Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family
Positive and negative costimulation by members of the CD28 family is critical for the development of productive immune responses against foreign pathogens and their proper termination to prevent inflammation‐induced tissue damage. In addition, costimulatory signals are critical for the establishment...
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| Published in | Immunological reviews Vol. 241; no. 1; pp. 180 - 205 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.05.2011
Blackwell |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0105-2896 1600-065X 1600-065X |
| DOI | 10.1111/j.1600-065X.2011.01011.x |
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| Abstract | Positive and negative costimulation by members of the CD28 family is critical for the development of productive immune responses against foreign pathogens and their proper termination to prevent inflammation‐induced tissue damage. In addition, costimulatory signals are critical for the establishment and maintenance of peripheral tolerance. This paradigm has been established in many animal models and has led to the development of immunotherapies targeting costimulation pathways for the treatment of cancer, autoimmune disease, and allograft rejection. During the last decade, the complexity of the biology of costimulatory pathways has greatly increased due to the realization that costimulation does not affect only effector T cells but also influences regulatory T cells and antigen‐presenting cells. Thus, costimulation controls T‐cell tolerance through both intrinsic and extrinsic pathways. In this review, we discuss the influence of costimulation on intrinsic and extrinsic pathways of peripheral tolerance, with emphasis on members of the CD28 family, CD28, cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4), and programmed death‐1 (PD‐1), as well as the downstream cytokine interleukin‐1 (IL‐2). |
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| AbstractList | Positive and negative costimulation by members of the CD28 family is critical for the development of productive immune responses against foreign pathogens and their proper termination to prevent inflammation-induced tissue damage. In addition, costimulatory signals are critical for the establishment and maintenance of peripheral tolerance. This paradigm has been established in many animal models and has led to the development of immunotherapies targeting costimulation pathways for the treatment of cancer, autoimmune disease, and allograft rejection. During the last decade, the complexity of the biology of costimulatory pathways has greatly increased due to the realization that costimulation does not affect only effector T cells but also influences regulatory T cells and antigen-presenting cells. Thus, costimulation controls T-cell tolerance through both intrinsic and extrinsic pathways. In this review, we discuss the influence of costimulation on intrinsic and extrinsic pathways of peripheral tolerance, with emphasis on members of the CD28 family, CD28, cytotoxic T-lymphocyte antigen-4 (CTLA-4), and programmed death-1 (PD-1), as well as the downstream cytokine interleukin-1 (IL-2). Positive and negative costimulation by members of the CD28 family is critical for the development of productive immune responses against foreign pathogens and their proper termination to prevent inflammation-induced tissue damage. In addition, costimulatory signals are critical for the establishment and maintenance of peripheral tolerance. This paradigm has been established in many animal models and has led to the development of immunotherapies targeting costimulation pathways for the treatment of cancer, autoimmune disease, and allograft rejection. During the last decade, the complexity of the biology of costimulatory pathways has greatly increased due to the realization that costimulation does not affect only effector T cells but also influences regulatory T cells and antigen-presenting cells. Thus, costimulation controls T-cell tolerance through both intrinsic and extrinsic pathways. In this review, we discuss the influence of costimulation on intrinsic and extrinsic pathways of peripheral tolerance, with emphasis on members of the CD28 family, CD28, cytotoxic T-lymphocyte antigen-4 (CTLA-4), and programmed death-1 (PD-1), as well as the downstream cytokine interleukin-1 (IL-2).Positive and negative costimulation by members of the CD28 family is critical for the development of productive immune responses against foreign pathogens and their proper termination to prevent inflammation-induced tissue damage. In addition, costimulatory signals are critical for the establishment and maintenance of peripheral tolerance. This paradigm has been established in many animal models and has led to the development of immunotherapies targeting costimulation pathways for the treatment of cancer, autoimmune disease, and allograft rejection. During the last decade, the complexity of the biology of costimulatory pathways has greatly increased due to the realization that costimulation does not affect only effector T cells but also influences regulatory T cells and antigen-presenting cells. Thus, costimulation controls T-cell tolerance through both intrinsic and extrinsic pathways. In this review, we discuss the influence of costimulation on intrinsic and extrinsic pathways of peripheral tolerance, with emphasis on members of the CD28 family, CD28, cytotoxic T-lymphocyte antigen-4 (CTLA-4), and programmed death-1 (PD-1), as well as the downstream cytokine interleukin-1 (IL-2). |
| Author | Penaranda, Cristina Stumpf, Melanie Martinez-Llordella, Marc Esensten, Jonathan H. Bluestone, Jeffrey A. Bour-Jordan, Hélène |
| Author_xml | – sequence: 1 givenname: Hélène surname: Bour-Jordan fullname: Bour-Jordan, Hélène organization: UCSF Diabetes Center, University of California at San Francisco, San Francisco, CA, USA – sequence: 2 givenname: Jonathan H. surname: Esensten fullname: Esensten, Jonathan H. organization: UCSF Diabetes Center, University of California at San Francisco, San Francisco, CA, USA – sequence: 3 givenname: Marc surname: Martinez-Llordella fullname: Martinez-Llordella, Marc organization: UCSF Diabetes Center, University of California at San Francisco, San Francisco, CA, USA – sequence: 4 givenname: Cristina surname: Penaranda fullname: Penaranda, Cristina organization: UCSF Diabetes Center, University of California at San Francisco, San Francisco, CA, USA – sequence: 5 givenname: Melanie surname: Stumpf fullname: Stumpf, Melanie organization: UCSF Diabetes Center, University of California at San Francisco, San Francisco, CA, USA – sequence: 6 givenname: Jeffrey A. surname: Bluestone fullname: Bluestone, Jeffrey A. organization: UCSF Diabetes Center, University of California at San Francisco, San Francisco, CA, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24073810$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21488898$$D View this record in MEDLINE/PubMed |
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| CODEN | IMRED2 |
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| SubjectTerms | Analytical, structural and metabolic biochemistry Animals Antigen-Presenting Cells - immunology Antigens, CD - immunology Apoptosis Regulatory Proteins - immunology Autoimmune Diseases - immunology Autoimmune Diseases - therapy B7-1 Antigen - immunology Biological and medical sciences CD28 CD28 Antigens - immunology costimulation CTLA-4 CTLA-4 Antigen Fundamental and applied biological sciences. Psychology Graft Rejection - immunology Graft Rejection - therapy Humans Immune Tolerance Immunotherapy - trends Neoplasms - immunology Neoplasms - therapy PD-1 Programmed Cell Death 1 Receptor Receptor Cross-Talk T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology tolerance Tregs |
| Title | Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family |
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