Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19 - Lee, Jimmy Tsz Hang; Barnett, Sam N.; Roberts, Kenny; Ashwin, Helen; Milross, Luke; Cho, Jae-Won; Huseynov, Alik; Woodhams, Benjamin; Aivazidis, Alexander; Li, Tong; Majo, Joaquim; Chaves, Patricia; et al. (Nature communications, 2025)
Keywords: 13; 14; 38/39; 45/91; 49; 631/114/2401; 631/326/596/4130; 692/699/1785; 692/699/255/2514; Alveoli; COVID-19; COVID-19 - genetics; COVID-19 - metabolism; COVID-19 - pathology; COVID-19 - virology; Damage detection; Fibrin; Fibrosis; Gene Expression Profiling; Histopathology; Humanities and Social Sciences; Humans; Immunoregulation; Lung - pathology; Lungs; Macrophages; Macrophages - metabolism; Macrophages - pathology; Male; Metallothionein; multidisciplinary; Osteopontin; Plasminogen Activator Inhibitor 1 - genetics; Plasminogen Activator Inhibitor 1 - metabolism; Pulmonary Alveoli - metabolism; Pulmonary Alveoli - pathology; Pulmonary Alveoli - virology; SARS-CoV-2; Science; Science (multidisciplinary); Signal Transduction; Signatures; Single-Cell Analysis - methods; Spatial data; Transcriptome; Transcriptomics; α-Interferon