Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial - Fulton, Cathy R; Zang, Yong; Desta, Zeruesenay; Rosenman, Marc B; Holmes, Ann M; Decker, Brian S; Zhang, Yifei; T Callaghan, John; Pratt, Victoria M; Levy, Kenneth D; Gufford, Brandon T; Dexter, Paul R; et al. (Pharmacogenomics, 2019)
Keywords: Adult; adverse side effects; Aged; Aged, 80 and over; Algorithms; Analgesics; Analgesics, Opioid - therapeutic use; Codeine; Codeine - therapeutic use; CYP2D6; CYP2D6 protein; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P450; Drug dosages; Drug Interactions - genetics; Enrollments; Female; Genomics; Genotype & phenotype; Genotyping; Humans; IGNITE; INGENIOUS; Male; Metabolism; Metabolites; Middle Aged; Narcotics; Opioids; Pain; Pharmacogenetics - methods; pharmacogenetics; opioids; Pharmacogenomics; phenoconversion; Prescription drugs; Tramadol; Tramadol - therapeutic use; Working groups; Young Adult; Indiana; pharmacogenomics; IGNITE; CYP2D6; phenoconversion; INGENIOUS; adverse side effects; pharmacogenetics; opioids