Differences between diaphragmatic compound muscle action potentials recorded from over the sternum and lateral chest wall in healthy subjects

• Published in: Scientific reports Vol. 12; no. 1; pp. 8925 - 14
• Main Authors: Younis, Gihan, El Sawy, Noha, Elnemr, Rehab, Madkour, Doaa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 692/617; Action Potentials - physiology; Body mass index; Chest; Consent; Diaphragm; Electrodes; Ethics; Female; Healthy Volunteers; Humanities and Social Sciences; Humans; Latency; Male; Medicine; multidisciplinary; Neural Conduction - physiology; Phrenic nerve; Regression analysis; Rib cage; Science; Science (multidisciplinary); Sternocleidomastoid muscle; Sternum; Thoracic Wall; Women
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-11930-1

To report normative data for diaphragmatic compound muscle action potentials (DCMAPs) recorded from over the sternum and lateral chest wall (LCW) and highlight factors that may contribute to variations in DCMAP parameters at the two sites. The phrenic nerve of seventy-three healthy subjects was bilaterally stimulated at the posterior border of the sternocleidomastoid muscle. DCMAPs from over the sternum and LCW were recorded (inspiration/expiration). Normative values of sternal and LCW DCMAPs were presented. The mean values of latency of LCW DCMAPs, duration of sternal DCMAPs and area from both recording sites are close to values reported by other studies. The mean values of latency of sternal DCMAPs are higher than that reported by other studies. Significant differences were found between sternal and LCW potentials in the mean latency, amplitude, and area ( p  < 0.001). The duration did not differ between the two sites. Differences were found between inspiration and expiration, right and left sides, and men and women. Regression analysis showed a relation between latency of sternal and LCW potentials and age. Latency (LCW potentials) and amplitude and area (sternal/LCW potentials) were related to gender. Amplitude (LCW potentials/inspiration) and area (sternal potentials/inspiration) were related to chest circumference ( p  = 0.023 and 0.013 respectively). Area (sternal potentials/expiration) was related to the BMI ( p  = 0.019). Our normative values for sternal and LCW DCMAPs are provided. Notable differences in the DCMAPs parameters were detected between the two recording sites, inspiration and expiration, right and left, and men and women. The technique of phrenic nerve should be standardized.