Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection
•Hyaluronan (HA) is deposited in inflamed lymph nodes by antigen presenting cells.•Inhibition of HA prevents inflammatory T-cell activation and promotes FoxP3+ Tregs.•Treatment with the HA inhibitor 4-methylumbelliferone (4MU) prevents antigen specific T-cell responses.•4MU prolongs time to rejectio...
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| Published in | Matrix biology Vol. 96; pp. 69 - 86 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.02.2021
Elsevier Science Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0945-053X 1569-1802 1569-1802 |
| DOI | 10.1016/j.matbio.2020.12.001 |
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| Abstract | •Hyaluronan (HA) is deposited in inflamed lymph nodes by antigen presenting cells.•Inhibition of HA prevents inflammatory T-cell activation and promotes FoxP3+ Tregs.•Treatment with the HA inhibitor 4-methylumbelliferone (4MU) prevents antigen specific T-cell responses.•4MU prolongs time to rejection of organ transplantation.
A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabilizes interactions between DC and T-cells, and prevents T-cell proliferation in vitro and in vivo. These effects were observed only when 4MU was added prior to initial antigen presentation but not later, consistent with 4MU-mediated inhibition of de novo antigenic responses. Building on these findings, we find that 4MU delays rejection of allogeneic pancreatic islet transplant and allogeneic cardiac transplants in mice and suppresses allogeneic T-cell activation in human mixed lymphocyte reactions. We conclude that 4MU, an approved drug, may have benefit as an adjunctive agent to delay transplantation rejection. |
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| AbstractList | A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabilizes interactions between DC and T-cells, and prevents T-cell proliferation in vitro and in vivo. These effects were observed only when 4MU was added prior to initial antigen presentation but not later, consistent with 4MU-mediated inhibition of de novo antigenic responses. Building on these findings, we find that 4MU delays rejection of allogeneic pancreatic islet transplant and allogeneic cardiac transplants in mice and suppresses allogeneic T-cell activation in human mixed lymphocyte reactions. We conclude that 4MU, an approved drug, may have benefit as an adjunctive agent to delay transplantation rejection. A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabilizes interactions between DC and T-cells, and prevents T-cell proliferation in vitro and in vivo . These effects were observed only when 4MU was added prior to initial antigen presentation but not later, consistent with 4MU-mediated inhibition of de novo antigenic responses. Building on these findings, we find that 4MU delays rejection of allogeneic pancreatic islet transplant and allogeneic cardiac transplants in mice and suppresses allogeneic T-cell activation in human mixed lymphocyte reactions. We conclude that 4MU, an approved drug, may have benefit as an adjunctive agent to delay transplantation rejection. •Hyaluronan (HA) is deposited in inflamed lymph nodes by antigen presenting cells.•Inhibition of HA prevents inflammatory T-cell activation and promotes FoxP3+ Tregs.•Treatment with the HA inhibitor 4-methylumbelliferone (4MU) prevents antigen specific T-cell responses.•4MU prolongs time to rejection of organ transplantation. A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabilizes interactions between DC and T-cells, and prevents T-cell proliferation in vitro and in vivo. These effects were observed only when 4MU was added prior to initial antigen presentation but not later, consistent with 4MU-mediated inhibition of de novo antigenic responses. Building on these findings, we find that 4MU delays rejection of allogeneic pancreatic islet transplant and allogeneic cardiac transplants in mice and suppresses allogeneic T-cell activation in human mixed lymphocyte reactions. We conclude that 4MU, an approved drug, may have benefit as an adjunctive agent to delay transplantation rejection. A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabilizes interactions between DC and T-cells, and prevents T-cell proliferation in vitro and in vivo. These effects were observed only when 4MU was added prior to initial antigen presentation but not later, consistent with 4MU-mediated inhibition of de novo antigenic responses. Building on these findings, we find that 4MU delays rejection of allogeneic pancreatic islet transplant and allogeneic cardiac transplants in mice and suppresses allogeneic T-cell activation in human mixed lymphocyte reactions. We conclude that 4MU, an approved drug, may have benefit as an adjunctive agent to delay transplantation rejection.A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabilizes interactions between DC and T-cells, and prevents T-cell proliferation in vitro and in vivo. These effects were observed only when 4MU was added prior to initial antigen presentation but not later, consistent with 4MU-mediated inhibition of de novo antigenic responses. Building on these findings, we find that 4MU delays rejection of allogeneic pancreatic islet transplant and allogeneic cardiac transplants in mice and suppresses allogeneic T-cell activation in human mixed lymphocyte reactions. We conclude that 4MU, an approved drug, may have benefit as an adjunctive agent to delay transplantation rejection. |
| Author | Nagy, Nadine Zhang, Xiangyue de Vries, Christiaan R. Vernon, Robert B. Engleman, Edgar G. Gurevich, Irina Xie, Bryan J. Bollyky, Paul L. Malkovskiy, Andrey V. Wight, Thomas N. Krams, Sheri M. Meyer, Everett H. Tran, Quynh-Lam Yadava, Koshika Wang, Xi Haddock, Naomi L. Lester, Colin A. Linde, Miles H. Kuipers, Hedwich F. Evanko, Stephen P. Hargil, Aviv Marshall, Payton L. Ramesh, Amrit Gebe, John A. Kaber, Gernot Martinez, Hunter A. Barlow, Graham L. de la Motte, Carol |
| AuthorAffiliation | b - Division of Blood and Marrow Transplantation , Dept. of Medicine, Stanford University School of Medicine, CCSR, 1291 Welch Road, Stanford, CA 94305, United States d - Biomaterials and Advanced Drug Delivery (BioADD) Laboratory Stanford School of Medicine, Stanford, CA 94304, United States g - Division of Abdominal Transplantation , Department of Surgery, Stanford University School of Medicine, Stanford University School of Medicine, 1201 Welch Rd, MSLS P313, Stanford, CA 94305, United States a - Division of Infectious Diseases and Geographic Medicine , Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States e - Department of Pathology , Stanford School of Medicine, 3373 Hillview Ave, Palo Alto CA 94304, United States f - Benaroya Research Institute , 1201 Ninth Avenue, Seattle, WA 98101, United States c - Division of Hematology , Dept. of Medicine, Cancer Institute, and Institute for Stem Cell Biology and Regenerative |
| AuthorAffiliation_xml | – name: b - Division of Blood and Marrow Transplantation , Dept. of Medicine, Stanford University School of Medicine, CCSR, 1291 Welch Road, Stanford, CA 94305, United States – name: a - Division of Infectious Diseases and Geographic Medicine , Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – name: d - Biomaterials and Advanced Drug Delivery (BioADD) Laboratory Stanford School of Medicine, Stanford, CA 94304, United States – name: e - Department of Pathology , Stanford School of Medicine, 3373 Hillview Ave, Palo Alto CA 94304, United States – name: h - Department of Inflammation and Immunity , Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue Cleveland, OH 4419, United States – name: g - Division of Abdominal Transplantation , Department of Surgery, Stanford University School of Medicine, Stanford University School of Medicine, 1201 Welch Rd, MSLS P313, Stanford, CA 94305, United States – name: c - Division of Hematology , Dept. of Medicine, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, SIM1, 265 Campus Drive, Stanford, CA, 94305, United States – name: f - Benaroya Research Institute , 1201 Ninth Avenue, Seattle, WA 98101, United States |
