Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection - Macal, Monica; Jo, Yeara; Dallari, Simone; Chang, Aaron Y.; Dai, Jihong; Swaminathan, Shobha; Wehrens, Ellen J.; Fitzgerald-Bocarsly, Patricia; Zúñiga, Elina I. (Immunity (Cambridge, Mass.), 2018)
Keywords: 3T3 Cells; Adaptations; Animals; Bone marrow; Cancer; Carrier Proteins - biosynthesis; CD4 antigen; Cell Line; Cell Proliferation; Cell Self Renewal - immunology; Chronic infection; chronic viral infection; Dendritic cells; Dendritic Cells - cytology; Dendritic Cells - immunology; Design; DNA-Binding Proteins - biosynthesis; Exhaustion; Experiments; Flow cytometry; HIV; Human subjects; Humans; Immunotherapy; Infections; Inflammation; Inflammation - immunology; Interferon; Interferon Type I - immunology; LCMV; Lymphocytes T; Lymphocytic Choriomeningitis - immunology; Lymphocytic choriomeningitis virus - immunology; Membrane Glycoproteins - immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Proteins - biosynthesis; Pathogens; plasmacytoid dendritic cells; Production capacity; Repressor Proteins; Rodents; Secondary infection; Signal Transduction - immunology; Spleen; TLR; TLR7 protein; Toll-Like Receptor 7 - immunology; Toll-like receptors; Transcription Factor 4 - biosynthesis; Transcription Factors - biosynthesis; Tumor necrosis factor-TNF; type I interferon; Viral infections; Viruses; type I interferon; plasmacytoid dendritic cells; chronic viral infection; LCMV; HIV; exhaustion; cancer; TLR