BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects - Sheikh, Ashfaq M.; Malik, Mazhar; Wen, Guang; Chauhan, Abha; Chauhan, Ved; Gong, Cheng-Xin; Liu, Fei; Brown, William T.; Li, Xiaohong (Journal of neuroscience research, 2010)
Keywords: Adolescent; apoptosis; Apoptosis - physiology; Apoptosis Regulatory Proteins - antagonists & inhibitors; Apoptosis Regulatory Proteins - physiology; autism; bcl-Associated Death Protein - antagonists & inhibitors; bcl-Associated Death Protein - physiology; Bcl2; Brain - metabolism; Brain - physiopathology; brain-derived neurotrophic factor (BDNF); Brain-Derived Neurotrophic Factor - physiology; Child; Child Development Disorders, Pervasive - etiology; Child Development Disorders, Pervasive - metabolism; Child, Preschool; Down-Regulation - physiology; Female; Humans; Male; p53; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - physiology; Signal Transduction - physiology; signaling transduction; Up-Regulation - physiology