| Author_xml | – sequence: 1 givenname: Payton L. orcidid: 0000-0002-0921-3016 surname: Marshall fullname: Marshall, Payton L. organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 2 givenname: Nadine surname: Nagy fullname: Nagy, Nadine organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 3 givenname: Gernot orcidid: 0000-0002-6184-5192 surname: Kaber fullname: Kaber, Gernot organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 4 givenname: Graham L. surname: Barlow fullname: Barlow, Graham L. organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 5 givenname: Amrit surname: Ramesh fullname: Ramesh, Amrit organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 6 givenname: Bryan J. surname: Xie fullname: Xie, Bryan J. organization: Division of Blood and Marrow Transplantation, Dept. of Medicine, Stanford University School of Medicine, CCSR, 1291 Welch Road, Stanford, CA 94305, United States – sequence: 7 givenname: Miles H. orcidid: 0000-0003-2553-2890 surname: Linde fullname: Linde, Miles H. organization: Division of Hematology, Dept. of Medicine, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, SIM1, 265 Campus Drive, Stanford, CA 94305, United States – sequence: 8 givenname: Naomi L. surname: Haddock fullname: Haddock, Naomi L. organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 9 givenname: Colin A. surname: Lester fullname: Lester, Colin A. organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 10 givenname: Quynh-Lam surname: Tran fullname: Tran, Quynh-Lam organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 11 givenname: Christiaan R. orcidid: 0000-0002-4667-5973 surname: de Vries fullname: de Vries, Christiaan R. organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 12 givenname: Aviv surname: Hargil fullname: Hargil, Aviv organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 13 givenname: Andrey V. surname: Malkovskiy fullname: Malkovskiy, Andrey V. organization: Biomaterials and Advanced Drug Delivery (BioADD) Laboratory Stanford School of Medicine, Stanford, CA 94304, United States – sequence: 14 givenname: Irina surname: Gurevich fullname: Gurevich, Irina organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 15 givenname: Hunter A. orcidid: 0000-0003-1129-3382 surname: Martinez fullname: Martinez, Hunter A. organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 16 givenname: Hedwich F. surname: Kuipers fullname: Kuipers, Hedwich F. organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 17 givenname: Koshika surname: Yadava fullname: Yadava, Koshika organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States – sequence: 18 givenname: Xiangyue surname: Zhang fullname: Zhang, Xiangyue organization: Department of Pathology, Stanford School of Medicine, 3373 Hillview Ave, Palo Alto CA 94304, United States – sequence: 19 givenname: Stephen P. surname: Evanko fullname: Evanko, Stephen P. organization: Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101, United States – sequence: 20 givenname: John A. surname: Gebe fullname: Gebe, John A. organization: Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101, United States – sequence: 21 givenname: Xi surname: Wang fullname: Wang, Xi organization: Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford University School of Medicine, 1201 Welch Rd, MSLS P313, Stanford, CA 94305, United States – sequence: 22 givenname: Robert B. surname: Vernon fullname: Vernon, Robert B. organization: Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101, United States – sequence: 23 givenname: Carol surname: de la Motte fullname: de la Motte, Carol organization: Department of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue Cleveland, OH 4419, United States – sequence: 24 givenname: Thomas N. surname: Wight fullname: Wight, Thomas N. organization: Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101, United States – sequence: 25 givenname: Edgar G. surname: Engleman fullname: Engleman, Edgar G. organization: Division of Hematology, Dept. of Medicine, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, SIM1, 265 Campus Drive, Stanford, CA 94305, United States – sequence: 26 givenname: Sheri M. surname: Krams fullname: Krams, Sheri M. organization: Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford University School of Medicine, 1201 Welch Rd, MSLS P313, Stanford, CA 94305, United States – sequence: 27 givenname: Everett H. surname: Meyer fullname: Meyer, Everett H. organization: Division of Blood and Marrow Transplantation, Dept. of Medicine, Stanford University School of Medicine, CCSR, 1291 Welch Road, Stanford, CA 94305, United States – sequence: 28 givenname: Paul L. surname: Bollyky fullname: Bollyky, Paul L. email: pbollyky@stanford.edu organization: Division of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Beckman Center, 279 Campus Drive, Stanford, CA 94305, United States |
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| Cites_doi | 10.1098/rstb.1974.0015 10.1126/scitranslmed.aat9284 10.1369/jhc.2008.951665 10.1111/j.1600-6143.2011.03958.x 10.3389/fimmu.2019.02172 10.1074/jbc.M704339200 10.1038/nri.2016.26 10.4049/jimmunol.179.12.8191 10.1242/jcs.231597 10.1016/j.matbio.2018.03.022 10.1096/fasebj.7.13.7691670 10.1038/nrm1699 10.1111/j.0021-8782.2004.00350.x 10.1016/j.matbio.2018.03.003 10.1126/science.aat9691 10.1038/ni1265 10.1038/cmi.2010.9 10.1002/art.37861 10.3389/fimmu.2016.00006 10.4049/jimmunol.0901459 10.2337/db13-1658 10.1002/1521-4141(200207)32:7<2074::AID-IMMU2074>3.0.CO;2-S 10.1074/jbc.M115.708305 10.1016/j.matbio.2018.04.007 10.1016/j.addr.2007.08.008 10.1016/j.matbio.2019.02.002 10.1016/j.yexcr.2009.03.002 10.1016/0022-2828(80)90079-6 10.1016/S0021-9258(19)38463-7 10.1074/jbc.272.22.13997 10.1371/journal.pone.0186116 10.1046/j.1365-2567.1999.00894.x 10.1016/j.matbio.2020.02.001 10.1016/j.matbio.2018.01.011 10.3389/fimmu.2015.00123 10.1182/blood-2010-08-301275 10.1146/annurev.bioeng.9.060906.151959 10.1016/j.matbio.2011.10.004 10.1074/jbc.R100036200 10.1016/j.matbio.2018.12.002 10.1172/jci.insight.127244 10.1073/pnas.1525086113 10.1073/pnas.1017360108 10.1016/j.matbio.2014.08.009 10.1016/j.matbio.2018.09.003 10.1111/j.1600-065X.2008.00589.x 10.1111/cei.12815 10.1111/anae.12661 10.1165/rcmb.2016-0111OC 10.1073/pnas.96.1.185 10.4049/jimmunol.1003880 10.1038/ni.3750 10.1073/pnas.052026799 10.4049/jimmunol.179.2.744 10.4049/jimmunol.1000820 10.1152/physrev.00052.2009 10.2215/CJN.08570814 10.1016/j.immuni.2006.10.011 10.1074/jbc.RA118.006166 10.1039/C9FD00024K 10.1016/j.bpj.2017.05.033 10.1111/cmi.12711 10.1189/jlb.0109001 10.3389/fimmu.2020.01982 10.1074/jbc.M114.559583 10.3390/ijms19092484 10.1016/j.bpj.2016.05.027 10.1084/jem.180.3.807 10.1016/j.matbio.2018.01.017 10.1172/JCI79271 10.1016/0092-8674(82)90221-5 10.1111/j.1600-065X.2009.00803.x 10.1016/j.ccm.2016.01.009 10.4049/jimmunol.169.8.4322 10.1016/j.matbio.2018.04.012 10.1177/089686080802800102 10.1074/jbc.M405918200 10.1007/s10753-014-0092-y 10.1096/fj.06-6207com 10.4049/jimmunol.1003650 10.1097/00007890-197310000-00010 10.1006/excr.1996.0320 10.1038/icb.2008.54 |
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| Keywords | 4-methylumbelliferone Antigen presentation Dendritic cells Transplantation IS Hyaluronan Glycocalyx APC BMDC HA PCM HAS 4MU HYAL DC |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 P.L.M. and N.N conceived of the work, performed experiments and wrote the manuscript with contributions from all authors. G.K. assisted in experimental design and performed experiments. G.L.B., A.R., C.A.L., S.P.E., J.A.G, T.N.W. and I.G. performed experiments and analysis for in vitro and in vivo imaging. B.J.X. and E.M. designed and performed the human MLR experiments. X.Z. and E.G.E assisted in design and performing of human allogeneic Treg inductions. Q.T., H.M., H.K., M.H.L. and C.V. performed flow cytometry experiments. A.M. performed scanning electron microscopy. X.W. performed cardiac allotransplants. S.M.K assisted with design of cardiac transplant experiments. C.M. assisted in project planning and use of transgenic animals. P.L.B. supervised the project and assisted in manuscript preparation. authors contributed equally Author Contributions |
