gov/pubmed/39730524
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https://www.proquest.com/docview/3149757796
https://pubmed.ncbi.nlm.nih.gov/PMC11681036
https://www.nature.com/articles/s41598-024-81597-3.pdf
https://doaj.org/article/0ce84c3ad47049e49f30f678be2788d5
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