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| References | V??rnai, T??th, T??th, Hunyady, Balla (bib0028) 2007; 282 Fischer (bib0029) 2019; 78–79 Alphonsus, Rodseth (bib0007) 2014; 69 Wei, Wang, Qu, Mah, Xiong, Harris, Phillips, Martinez, Krams (bib0063) 2012; 12 Chang, McLane, Fogg, Scrimgeour, Temenoff, Granqvist, Curtis (bib0024) 2016; 110 Sweere, Van Belleghem, Ishak, Bach, Popescu, Sunkari, Kaber, Manasherob, Suh, Cao, de Vries, Lam, Marshall, Birukova, Katznelson, Lazzareschi, Balaji, Keswani, Hawn, Secor, Bollyky (bib0086) 2019; 363 M.F. Flessner, Endothelial glycocalyx and the peritoneal barrier., Perit. Dial. Int. 28 (n.d.) 6–12. Johnson, Banerji, Lawrance, Gileadi, Prota, Holder, Roshorm, Hanke, Cerundolo, Gale, Jackson (bib0069) 2017; 18 Kretschmer, Apostolou, Hawiger, Khazaie, Nussenzweig, von Boehmer (bib0077) 2005; 6 Nagy, Gurevich, Kuipers, Ruppert, Marshall, Xie, Sun, Malkovskiy, Rajadas, Grandoch, Fischer, Frymoyer, Kaber, Bollyky (bib0051) 2019; 294 Zhang, Zheng, Prestwood, Zhang, Carmi, Tolentino, Wu, Choi, Winer, Strober, Kang, Alonso, Engleman (bib0061) 2020; 11 Kuipers, Rieck, Gurevich, Nagy, Butte, Negrin, Wight, Steinman, Bollyky (bib0047) 2016; 113 Corry, Winn, Russell (bib0062) 1973; 16 Evanko, Tammi, Tammi, Wight (bib0001) 2007; 59 Kang, Wu, Sun, Liu, Fan, Deng (bib0012) 2018; 19 Turner, Kane, Morel (bib0054) 2009; 183 Ito (bib0004) 1974; 268 Garantziotis, Savani (bib0005) 2019; 78–79 Weinbaum, Tarbell, Damiano (bib0015) 2007; 9 Day, Milner (bib0033) 2019; 78–79 Jackson (bib0039) 2009; 230 Nagy, Kuipers, Frymoyer, Ishak, Bollyky, Wight, Bollyky (bib0045) 2015; 6 Dustin (bib0068) 2008; 221 Jiang, Liang, Noble (bib0025) 2011; 91 Nagy, Sunkari, Kaber, Hasbun, Lam, Speake, Sanda, McLaughlin, Wight, Long, Bollyky (bib0034) 2019; 80 Mahaffey, Mummert (bib0059) 2007; 179 Semple, Nguyen, Yu, Wang, Anasetti, Yu (bib0066) 2011; 117 Evanko, Potter-Perigo, Bollyky, Nepom, Wight (bib0083) 2012; 31 Haslam, Julien, Burchell, Monk, Ceroni, Garden, Dell (bib0002) 2008; 86 Bollyky, Evanko, Wu, Potter-Perigo, Long, Kinsella, Reijonen, Guebtner, Teng, Chan, Braun, Gebe, Nepom, Wight (bib0037) 2010; 7 Nagy, Kuipers, Marshall, Wang, Kaber, Bollyky (bib0074) 2019; 78–79 Bollyky, Wu, Falk, Lord, Long, Preisinger, Teng, Holt, Standifer, Braun, Xie, Samuels, Vernon, Gebe, Wight, Nepom (bib0087) 2011; 108 Orenstein, Hogan, Bloom (bib0009) 1980; 12 Tammi, Oikari, Pasonen-Seppänen, Rilla, Auvinen, Tammi (bib0014) 2019; 78–79 F. Casiraghi, S. Aiello, G. Remuzzi, Transplant tolerance: progress and challenges., J. Nephrol. 23 (n.d.) 263–70. Kakizaki, Kojima, Takagaki, Endo, Kannagi, Ito, Maruo, Sato, Yasuda, Mita, Kimata, Itano (bib0042) 2004; 279 Gumbiner (bib0018) 2005; 6 . Grigorov, Reungoat, Gentil Dit Maurin, Varbanov, Blaising, Michelet, Manuel, Parent, Bartosch, Zoulim, Ruggiero, Pécheur (bib0010) 2017; 19 Bartosch, Mathews, Tarbell (bib0021) 2017; 113 van Panhuys (bib0067) 2016; 7 Liao, Spremulli (bib0081) 1990; 265 Colbert, Schmidt (bib0013) 2016; 37 Yoshioka, Kozawa, Urakawa, Arai, Futamura, Zhuo, Kimata, Ishiguro, Nishida (bib0049) 2013; 65 Wesley, Sather, Perdue, Ziegler, Campbell (bib0057) 2010; 185 Bollyky, Falk, Wu, Buckner, Wight, Nepom (bib0052) 2009; 86 Gebe, Yadava, Ruppert, Marshall, Hill, Falk, Sweere, Han, Kaber, Harten, Medina, Mikecz, Ziegler, Balaji, Keswani, de J. Perez, Butte, Nadeau, Altemeier, Fanger, Bollyky (bib0085) 2017; 56 Honigfort, Zhang, Verespy, Godula (bib0019) 2019 Mueller, Yoon, Sadiq (bib0048) 2014; 289 Bretscher (bib0084) 1999; 96 Savinov, Rozanov, Strongin (bib0082) 2006; 20 Heldin, Lin, Kolliopoulos, Chen, Skandalis (bib0036) 2019; 78–79 Swetman, Leverrier, Garg, Gan, Ridley, Katz, Chain (bib0058) 2002; 32 Lazaar, Albelda, Pilewski, Brennan, Puré, Panettieri (bib0080) 1994; 180 Long, Rieck, Tatum, Bollyky, Wu, Muller, Ho, Shilling, Buckner (bib0055) 2011; 187 Bajénoff, Egen, Koo, Laugier, Brau, Glaichenhaus, Germain (bib0071) 2006; 25 Nagy, Kuipers, Marshall, Wang, Kaber, Bollyky (bib0050) 2019; 78–79 Yoshioka, Kozawa, Urakawa, Arai, Futamura, Zhuo, Kimata, Ishiguro, Nishida (bib0064) 2013; 65 Rilla, Tiihonen, Kultti, Tammi, Tammi (bib0023) 2008; 56 Knudson, Aguiar, Hua, Knudson (bib0027) 1996; 228 Chi, Rattner, Matyas (bib0016) 2004; 205 Corse, Gottschalk, Allison (bib0076) 2011; 186 Weigel, Hascall, Tammi (bib0026) 1997; 272 Kultti, Pasonen-Seppänen, Jauhiainen, Rilla, Kärnä, Pyöriä, Tammi, Tammi (bib0041) 2009; 315 Lawrance, Banerji, Day, Bhattacharjee, Jackson (bib0070) 2016; 291 Chen, Gubbiotti, Kapoor, Han, Yu, Linhardt, Iozzo (bib0030) 2020; 90 Wilusz, Sanchez-Adams, Guilak (bib0006) 2014; 39 Bogdani, Johnson, Potter-Perigo, Nagy, Day, Bollyky, Wight (bib0040) 2014; 63 Brennan, O'Neill, Allen, Butter, Nuki, Baker (bib0079) 1999; 98 Mensah, Cheng, Homayoni, Plouffe, Coury, Ebong (bib0017) 2017; 12 Suarez-Fueyo, Tsokos, Kwok, Maeda, Katsuyama, Lapchak, Tsokos (bib0065) 2019; 10 Itano, Atsumi, Sawai, Yamada, Miyaishi, Senga, Hamaguchi, Kimata (bib0078) 2002; 99 Wiseman (bib0072) 2016; 11 Davies, Baranova, El Amri, Coche-Guérente, Verdier, Bureau, Richter, Débarre (bib0020) 2019; 78–79 Knudson, Knudson (bib0031) 1993; 7 Karalis, Heldin, Vynios, Neill, Buraschi, Iozzo, Karamanos, Skandalis (bib0035) 2019; 78–79 Nagy, Kaber, Johnson, Gebe, Preisinger, Falk, Sunkari, Gooden, Vernon, Bogdani, Kuipers, Day, Campbell, Wight, Bollyky (bib0046) 2015; 125 Meyer, Laport, Xie, MacDonald, Heydari, Sahaf, Tang, Baker, Armstrong, Tate, Tadisco, Arai, Johnston, Lowsky, Muffly, Rezvani, Shizuru, Weng, Sheehan, Miklos, Negrin (bib0060) 2019; 4 Mummert, Mummert, Edelbaum, Hui, Matsue, Takashima (bib0038) 2002; 169 McKallip, Ban, Uchakina (bib0044) 2015; 38 Li, Rudensky (bib0056) 2016; 16 Hedman, Johansson, Vartio, Kjellén, Vaheri, Höök (bib0008) 1982; 28 Day, Prestwich (bib0032) 2002; 277 Winklbauer (bib0022) 2019; 132 S. Ito, Structure and function of the glycocalyx., Fed. Proc. 28 (n.d.) 12–25. Yang, Noureddin, Liu, Ohashi, Kim, Ramnath, Powell, Sweet, Roh, Hsin, Deng, Liu, Liang, Mena, Shouhed, Schwabe, Jiang, Lu, Noble, Seki (bib0043) 2019; 11 Kuipers, Nagy, Ruppert, Sunkari, Marshall, Gebe, Ishak, Keswani, Bollyky, Frymoyer, Wight, Steinman, Bollyky (bib0075) 2016; 185 Bollyky, Lord, Masewicz, Evanko, Buckner, Wight, Nepom (bib0053) 2007; 179 Kang (10.1016/j.matbio.2020.12.001_bib0012) 2018; 19 Liao (10.1016/j.matbio.2020.12.001_bib0081) 1990; 265 Karalis (10.1016/j.matbio.2020.12.001_bib0035) 2019; 78–79 Honigfort (10.1016/j.matbio.2020.12.001_bib0019) 2019 Rilla (10.1016/j.matbio.2020.12.001_bib0023) 2008; 56 Semple (10.1016/j.matbio.2020.12.001_bib0066) 2011; 117 Sweere (10.1016/j.matbio.2020.12.001_bib0086) 2019; 363 Bollyky (10.1016/j.matbio.2020.12.001_bib0087) 2011; 108 Mahaffey (10.1016/j.matbio.2020.12.001_bib0059) 2007; 179 Davies (10.1016/j.matbio.2020.12.001_bib0020) 2019; 78–79 Turner (10.1016/j.matbio.2020.12.001_bib0054) 2009; 183 Savinov (10.1016/j.matbio.2020.12.001_bib0082) 2006; 20 Evanko (10.1016/j.matbio.2020.12.001_bib0001) 2007; 59 Kuipers (10.1016/j.matbio.2020.12.001_bib0047) 2016; 113 Corry (10.1016/j.matbio.2020.12.001_bib0062) 1973; 16 Mueller (10.1016/j.matbio.2020.12.001_bib0048) 2014; 289 Haslam (10.1016/j.matbio.2020.12.001_bib0002) 2008; 86 Fischer (10.1016/j.matbio.2020.12.001_bib0029) 2019; 78–79 Nagy (10.1016/j.matbio.2020.12.001_bib0050) 2019; 78–79 Dustin (10.1016/j.matbio.2020.12.001_bib0068) 2008; 221 Wei (10.1016/j.matbio.2020.12.001_bib0063) 2012; 12 Chang (10.1016/j.matbio.2020.12.001_bib0024) 2016; 110 McKallip (10.1016/j.matbio.2020.12.001_bib0044) 2015; 38 Winklbauer (10.1016/j.matbio.2020.12.001_bib0022) 2019; 132 Jiang (10.1016/j.matbio.2020.12.001_bib0025) 2011; 91 Heldin (10.1016/j.matbio.2020.12.001_bib0036) 2019; 78–79 Evanko (10.1016/j.matbio.2020.12.001_bib0083) 2012; 31 Long (10.1016/j.matbio.2020.12.001_bib0055) 2011; 187 Chi (10.1016/j.matbio.2020.12.001_bib0016) 2004; 205 Kretschmer (10.1016/j.matbio.2020.12.001_bib0077) 2005; 6 Grigorov (10.1016/j.matbio.2020.12.001_bib0010) 2017; 19 Wesley (10.1016/j.matbio.2020.12.001_bib0057) 2010; 185 Kuipers (10.1016/j.matbio.2020.12.001_bib0075) 2016; 185 Itano (10.1016/j.matbio.2020.12.001_bib0078) 2002; 99 Swetman (10.1016/j.matbio.2020.12.001_bib0058) 2002; 32 Garantziotis (10.1016/j.matbio.2020.12.001_bib0005) 2019; 78–79 Gumbiner (10.1016/j.matbio.2020.12.001_bib0018) 2005; 6 Bollyky (10.1016/j.matbio.2020.12.001_bib0037) 2010; 7 Nagy (10.1016/j.matbio.2020.12.001_bib0046) 2015; 125 10.1016/j.matbio.2020.12.001_bib0011 Bretscher (10.1016/j.matbio.2020.12.001_bib0084) 1999; 96 Jackson (10.1016/j.matbio.2020.12.001_bib0039) 2009; 230 Yang (10.1016/j.matbio.2020.12.001_bib0043) 2019; 11 Bollyky (10.1016/j.matbio.2020.12.001_bib0053) 2007; 179 Brennan (10.1016/j.matbio.2020.12.001_bib0079) 1999; 98 Knudson (10.1016/j.matbio.2020.12.001_bib0031) 1993; 7 Zhang (10.1016/j.matbio.2020.12.001_bib0061) 2020; 11 Corse (10.1016/j.matbio.2020.12.001_bib0076) 2011; 186 Mummert (10.1016/j.matbio.2020.12.001_bib0038) 2002; 169 Weinbaum (10.1016/j.matbio.2020.12.001_bib0015) 2007; 9 Mensah (10.1016/j.matbio.2020.12.001_bib0017) 2017; 12 Chen (10.1016/j.matbio.2020.12.001_bib0030) 2020; 90 Kultti (10.1016/j.matbio.2020.12.001_bib0041) 2009; 315 Alphonsus (10.1016/j.matbio.2020.12.001_bib0007) 2014; 69 Nagy (10.1016/j.matbio.2020.12.001_bib0045) 2015; 6 Yoshioka (10.1016/j.matbio.2020.12.001_bib0049) 2013; 65 Day (10.1016/j.matbio.2020.12.001_bib0033) 2019; 78–79 Bollyky (10.1016/j.matbio.2020.12.001_bib0052) 2009; 86 10.1016/j.matbio.2020.12.001_bib0003 Bajénoff (10.1016/j.matbio.2020.12.001_bib0071) 2006; 25 Suarez-Fueyo (10.1016/j.matbio.2020.12.001_bib0065) 2019; 10 Weigel (10.1016/j.matbio.2020.12.001_bib0026) 1997; 272 Nagy (10.1016/j.matbio.2020.12.001_bib0051) 2019; 294 Li (10.1016/j.matbio.2020.12.001_bib0056) 2016; 16 Orenstein (10.1016/j.matbio.2020.12.001_bib0009) 1980; 12 Bartosch (10.1016/j.matbio.2020.12.001_bib0021) 2017; 113 Yoshioka (10.1016/j.matbio.2020.12.001_bib0064) 2013; 65 V??rnai (10.1016/j.matbio.2020.12.001_bib0028) 2007; 282 Colbert (10.1016/j.matbio.2020.12.001_bib0013) 2016; 37 Tammi (10.1016/j.matbio.2020.12.001_bib0014) 2019; 78–79 Ito (10.1016/j.matbio.2020.12.001_bib0004) 1974; 268 Kakizaki (10.1016/j.matbio.2020.12.001_bib0042) 2004; 279 Lazaar (10.1016/j.matbio.2020.12.001_bib0080) 1994; 180 Johnson (10.1016/j.matbio.2020.12.001_bib0069) 2017; 18 Knudson (10.1016/j.matbio.2020.12.001_bib0027) 1996; 228 Wilusz (10.1016/j.matbio.2020.12.001_bib0006) 2014; 39 Nagy (10.1016/j.matbio.2020.12.001_bib0034) 2019; 80 Meyer (10.1016/j.matbio.2020.12.001_bib0060) 2019; 4 Hedman (10.1016/j.matbio.2020.12.001_bib0008) 1982; 28 10.1016/j.matbio.2020.12.001_bib0073 Wiseman (10.1016/j.matbio.2020.12.001_bib0072) 2016; 11 Day (10.1016/j.matbio.2020.12.001_bib0032) 2002; 277 Lawrance (10.1016/j.matbio.2020.12.001_bib0070) 2016; 291 Nagy (10.1016/j.matbio.2020.12.001_bib0074) 2019; 78–79 Gebe (10.1016/j.matbio.2020.12.001_bib0085) 2017; 56 Bogdani (10.1016/j.matbio.2020.12.001_bib0040) 2014; 63 van Panhuys (10.1016/j.matbio.2020.12.001_bib0067) 2016; 7 |
| References_xml | – reference: F. Casiraghi, S. Aiello, G. Remuzzi, Transplant tolerance: progress and challenges., J. Nephrol. 23 (n.d.) 263–70. – volume: 19 year: 2017 ident: bib0010 article-title: Hepatitis C virus infection propagates through interactions between Syndecan-1 and CD81 and impacts the hepatocyte glycocalyx publication-title: Cell. Microbiol. – volume: 315 start-page: 1914 year: 2009 end-page: 1923 ident: bib0041 article-title: 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3 publication-title: Exp. Cell Res. – volume: 28 start-page: 663 year: 1982 end-page: 671 ident: bib0008 article-title: Structure of the pericellular matrix: association of heparan and chondroitin sulfates with fibronectin-procollagen fibers publication-title: Cell – volume: 18 start-page: 762 year: 2017 end-page: 770 ident: bib0069 article-title: Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1 publication-title: Nat. Immunol. – volume: 7 start-page: 211 year: 2010 end-page: 220 ident: bib0037 article-title: Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse publication-title: Cell. Mol. Immunol. – volume: 65 start-page: 1160 year: 2013 end-page: 1170 ident: bib0064 article-title: Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in hUMAN RHEUMATOID SYNOVIAL FIBROblasts publication-title: Arthritis Rheum. – volume: 205 start-page: 363 year: 2004 end-page: 370 ident: bib0016 article-title: Communication between paired chondrocytes in the superficial zone of articular cartilage publication-title: J. Anat. – volume: 98 start-page: 427 year: 1999 end-page: 435 ident: bib0079 article-title: CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease publication-title: Immunology – volume: 65 start-page: 1160 year: 2013 end-page: 1170 ident: bib0049 article-title: Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts publication-title: Arthritis Rheum – volume: 91 start-page: 221 year: 2011 end-page: 264 ident: bib0025 article-title: Hyaluronan as an immune regulator in human diseases publication-title: Physiol. Rev. – volume: 279 start-page: 33281 year: 2004 end-page: 33289 ident: bib0042 article-title: A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone publication-title: J. Biol. Chem. – volume: 125 start-page: 3928 year: 2015 end-page: 3940 ident: bib0046 article-title: Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis publication-title: J. Clin. Invest. – volume: 80 start-page: 46 year: 2019 end-page: 58 ident: bib0034 article-title: Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control publication-title: Matrix Biol. – volume: 187 start-page: 3511 year: 2011 end-page: 3520 ident: bib0055 article-title: Low-dose antigen promotes induction of FOXP3 in human CD4+ T cells publication-title: J. Immunol. – volume: 113 start-page: 1339 year: 2016 end-page: 1344 ident: bib0047 article-title: Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization publication-title: Proc. Natl. Acad. Sci. – volume: 113 start-page: 101 year: 2017 end-page: 108 ident: bib0021 article-title: Endothelial glycocalyx-mediated nitric oxide production in response to selective AFM pulling publication-title: Biophys. J. – volume: 179 start-page: 8191 year: 2007 end-page: 8199 ident: bib0059 article-title: Hyaluronan synthesis is required for IL-2-mediated T cell proliferation publication-title: J. Immunol. – volume: 268 start-page: 55 year: 1974 end-page: 66 ident: bib0004 article-title: Form and function of the glycocalyx on free cell surfaces publication-title: Philos. Trans. R. Soc. Lond. B. Biol. Sci. – volume: 186 start-page: 5039 year: 2011 end-page: 5045 ident: bib0076 article-title: Strength of TCR–peptide/MHC interactions and In Vivo T Cell responses publication-title: J. Immunol – volume: 185 start-page: 4760 year: 2010 end-page: 4768 ident: bib0057 article-title: Cellular requirements for diabetes induction in DO11.10xRIPmOVA Mice publication-title: J. Immunol. – volume: 291 start-page: 8014 year: 2016 end-page: 8030 ident: bib0070 article-title: Binding of hyaluronan to the native lymphatic vessel endothelial receptor LYVE-1 Is critically dependent on receptor clustering and hyaluronan organization publication-title: J. Biol. Chem. – volume: 78–79 start-page: 1 year: 2019 end-page: 10 ident: bib0005 article-title: Hyaluronan biology: a complex balancing act of structure, function, location and context publication-title: Matrix Biol. – volume: 183 start-page: 4895 year: 2009 end-page: 4903 ident: bib0054 article-title: Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion publication-title: J. Immunol. – volume: 69 start-page: 777 year: 2014 end-page: 784 ident: bib0007 article-title: The endothelial glycocalyx: a review of the vascular barrier publication-title: Anaesthesia – volume: 11 start-page: 332 year: 2016 end-page: 343 ident: bib0072 article-title: Immunosuppressive medications publication-title: Clin. J. Am. Soc. Nephrol. – volume: 294 start-page: 7864 year: 2019 end-page: 7877 ident: bib0051 article-title: 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition publication-title: J. Biol. Chem. – volume: 289 start-page: 22888 year: 2014 end-page: 22899 ident: bib0048 article-title: Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS publication-title: J. Biol. Chem. – volume: 11 start-page: 1982 year: 2020 ident: bib0061 article-title: Human regulatory dendritic cells develop from monocytes in response to signals from regulatory and helper T cells publication-title: Front. Immunol. – volume: 179 start-page: 744 year: 2007 end-page: 747 ident: bib0053 article-title: Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells publication-title: J. Immunol. – volume: 6 start-page: 123 year: 2015 ident: bib0045 article-title: 4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer publication-title: Front. Immunol. – volume: 78–79 start-page: 292 year: 2019 end-page: 313 ident: bib0074 article-title: Hyaluronan in immune dysregulation and autoimmune diseases publication-title: Matrix Biol – volume: 230 start-page: 216 year: 2009 end-page: 231 ident: bib0039 article-title: Immunological functions of hyaluronan and its receptors in the lymphatics publication-title: Immunol. Rev. – volume: 38 start-page: 1250 year: 2015 end-page: 1259 ident: bib0044 article-title: Treatment with the hyaluronic Acid synthesis inhibitor 4-methylumbelliferone suppresses LPS-induced lung inflammation publication-title: Inflammation – volume: 272 start-page: 13997 year: 1997 end-page: 14000 ident: bib0026 article-title: Hyaluronan synthases publication-title: J. Biol. Chem. – volume: 78–79 start-page: 47 year: 2019 end-page: 59 ident: bib0020 article-title: An integrated assay to probe endothelial glycocalyx-blood cell interactions under flow in mechanically and biochemically well-defined environments publication-title: Matrix Biol. – volume: 132 year: 2019 ident: bib0022 article-title: Dynamic cell-cell adhesion mediated by pericellular matrix interaction - a hypothesis publication-title: J. Cell Sci. – volume: 86 start-page: 567 year: 2009 end-page: 572 ident: bib0052 article-title: Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells publication-title: J. Leukoc. Biol. – volume: 37 start-page: 263 year: 2016 end-page: 275 ident: bib0013 article-title: Endothelial and Microcirculatory Function and Dysfunction in Sepsis publication-title: Clin. Chest Med. – volume: 7 year: 2016 ident: bib0067 article-title: TCR signal strength alters T–DC activation and interaction times and directs the outcome of differentiation publication-title: Front. Immunol. – volume: 20 start-page: 1793 year: 2006 end-page: 1801 ident: bib0082 article-title: Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes publication-title: FASEB J – volume: 32 start-page: 2074 year: 2002 end-page: 2083 ident: bib0058 article-title: Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases publication-title: Eur. J. Immunol. – volume: 99 start-page: 3609 year: 2002 end-page: 3614 ident: bib0078 article-title: Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration publication-title: Proc. Natl. Acad. Sci. – volume: 108 start-page: 7938 year: 2011 end-page: 7943 ident: bib0087 article-title: ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 12 year: 2017 ident: bib0017 article-title: Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication publication-title: PLoS One – volume: 363 year: 2019 ident: bib0086 article-title: Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection publication-title: Science – volume: 16 start-page: 220 year: 2016 end-page: 233 ident: bib0056 article-title: T cell receptor signalling in the control of regulatory T cell differentiation and function publication-title: Nat. Rev. Immunol. – volume: 4 year: 2019 ident: bib0060 article-title: Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients publication-title: JCI Insight – volume: 228 start-page: 216 year: 1996 end-page: 228 ident: bib0027 article-title: CD44-anchored hyaluronan-rich pericellular matrices: an ultrastructural and biochemical analysis publication-title: Exp. Cell Res. – volume: 221 start-page: 77 year: 2008 end-page: 89 ident: bib0068 article-title: T-cell activation through immunological synapses and kinapses publication-title: Immunol. Rev. – volume: 110 start-page: 2739 year: 2016 end-page: 2750 ident: bib0024 article-title: Cell surface access is modulated by tethered bottlebrush proteoglycans publication-title: Biophys. J. – volume: 78–79 start-page: 118 year: 2019 end-page: 138 ident: bib0035 article-title: Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: regulation of hyaluronan/HAS2/CD44 and specific matrix effectors publication-title: Matrix Biol – volume: 96 start-page: 185 year: 1999 end-page: 190 ident: bib0084 article-title: A two-step, two-signal model for the primary activation of precursor helper T cells publication-title: Proc. Natl. Acad. Sci. – volume: 6 start-page: 1219 year: 2005 end-page: 1227 ident: bib0077 article-title: Inducing and expanding regulatory T cell populations by foreign antigen publication-title: Nat. Immunol. – volume: 56 start-page: 901 year: 2008 end-page: 910 ident: bib0023 article-title: Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions publication-title: J. Histochem. Cytochem. – volume: 282 start-page: 29678 year: 2007 end-page: 29690 ident: bib0028 article-title: Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 complex publication-title: J. Biol. Chem. – volume: 11 year: 2019 ident: bib0043 article-title: Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis publication-title: Sci. Transl. Med. – volume: 78–79 start-page: 60 year: 2019 end-page: 83 ident: bib0033 article-title: TSG-6: a multifunctional protein with anti-inflammatory and tissue-protective properties publication-title: Matrix Biol. – volume: 265 start-page: 11761 year: 1990 end-page: 11765 ident: bib0081 article-title: Effects of length and mRNA secondary structure on the interaction of bovine mitochondrial ribosomes with messenger RNA publication-title: J. Biol. Chem. – volume: 39 start-page: 25 year: 2014 end-page: 32 ident: bib0006 article-title: The structure and function of the pericellular matrix of articular cartilage publication-title: Matrix Biol. – volume: 117 start-page: 3096 year: 2011 end-page: 3103 ident: bib0066 article-title: Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling publication-title: Blood – volume: 180 start-page: 807 year: 1994 end-page: 816 ident: bib0080 article-title: T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis publication-title: J. Exp. Med. – reference: S. Ito, Structure and function of the glycocalyx., Fed. Proc. 28 (n.d.) 12–25. – volume: 7 start-page: 1233 year: 1993 end-page: 1241 ident: bib0031 article-title: Hyaluronan-binding proteins in development, tissue homeostasis, and disease publication-title: FASEB J. – volume: 6 start-page: 622 year: 2005 end-page: 634 ident: bib0018 article-title: Regulation of cadherin-mediated adhesion in morphogenesis publication-title: Nat. Rev. Mol. Cell Biol. – volume: 169 start-page: 4322 year: 2002 end-page: 4331 ident: bib0038 article-title: Synthesis and surface expression of hyaluronan by dendritic cells and its potential role in antigen presentation publication-title: J. Immunol. – volume: 31 start-page: 90 year: 2012 end-page: 100 ident: bib0083 article-title: Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration publication-title: Matrix Biol – volume: 12 start-page: 1113 year: 2012 end-page: 1123 ident: bib0063 article-title: Differential expression of microRNAs during allograft rejection publication-title: Am. J. Transplant. – volume: 90 start-page: 1 year: 2020 end-page: 19 ident: bib0030 article-title: Autophagic degradation of HAS2 in endothelial cells: a novel mechanism to regulate angiogenesis publication-title: Matrix Biol. – volume: 63 start-page: 2727 year: 2014 end-page: 2743 ident: bib0040 article-title: Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis publication-title: Diabetes – volume: 86 start-page: 564 year: 2008 end-page: 573 ident: bib0002 article-title: Characterizing the glycome of the mammalian immune system publication-title: Immunol. Cell Biol. – volume: 59 start-page: 1351 year: 2007 end-page: 1365 ident: bib0001 article-title: Hyaluronan-dependent pericellular matrix publication-title: Adv. Drug Deliv. Rev. – volume: 78–79 start-page: 324 year: 2019 end-page: 336 ident: bib0029 article-title: Role of hyaluronan in atherosclerosis: current knowledge and open questions publication-title: Matrix Biol – reference: . – volume: 25 start-page: 989 year: 2006 end-page: 1001 ident: bib0071 article-title: Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes publication-title: Immunity – volume: 277 start-page: 4585 year: 2002 end-page: 4588 ident: bib0032 article-title: Hyaluronan-binding proteins: tying up the giant publication-title: J. Biol. Chem. – volume: 19 year: 2018 ident: bib0012 article-title: Cancer Cell Glycocalyx and Its Significance in Cancer Progression publication-title: Int. J. Mol. Sci. – volume: 12 start-page: 771 year: 1980 end-page: 780 ident: bib0009 article-title: Surface cables of cardiac myocytes publication-title: J. Mol. Cell. Cardiol. – reference: M.F. Flessner, Endothelial glycocalyx and the peritoneal barrier., Perit. Dial. Int. 28 (n.d.) 6–12. – year: 2019 ident: bib0019 article-title: Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries publication-title: Faraday Discuss – volume: 78–79 start-page: 147 year: 2019 end-page: 164 ident: bib0014 article-title: Activated hyaluronan metabolism in the tumor matrix — Causes and consequences publication-title: Matrix Biol – volume: 78–79 start-page: 100 year: 2019 end-page: 117 ident: bib0036 article-title: Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production publication-title: Matrix Biol. – volume: 185 start-page: 372 year: 2016 end-page: 381 ident: bib0075 article-title: The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice publication-title: Clin. Exp. Immunol. – volume: 9 start-page: 121 year: 2007 end-page: 167 ident: bib0015 article-title: The structure and function of the endothelial glycocalyx layer publication-title: Annu. Rev. Biomed. Eng. – volume: 10 start-page: 2172 year: 2019 ident: bib0065 article-title: Hyaluronic acid synthesis contributes to tissue damage in systemic lupus erythematosus publication-title: Front. Immunol. – volume: 16 start-page: 343 year: 1973 end-page: 350 ident: bib0062 article-title: Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection publication-title: Transplantation – volume: 78–79 start-page: 292 year: 2019 end-page: 313 ident: bib0050 article-title: Hyaluronan in immune dysregulation and autoimmune diseases publication-title: Matrix Biol – volume: 56 start-page: 109 year: 2017 end-page: 120 ident: bib0085 article-title: Modified high-molecular-weight hyaluronan promotes allergen-specific immune tolerance publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 268 start-page: 55 year: 1974 ident: 10.1016/j.matbio.2020.12.001_bib0004 article-title: Form and function of the glycocalyx on free cell surfaces publication-title: Philos. Trans. R. Soc. Lond. B. Biol. Sci. doi: 10.1098/rstb.1974.0015 – volume: 11 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0043 article-title: Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aat9284 – volume: 56 start-page: 901 year: 2008 ident: 10.1016/j.matbio.2020.12.001_bib0023 article-title: Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions publication-title: J. Histochem. Cytochem. doi: 10.1369/jhc.2008.951665 – volume: 12 start-page: 1113 year: 2012 ident: 10.1016/j.matbio.2020.12.001_bib0063 article-title: Differential expression of microRNAs during allograft rejection publication-title: Am. J. Transplant. doi: 10.1111/j.1600-6143.2011.03958.x – volume: 10 start-page: 2172 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0065 article-title: Hyaluronic acid synthesis contributes to tissue damage in systemic lupus erythematosus publication-title: Front. Immunol. doi: 10.3389/fimmu.2019.02172 – volume: 282 start-page: 29678 year: 2007 ident: 10.1016/j.matbio.2020.12.001_bib0028 article-title: Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 complex publication-title: J. Biol. Chem. doi: 10.1074/jbc.M704339200 – volume: 16 start-page: 220 year: 2016 ident: 10.1016/j.matbio.2020.12.001_bib0056 article-title: T cell receptor signalling in the control of regulatory T cell differentiation and function publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2016.26 – volume: 179 start-page: 8191 year: 2007 ident: 10.1016/j.matbio.2020.12.001_bib0059 article-title: Hyaluronan synthesis is required for IL-2-mediated T cell proliferation publication-title: J. Immunol. doi: 10.4049/jimmunol.179.12.8191 – volume: 132 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0022 article-title: Dynamic cell-cell adhesion mediated by pericellular matrix interaction - a hypothesis publication-title: J. Cell Sci. doi: 10.1242/jcs.231597 – volume: 78–79 start-page: 292 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0050 article-title: Hyaluronan in immune dysregulation and autoimmune diseases publication-title: Matrix Biol doi: 10.1016/j.matbio.2018.03.022 – volume: 7 start-page: 1233 year: 1993 ident: 10.1016/j.matbio.2020.12.001_bib0031 article-title: Hyaluronan-binding proteins in development, tissue homeostasis, and disease publication-title: FASEB J. doi: 10.1096/fasebj.7.13.7691670 – volume: 6 start-page: 622 year: 2005 ident: 10.1016/j.matbio.2020.12.001_bib0018 article-title: Regulation of cadherin-mediated adhesion in morphogenesis publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1699 – volume: 205 start-page: 363 year: 2004 ident: 10.1016/j.matbio.2020.12.001_bib0016 article-title: Communication between paired chondrocytes in the superficial zone of articular cartilage publication-title: J. Anat. doi: 10.1111/j.0021-8782.2004.00350.x – volume: 78–79 start-page: 324 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0029 article-title: Role of hyaluronan in atherosclerosis: current knowledge and open questions publication-title: Matrix Biol doi: 10.1016/j.matbio.2018.03.003 – volume: 363 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0086 article-title: Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection publication-title: Science doi: 10.1126/science.aat9691 – volume: 6 start-page: 1219 year: 2005 ident: 10.1016/j.matbio.2020.12.001_bib0077 article-title: Inducing and expanding regulatory T cell populations by foreign antigen publication-title: Nat. Immunol. doi: 10.1038/ni1265 – volume: 7 start-page: 211 year: 2010 ident: 10.1016/j.matbio.2020.12.001_bib0037 article-title: Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse publication-title: Cell. Mol. Immunol. doi: 10.1038/cmi.2010.9 – volume: 65 start-page: 1160 year: 2013 ident: 10.1016/j.matbio.2020.12.001_bib0049 article-title: Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts publication-title: Arthritis Rheum doi: 10.1002/art.37861 – volume: 7 year: 2016 ident: 10.1016/j.matbio.2020.12.001_bib0067 article-title: TCR signal strength alters T–DC activation and interaction times and directs the outcome of differentiation publication-title: Front. Immunol. doi: 10.3389/fimmu.2016.00006 – ident: 10.1016/j.matbio.2020.12.001_bib0073 – volume: 183 start-page: 4895 year: 2009 ident: 10.1016/j.matbio.2020.12.001_bib0054 article-title: Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion publication-title: J. Immunol. doi: 10.4049/jimmunol.0901459 – volume: 63 start-page: 2727 year: 2014 ident: 10.1016/j.matbio.2020.12.001_bib0040 article-title: Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis publication-title: Diabetes doi: 10.2337/db13-1658 – volume: 32 start-page: 2074 year: 2002 ident: 10.1016/j.matbio.2020.12.001_bib0058 article-title: Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases publication-title: Eur. J. Immunol. doi: 10.1002/1521-4141(200207)32:7<2074::AID-IMMU2074>3.0.CO;2-S – volume: 291 start-page: 8014 year: 2016 ident: 10.1016/j.matbio.2020.12.001_bib0070 article-title: Binding of hyaluronan to the native lymphatic vessel endothelial receptor LYVE-1 Is critically dependent on receptor clustering and hyaluronan organization publication-title: J. Biol. Chem. doi: 10.1074/jbc.M115.708305 – volume: 78–79 start-page: 118 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0035 article-title: Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: regulation of hyaluronan/HAS2/CD44 and specific matrix effectors publication-title: Matrix Biol doi: 10.1016/j.matbio.2018.04.007 – volume: 59 start-page: 1351 year: 2007 ident: 10.1016/j.matbio.2020.12.001_bib0001 article-title: Hyaluronan-dependent pericellular matrix publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2007.08.008 – volume: 78–79 start-page: 1 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0005 article-title: Hyaluronan biology: a complex balancing act of structure, function, location and context publication-title: Matrix Biol. doi: 10.1016/j.matbio.2019.02.002 – volume: 315 start-page: 1914 year: 2009 ident: 10.1016/j.matbio.2020.12.001_bib0041 article-title: 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3 publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2009.03.002 – volume: 12 start-page: 771 year: 1980 ident: 10.1016/j.matbio.2020.12.001_bib0009 article-title: Surface cables of cardiac myocytes publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/0022-2828(80)90079-6 – volume: 265 start-page: 11761 year: 1990 ident: 10.1016/j.matbio.2020.12.001_bib0081 article-title: Effects of length and mRNA secondary structure on the interaction of bovine mitochondrial ribosomes with messenger RNA publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)38463-7 – volume: 272 start-page: 13997 year: 1997 ident: 10.1016/j.matbio.2020.12.001_bib0026 article-title: Hyaluronan synthases publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.22.13997 – volume: 12 year: 2017 ident: 10.1016/j.matbio.2020.12.001_bib0017 article-title: Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication publication-title: PLoS One doi: 10.1371/journal.pone.0186116 – volume: 98 start-page: 427 year: 1999 ident: 10.1016/j.matbio.2020.12.001_bib0079 article-title: CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease publication-title: Immunology doi: 10.1046/j.1365-2567.1999.00894.x – volume: 90 start-page: 1 year: 2020 ident: 10.1016/j.matbio.2020.12.001_bib0030 article-title: Autophagic degradation of HAS2 in endothelial cells: a novel mechanism to regulate angiogenesis publication-title: Matrix Biol. doi: 10.1016/j.matbio.2020.02.001 – volume: 78–79 start-page: 60 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0033 article-title: TSG-6: a multifunctional protein with anti-inflammatory and tissue-protective properties publication-title: Matrix Biol. doi: 10.1016/j.matbio.2018.01.011 – volume: 6 start-page: 123 year: 2015 ident: 10.1016/j.matbio.2020.12.001_bib0045 article-title: 4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer publication-title: Front. Immunol. doi: 10.3389/fimmu.2015.00123 – volume: 117 start-page: 3096 year: 2011 ident: 10.1016/j.matbio.2020.12.001_bib0066 article-title: Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling publication-title: Blood doi: 10.1182/blood-2010-08-301275 – volume: 9 start-page: 121 year: 2007 ident: 10.1016/j.matbio.2020.12.001_bib0015 article-title: The structure and function of the endothelial glycocalyx layer publication-title: Annu. Rev. Biomed. Eng. doi: 10.1146/annurev.bioeng.9.060906.151959 – volume: 31 start-page: 90 year: 2012 ident: 10.1016/j.matbio.2020.12.001_bib0083 article-title: Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration publication-title: Matrix Biol doi: 10.1016/j.matbio.2011.10.004 – volume: 277 start-page: 4585 year: 2002 ident: 10.1016/j.matbio.2020.12.001_bib0032 article-title: Hyaluronan-binding proteins: tying up the giant publication-title: J. Biol. Chem. doi: 10.1074/jbc.R100036200 – ident: 10.1016/j.matbio.2020.12.001_bib0003 – volume: 78–79 start-page: 47 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0020 article-title: An integrated assay to probe endothelial glycocalyx-blood cell interactions under flow in mechanically and biochemically well-defined environments publication-title: Matrix Biol. doi: 10.1016/j.matbio.2018.12.002 – volume: 4 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0060 article-title: Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients publication-title: JCI Insight doi: 10.1172/jci.insight.127244 – volume: 113 start-page: 1339 year: 2016 ident: 10.1016/j.matbio.2020.12.001_bib0047 article-title: Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.1525086113 – volume: 108 start-page: 7938 year: 2011 ident: 10.1016/j.matbio.2020.12.001_bib0087 article-title: ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1017360108 – volume: 39 start-page: 25 year: 2014 ident: 10.1016/j.matbio.2020.12.001_bib0006 article-title: The structure and function of the pericellular matrix of articular cartilage publication-title: Matrix Biol. doi: 10.1016/j.matbio.2014.08.009 – volume: 80 start-page: 46 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0034 article-title: Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control publication-title: Matrix Biol. doi: 10.1016/j.matbio.2018.09.003 – volume: 221 start-page: 77 year: 2008 ident: 10.1016/j.matbio.2020.12.001_bib0068 article-title: T-cell activation through immunological synapses and kinapses publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2008.00589.x – volume: 185 start-page: 372 year: 2016 ident: 10.1016/j.matbio.2020.12.001_bib0075 article-title: The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice publication-title: Clin. Exp. Immunol. doi: 10.1111/cei.12815 – volume: 69 start-page: 777 year: 2014 ident: 10.1016/j.matbio.2020.12.001_bib0007 article-title: The endothelial glycocalyx: a review of the vascular barrier publication-title: Anaesthesia doi: 10.1111/anae.12661 – volume: 56 start-page: 109 year: 2017 ident: 10.1016/j.matbio.2020.12.001_bib0085 article-title: Modified high-molecular-weight hyaluronan promotes allergen-specific immune tolerance publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2016-0111OC – volume: 96 start-page: 185 year: 1999 ident: 10.1016/j.matbio.2020.12.001_bib0084 article-title: A two-step, two-signal model for the primary activation of precursor helper T cells publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.96.1.185 – volume: 187 start-page: 3511 year: 2011 ident: 10.1016/j.matbio.2020.12.001_bib0055 article-title: Low-dose antigen promotes induction of FOXP3 in human CD4+ T cells publication-title: J. Immunol. doi: 10.4049/jimmunol.1003880 – volume: 18 start-page: 762 year: 2017 ident: 10.1016/j.matbio.2020.12.001_bib0069 article-title: Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1 publication-title: Nat. Immunol. doi: 10.1038/ni.3750 – volume: 99 start-page: 3609 year: 2002 ident: 10.1016/j.matbio.2020.12.001_bib0078 article-title: Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.052026799 – volume: 78–79 start-page: 292 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0074 article-title: Hyaluronan in immune dysregulation and autoimmune diseases publication-title: Matrix Biol doi: 10.1016/j.matbio.2018.03.022 – volume: 179 start-page: 744 year: 2007 ident: 10.1016/j.matbio.2020.12.001_bib0053 article-title: Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells publication-title: J. Immunol. doi: 10.4049/jimmunol.179.2.744 – volume: 185 start-page: 4760 year: 2010 ident: 10.1016/j.matbio.2020.12.001_bib0057 article-title: Cellular requirements for diabetes induction in DO11.10xRIPmOVA Mice publication-title: J. Immunol. doi: 10.4049/jimmunol.1000820 – volume: 91 start-page: 221 year: 2011 ident: 10.1016/j.matbio.2020.12.001_bib0025 article-title: Hyaluronan as an immune regulator in human diseases publication-title: Physiol. Rev. doi: 10.1152/physrev.00052.2009 – volume: 11 start-page: 332 year: 2016 ident: 10.1016/j.matbio.2020.12.001_bib0072 article-title: Immunosuppressive medications publication-title: Clin. J. Am. Soc. Nephrol. doi: 10.2215/CJN.08570814 – volume: 25 start-page: 989 year: 2006 ident: 10.1016/j.matbio.2020.12.001_bib0071 article-title: Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes publication-title: Immunity doi: 10.1016/j.immuni.2006.10.011 – volume: 294 start-page: 7864 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0051 article-title: 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition publication-title: J. Biol. Chem. doi: 10.1074/jbc.RA118.006166 – year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0019 article-title: Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries publication-title: Faraday Discuss doi: 10.1039/C9FD00024K – volume: 113 start-page: 101 year: 2017 ident: 10.1016/j.matbio.2020.12.001_bib0021 article-title: Endothelial glycocalyx-mediated nitric oxide production in response to selective AFM pulling publication-title: Biophys. J. doi: 10.1016/j.bpj.2017.05.033 – volume: 19 year: 2017 ident: 10.1016/j.matbio.2020.12.001_bib0010 article-title: Hepatitis C virus infection propagates through interactions between Syndecan-1 and CD81 and impacts the hepatocyte glycocalyx publication-title: Cell. Microbiol. doi: 10.1111/cmi.12711 – volume: 86 start-page: 567 year: 2009 ident: 10.1016/j.matbio.2020.12.001_bib0052 article-title: Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0109001 – volume: 11 start-page: 1982 year: 2020 ident: 10.1016/j.matbio.2020.12.001_bib0061 article-title: Human regulatory dendritic cells develop from monocytes in response to signals from regulatory and helper T cells publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.01982 – volume: 289 start-page: 22888 year: 2014 ident: 10.1016/j.matbio.2020.12.001_bib0048 article-title: Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.559583 – volume: 19 year: 2018 ident: 10.1016/j.matbio.2020.12.001_bib0012 article-title: Cancer Cell Glycocalyx and Its Significance in Cancer Progression publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19092484 – volume: 110 start-page: 2739 year: 2016 ident: 10.1016/j.matbio.2020.12.001_bib0024 article-title: Cell surface access is modulated by tethered bottlebrush proteoglycans publication-title: Biophys. J. doi: 10.1016/j.bpj.2016.05.027 – volume: 180 start-page: 807 year: 1994 ident: 10.1016/j.matbio.2020.12.001_bib0080 article-title: T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis publication-title: J. Exp. Med. doi: 10.1084/jem.180.3.807 – volume: 78–79 start-page: 100 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0036 article-title: Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production publication-title: Matrix Biol. doi: 10.1016/j.matbio.2018.01.017 – volume: 125 start-page: 3928 year: 2015 ident: 10.1016/j.matbio.2020.12.001_bib0046 article-title: Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis publication-title: J. Clin. Invest. doi: 10.1172/JCI79271 – volume: 28 start-page: 663 year: 1982 ident: 10.1016/j.matbio.2020.12.001_bib0008 article-title: Structure of the pericellular matrix: association of heparan and chondroitin sulfates with fibronectin-procollagen fibers publication-title: Cell doi: 10.1016/0092-8674(82)90221-5 – volume: 230 start-page: 216 year: 2009 ident: 10.1016/j.matbio.2020.12.001_bib0039 article-title: Immunological functions of hyaluronan and its receptors in the lymphatics publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2009.00803.x – volume: 37 start-page: 263 year: 2016 ident: 10.1016/j.matbio.2020.12.001_bib0013 article-title: Endothelial and Microcirculatory Function and Dysfunction in Sepsis publication-title: Clin. Chest Med. doi: 10.1016/j.ccm.2016.01.009 – volume: 169 start-page: 4322 year: 2002 ident: 10.1016/j.matbio.2020.12.001_bib0038 article-title: Synthesis and surface expression of hyaluronan by dendritic cells and its potential role in antigen presentation publication-title: J. Immunol. doi: 10.4049/jimmunol.169.8.4322 – volume: 78–79 start-page: 147 year: 2019 ident: 10.1016/j.matbio.2020.12.001_bib0014 article-title: Activated hyaluronan metabolism in the tumor matrix — Causes and consequences publication-title: Matrix Biol doi: 10.1016/j.matbio.2018.04.012 – ident: 10.1016/j.matbio.2020.12.001_bib0011 doi: 10.1177/089686080802800102 – volume: 279 start-page: 33281 year: 2004 ident: 10.1016/j.matbio.2020.12.001_bib0042 article-title: A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone publication-title: J. Biol. Chem. doi: 10.1074/jbc.M405918200 – volume: 38 start-page: 1250 year: 2015 ident: 10.1016/j.matbio.2020.12.001_bib0044 article-title: Treatment with the hyaluronic Acid synthesis inhibitor 4-methylumbelliferone suppresses LPS-induced lung inflammation publication-title: Inflammation doi: 10.1007/s10753-014-0092-y – volume: 20 start-page: 1793 year: 2006 ident: 10.1016/j.matbio.2020.12.001_bib0082 article-title: Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes publication-title: FASEB J doi: 10.1096/fj.06-6207com – volume: 186 start-page: 5039 year: 2011 ident: 10.1016/j.matbio.2020.12.001_bib0076 article-title: Strength of TCR–peptide/MHC interactions and In Vivo T Cell responses publication-title: J. Immunol doi: 10.4049/jimmunol.1003650 – volume: 16 start-page: 343 year: 1973 ident: 10.1016/j.matbio.2020.12.001_bib0062 article-title: Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection publication-title: Transplantation doi: 10.1097/00007890-197310000-00010 – volume: 228 start-page: 216 year: 1996 ident: 10.1016/j.matbio.2020.12.001_bib0027 article-title: CD44-anchored hyaluronan-rich pericellular matrices: an ultrastructural and biochemical analysis publication-title: Exp. Cell Res. doi: 10.1006/excr.1996.0320 – volume: 86 start-page: 564 year: 2008 ident: 10.1016/j.matbio.2020.12.001_bib0002 article-title: Characterizing the glycome of the mammalian immune system publication-title: Immunol. Cell Biol. doi: 10.1038/icb.2008.54 – volume: 65 start-page: 1160 year: 2013 ident: 10.1016/j.matbio.2020.12.001_bib0064 article-title: Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in hUMAN RHEUMATOID SYNOVIAL FIBROblasts publication-title: Arthritis Rheum. doi: 10.1002/art.37861 |
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| Snippet | •Hyaluronan (HA) is deposited in inflamed lymph nodes by antigen presenting cells.•Inhibition of HA prevents inflammatory T-cell activation and promotes FoxP3+... A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone... |
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| SubjectTerms | 4-methylumbelliferone Animals Antigen presentation Antigen Presentation - drug effects Cell activation Cell interactions Cell proliferation Cell Proliferation - drug effects Cells, Cultured Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - metabolism Disease Models, Animal Glycocalyx Graft rejection Graft Rejection - immunology Graft Rejection - prevention & control Heart transplantation Heart Transplantation - adverse effects Humans Hyaluronan Hyaluronic acid Hyaluronic Acid - biosynthesis Hymecromone - administration & dosage Hymecromone - pharmacology Leukocytes - cytology Leukocytes - drug effects Leukocytes - immunology Lymphocytes T Mice Pancreas transplantation Pancreas Transplantation - adverse effects Pancreatic islet transplantation T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism Transplantation Transplantation, Homologous Transplants & implants |
| Title | Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection |
| URI | https://dx.doi.org/10.1016/j.matbio.2020.12.001 https://www.ncbi.nlm.nih.gov/pubmed/33290836 https://www.proquest.com/docview/2533405782 https://www.proquest.com/docview/2468659132 https://pubmed.ncbi.nlm.nih.gov/PMC8147171 |
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